BID links ferroptosis to mitochondrial cell death pathways
Keywords: Ferroptosis; BID; Mitochondria; CRISPR; Oxytosis; Neuronal death;
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SAMHD1 is active in cycling cells permissive to HIV-1 infection
Keywords: CRISPR; Genome editing; SAMHD1; dNTPase activity;
Gene editing in mouse zygotes using the CRISPR/Cas9 system
Keywords: CRISPR; Cas9; Mouse; Zygotes; Gene editing;
Back to the Basics: Cnidarians Start to Fire
Keywords: BRAIN Initiative; imaging; CRISPR; Hydra; Nematostella;
ReviewEndoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
Keywords: Diabetes; Endoplasmic reticulum stress; eIF2α; Pancreatic β cell; Insulin; Islet; ATF; activating transcription factor; CHOP; C/EBP homologous protein; CReP; constitutive repressor of eIF2α phosphorylation; CRISPR; clustered regularly interspaced short
CRISPR knock out CTLA-4 enhances the anti-tumor activity of cytotoxic T lymphocytes
Keywords: CRISPR-Cas9; Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9; CTLA-4; cytotoxic T-lymphocyte-associated protein 4; KO; knock out; CTL; cytotoxic T lymphocytes; TNF-α; Tumor necrosis factor-α; IFN-γ; interferon
Fusion of SpCas9 to E. coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells
Keywords: CRISPR; SpCas9; Rec A; SpCas9(1.1); DSB; SSA;
Identification of a novel splicing mutation within SLC17A8 in a Korean family with hearing loss by whole-exome sequencing
Keywords: ADNSHL; autosomal dominant non-syndromic hearing loss; CRISPR; clustered regularly interspaced short palindromic repeats; CV; consensus values; DNA; deoxyribonucleic acid; HHL; hereditary hearing loss; HL; hearing loss; HSF; Human Splicing Finder; IHCs; i
First report of two complete Clostridium chauvoei genome sequences and detailed in silico genome analysis
Keywords: PacBio; Pacific Biosciences; CRISPR; Clustered Regularly Interspaced Short Palindromic Repeats; LCBs; locally collinear blocks; fliC; flagellin type C; Clostridium chauvoei; Complete circular genomes; Spo0A; CRISPR; fliC;
Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells
Keywords: APB; 2-aminoethoxydiphenylborane; ANOVA; One way analysis of variance; ATPase; Adenosine triphosphate synthase; bEnd5; Mouse brain endothelioma cell line; bpV; bisperoxovanadium; BSA; Bovine serum albumin; Cas9; CRISPR-associated protein 9; CHOP; CCAAT-en
Functional genomics provides insights into the role of Propionibacterium freudenreichii ssp. shermanii JS in cheese ripening
Keywords: Cas; CRISPR-associated protein; CDS; coding sequence; COG; clusters of orthologous groups; CRISPR; clustered regularly interspaced short palindromic repeats; EMPP; Embden-Meyerhof-Parnas-pathway; FDR; false discovery rate; GI; genomic island; HGT; horizon
Glycosylation with ribitol-phosphate in mammals: New insights into the O-mannosyl glycan
Keywords: α-DG; α-dystroglycan; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase 2; B4GAT1; β-1,4-glucuronyltransferase 1; core M1; GlcNAcβ1-2Man; core M2; GlcNAcβ1-2 (GlcNAcβ1-6)Man; core M3; GalNAcβ1-3GlcNAcβ1-4Man; CRISPR; clustered regularly interspac
Distinct roles of neuronal and microglial CB2 cannabinoid receptors in the mouse hippocampus
Keywords: AAV; adeno-associate virus; AP; anterior posterior; CaMKII; calcium/calmodulin-dependent protein kinase II; Cas9; CRISPR-associated protein 9; CB1R; type-1 cannabinoid receptor; CB2R; type-2 cannabinoid receptor; CNS; central nervous system; CRISPR; clust
Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9
Keywords: Pluripotent stem cells; Gene editing; CRISPR; Cas9; Knockout; Knockin;
Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice
Keywords: Inflammation; Tumorigenesis; Villus Regeneration; Mouse Model; ANKRD1; ankyrin repeat domain 1; APC; adenomatous polyposis coli; ChIP; chromatin immunoprecipitation; COX-2; cyclooxygenase 2; CREB; cyclic adenosine monophosphate response element binding pr
CRISPR system in filamentous fungi: Current achievements and future directions
Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; NHEJ; non-homologous end joining; HDR; high-fidelity homology-directed repair; ZFN; zinc finger nucleases; TALEN; transcription activator-like effector nucleases; tef1; translation-elongat
Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function
