COX-2 regulates the proliferation of glioma stem like cells
Keywords: Glioblastoma; COX-2; IL-1β; p53;
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FRET analysis of protein tyrosine kinase c-Src activation mediated via aryl hydrocarbon receptor
Keywords: AhR; COX-2; c-Src; EGF; FRET; TCDD;
Cryptotanshinone inhibits LPS-induced proinflammatory mediators via TLR4 and TAK1 signaling pathway
Keywords: COX-2; cyclooxygenase-2; DMSO; dimethyl sulfoxide; D-GlaN; D-galactosamine; IL-1; interleukin-1; IκB-α; inhibitory kappa B-α; IKK; IκB kinase; iNOS; inducible nitric oxide synthase; IRAK; interleukin-1 receptor-associated kinase; LPS; lipopolysacchari
Immunohistochemical COX-2 overexpression correlates with HER-2/neu overexpression in invasive breast carcinomas: A pilot study
Keywords: COX-2; HER-2/neu; Breast cancer; Immunohistochemistry;
Native Australian fruit polyphenols inhibit COX-2 and iNOS expression in LPS-activated murine macrophages
Keywords: COX-2; iNOS; Kakadu Plum (Terminalia ferdinandiana); Native Australian fruits; Polyphenols;
Inhibitory effects of (â)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages
Keywords: (â)-α-Bisabolol; iNOS; COX-2; NF-κB; AP-1;
Acrylamide up-regulates cyclooxygenase-2 expression through the MEK/ERK signaling pathway in mouse epidermal cells
Keywords: Acrylamide; COX-2; MEK/ERK;
Pycnogenol modulates apoptosis by suppressing oxidative stress and inflammation in high glucose-treated renal tubular cells
Keywords: COX-2; cyclooxygenase-2; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride n-hydrate; DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; DHR 123; dihydrorhodamine 123; DMEM/F-12; Dulbecco's modified Eagle medium/nutrient mixture F-12; FCS; fetal calf
In vitro anti-inflammatory and anti-cancer activities of Cuscuta reflexa Roxb.
Keywords: DMEM; Dulbecco's modified Eagle medium; TNF-α; tumour necrosis factor α; COX-2; cyclooxygenase-2; dNTPs; di nucleotide triphosphates; EMSA; electrophoretic mobility shift assay; NF-κB; nuclear factor κB; DTTD; di thiothretol; DAPI; 4â²,6-diamidino-2-
Anti-atherogenic effect of San-Huang-Xie-Xin-Tang, a traditional Chinese medicine, in cultured human aortic smooth muscle cells
Keywords: SHXXT; San-Huang-Xie-Xin-Tang; HASMC; human aortic smooth muscle cell; LPS; lipopolysaccharides; ROS; reactive oxygen species; MTT; dimethyl-thiazol-diphenyltetrazoliumbromide; IL-1β; interleukin 1β; IL-6; interleukin 6; IL-8; interleukin 8; MCP-1; mono
Anti-inflammatory activities and mechanisms of action of the petroleum ether fraction of Rosa multiflora Thunb. hips
Keywords: Rose hips; Rosa multiflora Thunb.; Anti-inflammation; COX-2; iNOS;
Salvianolic acid A suppress lipopolysaccharide-induced NF-κB signaling pathway by targeting IKKβ
Keywords: LPS; lipopolysaccharide; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; NF-κB; nuclear factor-kappa B; IκBα; inhibitory kappa B-α; IKKβ; IκB kinase β; IMAP-TR-FRET; immobilized metal affini
Measurement of cyclooxygenase inhibition using liquid chromatography–tandem mass spectrometry
Keywords: LC–MS–MS; COX-1; COX-2; Cyclooxygenase; Prostaglandin E2
Impact of the composition of gastric reflux bile acids on Barrett's oesophagus
Keywords: Barrett's oesophagus; COX-2; Erosive oesophagitis; Reflux bile acids
Upregulated Expression of Toll-like Receptor 4 in Peripheral Blood of Ischaemic Stroke Patients Correlates with Cyclooxygenase 2 Expression
Keywords: COX-2; Gene expression; Ischaemic stroke; Peripheral blood; TLR4
Correlation of E-cadherin, VEGF, COX-2 expression to prognostic parameters in papillary thyroid carcinoma
Keywords: PTC; COX-2; VEGF; E-cadherin; Prognostic factors
Prognostic relevance of cyclooxygenase-2 (COX-2) expression in Chinese patients with prostate cancer
