Keywords: Genome editing; ZFN; TALEN; CRISPR; Hematological disease;
مقالات ISI (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: AAV4; adeno-associated virus serotype 4; BDNF; brain-derived neurotrophic factor; bFGF; fibroblast growth factor 2; BME; β-mercaptoethanol; BMP; bone morphogenetic protein; Cas9; CRISPR associated protein 9; Cla; claustrum; CN; caudate nucleus; CRISPR; c
Keywords: AAV; Adeno-associated virus; ARHL; age-related hearing loss; Cas9; CRISPR-associated nuclease 9; CRISPR; clustered, regularly interspaced, short palindromic repeat; crRNA; CRISPR RNA; dCas9; defective Cas9; DSBs; double-strand breaks; gRNA; guide RNA; HDR
Keywords: Atg; autophagy related; BafA; Bafilomycin A1; CrispR; clustered regularly interspaced short palindromic repeats; EBSS; Earle's balanced salt solution; HTS; high-throughput screen; LIR; LC3-interacting region; MAD; median absolute deviation; PE; phosphat
Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; DSB; double stranded break; EMS; ethyl methane sulfonate; EPA; eicosapentaenoic acid; GMO; genetically modified organism; MNNG; methylnitronitrosoguanidine; TAG; triacylglycerol; TALEs; tr
Keywords: Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator protein; CFTR2; Correctors; Potentiators; Trial end-points; Amil; Amiloride; AMP; Accelerating Medicine Partnership; ANO; anoctamins; AONs; antisense oligonucleotides; ASL; airway surfac
Keywords: genome engineering; ZFNs; TALENs; CRISPR; Cas9; plant;
Keywords: Zinc finger nuclease; Gene therapy; Linker design; Zif268; Krüppel type linker; TALENs; transcription activator-like effector nucleases; CRISPR; clustered regularly interspaced short palindromic repeats; ZFP; zinc finger proteins; ZFM; zinc-finger motifs
Keywords: functional genomics; noncoding; gene regulation; enhancer; CRISPR; Cas9
Keywords: CRISPR; Cas9; sgRNA; Guide RNA; Genome editing; Genome engineering
Keywords: Molecular evolution; CRISPR; Tuberculosis; Spoligotyping; Genomics
Keywords: Immunology; primary immunodeficiency; nuclear factor κB; autoimmunity; intravenous immunoglobulin; common variable immunodeficiency; severe combined immunodeficiency; newborn screening; gene therapy; ADA; Adenosine deaminase; ADAM; A disintegrin and meta
MicroRNA
Keywords: Allergy; antagomiRs; antimiRs; CRISPR; CRISPR/Cas9; gene silencing; in situ hybridization; microarray; microRNA; microRNA methods; miRNA; miRNA expression; miRNA inhibitors; miRNA isolation; miRNA mimics; miRNA profiling; miRNA quantitation; miRNA targets
Simple method for assembly of CRISPR synergistic activation mediator gRNA expression array
Keywords: CRISPR; CRISPRa; SAM; Golden gate assembly; Gene activation;
The Implications of CRISPR-Cas9 Genome Editing for IR
Keywords: CRISPR; Clustered Regularly Interspaced Short Palindromic Repeats; DSB; double-strand break; HDR; homology-directed repair; HR; homologous recombination; NHEJ; nonhomologous end-joining; PAM; protospacer-adjacent motif; sgRNA; single guide RNA;
The epithelial-mesenchymal transition induced by transcription factor LEF-1 is independent of β-catenin
Keywords: EMT; epithelial-mesenchymal transition; LEF-1; lymphoid-enhancer-binding factor 1; TCF; T-cell factor; KO; knockout; CRISPR; clustered regularly interspaced short palindromic repeats; Cas9; CRISPR-associated 9; PAM; protospacer-adjacent motif; DKO; do
Platelet endothelial aggregation receptor-1 (PEAR1) is involved in C2C12 myoblast differentiation
Keywords: EGF; epidermal growth factor; DMEM; Dulbecco's modified Eagle's medium; PBST; PBS containing 0.5% Triton X-100; BSA; bovine serum albumin; DAPI; 4â²,6-diamino-2-phenylindole; TA; tibialis anterior; CRISPR; clustered regularly interspaced short palindromi
CRISPR/Cas9-mediated genome editing of the fatty acid desaturase 2 gene in Brassica napus
Keywords: Brassica napus; Breeding; Fatty acid desaturase 2 gene; Genome editing; Oleic acid; BC1; first generation of backcross; BC1S1; self-pollinated progenies of BC1; CAPSs; Cleaved amplified polymorphic sequences; CRISPR; Clustered regularly interspaced short
Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice
Keywords: Interleukin 11; Proliferation; STAT3; CRISPR-Cas9; Knockout mice; CRISPR; Clustered regularly interspaced short palindromic repeats; STAT; Signal transducer and activator of transcription; AOM; Azoxymethane; DSS; dextran sulfate sodium; IL; Interleukin; J
Genetic analysis and CRISPR typing of Salmonella enterica serovar Enteritidis from different sources revealed potential transmission from poultry and pig to human
Keywords: Salmonella enterica serovar Enteritidis (S. Enteritidis); CRISPR; Whole genome sequence typing (WGST); Transmission;
