Keywords: پروتئین جعبه ی جعبه ای O1; T2DM; Type 2 diabetes mellitus; NG; normal glucose concentration; HG; high glucose concentration; mTORC; mammalian target of rapamycin complex; GLUT; glucose transporters; LKB1; Liver kinase B1; AMPK; AMP-activated protein kinase; AKT; Protein kinase B; A
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Keywords: پروتئین جعبه ی جعبه ای O1; AP-1; activator protein 1; BALF; bronchoalveolar lavage fluid; BCL; B-cell lymphoma; CFTR; cystic fibrosis transmembrane conductance regulator; CXCL; chemokine CXC motif ligand; EGR-1; early growth protein 1; FOXO1; forkhead box protein O1; HDAC2; histone
Keywords: پروتئین جعبه ی جعبه ای O1; KME; aqueous extract of Korean mistletoe; EMG; electromyography; FoxO1; forkhead box protein O1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSK3; glycogen synthase kinase 3; IGF; insulin growth factor; IR; insulin receptor; IRS1; insulin receptor su
Keywords: پروتئین جعبه ی جعبه ای O1; ACSL1; long-chain acyl-CoA synthetase 1; ATGL; adipose triglyceride lipase; CerS5; ceramide synthase 5; CPT; carnitine palmitoyltransferase; DAG; diacylglycerol; DGAT; diacylglycerol acyltransferase; ER; endoplasmic reticulum; ERK; extracellular signal re
Keywords: پروتئین جعبه ی جعبه ای O1; AA; arachidonic acid; ABCA1; adenosine triphosphate-binding cassette transporter A1; ACE-I; angiotensin-converting enzyme inhibitor; ACSL1; acyl-CoA synthase 1; ADMA; asymmetric dimethylarginine; Akt; protein kinase B; Aldo; aldosterone; AMPK; adenosine m
Keywords: پروتئین جعبه ی جعبه ای O1; ACOX; peroxisomal acyl-coenzyme A oxidase 1; BDNF; Brain-derived neurotrophic factor; BM; bardoxolone methyl; CDDO-Im; 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; FAS; fatty acid synthase; FOXO1; Forkhead box protein O1; HF; high fat; LC; l
Keywords: پروتئین جعبه ی جعبه ای O1; BMI; body mass index; ARC; arcuate nucleus of hypothalamus; NPY; neuropeptide Y; AgRP; agouti-related peptide; POMC; pro-opiomelanocortin; CART; cocaine- and amphetamine-related transcript; LepRb; leptin receptor; JAK2; janus kinase 2; STAT3; signal trans
Keywords: پروتئین جعبه ی جعبه ای O1; BBB; blood brain barrier; ARC; arcuate nucleus of hypothalamus; NPY; neuropeptide Y; AgRP; agouti-related peptide; POMC; pro-opiomelanocortin; αMSH; α-melanocyte stimulating hormone; LepRb; leptin receptor; JAK2; janus kinase 2; STAT3; signal transducer
E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes
Keywords: پروتئین جعبه ی جعبه ای O1; Gluconeogenesis; E2F1; Liver metabolism; Hyperglycemia; Diabetes; Cell cycle regulators; PCK1; Phosphoenolpyruvate carboxykinase 1; G6PC; glucose-6-phosphatase G6PC; PTT; Pyruvate tolerance test; CDK4; cyclin-cyclin-dependent kinase 4; PKA; protein kina
Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment
Keywords: پروتئین جعبه ی جعبه ای O1; Inflammation-associated cancer; Ubiquitin-proteasome system (UPS); Small ubiquitin-like modifier (SUMO); Tumor microenvironment; Cytokine profile; Transcription factors; 15d-PGJ2; 15-Deoxy-Delta-12,14-prostaglandin J2; AR; androgen receptor; Ala; alanine;
Circadian control of p75 neurotrophin receptor leads to alternate activation of Nrf2 and c-Rel to reset energy metabolism in astrocytes via brain-derived neurotrophic factor
