کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2825710 | 1162165 | 2016 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Lessons from Domestication: Targeting Cis-Regulatory Elements for Crop Improvement Lessons from Domestication: Targeting Cis-Regulatory Elements for Crop Improvement](/preview/png/2825710.png)
Domestication of wild plant species has provided us with crops that serve our human nutritional needs. Advanced DNA sequencing has propelled the unveiling of underlying genetic changes associated with domestication. Interestingly, many changes reside in cis-regulatory elements (CREs) that control the expression of an unmodified coding sequence. Sequence variation in CREs can impact gene expression levels, but also developmental timing and tissue specificity of expression. When genes are involved in multiple pathways or active in several organs and developmental stages CRE modifications are favored in contrast to mutations in coding regions, due to the lack of detrimental pleiotropic effects. Therefore, learning from domestication, we propose that CREs are interesting targets for genome editing to create new alleles for plant breeding.
TrendsCrop domestication traits are often caused by mutations in cis-regulatory elements.Subtle alterations in expression are favored to avoid pleiotropic effects.Regulatory networks affecting domestication traits are beginning to be unraveled.Genome editing holds promise for engineering of cis-regulatory elements.
Journal: - Volume 21, Issue 6, June 2016, Pages 506–515