Keywords: PSC-Based Model; Neural Development; Enteric Nervous System; Congenital; CD; coding; CNS; central nervous system; CRISPR; clustered regularly interspaced short palindromic repeats; ENCC; enteric neural crest cell; FA; focal adhesion; GDNF; glial cell-deri
Draft genome sequence of Shimia marina CECT 7688T
Keywords: CPBP; Capsule polysaccharide biosynthesis protein; Kdo; 3-Deoxy-d-manno-octulosonic acid; EPS; Exopolysaccharide; TOMM; Thiazole-oxazole modified microcin; CRISPR; Clustered regularly interspaced short palindromic repeats; CHOS; Chitooligosaccharides; Rho
CRISPR/Cas9-mediated target validation of the splicing inhibitor Pladienolide B
Keywords: CRIPSR/Cas9; Pladienolide B; Spliceosome; Pre-mRNA splicing; Drug target validation; Drug discovery; SSNs; Site Specific Nucleases; ZFN; Zing Finger Nucleases; TALENs; Transcription Like Effector Nucleases; CRISPR; Clustered Regulatory Interspaced Short P
CRISPR/Cas9-mediated mutagenesis of the white and Sex lethal loci in the invasive pest, Drosophila suzukii
Keywords: Drosophila suzukii; CRISPR; Cas9; white; Sex-lethal;
Controlling transcription in human pluripotent stem cells using CRISPR-effectors
Keywords: CAG; hybrid of cytomegalovirus immediate early enhancer, chicken β-actin promoter and intron, rabbit β-globin splice acceptor; Cas; CRISPR-associated; CRISPR; clustered regularly interspaced short palindromic repeats; crRNA; CRISPR-derived RNA; dCas9; n
SHCBP1 is over-expressed in breast cancer and is important in the proliferation and apoptosis of the human malignant breast cancer cell line
Keywords: SHCBP1; SHC SH2-binding protein 1; CRISPR; clustered regularly interspaced short palindromic repeat sequences; SHCBP1; Breast cancer; CRISPR/CAS9; Proliferation;
The importance of evo-devo to an integrated understanding of molluscan biomineralisation
Keywords: AP; alkaline phosphatase; CRISPR; Clustered Regularly Interspersed Short Palindromic Repeats; Dlx; Distal-less; GRN; gene regulatory network; Hox; homeobox; hpfc; hours post first cleavage; PO; peroxidase; sf; shell field; sg; shell gland; sp; shell plate
A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor confers resistance to spinosad in Drosophila melanogaster
Keywords: CRISPR; Nicotinic acetylcholine receptor; nAChR; Spinosad; Insecticide resistance;
Circadian Rhythm Disruption Promotes Lung Tumorigenesis
Keywords: lung cancer; circadian rhythms; jet lag; physiology; CRISPR
CRISPR-mediated genome editing and human diseases
Keywords: CRISPR; DNA double-stranded break; Genome editing; Human diseases; iPS cells;
Generation and validation of PAX7 reporter lines from human iPS cells using CRISPR/Cas9 technology
Keywords: PAX7; Human iPS cells; GFP reporter; Cas9; dCas9; CRISPR; Cas9 nickase; Knock-in; Homologous recombination
CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity
Keywords: CRISPR; Clustered regulatory interspaced short palindromic repeats; Cas9; CRISPR-associated protein 9; HEK293; human embryonic kidney 293 cells; HRP; horseradish peroxidase; Nox4-HEK293; HEK293 cells stably expressing Nox4; PMA; phorbol 12-myristate 13-ac
Lessons from Domestication: Targeting Cis-Regulatory Elements for Crop Improvement
Keywords: non-coding; transcription factor; microRNA; pleiotropy; CRISPR; new breeding techniques
CRISPR-Cas9 therapeutics in cancer: promising strategies and present challenges
Keywords: AAVs; adeno-associated virus vectors; AdV; adenoviral; BL; Burkitt lymphoma; CAR; chimeric antigen receptor; Cas9; CRISPR-associated protein 9; CPPs; cell-penetrating peptides; CRISPR; clustered regularly interspaced short palindromic repeat; crRNA; CRISP
Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish
Keywords: Zebrafish; CRISPR/Cas9; mgat5a; N-glycosylation; Regeneration; Cas9; CRISPR-associated protein 9; CRISPR; Clustered regularly interspaced short palindromic repeats; DAPT; N-[(3,5-Difluorophenyl) acetyl-L-alanyl-2-phenyl] glycine-1,1-dimethylethyl ester; D
Insert, remove or replace: A highly advanced genome editing system using CRISPR/Cas9
Keywords: Genome editing; CRISPR; Cas9; Mutation; Indel; sgRNA; Double stranded breaks
T-cell therapies for HIV: Preclinical successes and current clinical strategies
Keywords: adoptive T-cell therapy; artificial TCR; chimeric antigen receptors; CRISPR; gene editing; HDACIs; HIV; ZFN;
Research review paperPrecision control of recombinant gene transcription for CHO cell synthetic biology