Keywords: پروتئین جعبه ی جعبه ای O1; AQP4; aquaporin 4; BDNF; brain-derived neurotrophic factor; CK2; casein kinase 2; Cry; cryptochrome; CREB; cAMP-response elements binding protein; DARPP-32; dopamine- and cAMP-regulated phosphoprotein of 32 kDa; FoxO1; forkhead box protein O1; Gbe1; glyco
A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity
Keywords: پروتئین جعبه ی جعبه ای O1; Ac-INH; acetyl-Isoniazid; Ac-PABA; acetyl-p-aminobenzoic acid; APC; allophycocyanin; CHO; Chinese hamster ovary cells; DMEM; Dulbecco's modified Eagle's medium; E2F1; E2F transctriptios factor 1; ER81; ETS-related protein 81; FITC; fluorescein IsoTioCyana
Liraglutide ameliorates early renal injury by the activation of renal FoxO1 in a type 2 diabetic kidney disease rat model
Keywords: پروتئین جعبه ی جعبه ای O1; Diabetic kidney disease; Glucagon-like peptide-1; Forkhead box protein O1; Oxidative stress;
Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats
Keywords: پروتئین جعبه ی جعبه ای O1; Rg3; Ginsenoside Rg3; Rg3 group; Rg3-treated normal group; POFS; postoperative fatigue syndrome; POFS group; postoperative fatigue syndrome model group; POFSâ+âRg3 group; Rg3-treated postoperative fatigue syndrome model group; OFT; the open field test
Atorvastatin prevents endothelial dysfunction in high glucose condition through Skp2-mediated degradation of FOXO1 and ICAM-1
Keywords: پروتئین جعبه ی جعبه ای O1; Endothelial cells; Diabetes complications; Forkhead box protein O1; Intercellular adhesion molecule-1; S-Phase kinase-associated proteins; Ubiquitination;
High-fat diet alters PAS kinase regulation by fasting and feeding in liver
Keywords: پروتئین جعبه ی جعبه ای O1; ACC; acetyl CoA carboxylase; Akt/PKB; protein kinase B; CHREBP; carbohydrate-responsive element-binding protein; CPT1-A; carnitine palmitoyltransferase 1A; DAPI; 4,6-diamidino-2-phenylindole; FAS; fatty acid synthase; FOXO1; forkhead box protein O1; GCK;
Evolution, regulation, and function of porcine selenogenome
Keywords: پروتئین جعبه ی جعبه ای O1; ACC; acetyl CoA carboxylase; AKT; protein kinase B; Cys; cysteine; DIO1; type 1 iodothyronine deiodinase; ER; endoplasmic reticulum; FAS; fatty acid synthase; FOXO1; forkhead box protein O1; GPX; glutathione peroxidase; INSR; insulin receptor; MIEN; migra
ZBTB38, a novel regulator of autophagy initiation targeted by RB1CC1/FIP200 in spinal cord injury
Keywords: پروتئین جعبه ی جعبه ای O1; ATG2; autophagy-related protein 2; ATG13; autophagy-related protein 13; ATG14; autophagy-related protein 14; ATG101; autophagy-related protein 101; ATM; ataxia telangiectasia-mutated gene; BECN1; the homologue of yeast autophagy-related protein 6; CCK-8;
The role of T cells in the pathogenesis of Parkinson's disease
Keywords: پروتئین جعبه ی جعبه ای O1; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APC; antigen-presenting cell; AQP4; Aquaporin-4; BBB; blood-brain barrier; BCL6; B cell lymphoma 6; BCR; B cell receptor; BEC; brain endothelial cells; CCL20; C-C motif ligand 20; CCR2; C-C
Phytol increases adipocyte number and glucose tolerance through activation of PI3K/Akt signaling pathway in mice fed high-fat and high-fructose diet
Keywords: پروتئین جعبه ی جعبه ای O1; Adipocyte number; Adipogenesis; Glucose tolerance; Phytol; PI3K/Akt; Mice; Akt; protein kinase B; aP2; adipocyte protein 2; AS160; Akt substrate of 160 kDa; AUC; area under the curve; C/EBPα; CCAAT-enhancer-binding proteins; FoxO1; Forkhead box protein
