Osteoactivin inhibits dexamethasone-induced osteoporosis through up-regulating integrin β1 and activate ERK pathway
Keywords: BMSC; ERK; Intergrin β1; Osteoactivin; Osteoporosis;
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Altered TNF-α response by Aconibal® and methotrexate in a lipopolysaccharide-induced setting of inflammatory conditions: Potential on a synergistic combination
Keywords: AC; Aconitum carmichaelii; AMC; AC (Aconibal®) and methotrexate; Cox-2; Cyclooxygenase-2; DMSO; Dimethyl sulfoxide; ERK; Extracellular signal-regulated kinase; GCSF; Granulocyte-colony stimulating factor; HRP; Horseradish peroxidase; IFN; Interferon; IL;
Cytoprotective mechanisms of DJ-1 against oxidative stress through modulating ERK1/2 and ASK1 signal transduction
Keywords: DJ-1; Oxidative stress; Signal transduction; Cell signaling; ERK; MAPK; ASK1; Daxx; Trx1; JNK; p38;
Osteon Myospalacem Baileyi attenuates osteoclast differentiation through RANKL induced NFAT pathways
Keywords: Osteon Myospalacem Baileyi; RANKL; Osteoclast differentiation; ERK; NFATc1;
Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors
Keywords: MAPK; mitogen-activated protein kinase; BRAF; v-raf murine sarcoma viral oncogene homolog B1; MEK; mitogen-activated protein/extracellular signal- regulated kinase kinase; ERK; extracellular signal-regulated kinase; HIF-1α; hypoxia inducible factor 1 alp
The effects of glucose concentrations associated with lipopolysaccharide and interferon-gamma stimulus on mediators' production of RAW 264.7 cells
Keywords: AGE; advanced glycation end-products; α-MEM; minimum essential medium alpha medium; ANOVA; analysis of variance; DM; Diabetes Mellitus; DMSO; dimethylsulfoxide; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular signal regulated kinase; IL; int
C1q tumor necrosis factor-related protein 9 in atherosclerosis: Mechanistic insights and therapeutic potential
Keywords: CTRP9; AdipoR1; N-cadherin; Atherosclerosis; Adiponectin; CVD; cardiovascular disease; CTRPs; C1q tumor necrosis factor-related proteins; AMI; acute myocardial infarction; HMW; high molecular weight; AMPK; adenosine monophosphate-activated protein kinase;
Sargaquinoic acid ameliorates hyperpigmentation through cAMP and ERK-mediated downregulation of MITF in α-MSH-stimulated B16F10 cells
Keywords: α-MSH; α-melanocyte stimulating hormone; BISA; bisabolangelone; cAMP; cyclic adenosine monophosphate; CREB; cAMP-responsive element-binding protein; DOPA; 3, 4-dihydroxyphenylalanine; ESS; ethanolic extract of Sargassum serratifolium; ERK; extracellular
Modulation of alveolar macrophage innate response in proinflammatory-, pro-oxidant-, and infection- models by mint extract and chemical constituents: Role of MAPKs
Keywords: ME; mint leaf extract; LPS; lipopolysaccharide; H2O2; hydrogen peroxide; ROS; reactive oxygen species; NO; nitric oxide; NAC; N-acetyl cysteine; MAPKs; mitogen-activated protein kinases; JNK; c-Jun N-terminal kinases; p38; the p38 mitogen-activated protei
Acetylation regulates the MKK4-JNK pathway in T cell receptor signaling
Keywords: AP-1; activation protein 1; CBP; CREB-binding protein; CREB; camp response element binding; ER; estrogen receptor; ERK; extracellular-signlaing-regulated kinase; JNK; c-Jun HN2 terminal kinase; NFAT; nuclear factor of activated T cell; NF-κB; nuclear fac
Anti-inflammatory activity of mulberrofuran K isolated from the bark of Morus bombycis
Keywords: CC; column chromatography; CCK; cell counting kit; COX-2; cyclooxygenase-2; DCFH-DA; 2â²,7â²-dichlorofluorescin diacetate; DMSO; 4â²6â²-dimethyl sulfoxide; ERK; intracellular-regulated kinases; IL; interleukin; iNOS; inducible nitric oxide synthase; J
Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer
Keywords: CIP2A; SET; PME-1; MAPK; JAK2; ERK; PPP2R1A; PPP2R2A; PPP2R5A; PPP2R5C; MYC; TP53; E2F1; AKT; Feedback;
The reciprocal link between EVI1 and miRNAs in human malignancies
Keywords: EVI1; ecotropic virus integration site-1; MiR; microRNA; 3â²-UTR; 3â²-untranslated regions; AML; acute myeloid leukemia; DNA; deoxyribonucleic acid; RNA; ribonucleic acid; NF-κβ; nuclear factor kappa β; CHIP; Chromatin Immunoprecipitation; c-Myb; c-m
