The proto-oncogene Ret is required for male foetal germ cell survival
Keywords: Germ cells; GDNF; RET;
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Promoting engraftment of transplanted neural stem cells/progenitors using biofunctionalised electrospun scaffolds
Keywords: Polycaprolactone; Scaffold; Neural stem cell; Transplantation; GDNF; PlasticityCNS, central nervous system; CRT, cell replacement therapy; E, embryonic day; ED, ethylene diamine; ELISA, enzyme-linked immunosorbent assay; GDNF, glial-cell derived neurotrop
GDNF induces mechanical hyperalgesia in muscle by reducing IBK in isolectin B4-positive nociceptors
Keywords: AHP; after-hyperpolarization; ANOVA; analysis of variance; BK channel; large-conductance voltage- and calcium-activated potassium channel; CDK5; cyclin-dependent kinase 5; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²-tertamethyllindocarbocyanine perchlorate; DRG
Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signalling in mouse stem-progenitor spermatogonia
Keywords: Spermatogonial stem cells; Phthalates; Self-renewal; Infertility; GDNF
High-fat diet exacerbates MPTP-induced dopaminergic degeneration in mice
Keywords: ARA; arachidonic acid; BDNF; brain-derived neurotrophic factor; CD; control diet; DA; dopamine; DAT; dopamine transporter; DHA; docosahexaenoic acid; DOPAC; 3,4-dihydroxyphenylacetic acid; DPA; docosapentaenoic acid; DTA; docosatetraenoic acid; GDNF; glia
Regular ArticleCometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo
Keywords: AP; Artificial perilymph; BDNF; Brain-derived neurotrophic factor; CMTN; Cometin; DCX; Doublecortin; DRG; Dorsal root ganglion; eABR; Electrically-evoked brainstem responses; EST; Expressed sequence tag; FITC; Fluorescein isothiocyanate; GDNF; Glial cell
Valproic acid mediates the synaptic excitatory/inhibitory balance through astrocytes - A preliminary study
Keywords: BDNF; brain derived neurotrophic factor; CAM; cell adhesion molecules; E/I; excitatory/inhibitory; EAAT2; excitatory amino acid transporter 2; ECM; extracellular matrix; GDNF; glial derived neurotrophic factor; GSK; glycogen synthase kinase; HDAC; histone
Research ReportExogenous GDNF increase the migration of the neural stem cells with no protection against kainic acid-induced excitotoxic cell death in rats
Keywords: Adenoviral vector; GDNF; Kainic acid; Hippocampal neural stem cell (NSC); TUNEL; Excitotoxicity;
Research ReportAcute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury
Keywords: BDNF; Brain-derived neurotrophic factor; DRG; Dorsal root ganglion; Ex; Exercise; GDNF; Glial cell line-derived neurotrophic factor; GFAP; Glial fibrillary acidic protein; HSP; Heat shock protein; LMD; Laser micro dissection; NT-3; Neurotrophin-3; NT-4; N
Neurotrophins and their role in the cochlea
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; BDNF; brain-derived neurotrophic factor; CI; cochlear implant; CNTF; ciliary neurotrophic factor; eABR; electrically evoked auditory brainstem response; eCAP; electrically evoked compound action
Closing the gap between clinic and cage: Sensori-motor and cognitive behavioural testing regimens in neurotoxin-induced animal models of Parkinson's disease
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; PACAP; adenylate cyclase activating polypeptide; Aβ; amyloid-β; SNCA [gene]; α-synuclein; α-SYN [protein]; α-synuclein; AD; Alzheimer's disease; CeA; central nucleus of the amygdala; DCS; D
Specificity of peripheral nerve regeneration: Interactions at the axon level
Keywords: AKT/PKB; protein kinase B; BDNF; brain derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; CAMs; cell adhesion molecules; Cdc42; cell division control protein 42 homolog; cGMP; cyclic guanosine monophosphate; ChAT; choline acetyltransferase
Neuroplasticity in vagal afferent neurons involved in cough
Keywords: Vagus; Vagal reflex; TRPV1; BDNF; GDNF; TRKB; GFL; Neurotrophins;
