Keywords: حمل مواد مخدر; Drug metabolism; Cytochrome P450; Conjugation; Drug transporters; Liver metabolism; Phase I, II, and III metabolism enzyme;
مقالات ISI ترجمه شده حمل مواد مخدر
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Keywords: حمل مواد مخدر; Cardiovascular drugs; Natural products; Drug transporters; Natural product-drug interaction; Pharmacokinetics;
Keywords: حمل مواد مخدر; DRE; drug resistant epilepsy; PWE; patients with epilepsies; AEDs; anti-epileptic drugs; MTLE; mesial temporal lobe epilepsy; FCD; focal cortical dysplasia; BCRP; breast cancer resistance protein; MVP; major vault protein; MDT; smultidrug transporters; BB
Keywords: حمل مواد مخدر; Blood-brain barrier; Fetal brain development; Drug transporters; P-glycoprotein;
Keywords: حمل مواد مخدر; mastitis; drug transporters; mammary gland; Staphylococcus aureus;
Keywords: حمل مواد مخدر; Tween; Drug transporters; Kidney; Liver; Excipients;
Keywords: حمل مواد مخدر; Clementine; CYPs; Drug transporters; Grapefruit; Mandarin; HPLC-DAD-ESI-MS-MS;
Keywords: حمل مواد مخدر; lipoidal bilayer diffusion; drug transporters; systems pharmacology; physiologically based pharmacokinetic modelling;
Keywords: حمل مواد مخدر; drug interactions; absorption; protein binding; regulatory science; drug development; drug transporters;
Keywords: حمل مواد مخدر; Drug transporters; Biophysics; Recon2; Narcotics; General anaesthetics; Permeability; Systems pharmacology
Keywords: حمل مواد مخدر; Kidney-on-a-chip; Microfluidics; Proximal tubule; Drug interaction; Drug-induced toxicity; Drug transporters;
Food-drug interactions involving multiple mechanisms: A case study with effect of Capsaicin on the pharmacokinetics of Irinotecan and its main metabolites in rat
Keywords: حمل مواد مخدر; APC; 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxy-camptothecin; AUC; Area under the plasma concentration-time curve; CAP; Capsaicin; CES; Carboxylesterase; CPT; Camptothecin; CPT-11; Irinotecan; CYP; cytochrome P450; DMEs; Drug-meta
Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
Keywords: حمل مواد مخدر; AhR; aryl hydrocarbon receptor; AP1; activating protein 1; ARE; antioxidant-response element; CAR; constitutive androstane receptor; CYP; cytochrome P450; DREs; dioxin-responsive elements; EMSA; electromobility gel shift assay; FBS; fetal bovine serum; GS
Efflux transport of estrogen glucuronides by human MRP2, MRP3, MRP4 and BCRP
Keywords: حمل مواد مخدر; E1-S; estrone sulfate; E1-G; estrone glucuronide; E2-3G; estradiol-3-glucuronide; E2-17G; estradiol-17β-glucuronide; E3-3G; estriol-3-glucuronide; E3-16G; estriol-16α-glucuronide; BCRP, ABCG2; breast cancer resistance protein; MRP, ABCC; multidrug resis
Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV
Keywords: حمل مواد مخدر; Efavirenz; Drug transporters; Drug-drug interactions; Liquid chromatography; Pharmacokinetics; Stability;
Impact of Fusarium mycotoxins on hepatic and intestinal mRNA expression of cytochrome P450 enzymes and drug transporters, and on the pharmacokinetics of oral enrofloxacin in broiler chickens
Keywords: حمل مواد مخدر; Broiler chicken; Cytochrome P450; Drug transporters; Enrofloxacin; Fumonisins; Mycotoxins;
Inhibition of SLC drug transporter activities by environmental bisphenols
Keywords: حمل مواد مخدر; Drug transporters; Bisphenol A; Bisphenol F; Bisphenol S; Tetrabromobisphenol A; Inhibition;
β2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine
Keywords: حمل مواد مخدر; Epinephrine; Drug transporters; Hepatocyte; β2-adrenoreceptor; cAMP;
Ipratropium is 'luminally recycled' by an inter-play between apical uptake and efflux transporters in Calu-3 bronchial epithelial cell layers