Effect of gamma irradiation on the anti-oxidant and anti-melanogenic activity of black ginseng extract in B16F10 melanoma cells
Keywords: DPPH; 2,2-diphenyl-1-picrylhydrazyl; ABTS; 2,2â²-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid; FRAP; ferric reducing antioxidant power; AEAC; ascorbic acid equivalent antioxidant capacity; TRP-1; tyrosinase related protein-1; TRP-2; tyrosinase related
KIF26B promotes cell proliferation and migration through the FGF2/ERK signaling pathway in breast cancer
Keywords: KIF26B; FGF2; ERK; Breast cancer; Proliferation; Migration;
Protective effect of rutin against carbon tetrachloride-induced oxidative stress, inflammation and apoptosis in mouse kidney associated with the ceramide, MAPKs, p53 and calpain activities
Keywords: Rutin; CCl4; Kidney; Oxidative stress; Inflammation; Apoptosis; ROS; reactive oxygen species; JNK; the c-Jun N-terminal kinases; ERK; the extracellular-receptor kinases; MAPKs; mitogen-activated protein kinases; MDA; malondialdehyde; ICR; Institute of Can
The ginsenoside metabolite compound K inhibits hormone-independent breast cancer through downregulation of cyclin D1
Keywords: Compound K; Hormone-independent breast cancer; Cyclin D1; CK; compound K; CDK; cyclin-dependent kinase; ERK; extracellular signal-regulated kinase; PPD; 20(S)-protopanaxadiol; CHX; cyclohexamide;
Alleviating airway inflammation by inhibiting ERK-NF-κB signaling pathway by blocking Kv1.3 channels
Keywords: Asthma; Airway inflammation; Kv1.3 channel; T lymphocyte; ERK; NF-κB;
Stimulation of transient receptor potential M3 (TRPM3) channels increases interleukin-8 gene promoter activity involving AP-1 and extracellular signal-regulated protein kinase
Keywords: ATF2; c-Jun; ERK; Interleukin-8; MKP-1; TCF; TRPC6; TRPM3;
6,7,4â²-Trihydroxyisoflavone suppressed the estrogen receptor negative breast cancer growth via regulating glycogen synthase kinase-3β/β-catenin signaling
Keywords: Breast cancer; β-catenin; Cell cycle; Glycogen synthase kinase-3β; Trihydroxyisoflaovone; CDK; cyclin dependent kinase; CDKI; cyclin dependent kinase inhibitor; ER; estrogen receptor; ERK; extracellular signal-regulated kinase; GSK; glycogen synthase ki
Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways
Keywords: Akt; protein kinase B; Atg; autophagy related gene; CNS; central nervous system; COX-2; cyclooxygenase-2; CQ; chloroquine; ERK; extracellular signal-regulated kinase; IL-1β; interleukin-1β; iNOS; inducible nitric oxide synthase; JNK; c-jun NH2-terminal
Dibromoacetic acid induced Cl.Ly1Â +Â 2/â9 T-cell apoptosis and activation of MAPKs signaling cascades
Keywords: DBA; dibromoacetic acid; FITC; fluorescein isothiocyanate; PI; propidium iodide; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; JNK; c-Jun N-terminal kinase; MMP; mitochondrial membrane potential; Rh123; Rhodamine 123;
Pharmacological effects and potential therapeutic targets of DT-13
Keywords: ADP; adenosine diphosphate; Akt; protein kinsase B; ALT; alanine transaminase; APD; action potential duration; AST; aspartate transaminase; Atg; autophagocytosis associated protein; CCR5; C, C chemokine receptor type 5; CXCR4; C-X-C chemokine receptor typ
Resveratrol inhibits proliferation, migration and invasion via Akt and ERK1/2 signaling pathways in renal cell carcinoma cells
Keywords: RES; resveratrol; RCC; renal cell carcinoma; EMT; epithelial-mesenchymal transition; MMP; matrix metalloproteinase; ECM; extracellular matrix; ERK; extracellular signal-regulated protein kinase; MAPK; mitogen-activated protein kinases; DMEM; Dulbecco's
Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca2+ mobilization and ERK phosphorylation in healthy Japanese subjects
Keywords: Thrombin receptor; PAR4; Polymorphism; ERK;
The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms
Keywords: DMEM; Dulbecco's modified Eagle medium; DPCs; dermal papilla cells; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; H&E; hematoxylin and eosin; HFs; hair follicles; HGF; hepatocyte growth factor; IGF; insulin-like growth factor; IGF
