دانلود مقالات ISI درباره مطالعات مرتبط با ژنوم + ترجمه فارسی

Missense variant in TREML2 protects against Alzheimer's disease

Keywords: مطالعات مرتبط با ژنوم; TREM2; Genome-wide association studies; Conditional analysis; Endophenotype; Gene; Alzheimer's disease; Association;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold

Keywords: مطالعات مرتبط با ژنوم; AD; Alzheimer's disease; ANK; ankyrin repeat domain; ARM; armadillo repeat domain; AUC; area under the curve; BA; brain availability; BBB; blood brain barrier; BCRP; breast cancer related protein; BI; brain impairment; CSD; Cambridge Structural Database

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Genetic evidence for a pathogenic role for the vitamin D3 metabolizing enzyme CYP24A1 in multiple sclerosis

Keywords: مطالعات مرتبط با ژنوم; Multiple sclerosis; Genetics; Vitamin D; CYP24A1; Expression quantitative trait loci; Genome-wide association studies;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Rα−/− mice

Keywords: مطالعات مرتبط با ژنوم; IL-12p40; Primary biliary cirrhosis; Fibrosis; IFN-γ; Effector memory cells; ALT; serum alanine aminotransferase; ANOVA; one-way analysis of variance; CCL2; chemokine (C-C motif) ligand 2; dnTGFβRII; dominant negative form of transforming growth facto

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Genetic insights on host and hepatitis B virus in liver diseases

Keywords: مطالعات مرتبط با ژنوم; Hepatitis B virus; Liver disease; Hepatocellular carcinoma; Host genetics; Genome-wide association studies; Next generation sequencing

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Basic research in PCOS: are we reaching new frontiers?

Keywords: مطالعات مرتبط با ژنوم; anovulation; candidate genes; genome-wide association studies; hyperandrogenism; insulin resistance; polycystic ovary syndrome

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism

Keywords: مطالعات مرتبط با ژنوم; BPD; bipolar disorder; SZ; schizophrenia; SNP; single nucleotide polymorphism; GWAS; genome-wide association studies; ANK3; ankyrin-G protein; KCTD12; potassium channel tetramerization domain containing 12; LMAN2L; lectin, mannose-binding 2-like; UMMC; Un

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2014 سفارش ترجمه

Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

Keywords: مطالعات مرتبط با ژنوم; Autoimmunity; Genetics; GWAS; SH2B Adaptor Protein 3; AIH; autoimmune hepatitis; ALT; alanine aminotransferase; GWAS; genome-wide association studies; LD; linkage disequilibrium; LKM-1; liver kidney microsomal 1 antibodies; MHC; major histocompatibility c

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2014 سفارش ترجمه

Association of POL1, MALT1, MC4R, PHLPP and DSEL single nucleotide polymorphisms in chromosome 18q region with type 2 diabetes in Tunisians

Keywords: مطالعات مرتبط با ژنوم; AER; albumin excretion rate; BMI; body-mass index; DN; diabetic nephropathy; DWN; diabetes without nephropathy; ESRD; end-stage renal disease; FPG; fasting plasma glucose; GWAS; genome-wide association studies; MAF; minor allele frequency; OGTT; oral gluc

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Identification of somatic mutations in human prostate cancer by RNA-Seq

Keywords: مطالعات مرتبط با ژنوم; GWAS; genome-wide association studies; ENA; European Nucleotide Archive; SPORE; Specialized Programs of Research Excellence; SNV; single nucleotide variants; GO; gene ontology; TRAIL; TNF-related apoptosis-inducing ligand; TNF; tumor necrosis factor; RNA-

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status

Keywords: مطالعات مرتبط با ژنوم; GWAS; genome-wide association studies; SNP; single nucleotide polymorphism; AD; Alzheimer's disease; ABCA7; ATP binding cassette A7; qPCR; quantitative polymerase chain reaction; Aβ; amyloid-beta; EIF4H; eukaryotic translation initiation factor 4H; RPL32

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population

Keywords: مطالعات مرتبط با ژنوم; Genome-wide association studies; BIN1 gene rs744373 polymorphism; East Asian; Caucasian;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia

Keywords: مطالعات مرتبط با ژنوم; ZNF804A; zinc finger protein 804A; GWAS; Genome-wide association studies; ANKRD; ankyrin repeat domain 1; INHBE; inhibin, beta E; PIK3AP1; phosphoinositide-3-kinase adaptor protein 1; DDIT3; DNA-damage-inducible transcript 3; CLIC2; chloride intracellular

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

A Genome-Wide Methylation Study of Severe Vitamin D Deficiency in African American Adolescents

Keywords: مطالعات مرتبط با ژنوم; 25(OH)D; 25-Hydroxyvitamin D; FDR; False discovery rate; GO; Gene ontology; GWAS; Genome-Wide Association Studies; IL; Interleukin; LC-MS/MS; Liquid chromatography tandem mass spectroscopy; NHANES; National Health and Nutrition Examination Survey;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