Circulating levels of GDNF in bipolar disorder
Keywords: BD; bipolar disorder; BDNF; brain-derived neurotrophic factor; DSM-IV-TR; diagnostic and statistical manual of mental disorders; text; revision; ELISA; enzyme-linked immunosorbent assay; GDNF; glial cell-line derived neurotrophic factor; HDRS; Hamilton De
Correlation of cerebral spinal fluid pH and HCO3- with disease progression in ALS
Keywords: ALS; amyotrophic lateral sclerosis; ALSFRS-R; ALS functional rating scale; CBD; corticobasal degeneration; CCA; cortical cerebellar atrophy; CS; cervical spondylosis; CSF; cerebrospinal fluid; DRPLA; dentatorubral-pallidoluysian atrophy; FALS; familial AL
Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease
Keywords: CDNF; cerebral dopamine neurotrophic factor; PD; Parkinson disease; SNP; single nucleotide polymorphism; EOPD; early-onset Parkinson disease; GDNF; glial-cell line derived neurotrophic factors; OR; odd ratio; CI; confidence interval; MAF; minor allele fre
Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population
Keywords: MAP; methamphetamine; GDNF; Glial cell line-derived neurotrophic factor; DA; dopamine; UTR; untranslated region; SNP; single nucleotide polymorphism; GFRA; GDNF family receptor alpha; RET; rearranged during transfection; JGIDA; Japanese Genetics Initiativ
Adhesion molecules as potential targets for neuroprotection in a rodent model of Parkinson's disease
Keywords: 6-OHDA; 6-hydroxydopamine; AM; adhesion molecule; BBB; Blood-brain barrier; CFA; complete Freund's adjuvant; GDNF; glial derived neurotrophic factor; ICAM-1; intercellular cell adhesion molecules; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NCAM
Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from the pro- and mature GDNF sequence
Keywords: Propeptides; GDNF; Biotherapeutic; Heparin; Neuroprotection
Prognostic Value of Chromosomal Imbalances in Squamous Cell Carcinoma and Adenocarcinoma of the Lung
Keywords: AC; adenocarcinoma; A-CDK2; active cyclin-dependent kinase 2; ANCA; average number of copy alterations; APC; Adenomatous Polyposis coli; ARG; Abelson-related oncogene; CGH; comparative genomic hybridization; CI; confidence interval; DNA; deoxyribonucleic
Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels
Keywords: BDNF; Brain-derived neurotrophic factor; FST; Forced Swim Test; GDNF; Glial cell-derived neurotrophic factor; HD; Huntington's disease; NGF; Nerve growth factor; 3-NP; 3-Nitropropionic acid; OFT; Open field test; SDH; Succinate dehydrogenase; Cell damage;
Research ReportFunctional endothelin receptors are selectively expressed in isolectin B4-negative sensory neurons and are upregulated in isolectin B4-positive neurons by neurturin and glia-derived neurotropic factor
Keywords: DRG; dorsal root ganglia; ET-1,2,3; endothelin 1,2,3; ETA-R; endothelin receptor A; ETB-R; endothelin receptor B; ETFR; endothelin functional receptors; ETAFR; endothelin functional receptors A; GDNF; glia-derived neurotropic factor; IB4; isolectin B4; NF
Research ReportResponsiveness of rat vestibular ganglion neurons to exogenous neurotrophic factors during postnatal development in dissociated cultures
Keywords: Vestibular; Ganglion; Neurotrophin; BDNF; NT-3; GDNF; VNG; vestibular ganglion neuron; NTFs; neurotrophic factors; NGF; nerve growth factor; GDNF; glial cell line-derived neurotrophic factor; BDNF; brain-derived neurotrophic factor; NT-3; neurotrophin-3;
l-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects
Keywords: PARP; poly-(ADP-ribose) polymerase; MMP; matrix metalloproteinase; GDNF; glial cell line-derived neurotrophic factor; MEN2A; multiple endocrine neoplasia type 2A; MBP; myelin basic protein; RET tyrosine kinase; l-cysteine; Arsenic; Cancer;
Neurotrophic activity of DA-9801, a mixture extract of Dioscorea japonica Thunb. and Dioscorea nipponica Makino, in vitro