Maternal exposure to nonylphenol during pregnancy and lactation induces microglial cell activation and pro-inflammatory cytokine production in offspring hippocampus
Keywords: AD; Alzheimer's disease; AP-1; activator protein 1; BBB; blood-brain barrier; BPA; bisphenol A; CNS; central nervous system; COX-2; cyclooxygenase-2; DAPI; 4â²,6âdiamidinoâ2âphenylindole; EDC; endocrine disrupting chemical; ELISA; enzyme-linked imm
Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells
Keywords: Signal transduction; Serine threonine phosphorylation; Erk; Cancer;
Phoenixin participated in regulation of food intake and growth in spotted scat, Scatophagus argus
Keywords: Pnx; phoenixin; ghrhr; growth hormone-releasing hormone receptor; gh; growth hormone; ghr; growth hormone receptor; Igf; insulin-like growth factor; Ghrh; growth hormone-releasing hormone; PVN; paraventricular nucleus; Arc; arcuate nucleus; VMH; ventromed
Involvement of NADPH oxidase 1 in UVB-induced cell signaling and cytotoxicity in human keratinocytes
Keywords: UV; Ultraviolet; ROS; Reactive Oxygen Species; O2-; Superoxide; OH; Hydroxyl radical; H2O2; Hydrogen peroxide; NOX; NADPH oxidase; PBS; Phosphate-buffered saline; DNA; Deoxyribonucleic acid; RNA; Ribonucleic acid; DPI; Diphenyleneiodonium; NAC; N-acetyl c
Leucodine blocks mitotic clonal expansion during preadipoctye differentiation through cell cycle arrest
Keywords: Adipogenesis; Mitotic clonal expansion; Sesquiterpene lactone; Erk; Akt; Rb; Cell cycle;
Flavonoids from Chinese bayberry leaves induced apoptosis and G1 cell cycle arrest via Erk pathway in ovarian cancer cells
Keywords: Flavonids; Apoptosis; Cell cycle arrest; ERK; Ovarian cancer;
Treatment-damaged hepatocellular carcinoma promotes activities of hepatic stellate cells and fibrosis through GDF15
Keywords: TACE; transarterial chemoembolization; HCC; hepatocellular carcinoma; GDF15; growth-differentiation factor 15; HSCs; hepatic stellate cells; TGF; transforming growth factor; JNK; c-Jun N-terminal kinase; pHSCs; primary hepatic stellate cells; DMEM; Dulbec
AKR1C3, a crucial androgenic enzyme in prostate cancer, promotes epithelial-mesenchymal transition and metastasis through activating ERK signaling
Keywords: Prostate cancer; Metastasis; Epithelial-to-mesenchymal transition; AKR1C3; ERK; Transcription factor;
Jatrophane diterpenoids from Euphorbia helioscopia and their lipid-lowering activities
Keywords: Euphorbia helioscopia; Jatrophanes; Hyperlipidemia; Lipid-lowering; LDL receptor; CVD; cardiovascular disease; CHD; coronary heart disease; LDL; low density lipoprotein; LDL-C; low density lipoprotein cholesterol; LDLR; low density lipoprotein receptor; H
Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice
Keywords: IGF-1R; insulin-like growth factor-1 receptor; Akt2; serine-threonine protein kinase 2; HMGCR; HMG CoA reductase; FASN; fatty acid synthase; PEPCK; phosphoenolpyruvate carboxykinase; PCNA; proliferating cell Nuclear antigen; HNF4α; hepatocyte nuclear fac
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17
Keywords: SAHH; S-adenosyl-l-homocysteine hydrolase; IMQ; imiquimod; KC; keratinocytes; IL; interleukin; ICAM-1; intercellular adhesion molecule-1; EGFR; epidermal growth factor receptor; MAPKs; mitogen activated protein kinases; ERK; extracellular signal-regulated
Diarylheptanoid from rhizomes of Curcuma kwangsiensis (DCK) inhibited imiquimod-induced dendritic cells activation and Th1/Th17 differentiation
Keywords: APCs; antigen presenting cells; CCL; chemokine (CC motif) ligand; CCR; CC chemokine receptor type; DAPI; 40,6-diamidino-2-phenylindole; DCK; diarylheptanoid from Curcuma kwangsiensis; DCs; dendritic cells; ERK; extracellular signal-regulated kinase; GM-CS
Alpha, 2'-dihydroxy-4,4'-dimethoxydihydrochalcone inhibits cell proliferation, invasion, and migration in gastric cancer in part via autophagy
Keywords: TEM; transmission electron microscope; DCFDA; dihydrodichloroï¬uorescein diacetate; MEK; mitogen activated protein kinase kinase; ERK; extracellular signal-regulated kinase; mTOR; mammalian target of rapamycin; ROS; reactive oxygen species; PDX; patient