First description of novel arginine catabolic mobile elements (ACMEs) types IV and V harboring a kdp operon in Staphylococcus epidermidis characterized by whole genome sequencing
Keywords: ACME; Staphylococcus epidermidis; kdp operon; arc operon; opp3 operon; Oral cavity; ACME; arginine catabolic mobile element; WGS; whole genome sequencing; DRs; direct repeat sequences; MLST; multilocus sequence typing; STs; sequence types; CRISPR; Cluster
Detecting pathogens with Zinc-Finger, TALE and CRISPR- based programmable nucleic acid binding proteins
Keywords: DNA binding proteins; Nucleic acid detection; Molecular diagnostics; CRISPR; ZFP; Zinc-Finger proteins; SEER; SEquence-Enabled Reassembly; TALE; Transcription Activator-like Effector; CRISPR; Clustered Regularly Interspaced Short Palindromic Repeats; RPA;
Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression
Keywords: HOX genes; ncRNAs; Chromatin boundary; Transcriptional regulation; Positional identity; CTCF; CCCTC-binding factor; HOTTIP; HOXA transcript at the distal tip; ChIP; chromatin immunoprecipitation; RIP; RNA immunoprecipitation; CRISPR; clustered regularly i
Bombyx ortholog of the Drosophila eye color gene brown controls riboflavin transport in Malpighian tubules
Keywords: ABC transporter; Riboflavin; CRISPR/Cas9; Gene knockout; Malpighian tubules; Silkworm; ABC; ATP-binding cassette; ABCG; ABC transporter G family; AP-3; Adaptor Protein-3; BLOC; biogenesis of lysosome-related organelles complex; BLOS2; biogenesis of lysoso
The truncated Rv2820c of Mycobacterium tuberculosis Beijing family augments intracellular survival of M. smegmatis by altering cytokine profile and inhibiting NO generation
Keywords: RD207; region of difference 207; CRISPR; clustered regularly interspaced short palindromic repeats; Cas genes; CRISPR-Cas associated genes; iNOS; inducible nitric oxide synthase; NO; nitric oxide; IL-10; interleukin-10; IL-6; interleukin-6; IL-1β; interl
Cyclin-dependent kinase 1-mediated phosphorylation of YES links mitotic arrest and apoptosis during antitubulin chemotherapy
Keywords: YES; Mitotic phosphorylation; CDK1; Taxol sensitivity; Chemotherapy; CDK1; cyclin-dependent kinase 1; CDKN1A (p21); cyclin-dependent kinase inhibitor 1A; CRISPR; clustered regularly-interspaced short palindromic repeats; KO; knockout; Plk1; Polo-like kina
Application and development of genome editing technologies to the Solanaceae plants
Keywords: Genome editing; Nuclease; Targeted mutagenesis; AGL; agamous-like; AID; activation-induced cytidine deaminase; ALOG; Arabidopsis LSH1 and Oryza G1; ANT; anthocyanin mutant; ARF; auxin-response factor; Aux; auxin-induced; BAK; brassinosteroid kinase; BOP;
Clustered Regularly Interspaced Short Palindromic Repeats-Based Genome Surgery for the Treatment of Autosomal Dominant Retinitis Pigmentosa
Keywords: AAV; adeno-associated virus; adRP; autosomal dominant retinitis pigmentosa; bp; base pair; CRISPR; clustered regularly interspaced short palindromic repeat; CRISPRd; clustered regularly interspaced short palindromic repeats using Cas9 and double guide RNA
Genome variation in nine co-occurring toxic Cylindrospermopsis raciborskii strains
Keywords: OG; orthologous groups; KEGG; Kyoto encyclopaedia of genes and genomes; BLAST; basic local alignment search tool; CYN; cylindrospermopsind; CYN; deoxy cylindrospermopsin; SNPs; single nucleotide polymorphism; CRISPR; cluster regularly interspaced short pa
CRISPR Gene Editing in the Kidney
Keywords: CRISPR; gene editing; genome; organoids; polycystic kidney disease (PKD); nephrotic syndrome; human pluripotent stem cells (hPSC); chimeric antigen receptor T-cells (CAR-T); gene therapy; animal model; in vitro culture; gene knockout; review;
Barhl1 is required for the differentiation of inner ear hair cell-like cells from mouse embryonic stem cells
Keywords: mESCs; mouse embryonic stem cells; iPSCs; induced pluripotent stem cells; CRISPR; clustered regularly interspaced short palindromic repeat; Cas9; CRISPR- associated protein 9; MEF; mouse embryonic fibroblast; EBs; embryoid bodies; EPL; early primitive ect
The independent loss model with ordered insertions for the evolution of CRISPR spacers
Keywords: primary; 92D15; secondary; 60K35; 92D20; CRISPR; Evolutionary model; Estimation; Loss rate; Gain rate;
Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing experiments
Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; gRNA; guide RNA; OTE; off-target effects; KO; knock out; NHEJ; non-homologous end joining; KI; knock in; HDR; homology directed repair; GOI; gene of interest; LOI; locus of interest; iPSC;
