Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway
Keywords: فساد; Akt; FASN; Her2; PI3K; Resveratrol; SKBR-3;
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Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype
Keywords: فساد; DCFDA; dichlorodihydrofluorescein diacetate; DL; Dalton's lymphoma; FASN; fatty acid synthase; iNOS; inducible nitric oxide synthase; MRP-1; multidrug resistant associated protein-1; MDR; multidrug resistant protein; NO; nitric oxide; ROS; reactive oxygen
Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels
Keywords: فساد; ABCA1; adenosine triphosphate-binding cassette transporter A1; ACACA; cetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOX2; acyl-CoA oxidase 2; ARTD2; ADP-ribosyl transferase diphtheria toxin-like 2; cyp51A1; cytochrome P450, family 51 subfamily A,
Associate editor: B. TeicherThe role of FAK in tumor metabolism and therapy
Keywords: فساد; Focal adhesion kinase; Lipogenesis; Glutamine; Proliferation; Motility; Molecular targeting; FAK; focal adhesion kinase; FASN; fatty acid synthase; IGF1R; insulin-like growth factor 1 receptor; ACLY; ATP citrate lyase; ECM; extracellular matrix; IRS; insu
Accumulation of lipids and oxidatively damaged DNA in hepatocytes exposed to particles
Keywords: فساد; ABCG5; ATP-binding cassette, sub-family G (WHITE), member 5; ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; CB; carbon black; DEP; diesel exhaust particles; FASN; fatty acid synthase; FFA; free fatty acids; FPG; formamidopyrimidine DNA glyco
Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet
Keywords: فساد; Acaca; acetyl-coenzyme A carboxylase alpha; Acly; ATP citrate lyase; Adrb; β-adrenergic receptor; ALT; alanine aminotransferase; Apob; apolipoprotein B; ATGL; adipose triglyceride lipase; CD; choline-deficient diet; Ces3; carboxylesterase 3; Dgat; diacyl
5â²Cis regulatory polymorphisms in candidate genes in Bos taurus and Bos indicus
Keywords: فساد; FASN; GPAM; MC4R; SCD; PLIN; Functional polymorphisms;
Genetic variation of FASN is associated with fatty acid composition of Hanwoo
Keywords: فساد; Single nucleotide polymorphism; FASN; Cattle; Fatty acid composition;
Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells
Keywords: فساد; CHO; Chinese hamster ovary; ER; endoplasmic reticulum; FASN; fatty acid synthase; FCS; foetal calf serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HMGCR; HMG-CoA reductase; LDH; lactate dehydrogenase; LDLR; low-density lipoprotein receptor; MT-ND1
Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia
Keywords: فساد; AAV; Adeno-associated virus; AAV-G6Pase; Adeno-associated viral vector expressing glucose-6-phosphatase; BCS; Body Condition Score; BMI; Body Mass Index; FASN; Fatty Acid Synthase; G6Pase; Glucose 6-phosphatase; GSD-Ia; Glycogen Storage Disease Ia; GH; Gr
Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis
Keywords: فساد; ACC; acetyl CoA carboxylase; ALD; alcoholic liver disease; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ACLY; ATP citrate lyase; ChREBP; carbohydrate response element binding protein; CYP2E1; cytochrome p450 2E1; ELOVL5; fatty acid e
3,5-Diiodo-l-thyronine induces SREBP-1 proteolytic cleavage block and apoptosis in human hepatoma (Hepg2) cells
Keywords: فساد; DAPI; 4,6-diamidino-2-phenylindole; ERK; extracellular signal-regulated kinase; FASN; fatty acid synthase; FL; firefly luciferase; IRES; internal ribosome entry site; mTOR-C1; mammalian target of rapamycin complex 1; MAPK; mitogen activated protein kinase
Identification of SNPs in the FASN gene and their effect on fatty acid milk composition in Holstein cattle
Keywords: فساد; FASN; Holstein; Fatty acid content; Milk; SNP;
Body weight management effect of burdock (Arctium lappa L.) root is associated with the activation of AMP-activated protein kinase in human HepG2 cells
Keywords: فساد; Body weight management; Burdock root; FASN; ACC; AMPK;
Coexisting role of fasting or feeding and dietary lipids in the control of gene expression of enzymes involved in the synthesis of saturated, monounsaturated and polyunsaturated fatty acids
Keywords: فساد; LC-PUFAs; long-chain polyunsaturated fatty acids; AA; arachidonic acid; EPA; eicosapentaenoic acid; DHA; docosahexaenoic acid; LA; linoleic acid; ALA; α-linolenic acid; Fads1; fatty acid desaturase 1; Fads2; fatty acid desaturase 2; Elovl; elongation of
Chitooligosaccharide ameliorates diet-induced obesity in mice and affects adipose gene expression involved in adipogenesis and inflammation
