دانلود مقالات ISI درباره Ecvam + ترجمه فارسی

آماده سازی نمونه های پلیمری تحریک کننده برای مطالعه در محیط آزمایشگاهی

Preparation of irritant polymer samples for an in vitro round robin study

Keywords: DEHP; Diethylhexyl phthalate; DINP; Diisononyl phthalate; DPBS; Dulbecco's phosphate-buffered saline; ECVAM; European Center for Validation of Alternative Methods; EC50; Effective concentration 50%; ESBO; Epoxidized soybean oil; HA; Heptanoic acid; IVLSL;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

یک روش شیمیایی ساده برای آزمایش پتانسیل حساس سازی پوست از مواد شیمیایی با استفاده از مولکول های اندوژن کوچک

A simple in chemico method for testing skin sensitizing potential of chemicals using small endogenous molecules

Keywords: LLNA; local lymph node assay; ECVAM; European centre for the validation of alternative methods; DPRA; direct peptide reactivity assay; HTS-DCYA; high-throughput dansyl-cysteamine; DABS-C1; 4-(4-dimethylaminophenylazo) benzenesulfonyl chloride; ROC; receiv

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

اثبات موفقیت مفهوم تست ژنوتوکسیک میکروونوکلئوس بر اپیدرم بازسازی، نشان دادن فعالیت متابولیک درونی

Successful proof of concept of a micronucleus genotoxicity assay on reconstructed epidermis exhibiting intrinsic metabolic activity

Keywords: AOO; acetone olive oil; DMSO; dimethyl sulfoxide; PBS; phosphate buffer saline; ECVAM; European Centre for the Validation of Alternative Methods; RI; replicative index; EDTA; ethylenediaminetetraacetic acid; DMEM; Dulbecco's Modified Eagle's Medium; F

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

مشخصه اموال معادل اپی ترومبوس بازسازی شده انسان و عملکرد آن به عنوان یک مدل تحریک پوست

Property characterization of reconstructed human epidermis equivalents, and performance as a skin irritation model

Keywords: Skin irritation model; reconstructed human epidermis; keratinocytes; human skin; 3D; Three Dimensional; BSA; Bovine Serum Albumin; ECVAM; European Centre for the Validation of Alternative Methods; ET50; Exposure Time 50; GHS; Globally Harmonized System; H

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

ارزیابی تطبیقی ​​تحمل موضعی الکل ها که معمولا در دست بر اساس الکل استفاده می شود، برای بهداشت دست است

Comparative assessment of local tolerance of alcohols commonly used in alcohol-based hand rubs for hand hygiene

Keywords: ATCC; American Type Culture Collection; COLIPA; Now Cosmetics Europe - The Personal Care Association; ECVAM; European Centre for the Validation of Alternative Methods; EFSA; European Food Safety Authority; ESAC; ECVAM Scientific Advisory Committee; GHS;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

یک مرور کلی از تکنیک های فعلی برای آزمایش سمیت چشم

An overview of current techniques for ocular toxicity testing

Keywords: BCOP; Bovine Cornea Opacity Permeability (test/assay); CAMVA; Chorioallantoic membrane vascular assay; CEET; Chicken enucleated eye test; CK; Cytokeratin; CM; Cytosensor Microphysiometer (test); CPSC; Consumer Product Safety Commission; CTPA; Cosmetic, To

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

بررسی اعتبار درون / بین آزمایشگاهی بر روی گونه های اکسایش واکنش پذیر برای ارزیابی ایمنی شیمیایی با استفاده از دو شبیه ساز خورشیدی مختلف

Intra-/inter-laboratory validation study on reactive oxygen species assay for chemical photosafety evaluation using two different solar simulators

Keywords: 3T3 NRU PT; 3T3 neutral red uptake phototoxicity test; 8-MOP; 8-methoxypsoralen; CV; coefficient of variation; ECVAM; Europe Center for the Validation of Alternative Methods; GLP; Good Laboratory Practice; ICCVAM; Interagency Coordinating Committee on the

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

واکنش آلرژن های تنفسی شیمیایی در آزمون واکنش پپتید پراکسیداز

Reactivity of chemical respiratory allergens in the Peroxidase Peptide Reactivity Assay

