Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K and ERK signaling pathways
Keywords: Mollugin; Apoptosis; Autophagy; PI3K/AKT/mTOR/p70S6K; ERK;
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Molecular characterization and immunomodulatory activity of sulfated fucans from Agarum cribrosum
Keywords: NO; nitric oxide; iNOS; inducible NO synthase; TNF-α; tumor necrosis factor-α; COX-2; cyclooxygenase-2; IL; interleukin; NF-κB; nuclear factor-kappa B; MAPKs; mitogen-activated protein kinases; ERK; including extracellular signal-regulated kinases; JNK
CDX2 can be regulated through the signalling pathways activated by IL-6 in gastric cells
Keywords: CDX; caudal type homeobox; ERK; extracellular-signal-regulated-kinase; H. pylori; Helicobacter pylori; IL; interleukin; JAK; Janus kinase; MAPK; mitogen-activated protein kinase; SHP; Src-homology protein tyrosine phosphatase; SOX; SRY-related HMG-box; ST
The differential proliferative response of fetal and adult human skin fibroblasts to TGF-β is retained when cultured in the presence of fibronectin or collagen
Keywords: TGF-β; Human skin fibroblast; Fetal; Adult; Fibronectin; Collagen gel; Proliferation; Smad; ERK; PKA;
Downstream effects of striatal-enriched protein tyrosine phosphatase reduction on RNA expression in vivo and in vitro
Keywords: ANOVA; analysis of variance; Arc; associated protein gene; Camk2a; calcium/calmodulin-dependent protein kinase II alpha gene; DMEM; Dulbecco's modified Eagle's medium; Dusp4; dual specificity phosphatase 4 gene; Egr2; Early growth response 2; ERK; ext
Cocaine- and amphetamine-regulated transcript facilitates the neurite outgrowth in cortical neurons after oxygen and glucose deprivation through PTN-dependent pathway
Keywords: BDNF; brain-derived neurotrophic factor; CART; cocaine- and amphetamine-regulated transcript; DMEM; dulbecco's modified eagle's medium; ECL; enhanced chemiluminescence; ERK; extracellular regulated protein kinases; FBS; fetal bovine serum; GAP43; growth-a
Melatonin enhances adult rat hippocampal progenitor cell proliferation via ERK signaling pathway through melatonin receptor
Keywords: EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; FGF2; fibroblast growth factor 2; HAT; histone acetyltransferase; MAPK; mitogen-activated protein kinase; MEK; mitogen-activated protein kinase kinase; MT1;
Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen
Keywords: Oxygen; SUR2A; Heart; ERK;
Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress
Keywords: ERK; Endoplasmic reticulum stress; UPR; Melanoma;
Nanomolar levels of PAHs in extracts from urban air induce MAPK signaling in HepG2 cells
Keywords: AP-1; activator protein 1; BP; benzo[a]pyrene; ERK; extracellular regulated kinase; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; MEK4; MAPK kinase 4; PAH; polycyclic aromatic hydrocarbon; PM; particulate matter; TEF; toxic equival
Epidermal growth factor inhibits transforming growth factor-β-induced fibrogenic differentiation marker expression through ERK activation
Keywords: TGF-β; EGF; EMT; Fibrosis; ERK; Smad2/3;
Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line
Keywords: ATCC; American Type Culture Collection; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide; NF-κB; nuclear factor kappa B; PTEN; phosphatase an
Tetrahydrocurcumin induces G2/M cell cycle arrest and apoptosis involving p38 MAPK activation in human breast cancer cells
Keywords: AO; acridine orange; cdc 2; cell division cycle 2; CDK; cyclin-dependent kinase; CDKI; cyclin-dependent kinase inhibitor; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; JNK; Jun N-terminal kinase; MAPK; mito
Loss of Sprouty4 in T cells ameliorates experimental autoimmune encephalomyelitis in mice by negatively regulating IL-1β receptor expression
Keywords: Helper T cells; Cytokine signaling; Th17; ERK; IL-1 receptor;
Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells
Keywords: Bcl-2; B-cell CLL/lymphoma 2; BSA; bovine serum albumin; DAPI; 4,6-diamidino-2-phenylindole; DMAC; 5-7-dihydroxy-4-methyl-6-(3-methylbutanoyl)-coumarin; DPI; diphenylene iodonium; ERK; extracellular-regulated protein kinase; JNK; c-Jun N-terminal kinase;
MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells
Keywords: S1PR1; sphingosine-1-phosphate receptor-1; miRs; microRNAs; SphK1; sphingosine kinases 1; S1P; sphingosine 1-phosphate; ERK; extracellular signal-regulated kinase; STAT3; signal transducers and activators of transcription 3; PDGF-A; platelet derived growt
Chlormadinone acetate promotes osteoblast differentiation of human mesenchymal stem cells through the ERK signaling pathway