Keywords: فساد; ANOVA; analysis of variance; cDNA; complementary DNA; Ctsk; cathepsin K; CO; chitooligosaccharide; ECM; extracellular matrix; Egr2; early growth response 2; Fasn; fatty acid synthase; FER; feed efficiency ratio; FFA; free fatty acid; Gdf3; growth differen
Suppression of FAT/CD36 mRNA by human growth hormone in pancreatic β-cells
Keywords: فساد; CA; constitutively active; DN; dominant negative; FA; fatty acid; GSIS; glucose-stimulated insulin secretion; FATP; fatty acid transport protein; FABP; fatty acid binding protein; FASN; fatty acid synthase; FAT; fatty acid translocase; GFP; green fluoresc
Docosapentaenoic acid (22:5n-3): A review of its biological effects
Keywords: فساد; n-3 Polyunsaturated fatty acids (VLCPUFA); Eicosapentaenoic acid (EPA); Docosapentaenoic acid (DPA); Docosahexaenoic acid (DHA); AA; arachidonic acid; ACC; Acetyl CoA Carboxylase; ALA; alpha linolenic acid; BAE; bovine aortic endothelial cells; ChREBP; ca
Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA
Keywords: فساد; ALOX5; arachidonate 5-lipoxygenase; CEPA; conjugated eicosapentanoic acid; CFA; conjugated fatty acid; CD; conjugated dienoic; CLA; conjugated linoleic acid; CLnA; conjugated linolenic acid; CRC; colorectal cancer; EC50; 50% effective concentration; ELOVL
Hepatosteatosis in peroxisome deficient liver despite increased β-oxidation capacity and impaired lipogenesis
Keywords: فساد; Hepatosteatosis; Fatty acid oxidation; Fatty acid uptake; PPARα; ACC; acetyl-CoA carboxylase; ACLY; ATP citrate lyase; Acox1; acyl-CoA oxidase; Adfp; adipose differentiation related protein; Apo; apolipoprotein; Cpt; carnitine palmitoyltransferase; DHA;
ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation
Keywords: فساد; Akt; protein kinase B; CAT; catalase; CDKs; cyclin-dependent kinases; ER; endoplasmic reticulum; ERK; extracellular signal-regulated kinase; FASN; fatty acid synthase; FFAs; free fatty acids; H2DCFDA; 2â²,7â²-dichlorofluorescin diacetate; JNK; c-Jun NH2
Weight gain induced by an isocaloric pair-fed high fat diet: A nutriepigenetic study on FASN and NDUFB6 gene promoters
Keywords: فساد; C; control; FASN; fatty acid synthase; FFA; Free fatty acids; HADHB; hydroxyacyl-coenzyme A dehydrogenase; HFD; high fat diet; HS; high-sucrose diet; NAFLD; non-alcoholic fatty liver disease; NDUFB6; NADH dehydrogenase (ubiquinone) 1β-subcomplex, 6; MDA;
Medium-chain triglycerides impair lipid metabolism and induce hepatic steatosis in very long-chain acyl-CoA dehydrogenase (VLCAD)-deficient mice
Keywords: فساد; VLCADD; very-long-chain acyl-CoA dehydrogenase deficiency; VLCAD KO; very-long-chain acyl-CoA dehydrogenase knock-out; WT; wild type; LCT; long-chain triglyceride; MCT; medium-chain triglyceride; ACC-1α; acyl-CoA carboxylase; FASN; fatty acid synthase; 1
Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice
Keywords: فساد; ACADM; acyl-coenzyme A dehydrogenase involved in medium-chain fatty acid breakdown; BHLHB2; basic helix-loop-helix domain containing, class B 2; BZA; benzylamine; CPT1A; carnitine palmitoyl transferase; 2-DG; 2-[1,2-3H]-deoxyglucose; FASN; fatty acid synt
Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes
Keywords: فساد; Akt; protein kinase B; ANOVA; one-way analysis of variance; ASP; acid-soluble products; BSA; bovine serum albumin; C2; C2-carnitine; DAG; diacylglycerides; DGAT; diacylglycerol acyltransferase; DMEM; Dulbecco's modified Eagle's medium; FCS; Fetal calf ser
Ellagitannins, ellagic acid and vascular health
Keywords: فساد; ACE; angiotensin converting enzyme; ACO; acyl CoA oxidase; AMPK; 5â²-AMP activated protein kinase; ApoB; apolipoprotein B; COMT; catechol ortho methyl transferase; CPT; carnitine palmitoyl transferase; CRP; C-reactive protein; CYP450; cytochrome P450; d.
Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma
Keywords: فساد; HCC; hepatocellular carcinoma; SREBF1; sterol regulatory element binding factor 1; HBV; hepatitis B virus; HCV; hepatitis C virus; SAGE; serial analysis of gene expression; RT-PCR; reverse transcription-polymerase chain reaction; IHC; immunohistochemistry
A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers
Keywords: فساد; BMI; body mass index; CI; confidence interval; CIMP; CpG island methylator phenotype; FASN; fatty acid synthase; HR; hazard ratio; LOH; loss of heterozygosity; MSI; microsatellite instability; MSS; microsatellite stable;
The pathogenesis of prostate cancer: from molecular to metabolic alterations
Keywords: فساد; FASN; genetic mutations; lipid metabolism; prostate cancer; risk stratification; therapeutic approaches
Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype
Keywords: فساد; Colon cancer; FASN; MSI; CIMP; DNA methylation