A new method for post Genome-Wide Association Study (GWAS) analysis of colorectal cancer in Taiwan

Keywords: مطالعات مرتبط با ژنوم; GWAS; Genome-wide association study; SNP; Single-nucleotide polymorphism; CRC; Colorectal Cancer; LD; Linkage disequilibrium; ACU; Area under curve; ROC; Receiver operating characteristic; Genome-Wide Association Studies; GWAS; Single-nucleotide polymorph

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Genetic variants in TERT-CLPTM1L genetic region associated with several types of cancer: A meta-analysis

Keywords: مطالعات مرتبط با ژنوم; OR; Odds ratio; CLPTM1L; Cleft lip and palate transmembrane 1-like; TERT; Telomerase reverse transcriptase; GWAS; Genome-wide association studies; LD; Linkage disequilibrium; CNKI; China National Knowledge Infrastructure; NOS; Newcastle-Ottawa assessmen

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Identifying SNP targeted pathways in partial epilepsies with genome-wide association study data

Keywords: مطالعات مرتبط با ژنوم; ADNFLE; autosomal dominant nocturnal frontal lobe epilepsy; epiGAD; Epilepsy Genetic Association Database; ECM; extracellular matrix; GWAS; genome-wide association study; KEGG; Kyoto Encyclopedia of Genes and Genomes; LD; linkage disequilibrium; MTLE; mes

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Original ResearchFull Report: Basic and Translational-Alimentary TractExpression Quantitative Trait Loci Analysis Identifies Associations Between Genotype and Gene Expression in Human Intestine

Keywords: مطالعات مرتبط با ژنوم; SNPdb; IBD; Transcriptomics; Systems Biology; eQTL; expression quantitative trait loci; eSNP; expressed single nucleotide polymorphism; FDR; false discovery rate; GC; GenCall; GWAS; genome-wide association studies; IBD; inflammatory bowel disease; kb; kil

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Genomics and transcriptomics in HIV and HIV/HCV coinfection—Review of basic concepts and genome-wide association studies

Keywords: مطالعات مرتبط با ژنوم; Transcriptomics; Genomics; Micro-RNA; Genome-wide association studies; GWAS

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Sortilin and the risk of cardiovascular disease

Keywords: مطالعات مرتبط با ژنوم; Genome-wide association studies; Coronary artery disease; Low-density lipoprotein cholesterol; Sortilin; Functional genetics; Lipoprotein metabolism; Genome wide association studies; Doença das artérias coronárias; Colesterol lipoproteína de baixa den

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Systemic sclerosis: Genetics and epigenetics

Keywords: مطالعات مرتبط با ژنوم; Systemic sclerosis; Genetics; Epigenetics; Genome-wide association studies; DNA methylation; Histone modifications; MicroRNAs

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Osteoarthritis year 2013 in review: genetics and genomics

Keywords: مطالعات مرتبط با ژنوم; Osteoarthritis; Genetics; Epigenetics; DNA methylation; microRNA; Transcriptomics; Cartilage; Review; Gene expression; Genome-wide association studies

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

NKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent

Keywords: مطالعات مرتبط با ژنوم; Genome-wide association studies; Alcohol dependence; eQTL; Risk region; Replication

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Genomic Approaches to Chronic Lymphocytic Leukemia

Keywords: مطالعات مرتبط با ژنوم; Chronic lymphocytic leukemia; Genomics; Comparative genomic hybridization; Single-nucleotide polymorphism arrays; Linkage mapping; Genome-wide association studies; Whole-exome sequencing; Whole-genome sequencing;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

SNPs affecting serum metabolomic traits may regulate gene transcription and lipid accumulation in the liver

Keywords: مطالعات مرتبط با ژنوم; SNP; single nucleotide polymorphism; GWAS; genome-wide association studies; HLC; hepatic lipid content; eQTL; expression quantitative trait loci; LD; linkage disequilibrium; FADS1; fatty acid desaturase 1; ELOVL2; ELOVL fatty acid elongase 2; ACADS; acyl-

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population

Keywords: مطالعات مرتبط با ژنوم; NRG1; Neuregulin-1; ErbB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; SNPs; single nucleotide polymorphisms; CHB; Han Chinese in Beijing, China; JPT; Japanese in Tokyo, Japan; CEU; Utah residents with ancestry from northern and western Euro

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Uncovering the biology of FTO

Keywords: مطالعات مرتبط با ژنوم; Obesity; Gene; Genome-wide association studies; Food intake; Nutrient; Enzyme

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARγ, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs

Keywords: مطالعات مرتبط با ژنوم; Type 2 diabetes; Genetics; Lebanon; Tunisia; Arab population; Genome-wide association studies; SNPs; ENPP1; IGF2BP2; KCNJ11; MLXIPL; PPARγ; SLC30A8; TCF7L2Diabète de type 2; Génétique; Liban; Tunisie; Populations arabes; Genome-wide association studies; P

