کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850756 | 1561778 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways
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کلمات کلیدی
T2DHPPAGSISDHBAPKCKRbPI3KERKDcfpKa2,3-dihydroxybenzoic acid - 2،3-دی هیدروکسی بنزوئیک اسید3,4-dihydroxyphenylacetic acid - 3،4-دی هیدروکسی فنیل اسیدهای اسیدt-BOOH - T-BOOHAkt/PKB - آکت / PKBKrebs–Ringer bicarbonate buffer - بافر کربنات کربن-رینگرGlucose-stimulated insulin secretion - ترشح انسولین تحریک شده توسط گلوکزOxidative stress - تنش اکسیداتیوType 2 diabetes - دیابت نوع 2Type 2 diabetes mellitus - دیابت نوع دوphosphatidylinositol-3-kinase - فسفاتیدیلینواستیل-3-کینازtert-butyl hydroperoxide - هیدروپراکسید تری بوتیلprotein kinase A - پروتئین کیناز Aprotein kinase B - پروتئین کیناز BProtein kinase C - پروتئین کیناز سیDietary polyphenols - پلی فنل های رژیمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Oxidative stress is accepted as one of the causes of beta cell failure in type 2 diabetes. Therefore, identification of natural antioxidant agents that preserve beta cell mass and function is considered an interesting strategy to prevent or treat diabetes. Recent evidences indicated that colonic metabolites derived from flavonoids could possess beneficial effects on various tissues. The aim of this work was to establish the potential anti-diabetic properties of the microbial-derived flavonoid metabolites 3,4-dihydroxyphenylacetic acid (DHPAA), 2,3-dihydroxybenzoic acid (DHBA) and 3-hydroxyphenylpropionic acid (HPPA). To this end, we tested their ability to influence beta cell function and to protect against tert-butyl hydroperoxide-induced beta cell toxicity. DHPAA and HPPA were able to potentiate glucose-stimulated insulin secretion (GSIS) in a beta cell line INS-1E and in rat pancreatic islets. Moreover, pre-treatment of cells with both compounds protected against beta cell dysfunction and death induced by the pro-oxidant. Finally, experiments with pharmacological inhibitors indicate that these effects were mediated by the activation of protein kinase C and the extracellular regulated kinases pathways. Altogether, these findings strongly suggest that the microbial-derived flavonoid metabolites DHPAA and HPPA may have anti-diabetic potential by promoting survival and function of pancreatic beta cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 66, April 2014, Pages 245-253
Journal: Food and Chemical Toxicology - Volume 66, April 2014, Pages 245-253
نویسندگان
Elisa Fernández-Millán, Sonia Ramos, Carmen Alvarez, Laura Bravo, Luis Goya, MarÃa Ángeles MartÃn,