Keywords: CHO; Chinese hamster ovary; Cirp; cold-inducible RNA-binding protein; CMV-IE; cytomegalovirus immediate early; CRISPR; clustered regularly interspaced short palindromic repeats; DBD; DNA binding domain; DTE; difficult-to-express; EF1α; elongation factor
Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair
Keywords: CRISPR; cell cycle; genome editing; MALAT1; homologous recombination; proteolysis; synthetic biology
CRISPR interference-guided balancing of a biosynthetic mevalonate pathway increases terpenoid production
Keywords: CRISPR; Clustered regularly interspaced short palindromic repeats; CRISPRi; Clustered regularly interspaced short palindromic repeats interference; MVA; mevalonate; sgRNA; single guide RNA; dCas9; inactive Cas9; IPP; isopentenyl diphosphate; DMAPP; dimeth
A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma
Keywords: SAHA; HDAC inhibitor; FGR; B-cell lymphoma; Drug resistance; BL; Burkitt lymphoma; CC; capture compound; CCMS; capture compound mass spectrometry; CRISPR; Clustered Regularly Interspaced Short Palindromic Repeats; DETECT; drug efficacy testing combined wi
Drivers of bacterial genomes plasticity and roles they play in pathogen virulence, persistence and drug resistance
Keywords: Genome plasticity; Mobile genetic elements; Horizontal transfer; CRISPR; Recombination
Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells
Keywords: DDR; DNA damage response; DSB; double-strand break; CRISPR; clustered regularly interspaced short palindromic repeats; CSK; cytoskeletal; DTT; dithiothreitol; EdU; 5-ethynyl-2â²-deoxyuridine; EM-CCD; electron multiplying-charge coupled device; γ-H2AX; p
A review of methods for subtyping Yersinia pestis: From phenotypes to whole genome sequencing
Keywords: Yersinia pestis; Subtyping; Genotyping; RFLP; IS element; DFR; LCB linking modes; VNTR; MLVA; CRISPR; SNP;
The effect of Mycobacterium tuberculosis CRISPR-associated Cas2 (Rv2816c) on stress response genes expression, morphology and macrophage survival of Mycobacterium smegmatis
Keywords: CRISPR; Cas2; Mycobacterium tuberculosis; Stress response; Sigma factors;
Ribose 5-phosphate isomerase inhibits LC3 processing and basal autophagy
Keywords: RPIA; Autophagy; CRISPR; Cas9; Pentose phosphate pathway; shRNA;
Efficient genomic correction methods in human iPS cells using CRISPR-Cas9 system
Keywords: iPS cells; CRISPR; Genome editing; Knock-out; Knock-in; Gene correction;
New insights and current tools for genetically engineered (GE) sheep and goats
Keywords: Transgenesis; Genome edition; ZFN; TALEN; CRISPR;
AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production
Keywords: 3-MA; 3-methyladenine; AID; autoinflammatory disorder; CRISPR; clustered regularly-interspaced short palindromic repeats; Cas9; CRISPR-associated endonuclease 9; GFP; green fluorescent protein; MALP-2; macrophage-activating lipopeptide 2; siRNA; small int
Current status of potential applications of repurposed Cas9 for structural and functional genomics of plants
Keywords: CRISPR; Crop improvement; dCas9; Epigenetics; Gene editing; Gene regulation; CRISPRa; CRISPR activation; CRISPR-Cas; Clustered Regularly Interspaced Short Palindromic Repeats - CRISPR associated proteins; CRISPRi; CRISPR interference; crRNA; CRISPR RNA; D
High-resolution genomic assays provide insight into the division of labor between TLS and HDR in mammalian replication of damaged DNA
Keywords: BER; base excision repair; BP-G; benzo[a]pyrene-guanine adduct; CPD; cyclobutane pyrimidine dimer; CRISPR; clustered regularly-interspaced short palindromic repeats; CSTR; complementary strand transfer repair; DDT; DNA damage tolerance; DSB; double strand
Advancements in zebrafish applications for 21st century toxicology
Keywords: CRISPR; Clustered, regularly interspaced, short palindromic repeats; Dpf; Days post fertilization; DSB; Double strand break; Hpf; Hours post fertilization; HSC; Hematopoietic stem cell; HTS; High-throughput screen; KO; Knockout; MO; Morpholino oligonucleo
Targeting respiratory complex I to prevent the Warburg effect
Keywords: OXPHOS; oxidative phosphorylation; CI; complex I; ROS; reactive oxygen species; TCA; tricarboxylic acid; PARP1; poly (ADP ribose) polymerase 1; AMPK; AMP activated kinase; mTORC1; mammalian target of rapamycin complex 1; HIF1α; hypoxia inducible factor 1
CRISPR mediated somatic cell genome engineering in the chicken
Keywords: CRISPR; Chicken; Cas9; Gene-targeted knockout; Electroporation; PAX7