کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8877492 1624133 2018 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The independent loss model with ordered insertions for the evolution of CRISPR spacers
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
The independent loss model with ordered insertions for the evolution of CRISPR spacers
چکیده انگلیسی
Today, the CRISPR (clustered regularly interspaced short palindromic repeats) region within bacterial and archaeal genomes is known to encode an adaptive immune system. We rely on previous results on the evolution of the CRISPR arrays, which led to the ordered independent loss model, introduced by Kupczok and Bollback (2013). When focusing on the spacers (between the repeats), new elements enter a CRISPR array at rate θ at the leader end of the array, while all spacers present are lost at rate ρ along the phylogeny relating the sample. Within this model, we compute the distribution of distances of spacers which are present in all arrays in a sample of size n. We use these results to estimate the loss rate ρ from spacer array data for n=2 and n=3.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Theoretical Population Biology - Volume 119, February 2018, Pages 72-82
نویسندگان
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