Keywords: DPRA; Direct Peptide Reactivity Assay; DTT; d,l-dithiothreitol; ECVAM; European Centre for the Validation of Alternative Methods; HHPA; hexahydrophthalic anhydride; HPLC; high performance liquid chromatography; HRP; horseradish peroxidase; MA; maleic anhy

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Assessing the impact of benzo[a]pyrene with the in vitro fish gut model: An integrated approach for eco-genotoxicological studies

Keywords: NF; naphthoflavone; 3Rs; Replace, Reduce, Refine; ADME; Adsorption, Distribution, Metabolism and Excretion; AHR; Aryl hydrocarbon receptor; AOP; Adverse Outcome Pathway; APH; Acid phosphatase; B[a]P; Benzo[a]pyrene; DMSO; Dimethyl sulfoxide; ECVAM; Europe

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Genotoxic evaluation of poly(anhydride) nanoparticles in the gastrointestinal tract of mice

Keywords: ALS; alkali-labile sites; DAPI; 4,6-diamidino-2-phenylindole; DMSO; dimethyl sulfoxide; ECVAM; european centre for the validation of alternative methods; EMA; european medicines agency; EMS; ethyl methanesulfonate; Fpg; formamidopyridine DNA glycosilase;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Transcriptomics analysis of early embryonic stem cell differentiation under osteoblast culture conditions: Applications for detection of developmental toxicity

Keywords: mEST; mouse embryonic stem cell test; mESCs; mouse embryonic stem cells; ESCs; embryonic stem cells; ECVAM; European centre for the validation of alternative methods; PMEF; primary mouse embryonic fibroblasts; FBS; fetal bovine serum; DMEM; Dulbecco's m

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Comparison and validation of an in vitro skin sensitization strategy using a data set of 33 chemical references

Keywords: Ac; Acylating agents; ACD; Allergic Contact Dermatitis; AOP; Adverse Outcome Pathway; ARE; Antioxidant Response Element; DC; dendritic cell; DMSO; dimethyl sulfoxide; DNCB; dinitrochlorobenzene; DPRA; Direct Peptide Reactivity Assay; ECVAM; European Centr

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates

Keywords: EST; embryonic stem cell test; ECVAM; European Center for the Validation of Alternative Methods; PBPK; physiologically based pharmacokinetics; MIC; metabolically inapplicable candidate; PBS; phosphate buffered saline; DMSO; dimethyl sulfoxide; MD; maximum

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A retrospective evaluation method for in vitro mammalian genotoxicity tests using cytotoxicity index transformation formulae

Keywords: CA; chromosomal aberration; DB; database; ECVAM; The European Centre for the Validation of Alternative Methods; IWGT; International Workshops on Genotoxicity Testing; JEC; Japan Existing Chemical; LOGEL; lowest observed genotoxicity effect level; MN; micr

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

Predictability of in vitro dermal assays when evaluating fatty amine derivatives

Keywords: ECVAM; European Centre for the Validation of Alternative Methods; GHS; UN Globally Harmonized System of Classification and Labelling of Chemicals; MTT; vital dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (Thiazolyl blue tetrazolium brom

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools

Keywords: 3T3 NRU PT; 3T3 neutral red uptake phototoxicity testing; DMSO; dimethyl sulfoxide; EBSS; Earle's balanced salt solution; ECVAM; European Centre for Validation of Alternative Methods; ICH; International Conference on Harmonization of Technical Requireme

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

BK/TD models for analyzing in vitro impedance data on cytotoxicity

Keywords: ICCVAM; the Interagency Coordinating Committee on the Validation of Alternative Methods; ECVAM; European Centre for Validation of Alternative Methods; OECD; Organisation for Economic Co-operation and Development; ECIS; electric cell-substrate impedance se

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

The 'BlueScreen HC' assay as a decision making test in the genotoxicity assessment of flavour and fragrance materials

Keywords: AIT; allyl isothiocyanate; CN; citronellyl nitrile; BSHC; BlueScreen HC; CA; chromosome aberration; CPDB; carcinogenic potency database; ECHA; European Chemicals Agency; ECVAM; European centre for the validation of alternative methods; EFSA; European food