Keywords: حمل مواد مخدر; a-b; apical to basolateral; ALI; air-liquid interface; b-a; basolateral to apical; FITC; fluorescein isothiocyanate; HBSS; Hank's Balanced Salt Solution; IPRL; isolated perfused rat lungs; MATE; multidrug and toxin extrusion transporters; MRP; Multidrug
Drug Transporter Function-Implications in CKD
Keywords: حمل مواد مخدر; ATP-binding cassette transporters; Organic anion transporters; Drug transporters; Pharmacogenomics;
Telaprevir is a substrate and moderate inhibitor of P-glycoprotein, a strong inductor of ABCG2, but not an activator of PXR in vitro
Keywords: حمل مواد مخدر; Telaprevir; Drug transporters; CYPs; PXR; Interaction
Expression of MDR1 and MDR3 gene products in paclitaxel-, doxorubicin- and vincristine-resistant cell lines
Keywords: حمل مواد مخدر; Drug-resistant cancer; Drug transporters; Expression levels; MDR3
Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line
Keywords: حمل مواد مخدر; Multidrug resistance; CDNA microarray; Drug transporters; Ovarian cancer
Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in vitro
Keywords: حمل مواد مخدر; Riociguat; Pulmonary arterial hypertension; Chronic thromboembolic pulmonary hypertension; Drug transporters; Drug metabolising enzymes; Interaction;
Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1
Keywords: حمل مواد مخدر; Drug transporters; Pulmonary absorption; Calu-3; In vitro models; Bronchial epithelium; In vitro/in vivo correlation;
Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2â²,7â²-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TRâ) rats
Keywords: حمل مواد مخدر; BC; bile canaliculae; CDF; 5(6)-carboxy-2â²,7â²-dichlorofluorescein; CDF-DA; CDF-diacetate; abcc1-6; ATP-binding cassette, sub-family C (CFTR/MRP) member 1-6; Mrp1-6; multidrug resistance associated protein 1-6; BEI; biliary excretion index; Oatp; organ
Microarray-based detection and expression analysis of ABC and SLC transporters in drug-resistant ovarian cancer cell lines
Keywords: حمل مواد مخدر; Multidrug resistance; cDNA microarray; Drug transporters; Ovarian cancer
Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes
Keywords: حمل مواد مخدر; Retinoic acid; Drug transporters; Hepatocytes; Regulation; RXR; RAR
Functional expression and regulation of drug transporters in monolayer- and sandwich-cultured mouse hepatocytes
Keywords: حمل مواد مخدر; Drug transporters; Primary hepatocytes; Mouse; Monolayer; Sandwich; Regulation
Evaluation of layers of the rat airway epithelial cell line RL-65 for permeability screening of inhaled drug candidates
Keywords: حمل مواد مخدر; In vitro models; Pulmonary delivery; Drug inhalation; Absorption prediction; Drug transporters; In vitro/in vivo correlation;
Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR
Keywords: حمل مواد مخدر; CAR; constitutive androstane receptor; PXR; pregnane X receptor; RXR; retinoid X receptor; PPAR; peroxisome proliferator-activated receptor; CYP; cytochrome P450; UGT; UDP-glucuronyltransferase; GST; glutathione S-transferase; SULT; sulfotransferase; ABC;
Phenotyping drug disposition in oncology
Keywords: حمل مواد مخدر; Phenotyping; Anticancer agents; Probe; Pharmacokinetics; Drug disposition; Metabolism; Phase I reactions; Phase II reactions; Drug transporters
The effect of sphingomyelin synthase 2 (SMS2) deficiency on the expression of drug transporters in mouse brain
Keywords: حمل مواد مخدر; Sphingomyelin synthase 2; Drug transporters; Brain; ERM proteins;
Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping
Keywords: حمل مواد مخدر; hPepT2; Drug transporters; Pharmacokinetic prediction; Fragmental homology modeling; Molecular docking; Pharmacophore mapping