Insulin-induced inhibition of gluconeogenesis genes, including glutamic pyruvic transaminase 2, is associated with reduced histone acetylation in a human liver cell line
Keywords: پروتئین جعبه ی جعبه ای O1; ChIP; chromatin immunoprecipitation; FOXO1; forkhead box protein O1; GCN5; general control of amino acid synthesis 5; G6PC; glucose-6-phosphatase; GGT; γ-glutamyltransferase; GOT; glutamic-oxaloacetic transaminase; GPT; glutamic pyruvic transaminase; P
Antiproliferative effects of Bortezomib in endothelial cells transformed by viral G protein-coupled receptor associated to Kaposi's sarcoma
Keywords: پروتئین جعبه ی جعبه ای O1; vGPCR; Kaposi's Sarcoma-associated Herpes virus G Protein-Coupled Receptor; NF-κB; nuclear factor kappa B; MAPK; mitogen-activated protein kinase; MKP-3; mitogen-activated protein (MAP) kinase-phosphatase-3; FOXO1; Forkhead box protein O1; VEGF; vascular
HNE and cholesterol oxidation products in colorectal inflammation and carcinogenesis
Keywords: پروتئین جعبه ی جعبه ای O1; 7K; 7-ketocholesterol; 7βOH; 7β-hydroxycholesterol; 22OH; 22-hydroxycholesterol; 24OH; 24-hydroxycholesterol; 25OH; 25-hydroxycholesterol; 27OH; 27-hydroxycholesterol; 8-OHdG; 8-hydroxy-2â²-deoxyguanosine; Akt; AKT serine/threonine kinase 1; AP-1; acti
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
Keywords: پروتئین جعبه ی جعبه ای O1; ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho
Metabolic roles of poly(ADP-ribose) polymerases
Keywords: پروتئین جعبه ی جعبه ای O1; ABCA1; ATP-binding cassette sub-family A member 1; ACACA; acetyl-CoA carboxylase alpha; ACBD3; acyl-CoA binding domain containing 3; ACLY; ATP citrate lyase; ADP; adenosine diphosphate; ADPR; ADP-ribose; AFLD; alcoholic fatty liver disease; AIF; apoptosis
The plasticizer BBP selectively inhibits epigenetic regulator sirtuin during differentiation of C3H10T1/2 stem cell line
Keywords: پروتئین جعبه ی جعبه ای O1; BBP; Benzyl butyl phthalate; PGC1α; Peroxisome proliferator-activated receptor gamma coactivator 1 alpha; NRF1; Nuclear respiratory factor 1; NRF2; Nuclear respiratory factor 2; Tfam; Mitochondrial transcription factor A; FOXO1; Forkhead box protein O1;
A global perspective on FOXO1 in lipid metabolism and lipid-related diseases
Keywords: پروتئین جعبه ی جعبه ای O1; Forkhead box protein O1; Lipid metabolism; Lipid-related diseases;
The roles of subcellularly located EGFR in autophagy
Keywords: پروتئین جعبه ی جعبه ای O1; AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e
Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal
Keywords: پروتئین جعبه ی جعبه ای O1; CAR; constitutive androstane receptor; CDK2; cyclin-dependent kinase 2; ChIP assay; chromatin immunoprecipitation assay; CYP; cytochrome P450; FOXO1; forkhead box protein O1; PCK1; phosphoenolpyruvate carboxykinase 1; PPARα; peroxisome proliferator-activ
Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies
Keywords: پروتئین جعبه ی جعبه ای O1; ACE; angiotensin converting enzyme; ADAM; a disintegrin and metalloproteinase; AKI; acute kidney injury; ANGII; angiotensin II; AT1; angiotensin II receptor type 1; AMPKα; AMP-activated protein kinase α; α-SMA; α-smooth muscle actin; CKD; chronic kidn
Original ArticlesThe oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells
Keywords: پروتئین جعبه ی جعبه ای O1; HBXIP; PCK1; Gluconeogenesis; FOXO1; PI3K/Akt; HCC; cAMP; cyclic adenosine monophosphate; DAPI; 4â²,6-diamidino-2-phenylindole; FOXO1; forkhead box protein O1; G6P; glucose-6-phosphatas; HBXIP; hepatitis B X-interacting protein; HMP; hexose monophosphate
Immune deficiencies, infection, and systemic immune disordersSphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human TÂ cells from the thymus to the periphery
Keywords: پروتئین جعبه ی جعبه ای O1; Sphingosine-1-phosphate; thymic egress; S1P-R1; S1P-R2; T-cell reconstitution; migration; thymus; human immunology; CD62L; CD62 ligand; FOXO1; Forkhead box protein O1; GAPDH; Glyceraldehyde-3-phosphate dehydrogenase; KLF2; Kruppel-like factor 2; NIH; Nati
A conjugated fatty acid present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD+/NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathway
Keywords: پروتئین جعبه ی جعبه ای O1; ACC; acetyl-CoA carboxylase; ACOX; acyl-CoA oxidase; AMPK; AMP-activated protein kinase; BMSO; bitter melon seed oil; c9,t11-CLA; cis-9, trans-11 isomer of conjugated linoleic acid; α-ESA; α-eleostearic acid; FASN; fatty acid synthase; FOXO1; forkhead b
SH2 domain-containing inositol 5-phosphatase (SHIP2) regulates de-novo lipogenesis and secretion of apoB100 containing lipoproteins in HepG2 cells
Keywords: پروتئین جعبه ی جعبه ای O1; De-novo lipogenesis; VLDL; SH2 domain-containing inositol 5-phosphatase (SHIP2); Insulin resistance; HepG2; Liver; ACC; acyl COA carboxylase; FAS; fatty acid synthase; FOXO1; forkhead box protein O1; GFP; green fluorescent protein; MTP; microsomal transfe
SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells
Keywords: پروتئین جعبه ی جعبه ای O1; AMPK; AMP-activated protein kinase; ACC; Acyl COA Carboxylase; BSA; Bovine Serum Albumin; DHE; Dihydroethidium; DPI; Diphenylene iodonium; ERK; Extracellular signal-regulated kinase; FAS; Fatty Acid Synthase; FBS; Fetal bovine serum; FOXO1; Forkhead box p
Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels
Keywords: پروتئین جعبه ی جعبه ای O1; ABCA1; adenosine triphosphate-binding cassette transporter A1; ACACA; cetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOX2; acyl-CoA oxidase 2; ARTD2; ADP-ribosyl transferase diphtheria toxin-like 2; cyp51A1; cytochrome P450, family 51 subfamily A,
Insulin drives glucose-dependent insulinotropic peptide expression via glucose-dependent regulation of FoxO1 and LEF1/β-catenin
Keywords: پروتئین جعبه ی جعبه ای O1; Akt; Serine/threonine-specific protein kinase also known as Protein Kinase B (PKB); ChIP; Chromatin immunoprecipitation; FoxO1; Forkhead box protein O1; GLP-1; Glucagon-Like Peptide 1; HDAC1; Histone Deacetylase 1; IRE; Insulin-Response Element; PI3K; Pho
Basic ScienceAcetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: Regulation by a polyphenol -(â)-epigallocatechin-3-gallate
Keywords: پروتئین جعبه ی جعبه ای O1; FoxO1; forkhead box protein O1; EGCG; (â)-epigallocatechin-3-gallate; ROS; reactive oxygen species; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Atg7; autophagy related 7; Atg5; autophagy related 5; LC3B; microtubule-associated protein 1 light chain
FOXO1-dependent up-regulation of MAP kinase phosphatase 3 (MKP-3) mediates glucocorticoid-induced hepatic lipid accumulation in mice
Keywords: پروتئین جعبه ی جعبه ای O1; MKP-3; MAP kinase phosphatase 3; Dex; Dexamethasone; FOXO1; forkhead box protein O1; GC; glucocorticoid; DUSP6; dual specificity protein phosphatase 6; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; PI3K; phosphoinosit
Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
Keywords: پروتئین جعبه ی جعبه ای O1; MSCs; mesenchymal stem cells; SIRT1; silent mating type information regulation 2 homolog 1; AMPK; AMP-activated protein kinase; ROS; reactive oxygen species; CR; calorie restriction; PPARγ; peroxisome proliferator-activated receptor gamma; C/EBP; CCAAT/e
Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells
Keywords: پروتئین جعبه ی جعبه ای O1; AKT/PKB; protein kinase B; AMPK; 5â²-AMP-activated protein kinase; BrdU; 5-bromo-2â²-deoxyuridine; CaMMK; Ca2+/calmodulin-dependent protein kinase kinase; CPE; cocoa phenolic extract; EC; (â)-epicatechin; EGCG; epigallocatechin gallate; ERK; extracell
MAP kinase phosphatase-3 (MKP-3) is transcriptionally and post-translationally up-regulated by hCG and modulates cAMP-induced p21 expression in MA-10 Leydig cells
Keywords: پروتئین جعبه ی جعبه ای O1; DAPI; 4â²,6-diamidino-2-phenylindole; DUSPs; dual specificity phosphatases; FGF; fibroblast growth factor; FOXO1; Forkhead box protein O1; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GnRH; gonadotropin releasing hormone; L19; ribosomal L19 protein;
Crosstalk between apoptosis, necrosis and autophagy
Keywords: پروتئین جعبه ی جعبه ای O1; AIF; Apoptosis Inducing Factor; AMPK; Adenosine Monophosphate activated Kinase; APAF1; Apoptotic Protease Activating Factor 1; BCL-2; B-cell lymphoma 2; BCL-Xl; B-cell lymphoma extra large; BEC1; Beclin-1; BH; Bcl-2 homology; cIAP1; cellular inhibitor of
The virtual element in proximal promoter of porcine myostatin is regulated by myocyte enhancer factor 2C
Keywords: پروتئین جعبه ی جعبه ای O1; FOXO; forkhead box protein O1; EMSA; electrophoretic mobility gel shift assay; MEF2; myocyte enhancer factor-2; siRNA; small interfering RNA; Porcine myostatin promoter; C2C12 myoblast; EMSA; MEF2C;
Birds and longevity: Does flight driven aerobicity provide an oxidative sink?
Keywords: پروتئین جعبه ی جعبه ای O1; CR; caloric restriction; DCA; dichloroacetic acid; ETF; electron transfer flavoprotein; ETS; electron transport system; FOXO1; Forkhead box protein O1; H2O2; hydrogen peroxide; Gp; DHglycerol 3-phosphate dehydrogenase; IGF-1R; insulin-like-growth factor r
Warts and all: Human papillomavirus in primary immunodeficiencies
Keywords: پروتئین جعبه ی جعبه ای O1; Immunodeficiency; human papillomavirus; warts; squamous; carcinoma; dysplastic; ADA; Adenosine deaminase; A-T; Ataxia-telangiectasia; ATM; Ataxia-telangiectasia mutated gene; CD40L; CD40 ligand; CMV; Cytomegalovirus; CVID; Common variable immunodeficiency
Post-translational modification of pregnane x receptor
Keywords: پروتئین جعبه ی جعبه ای O1; PXR; pregnane x receptor; NR; nuclear receptor; PCN; pregnenalone 16α-carbonitrile; Rif; rifampicin; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenolpyruvate carboxykinase; CYP3A; cytochrome P450 3A; CREs; cyclic AMP response elements; PKA; cyclic AMP-d
IL-4-mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways
Keywords: پروتئین جعبه ی جعبه ای O1; ChIP; chromatin immunoprecipitation; CYP; cytochrome P450; Elk1; member of ETS oncogene family; FOXO1; forkhead box protein O1; IL-4; interleukin-4; IL-4R; interleukin-4 receptor; IRS; insulin receptor substrate; JAK; janus protein kinase; MAPK; mitogen-a