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

An integrated testing strategy for in vitro skin corrosion and irritation assessment using SkinEthic™ Reconstructed Human Epidermis

Keywords: ECVAM; European Center for the Validation of Alternative Methods; ESAC; ECVAM Scientific Advisory Committee; EU; European Union; EU CLP; European Union System of Classification of Chemicals implemented in the EU Classification, Labelling and Packaging Reg

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of pathway-based toxicity in the BALB/c 3T3 cell model

Keywords: ACE; absolute clonal efficiency; AEI; average exposure indicator; CTA; cell transformation assay; DEG; differentially expressed genes; DMSO; dimethyl sulfoxide; EEA; European Environment Agency; ECVAM; European Centre for the Validation of Alternative Met

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Validation of a human cell based high-throughput genotoxicity assay 'Anthem's Genotoxicity screen' using ECVAM recommended lists of genotoxic and non-genotoxic chemicals

Keywords: In vitro genotoxicity screen; Human cell based; High-throughput; p21; GADD153; p53; Reporter based screen; ECVAM;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Cryopreservation of human monocytes for pharmacopeial monocyte activation test

Keywords: BET; bacterial endotoxins test; BSA; bovine serum albumin; DPBS; Dulbecco's phosphate buffered saline; ECVAM; European Centre for the Validation of Alternative Methods; EDQM; European Directorate for the Quality of Medicines & Health Care; ELISA; enzyme-l

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

The sensitivity of the KeratinoSens™ assay to evaluate plant extracts: A pilot study

Keywords: LLNA; local lymph node assay; Nrf2; nuclear factor-erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; SOP; standard operating procedure; ECVAM; European centre for the validation of alternative met

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Development of an in vitro skin sensitization test based on ROS production in THP-1 cells

Keywords: BH; 1-bromohaxane; BKC; benzalkonium chloride; CB; chlorobenzene; CM-H2DCFDA; 5-(and 6-)-chloromethyl-2′, 7′-dichlorodihydrofluorescein diacetate, acetyl ester; DCs; dendritic cells; DCV5; concentration showing 5% decrease of cell viability relative

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Cosmetics Europe multi-laboratory pre-validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation

Keywords: ANOVA; analysis of variance; BCOP; bovine corneal opacity and permeability test; BLV; between laboratory variability; CE; cosmetics Europe the personal care association; ECVAM; European centre for the validation of alternative methods; EIT; Eye Irritation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

Keywords: AP (D); Action Potential (Duration); ECG; electrocardiogram; ECVAM; European Centre for the Validation of Alternative Methods; FLIPR; FLuorescence Imaging Plate Reader; GSK; GlaxoSmithKline; hERG; human-Ether-a-go-go Related Gene; IC50; Concentration for

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Cosmetics Europe multi-laboratory pre-validation of the SkinEthic™ reconstituted human corneal epithelium test method for the prediction of eye irritation

Keywords: BLV; Between Laboratory Variability; BCOP; Bovine Corneal Opacity and Permeability Test; CE; Cosmetics Europe, The Personal Care Association; CM™; Cytosensor-Microphysiometer; DPRA; Direct Peptide Reactivity Assay; ECVAM; European Centre for the Validat

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches

Keywords: ICH; International Conference on Harmonisation of Technical Requirements for Pharmaceuticals for Human Use; REACH; Registration, Evaluation, Authorisation and restriction of Chemicals (Regulation (EC) No. 1907/2006); EST; embryonic stem cell tests; ECVAM;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Workshop ReportRegulatory assessment of in vitro skin corrosion and irritation data within the European framework: Workshop recommendations

Keywords: A.I.S.E; International Association for Soaps, Detergents and Maintenance products; BfR; German Federal Institute For Risk Assessment; Cat; category; ECHA; European Chemicals Agency; ECVAM; European Centre for the Validation of Alternative Methods; ESAC; E

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Prevalidation study of the Syrian hamster embryo (SHE) cell transformation assay at pH 7.0 for assessment of carcinogenic potential of chemicals

Keywords: CTA; cell transformation assay; DMEM-L; Dulbecco's modified Eagle's medium with LeBoeuf's modification; DMSO; dimethylsulfoxide; DRF; dose range finding; DRP; Detailed Review Paper; ECVAM; European Centre for the Validation of Alternative Methods; FBS; fo