CRMP2-Neurofibromin Interface Drives NF1-related Pain
Keywords: ANOVA; analysis of variance; AP; action potential; Cas9; CRISPR-associated protein-9 nuclease; CaV2.2; N-type voltage-gated calcium channel; CGRP; calcitonin gene-related peptide; CNRP1; CRMP2-neurofibromin regulating peptide 1; CRISPR; clustered regula
CRISPR/Cas and recombinase-based human-to-pig orthotopic gene exchange for xenotransplantation
Keywords: CRISPR; Cas9; Xenotransplantation; Thrombomodulin; Gene replacement;
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Keywords: 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous
Identifying knowledge gaps for gene drive research to control invasive animal species: The next CRISPR step
Keywords: Invasive species; Gene drive; CRISPR; Pest management; Islands;
In vivo methods for acute modulation of gene expression in the central nervous system
Keywords: AAV; adeno-associated viruses; ADV; adenoviruses; ApoE; apolypoprotein E; BBB; blood brain barrier; cap; encapsulation; Cas9; CRISPR associated protein 9; cDNA; coding DNA; CMV; cytomegalovirus; CNS; central nervous system; CNT; carbon nanotubes; CRISPR;
Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations
Keywords: Signal transducer and activator of transcription 1, gain of function; natural killer cell deficiency; perforin; Janus kinase inhibition; ruxolitinib; natural killer cell maturation; ADCC; Antibody-dependent cellular cytotoxicity; CCD; Coiled-coil domain;
Selection is required for efficient Cas9-mediated genome editing in Fusarium graminearum
Keywords: CRISPR; Fusarium head blight; MMEJ; Os1;
A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene
Keywords: aa; amino acid(s); bp; base pairs; Cas9; CRISPR associated protein 9; cDNA; DNA complementary to RNA; CRISPR; Clustered Regularly Interspaced Short Palindromic Repeats; DMSO; dimethylsulfoxide; Dox; doxycycline; dsDNA; double stranded DNA; FOXO; forkhead
Testing thousands of nanoparticles in vivo using DNA barcodes
Keywords: DNA barcoded nanoparticle; Nanotechnology; Drug delivery; CRISPR; RNAi; RNA;
CRISPR Cas9 â Licensing the unlicensable
Keywords: Crispr; Patent; License; Pool; Interference;
FTO demethylase activity is essential for normal bone growth and bone mineralization in mice
Keywords: BMC; (bone mineral content); BMD; (bone mineral density); BMI; (Body mass index); Cas9; (CRISPR associated protein 9); CRISPR; (clustered regularly interspaced short palindromic repeats); CV; (calorific value); DEXA; (Dual-energy X-ray absorptiometry); EE
A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment
Keywords: KRAS; CRISPR-Cas13a; mRNA knockdown; Oncogenic mutation; Pancreatic cancer; Pancreatic ductal adenocarcinoma; PDAC; wild-type; WT; microbial clustered regularly interspaced short palindromic repeats; CRISPR; CRISPR-associated adaptive immune systems; CRIS
New applications of CRISPR/Cas9 system on mutant DNA detection
Keywords: WT; wild type; MU; mutant type; CRISPR; Clustered Regularly Interspaced Short Palindromic Repeats; sgRNA; single-guide RNA; RGEN; Cas9-derived RNA-guided engineered nucleases; AFLPA; amplified fragment length polymorphism analysis; CRISPR/Cas9; Blocker; M
An investigation of oyster TGF-β receptor genes and their potential roles in early molluscan development
Keywords: BMP; bone morphogenetic protein; CRISPR; clustered regularly interspaced short palindromic repeats; DAPI; 6âdiamidinoâ2âphenyâlindole; DIG; Digoxin; DV; dorsal-ventral; hpf; hours post-fertilization; ML; maximum likelihood; PFA; paraformaldehyde;
CRAC channel-based optogenetics
Keywords: ER; endoplasmic reticulum; PM; plasma membrane; MCS; membrane contact site; SOCE; store-operated calcium entry; CRAC; calcium release-activated calcium channel; STIM; stromal interaction molecule; CRY2; cryptochrome 2; LOV2; light-oxygen-voltage domain 2;
Highly efficient genome editing by homology-directed repair using Cas9 protein in Ceratitis capitata
Keywords: ssODN-mediated homology-directed repair; CRISPR-Cas9 ribonucleoprotein complexes; Mediterranean fruit fly; Tephritids; Sterile insect technique; BFP; blue fluorescent protein; bp; base pair(s); Cas; CRISPR associated; CRISPR; Clustered Regularly Interspac
Diagnosis and therapy with CRISPR advanced CRISPR based tools for point of care diagnostics and early therapies
Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; Cas; CRISPR-associated protein; crRNA; CRISPR RNA; SgRNA; single guide RNA; tracrRNA; trans-activating RNA; PAM; protospacer-adjacent motif; DSB; DNA double strand break; SHERLOCK; Specifi