
Dose metric considerations in in vitro assays to improve quantitative in vitro-in vivo dose extrapolations
Keywords: DMSO; AUC; Area under the curve; TWA; Time weighted average; BED; Biologically effective dose; EC50; Median effect concentration; MeOA; Mechanism of action; PBBK; Physiological based biokinetic modelling, also referred to in literature as physiological based ph