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials

Keywords: ARE; antioxidant response element; AUC; area under the curve; C.C; control cells; CV75; concentration reducing viability to 75%; DC; dendritic cells; DMSO; dimethyl sulfoxide; DNCB; 1-chloro-2,4-dinitrobenzene; DPRA; Direct Peptide Reactivity Assay; ECHA;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Study of embryotoxicity of Fusarium mycotoxin butenolide using a whole rat embryo culture model

Keywords: BUT; butenolide; ECVAM; European centre for the validation of alternative methods; GPx; glutathione peroxidase; KBD; Kashin-Beck disease; ROS; reactive oxygen species; 3 Rs; reduction, refinement, and replacement of animal use; WEC; whole embryo culture

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The Short Time Exposure (STE) test for predicting eye irritation potential: Intra-laboratory reproducibility and correspondence to globally harmonized system (GHS) and EU eye irritation classification for 109 chemicals

Keywords: BCOP; bovine corneal opacity and permeability assay; CAS; chemical abstract system; CT; calcium thioglycolate; CV; coefficient of variation; DMSO; dimethyl sulfoxide; EC; estimated classification; ECVAM; European Council's Committee for the Validation o

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories

Keywords: LLNA; local lymph node assay; Nrf2; nuclear factor-erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; SOP; standard operating procedure; WLR; within laboratory reproducibility; BLR; between laborat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Integrated risk assessment of a hydroxyapatite-protein-composite for use in oral care products: A weight-of-evidence case study

Keywords: ANOVA; analysis of variance; ECETOC; European Centre for Ecotoxicology and Toxicology of Chemicals; ECVAM; European Center on the Validation of Alternative Methods; EPR; electron paramagnetic resonance; GCP; Good Clinical Practice; gd; glycerol/water disp

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors

Keywords: ADME; absorption, distribution, metabolism, and excretion; ADI; Acceptable Daily Intake; Colipa; the European Cosmetic Toiletry and Perfumery Association; CYPs; cytochrome P450s; DNEL; Derived No Effect Level; DG; Directorate General; ECHA; EU Chemicals A

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Eye irritation potential: Usefulness of the HET-CAM under the Globally Harmonized System of Classification and Labeling of Chemicals (GHS)

Keywords: ECVAM; European centre for the validation of alternative methods; EP; Endpoint assessment method (as part of the HET-CAM protocol); EU GHS or CLP; EU classification labeling and packaging regulation (1272/2008/EC); DSD; EU “dangerous substances directiv

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2011 سفارش ترجمه

A pre-validation transferability study of the GreenScreen HC GADD45a-GFP assay with a metabolic activation system (S9)

Keywords: GADD45a; GreenScreen HC; Genotoxicity; ECVAM; Transferability; Pre-validation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Enhancement of anamnestic immunospecific antibody response in orally immunized chickens

Keywords: AU; Arbitrary Units; BSA; Bovine Serum Albumin; CTB; Cholera Toxin B-subunit; ELISA; Enzyme Linked Immunosorbent Assay; ECVAM; European Centre for the Validation of Alternative Methods; FIA; Freund's Incomplete Adjuvant; IFER; The International Foundation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines

Keywords: Reconstructed human epidermis; Skin corrosion; Skin irritation; ECVAM

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Research perspectives for pre-screening alternatives to animal experimentation

Keywords: MEIC; Multicenter Evaluation of In vitro Cytotoxicity program; REACH; Registration, Evaluation, Authorisation and Restriction of Chemicals system; HTS; high throughput screening; MTS; medium throughput screening; ED; endocrine disruptor; ADME; absorption,

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Reconstructed epidermis versus human and animal skin in skin absorption studies

Keywords: Alternative methods; Skin absorption; Skin; Reconstructed human epidermis; Skin models; Epidermis models; Regulatory toxicology; Replacement of animal experiments; BSA; bovine serum albumin; ECVAM; European Centre for the Validation of Alternative Methods

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

The Integrated Project ReProTect: A novel approach in reproductive toxicity hazard assessment

Keywords: Integrated Project ReProTect; Reproductive toxicity; ECVAM; Developmental toxicity; Hazard assessment;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه