کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3979936 1257392 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phenotyping drug disposition in oncology
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Phenotyping drug disposition in oncology
چکیده انگلیسی

Efficacy and toxicity of anticancer agents are highly variable between patients and variation in drug disposition is thought to be an important determinant. Genetics, physiology, and environment all are underlying factors contributing to this variation. Phenotyping drug metabolizing enzymes and drug transporters by using in vivo probes is a method that can be used to individualize drug therapy. This review discusses drug disposition of anticancer agents and the potential of phenotyping probes for phase I, II metabolic enzymes, and drug transporters in oncology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 38, Issue 6, October 2012, Pages 715–725
نویسندگان
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