Keywords: DPN; Diabetic peripheral neuropathy; NGF; Nerve growth factor; DRG; Dorsal root ganglion; IMS32; Immortalized Schwann cell; GDNF; Glial cell line-derived neurotrophic factor; DA-9801; Diabetic peripheral neuropathy; Nerve growth factor; Dorsal root gangil
FSH acts on the proliferation of type A spermatogonia via Nur77 that increases GDNF expression in the Sertoli cells
Keywords: FSH; follicle-stimulating hormone; rFSH; recombinant FSH; GDNF; glial cell line-derived neurotrophic factor; NGFI-B; nerve growth factor inducible gene B; SSCs; spermtaogonial stem cells; NBRE; NGFI-B (Nur77)-response element; ChIP; chromatin immunoprecip
Protective effect of the glial cell line-derived neurotrophic factor (GDNF) on human mesencephalic neuron-derived cells against neurotoxicity induced by paraquat
Keywords: Paraquat; GDNF; Neurotoxicology; Mesencephalic cells; Parkinson's disease
Enhanced GDNF expression in dopaminergic cells of monkeys grafted with carotid body cell aggregates
Keywords: Parkinson's disease; Positron emission tomography; Carotid body graft; Macaca fascicularis; Neuroprotection; 18F-DOPA; [18]F-DOPA; BL-grafted; bilaterally grafted; CB; carotid body; CBCA; carotid body cell aggregates; DA; dopamine; DAergic; dopaminergic;
mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum
Keywords: GDNF; RET; mGluR2/3; LY379268; Erk1/2; TrK phosphorylationGDNF, glial cell line-derived neurotrophic factor; LY379268, (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dic arboxylic acid
Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage
Keywords: GAG; glycosaminoglycan; CS; chondroitin sulfate; GlcUA; D-glucuronic acid; IdoUA; L-Iduronic acid; GalNAc; N-acetyl-D-galactosamine; PTN; pleiotrophin; MK; midkine; HGF; hepatocyte growth factor; GDNF; glial cell line-derived neurotrophic factor; P-ORN; p
Neurodegeneration, Neuroprotection, and Disease-Oriented NeuroscienceResearch PaperImpact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease
Keywords: development; dopamine; GDNF; methamphetamine; monkey; Parkinson's disease; CSF; cerebrospinal fluid; DA; dopamine; ED; embryonic day; GDNF; glial-derived neurotrophic factor; HVA; homovanillic acid; OD; optical density; TH; tyrosine hydroxylase; TH-ir; ty
TGF-β/BMPs: Crucial crossroad in neural autoimmune disorders
Keywords: CNS; central nervous system; BMP; bone morphogenetic factor; TGF-β; transforming growth factor beta; GDFs; growth and differentiation factors; GDNF; glial cell line derived neurotrophic factor; SME; SMAD-binding elements SBE; XSmad4; Xenopus Smad4; R-SMA
GDNF levels in the lower lip skin in a rat model of trigeminal neuropathic pain: Implications for nonpeptidergic fiber reinnervation and parasympathetic sprouting
Keywords: Behavior testing; Chronic constriction injury; GDNF; Mental nerve; Neuropathic; P2X3; Parasympathetic; Trigeminal;
Lithium induces c-Ret expression in mouse inner medullary collecting duct cells
Keywords: Li+; lithium; mIMCD; murine inner medullary collecting duct; GSK-3β; glycogen synthase kinase 3β; BIO; 6-bromoindirubin-3â²-oxime; TCF/LEF; T cell factor/lymphoid enhancer factor; mTOR; mammalian target of rapamycin; Ret; REarranged during Transfection
Cholinergic neurons regulate secretion of glial cell line-derived neurotrophic factor by skeletal muscle cells in culture
Keywords: GDNF; Neuromuscular junction; Nerve–muscle co-culture; Secretion; C2C12 cell; NG108-15 cell
Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells
Keywords: Dexmedetomidine; Astrocyte cells; GDNF; α2A adrenoreceptor; PKCα; CREB
Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases
Keywords: BBB; blood-brain barrier; BDNF; brain-derived neurotrophic factor; Cox-2; cyclooxygenase-2; DAergic; dopaminergic; GDNF; glial cell line-derived neurotrophic factor; GSH; glutathione; htt; huntingtin; GST; glutathione S-transferase; HD; Huntington's disea
Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease
Keywords: MANF; CDNF; GDNF; 6-OHDA; Chronic infusion; RAT
Overexpression of GDNF in the Uninjured DRG Exerts Analgesic Effects on Neuropathic Pain Following Segmental Spinal Nerve Ligation in Mice
Keywords: DRG; GDNF; lentiviral vector; neuropathic pain; spinal cord
Analysis of glial cell line–derived neurotrophic factor–inducible zinc finger protein 1 expression in human diseased kidney
Keywords: GZF1; GDNF; Immunohistochemistry; Renal proximal tubule; Kidney tubulointerstitial damage; Renal cancer; Biomarker
Soluble growth factors stimulate spermatogonial stem cell divisions that maintain a stem cell pool and produce progenitors in vitro
Keywords: SSC; spermatogonial stem cells; GDNF; glial cell line-derived neurotrophic factor; Tissue-specific stem cells; Germline; Self-renewal; Cell culture; Stem cell transplantation;
Research ReportCombining glial cell line-derived neurotrophic factor gene delivery (AdGDNF) with l-arginine decreases contusion size but not behavioral deficits after traumatic brain injury
Keywords: AdGDNF; adenoviral vector harboring glial cell line-derived neurotrophic factor; AdGFP; adenoviral vector harboring green fluorescent protein; CCI; controlled cortical impact; FL-SMC; forelimb-sensorimotor cortex; GDNF; glial cell line derived neurotrophi
A new model to study spinal muscular atrophy: Neurite degeneration and cell death is counteracted by BCL-XL Overexpression in motoneurons
Keywords: SMA; Spinal Muscular Atrophy; MN; motoneuron; SMN; human survival motor neuron protein; Smn; murine survival motor neuron protein; NTF; neurotrophic factor; BDNF; brain derived neurotrophic factor; GDNF; glial cell line-derived neurotrophic factor; CNTF;
Glial cell-line derived neurotrophic factor is essential for electroconvulsive shock-induced neuroprotection in an animal model of Parkinson's disease
Keywords: neuroprotection; 6-OHDA; GDNF; Parkinson's disease; astrocytic reaction; electroconvulsive; AP; anterior-posterior; BDNF; brain-derived neurotrophic factor; DA; dopamine; ECS; electroconvulsive shock; GDNF; glial cell line-derived neurotrophic factor; G
Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons
Keywords: AIF; apoptosis inducing factor; DIV; day in vitro; ERK1/2; extracellular signal-regulated kinase 1/2; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GDNF; glia-derived neurotrophic factor; JNK; c-Jun N-terminal kinase; LC; lactacystin; LDH; lactate dehy
Mechanisms of antidepressant action: An integrated dopaminergic perspective
Keywords: MDD; Major depressive disorder; DA; dopamine/dopaminergic; NA; noradrenaline; 5-HT; serotonin; 5-HT1A; serotonin receptor 1A; SSRI; selective serotonin reuptake inhibitor; CSF; cerebrospinal fluid; 5-HIAA; 5-Hydroxyindoleacetic acid; NGF; nerve growth fac
The emergence of designed multiple ligands for neurodegenerative disorders
Keywords: ACh; acetylcholine; A2A; adenosine receptor subtype two-A; Aβ; amyloid-beta; ACE; angiotensin converting enzyme; BDNF; brain derived neurotrophic factor; GDNF; glial derived neurotrophic factors; MAO-B; monoamine oxidase B; AChE; acetylcholinesterase; AP
GDNF modifies reactive astrogliosis allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury
Keywords: Axonal regeneration; GDNF; Reactive astrocytes; Schwann cells; Spinal cord injury; Transplantation
Directed differentiation of porcine epiblast-derived neural progenitor cells into neurons and glia
Keywords: AA; Ascorbic acid; BDNF; Brain-derived neurotrophic factor; bFGF; Basic fibroblast growth factor; ESC; Embryonic stem cell; FGF8; Fibroblast growth factor 8; GDNF; Glial cell line-derived neurotrophic factor; ICM; Inner cell mass; iPSC; Induced pluripoten
Cytoprotective effects of growth factors: BDNF more potent than GDNF in an organotypic culture model of Parkinson's disease
Keywords: Organotypic culture; BDNF; GDNF; Parkinson's disease; Dopaminergic cell; Cytoprotection