Keywords: CMA; Chlormadinone acetate; hBMSCs; Human bone marrow-derived mesenchymal stem cells; ERK; Extracellular signal-regulated kinase; ALP; Alkaline phosphatase; OSX; Osterix; OCN; Osteocalcin; BSP; Bone sialoprotein; col1a1; Collagen type 1, alpha 1; PPAR-γ;
Activation of TOPK by lipopolysaccharide promotes induction of inducible nitric oxide synthase through NF-κB activity in leukemia cells
Keywords: iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B cells; IκBα; inhibitor of kappa light chain gene enhancer in B cells alpha; siRNA; small interfering RNA; IKK; IκB kinase;
ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes
Keywords: ARF6; ADP-ribosylation factor 6; ET-1; endothelin-1; ETAR; endothelin type A receptor; ETBR; endothelin type B receptor; GPCR; G-protein coupled receptor; IR; insulin resistance; GLUT4; glucose transporter type 4; ERK; extracellular-signal regulated kinas
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor
Keywords: Bcr-Abl1; B-cell receptor-Abelson tyrosine kinase 1; Brms1; breast carcinoma metastasis suppressor 1; cyto; cytoplasmic preparation; ER; estrogen receptor; ERM; Ezrin, Radixin, Moesin protein; ERK; extracellular signal regulated kinase; GAPDH; glyceraldeh
Effect of d-serine on spermatogenesis and extracellular signal-regulated protein kinase (ERK) phosphorylation in the testis of the silkworm, Bombyx mori
Keywords: ERK; d-Serine; Signal transduction; Silkworm; Spermatogenesis; Testis
BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB–ERK/Akt signaling cascade
Keywords: BDNF mimetic LM22A-4; TrkB; ERK; Akt; OPN
Antitumour effect and modulation of expression of the ABCB1 gene by perifosine in canine lymphoid tumour cell lines
Keywords: Canine; Lymphoma cell lines; ABCB1; P-glycoprotein; Multidrug resistance; Akt; ERK; JNK
mTORC1 signaling controls multiple steps in ribosome biogenesis
Keywords: 4E-BP; eIF4E-binding protein; 5â²-TOP; 5â²-terminal oligopyrimidine tract; BOP1; block of proliferation 1; eEF2; eukaryotic elongation factor; eEF2K; eEF2 kinase; eIF; eukaryotic initiation factor; ERK; extracellular ligand-regulated kinase; MEK; MAP an
3,5,4â²-Trihydroxy-6,7,3â²-trimethoxyflavone protects astrocytes against oxidative stress via interference with cell signaling and by reducing the levels of intracellular reactive oxygen species
Keywords: ABAP; 2,2â²-Azobis(amidinopropane); Af; Achillea fragrantissima; CAA; cellular antioxidant activity; CNS; central nervous system; COSY; correlation spectroscopy; CREB; cyclic AMP response element-binding protein; DCF-DA; 2â²7â²-dichlorofluorescein diac
Cocaine facilitates protein synthesis-dependent LTP: The role of metabotropic glutamate receptors
Keywords: Cocaine; Hippocampus; LTP; Metabotropic glutamate receptors; Learning; Plasticity; ERK; Dopamine and PKA;
Mice selectively bred for High and Low fear behavior show differences in the number of pMAPK (p44/42 ERK) expressing neurons in lateral amygdala following Pavlovian fear conditioning
Keywords: Resilience; Susceptibility; PTSD; Anxiety; ERK; MAPK; Fear and stress; Microanatomy;
Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages
Keywords: SAA; serum amyloid A; H3K27me3; trimethylation of histone H3 at lysine 27; HDACs; histone deacetylases; FPR2; formyl peptide receptor 2; G-CSF; granulocyte colony-stimulating factor; IL-23p19; interleukin-23 alpha subunit p19; IL-12p40; interleukin-12 p40
HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with β-arrestin2
Keywords: HSP27; β-Arrestin; Src; TRAIL; Akt; ERK;
The regulation and functions of MAPK pathways in Drosophila
Keywords: MAPK; ERK; Receptor tyrosine kinases; EGF receptor; FGF receptor;
Activation of ERK by sodium tungstate induces protein synthesis and prevents protein degradation in rat L6 myotubes
Keywords: DEX; dexamethasone; ERK; extracellular signal-regulated kinases 1 and 2; eIF4E; eukaryotic initiation factor E; 4E-BP1; eIF4E-binding protein 1; FoxO; Forkhead box O Family of Transcription Factors; IGF-I; Insulin Growth Factor I; MTOR; mechanistic target
“RAF” neighborhood: Protein-protein interaction in the Raf/Mek/Erk pathway
Keywords: Ras; Raf; Mek; Erk; Protein-protein interaction; Kinase inhibitor; Cancer therapy;
Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways
Keywords: AKT/PKB; protein kinase B; DCF; dichorofluorescein; DHBA; 2,3-dihydroxybenzoic acid; DHPAA; 3,4-dihydroxyphenylacetic acid; ERK; extra cellular regulated kinase; GSIS; glucose-stimulated insulin secretion; HPPA; 3-hydroxyphenylpropionic acid; KRB; Krebsâ
The role of nitric oxide in spatial memory stages, hippocampal ERK and CaMKII phosphorylation
Keywords: L-NAME; Water maze; Learning and memory; ERK; CaMKII; Hippocampus
Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells
Keywords: HCC, hepatocellular carcinoma; Hsp90, heat shock protein 90; Bcl-2, B-cell lymphoma-2; LC3, microtubule-associated protein 1 light chain 3; CQ, chloroquine; ERK, extracellular regulated kinase(-)-Gossypol; Bcl-2; Hsp90; Autophagy; ERK
TNF and MAP kinase signalling pathways
Keywords: TNF; MAP kinase; ERK; JNK; p38 MAP kinase
Protective effects of the melanocortin analog NDP-α-MSH in rats undergoing cardiac arrest
Keywords: ACTH-(1-24); adrenocorticotropic hormone (1-24); CA; Cardiac arrest; CPR; cardiopulmonary resuscitation; ECG; electrocardiogram; ERK; extracellular signal-regulated kinases; HCO3â; bicarbonate; HR; heart rate; Htc; hematocrit; IL-6; interleukin-6; IL-10
The aryl hydrocarbon receptor suppresses osteoblast proliferation and differentiation through the activation of the ERK signaling pathway
Keywords: Ahr; aryl hydrocarbon receptor; AIP; Ahr-interacting protein; ALP; alkaline phosphatase; ARNT; aryl hydrocarbon receptor nuclear translocator; BMD; bone mineral density; CFA; complete Freund's adjuvant; CH-223191; 2-methyl-2H-pyrazole-3-carboxylic acid; C
Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway
Keywords: COX-2; cyclooxygenase-2; CYP2E1; cytochrome P450 2E1; ERK; the extracellular-receptor kinases; IL-1β; interleukin-1beta; JNK; the c-Jun N-terminal kinases; NF-κB; nuclear factor-κB; MAPKs; mitogen-activated protein kinases; UA; ursolic acid; ROS; react
Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways
Keywords: CHOP; CCAAT/enhancer-binding protein homologous protein; DR4, -5; death receptor 4, -5; ERK; extracellular signal-regulated kinase; p38 MAPK; p38 mitogen-activated protein kinase; JNK; c-Jun N-terminal kinase; PARP; poly-ADPribose polymerase; ROS; reactiv
The paradox of FGFR3 signaling in skeletal dysplasia: Why chondrocytes growth arrest while other cells over proliferate
Keywords: FGFR3; RASopathies; ERK; Achondroplasia; Skeletal dyplasia; Cancer;
Regulation of T lymphocyte activation by microRNA-21
Keywords: MicroRNA-21; miR-21; Ab; antibody; AP-1; activator protein 1; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular signal-related kinase; IL-2; interleukin-2; Io; ionomycin; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; MEK
Regular ArticleChemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2
Keywords: CFA; complete Freund's adjuvant; COX-2; cyclooxygenase-2; ERK; extracellular signal-regulated kinase; GFAP; glial fibrillary acidic protein; NeuN; neuron-specific nuclear protein; NMDA; N-methyl-d-aspartate; RT-PCR; real-time quantitative polymerase chain
Estradiol enhances object recognition memory in Swiss female mice by activating hippocampal estrogen receptor α
Keywords: Estradiol; Estrogen receptors; Object memory; ERK;
Halofuginone improves muscle-cell survival in muscular dystrophies
Keywords: CMD; congenital MD; DMD; Duchenne MD; ECM; extracellular matrix; ERK; extracellular signal-regulated protein kinase; DAPI; 4â²,6-diamidino-2-phenylindole; MAPK; mitogen-activated protein kinase; MDs; muscular dystrophies; PI3K; phosphoinositide 3 kinase;
The effects of age and muscle contraction on AMPK activity and heterotrimer composition
Keywords: ACC; acetyl CoA carboxylase; ADP; adenosine diphosphate; AKT; protein kinase B; AMP; adenosine monophosphate; ATP; adenosine triphosphate; AMPK; AMP-activated protein kinase; ERK; extracellular signal-regulated kinase; GAST; gastrocnemius; HPLC; high perf
Respiratory sensitizer hexamethylene diisocyanate inhibits SOD 1 and induces ERK-dependent detoxifying and maturation pathways in dendritic-like cells
Keywords: Respiratory allergy; Mitochondria; ROS; SOD; ERK; MDR1; THP-1 dendritic cells; Free radicals;
Nicotinamide phosphoribosyltransferase can affect metastatic activity and cell adhesive functions by regulating integrins in breast cancer
Keywords: AMP; adenosine monophosphate; ATP; adenosine triphosphate; BRCA1; breast cancer 1; BRCA2; breast cancer 2; eNAMPT; extracellular nicotinamide phosphoribosyltransferase; ERK; extracellular signal-regulated kinases; iNAMPT; intracellular nicotinamide phosph
Increase in medial frontal cortex ERK activation following the induction of apomorphine sensitization
Keywords: ERK; Apomorphine; Sensitization; Medial prefrontal cortex; Amygdala; Nucleus accumbens;
Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity
Keywords: TCM; traditional Chinese medicine; COX; cyclooxygenase; PGE2; prostaglandin E2; ERK; extracellular signal-regulated kinase; NSAIDs; non-steroidal anti-inflammatory drugs; CVDs; cardiovascular diseases; ELISA; enzyme linked immunosorbent assay; NSCLC; non-