Regulation of drug transporter expression by oncostatin M in human hepatocytes
Keywords: حمل مواد مخدر; Drug transporters; Human hepatocytes; Inflammation; Oncostatin-M; Biliary elimination;
Drug transporters of platinum-based anticancer agents and their clinical significance
Keywords: حمل مواد مخدر; Platinum; Drug transporters; Solute carriers (SLCs); Organic cation transporters (OCTs); PK resistance; Cimetidine; Metformin
Nucleoside transporter expression profiles in human cardiac tissue show striking individual variability with overall predominance of hENT1
Keywords: حمل مواد مخدر; Nucleosides; Nucleoside transporters; Membrane transporters; Drug transporters; Drug uptake; Adenosine; Cardiovascular; Quantitative RT-PCR
Placental P-glycoprotein and breast cancer resistance protein: Influence of polymorphisms on fetal drug exposure and physiology
Keywords: حمل مواد مخدر; Placenta; Polymorphisms; P-glycoprotein; Breast cancer resistance protein; Drug transporters; Pregnancy
Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats
Keywords: حمل مواد مخدر; Dexamethasone; Methotrexate; Conjugated bilirubin; Drug transporters; Biliary excretion
Mécanismes des interactions médicamenteuses d’origine pharmacocinétique
Keywords: حمل مواد مخدر; Interaction médicamenteuse; Pharmacocinétique; Enzymes; TransporteursDrug-drug interaction; Pharmacokinetics; Enzymes; Drug transporters
Therapeutic implications of renal anionic drug transporters
Keywords: حمل مواد مخدر; Renal clearance; Drug transporters; Drug interactions; Transporter polymorphism; Nephrotoxicity; Renal failureABC, ATP-binding cassette; BCRP, breast cancer resistance protein; CMPF, 3-carboxy-4-methyl-5-propyl-2-furanpropionate; CsA, cyclosporine A; DHEA
Involvement of drug transporters in the synergistic action of FOLFOX combination chemotherapy
Keywords: حمل مواد مخدر; Colorectal cancer; FOLFOX; Synergism; Drug transporters; Glutathione; Oxalate
Improved Pharmacokinetic and Bioavailability Support of Drug Discovery Using Serial Blood Sampling in Mice
Keywords: حمل مواد مخدر; serial blood sampling; discrete blood sampling; pharmacokinetics; bioavailability; enterohepatic recirculation; indinavir; rosuvastatin; mouse; P450 enzymes; drug transporters;
Naturally-occurring shikonin analogues – A class of necroptotic inducers that circumvent cancer drug resistance
Keywords: حمل مواد مخدر; Necroptosis; Apoptosis; Drug resistance; Cancer; Shikonin analogues; Drug transporters
An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment
Keywords: حمل مواد مخدر; Polymorphisms; Drug metabolising enzymes; Drug transporters; Survival
Development and characterization of immobilized human organic anion transporter-based liquid chromatographic stationary phase: hOAT1 and hOAT2
Keywords: حمل مواد مخدر; hOAT1; hOAT2; Drug transporters; Affinity chromatography
Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese
Keywords: حمل مواد مخدر; Epilepsy; Drug resistance; ABCB1; P-glycoprotein; Pharmacogenetics; Genetic polymorphisms; Antiepileptic drugs; Chinese; MDR1; Drug transporters
Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04
Keywords: حمل مواد مخدر; Drug-metabolizing enzymes; Drug transporters; Immortalized human hepatocytes; Drug toxicity in vitro
MRP2 (ABCC2) and cisplatin sensitivity in hepatocytes and human ovarian carcinoma
Keywords: حمل مواد مخدر; Platinum-based chemotherapy; Drug resistance; Drug transporters
Development of immobilized membrane-based affinity columns for use in the online characterization of membrane bound proteins and for targeted affinity isolations
Keywords: حمل مواد مخدر; Nicotinic receptors; Drug transporters; Affinity chromatography; Displacement chromatography;