Keywords: Prostate cancer; Cyclooxygenase-2; COX-2; Immunohistochemistry; Disease-free survival; Overall survival; Prognosis
Cox-2 expression, PGE2 and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice
Keywords: Cox-2; Fat-1 mice; Colitis; Inflammation
COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary cancer
Keywords: Angiogenesis; Canine mammary tumours; COX-2; CD31; VEGF
Withaferin A down-regulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells
Keywords: Withaferin A; Microglia; COX-2; STAT
Preoperative Taxane-Based Chemotherapy and Celecoxib for Carcinoma of the Esophagus and Gastroesophageal Junction: Results of a Phase 2 Trial
Keywords: COX-2; Celecoxib; Esophageal cancer;
Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-α-treated A549 cells
Keywords: Triptolide; COX-2; mRNA stability; HuR
Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways
Keywords: WA; Withangulatin A; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; CsA; Cyclosporine A; CoPP; cobalt protoporphyrin; ConA; Concanavalin A; IL; interleukin; IFN-γ; interferon-γ; BCIP/NBT; 5-bromo-4-chloro-3-indolyl-phosphate/nitro bl
Vitamin D and cancer: Deciphering the truth
Keywords: AIF; apoptosis-inducing factor; CDK; cyclin-dependent kinase; COX-2; cyclo-oxygenase 2; E2F1; E2F transcription factor 1; HIF1a; hypoxia inducible factor 1 alpha; hTERT; human telomerase reverse transcriptase; IL-8; interleukin-8; NFkB; nuclear factor kap
Analiza ekspresji HIF-1α i COX-2 w utkaniu guza oraz korelacja ze stopniem inwazyjnoÅci zmian nowotworowych u chorych z rakiem krtani - badania wstÄpne
Keywords: rak pÅaskonabÅonkowy krtani; HIF-1α; COX-2; inwazyjnoÅÄ zmian nowotworowych; squamous cell laryngeal carcinoma; HIF-1α; COX-2; neoplastic invasiveness;
Research reportIntracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats
Keywords: ACSF; artificial cerebrospinal fluid; AP5; 2-amino-5-phosphonopentanoic acid; COX-2; cyclooxygenase-2; i.c.v.; intracerebroventricular; IL-1β; interleukin-1β; IL-1R; interleukin-1 receptor; IL-1ra; endogenous antagonist of interleukin-1 receptor; IL-6;
Anti-inflammatory effects of [6]-shogaol: Potential roles of HDAC inhibition and HSP70 induction
Keywords: CNS; central nervous system; COX-2; cyclooxygenase-2; GFAP; glial fibrillary acidic protein; HSP; heat-shock protein; HDAC; histone deacetylase; iNOS; inducible nitric oxide syntheses; LPS; lipopolysaccharide; MEM; minimal essential media; MS; MS-275; TSA
Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells
Keywords: Sulforaphane; Gemcitabine; Bcl-2; COX-2; IL-1β; Chemoprevention
Immunohistochemical expression of proinflammatory cytokines IL-1β, IL-6, TNF-α and involvement of COX-2, quantitatively confirmed by Western blot analysis, in Wernicke's encephalopathy
Keywords: Wernicke's encephalopathy; IL-1β; IL-6; TNF-α; COX-2; Immunohistochemistry; Western blot
Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease
Keywords: Cyclooxygenase-1 (COX-1); COX-2; COX-2 inhibitor; Arachidonic acid (AA); Prostacyclin or prostaglandin I2 (PGI2); PGI2 synthase (PGIS) and FRET;
Interleukin-6 plays a protective role in development of cisplatin-induced acute renal failure through upregulation of anti-oxidative stress factors
Keywords: Cisplatin; Renal failure; IL-6 deficiency; 4-HNE; cox-2; Oxidative stress
Anti-inflammatory effects of Pulvis Fellis Suis extract in mice with ulcerative colitis
Keywords: ANOVA; one-way analysis of variance; CD; Crohn's disease; COX-2; cyclooxygenase-2; ELISA; enzyme-linked immunosorbent assay; IBD; inflammatory bowel disease; IFN-γ; interferon-γ; IL; interleukin; iNOS; inducible nitric oxide synthase; MPO; myeloperoxida
Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways
Keywords: AS; Angelica sinensis; LPS; lipopolysaccharide; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; NF-κB; nuclear factor κB; AP-1; activator protein-1; TNF-α; tumor necrosis factor-α; iROS; intrac
Safety issues in the development of treatments for osteoarthritis: recommendations of the Safety Considerations Working Group
Keywords: Safety assessments; Serious adverse events; Cardiovascular risks; NSAIDs; COX-2
Polymorphisms in COX-2 Gene Influence Prostate Cancer Susceptibility in a Northern Indian Cohort
Keywords: COX-2; Prostate cancer; Inflammation
Nonsteroidal Anti-Inflammatory Treatment Prevents Delayed Effects of Early Life Stress in Rats
Keywords: Adolescence; COX-2; development; inflammation; parvalbumin; stress; working memory
Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in mice
Keywords: Ulcerative colitis; Taurohyodeoxycholic acid; MPO; TNF-α; IL-6; COX-2;
Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures
Keywords: Ketogenic diet; Kainic acid; PPARγ; COX-2; Hippocampus;
Inhibitory effect of plant-originated glycoprotein (27 kDa) on expression of matrix metalloproteinase-9 in cadmium chloride-induced BNL CL.2 cells
Keywords: Gardenia jasminoides Ellis glycoprotein (27 kDa); Cadmium; Arachidonic acid; COX-2; MMP-9
Identification and molecular characterization of two novel mutations in COL1A2 in two Chinese families with osteogenesis imperfecta
Keywords: Osteogenesis imperfecta; Mutation; COL1A2; COX-2
Inflammation and prevention of epileptogenesis
Keywords: Anti-inflammatory; Brain development; Cytokines; COX-2; Epilepsy; Interleukin; Lipopolysaccharide; Toll-like receptor
Mitragynine inhibits the COX-2 mRNA expression and prostaglandin E2 production induced by lipopolysaccharide in RAW264.7 macrophage cells
Keywords: Mitragyna speciosa; Mitragynine; COX-1; COX-2; Anti-inflammatory
Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells
Keywords: apoptosis; Bad; COX-2; osmotic stress; PGE2; renal medulla;
Predictive Factors for Malignant Pheochromocytoma: Analysis of 136 Patients
Keywords: adrenal glands; pheochromocytoma; diagnosis; differential; metanephrine; gene expression; Cox-2; cyclooxygenase-2; CSI; chemical shift imaging; CT; computerized tomography; FDG; fluorodeoxyglucose; MIBG; 131I-metaiodobenzylguanidine; MN; metanephrine; MRI
Inhibitory effects of tricin derivative from Sasa albo-marginata on replication of human cytomegalovirus
Keywords: Anti-cytomegalovirus activity; Tricin; HCMV; IE2; COX-2; Entry
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis
Keywords: OA; osteoarthritis; RA; rheumatoid arthritis; DRG; dorsal root ganglia; MMP; matrix metalloproteinase; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; UTRs; untranslated regions; TLR; Toll-like receptor; NFkB; nuclear factor-kappa
PGE2 decreases muscle cell proliferation in patients with non-asthmatic eosinophilic bronchitis
Keywords: Asthma; Hyperplasia; PGE2; EP receptors; COX-2; Airway inflammation
Alpha-lipoic acid protects against myocardial ischemia/reperfusion injury via multiple target effects
Keywords: CAT; catalase; CK; creatine kinase; COX; cyclooxygenase; COX-2; cyclooxygenase-2; DHLA; reduced forms of lipoic acid; GSH; glutathione; ICAM-1; inter-cellular adhesion molecule 1; IR; ischemia/reperfusion; LA; alpha-lipoic acid; MDA; malondialdehyde; MI/R
ReviewToll-like receptors in inflammation of the central nervous system
Keywords: CNS; central nervous systems; COX-2; cyclooxygenase-2; DAMP; damage-associated molecular pattern; EAE; experimental autoimmune encephalomyelitis; HMGB1; high mobility group box 1; IL; interleukin; iNOS; inducible nitric oxide synthase; IRF; interferon reg
The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model
Keywords: Prostaglandin E2; MPGES-1; COX-2; Endometriosis; Angiogenesis