Tea polysaccharide inhibits RANKL-induced osteoclastogenesis in RAW264.7 cells and ameliorates ovariectomy-induced osteoporosis in rats
Keywords: BMD; bone mineral density; RANKL; receptor activator nuclear factor-kappa B ligand; M-CSF; macrophage colony-stimulating factor; TPS; tea polysaccharide; OVX; ovariectomized; IL-1β; interleukin-1β; IL-6; interleukin-6; ELISA; enzyme-linked immunosorbent
Cancer-associated fibroblasts-stimulated interleukin-11 promotes metastasis of gastric cancer cells mediated by upregulation of MUC1
Keywords: IL-11; Interleukin 11; GC cells; gastric cancer cells; CAFs; cancer associated fibroblasts; STAT3; Signal Transducer and Activator of Transcription3; ERK; extracellular regulated protein kinases; KM-Plotter; Kaplan-Meier Plotter; EMT; epithelial to mesenc
Polysaccharide of Hericium erinaceus attenuates colitis in C57BL/6 mice via regulation of oxidative stress, inflammation-related signaling pathways and modulating the composition of the gut microbiota
Keywords: Akt; Protein kinase B; CD; Crohn's disease; COX-2; cyclooxygenase-2; DAI; disease activity index; DSS; dextran sulfate sodium; ERK; extracellular signal-regulated kinase; HECP; Polysaccharide of Hericium erinaceus (Mw: 86.67 kDa); H. erinaceus; Hericium e
Emerging roles and mechanisms of FOXC2 in cancer
Keywords: FOXC2; Forkhead box protein C2; EMT; epithelial-mesenchymal transition; NSCLC; non-small cell lung cancer; EGFR; epidermal growth factor receptor; siRNA; small (or short) interfering RNA; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinosito
(â)-Epicatechin and the colonic metabolite 3,4-dihydroxyphenylacetic acid protect renal proximal tubular cell against high glucose-induced oxidative stress by modulating NOX-4/SIRT-1 signalling
Keywords: Antioxidant defences; Colonic-derived flavonoid metabolites; Epicatechin; NRK-52E cells; Oxidative injury; Signalling pathways; CAT; catalase; DHBA; 2,3-dihydroxybenzoic acid; DHPAA; 3,4-dihydroxyphenylacetic acid; DPI; diphenyleneiodonium; EC; (â)-epic
Apelin, a promising target for Alzheimer disease prevention and treatment
Keywords: Alzheimer disease; Apelin; Amyloid beta; Central nervous system; Oxidative stress; AAA; Abdominal aortic aneurysm; ABCA1; ATP-binding cassette transporter A1; ACE; Angiotensin converting enzyme; ACh; Acetylcholine; AChE; Acetyl choline esterase; AD; Alzhe
Aminoacyl-tRNA synthetases, therapeutic targets for infectious diseases
Keywords: ARS; aminoacyl-tRNA synthetase; TLR; toll-like receptor; RIG-I; retinoic acid-inducible gene-I; MAVS; mitochondrial antiviral signaling protein; IFN; interferon; ITCH; E3 ubiquitin-protein ligase Itchy homolog; MSC; multi-tRNA synthetase complex; AIMP; AR
Re-evaluating the role of FOXOs in cancer
Keywords: RTK; receptor tyrosine kinase; GF; growth factor; PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase; PKB; protein kinase B; AKT; RAC-alpha serine/threonine-protein kinase; FOXO; forkhead box O; GFR; growth factor receptor; PDPK1; Phosphoinositide-depen
Environmentally relevant concentrations of di(2-ethylhexyl)phthalate exposure alter larval growth and locomotion in medaka fish via multiple pathways
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; AP-1; activator protein-1; ARE; antioxidant response element; CAT; catalase; DEHP; di(2-ethylhexyl)phthalate; dpe; day(s) post-exposure; ERK; extracellular signal-regulated kinase; GPx; glutathione peroxidas
Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis
Keywords: ADAMT; aggrecanase disintegrin and metalloproteinase with thrombospondin Motifs; AGE; advanced glycation end products; Akt; protein kinase B; AP; activator protein; CRP; C-reactive protein; ECM; extra cellular matrix; DAMP; damaged associated molecular pa
The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation
Keywords: Sesquiterpene lactones; Jurkat T cells; T cell receptor; Kinase; Phosphorylation; Calcium flux; Glutathione; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; FPR; N-formyl peptide receptor; HBSS; Hanks' balanced salt solution; IP3; inositol triphosphate