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Genomic determinants of motor and cognitive outcomes in Parkinson’s disease

Keywords: مطالعات مرتبط با ژنوم; Genome-wide association studies; Parkinson’s disease; Outcomes

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Complement receptor 1 (CR1) and Alzheimer's disease

Keywords: مطالعات مرتبط با ژنوم; AD; Alzheimer's disease; Aβ; amyloid-beta; ApoE; apolipoprotein E; BBB; blood-brain barrier; CCP; complement-control proteins; CFH; complement factor H; C3; complement factor 3; CR1; complement receptor 1; CSF; cerebrospinal fluid; E-CR1; erythrocyte c

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Modelling the contribution of family history and variation in single nucleotide polymorphisms to risk of schizophrenia: A Danish national birth cohort-based study

Keywords: مطالعات مرتبط با ژنوم; GWAS; genome-wide association studies; SNP; single-nucleotide polymorphism; PCA; principal component analysis; Schizophrenia; Familial history of psychiatric disorder; Epidemiology; Genome-wide association; Single-nucleotide polymorphisms;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Expression profiling in neuropsychiatric disorders: Emphasis on glutamate receptors in bipolar disorder

Keywords: مطالعات مرتبط با ژنوم; Expression profiling; Glutamate receptors; Genome-wide association studies; Major depressive disorder; Molecular fingerprint; Postmortem human brain; Schizophrenia; Single cell analysis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Obesity Susceptibility Loci on Body Mass Index and Weight Loss in Spanish Adolescents after a Lifestyle Intervention

Keywords: مطالعات مرتبط با ژنوم; BMI; Body mass index; GPS; Genetic predisposition score; GWAS; Genome-wide association studies; rs; RefSNP cluster; SNP; Single nucleotide polymorphism; TE; Total energy;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk

Keywords: مطالعات مرتبط با ژنوم; IRS1; GWAS; Genetic variation; Type-2 diabetes; Hyperinsulinemia; Insulin resistance; IRS1; Insulin receptor substrate-1; T2D; Type-2 diabetes; CVD; Cardiovascular disease; GWAS; Genome-wide association studies; SNP; Single nucleotide polymorphism; HOMA-I

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of candidate SNPs for drug induced toxicity from differentially expressed genes in associated tissues

Keywords: مطالعات مرتبط با ژنوم; CYP; cytochrome P450; GWAS; genome-wide association studies; GEO; Gene Expression Omnibus; NCI-CTC; National Cancer Institute Common Toxicity Criteria; SMD; Stanford Microarray Database; SNPs; single nucleotide polymorphisms; TCGA; The Cancer Genome Atlas

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Genetic prediction of common diseases. Still no help for the clinical diabetologist!

Keywords: مطالعات مرتبط با ژنوم; Common multifactorial diseases; Genome-wide association studies; Genetic counseling; Direct-to consumer testing; Ethical, legal and social issues; Diseases prediction models; Next generation sequencing;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Assessment of the value of a genetic risk score in improving the estimation of coronary risk

Keywords: مطالعات مرتبط با ژنوم; AHA; American Heart Association; CHD; coronary heart disease; CVD; Cardiovascular diseases; CVRFs; cardiovascular risk factors; DNA; deoxyribonucleic Acid; GRS; genetic risk score; GWAS; genome-wide association studies; IDI; integrated discrimination impr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Relating human genetic variation to variation in drug responses

Keywords: مطالعات مرتبط با ژنوم; pharmacogenomics; genome-wide association studies; next-generation sequencing; 1000 genome project; personalized medicine

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Identifying disease related sub-pathways for analysis of genome-wide association studies

Keywords: مطالعات مرتبط با ژنوم; GWAS; genome-wide association studies; SNPs; single-nucleotide polymorphisms; RA; rheumatoid arthritis; CD; Crohn's disease; T1D; type 1 diabetes; BD; bipolar disorder; HT; hypertension; CAD; coronary artery disease; T2D; type 2 diabetes; KEGG; Kyoto Ency

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Common and specific liability to addiction: Approaches to association studies of opioid addiction

Keywords: مطالعات مرتبط با ژنوم; Genome-wide association studies; Opioid; Genetics; Heroin; Addiction

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Allelic and phenotypic spectrum of plasma triglycerides

Keywords: مطالعات مرتبط با ژنوم; ABL; abetalipoproteinemia; ANGPTL3; angiopoietin-like 3; ANGPTL4; angiopoietin-like 4; APOA4; apolipoprotein A-IV; APOA5; apolipoprotein A-V; APOB; apolipoprotein B; APOC2; apolipoprotein C-II; APOC3; apolipoprotein C-III; APOE; apolipoprotein E; CAD; cor

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

The Membrane-Bound Mucin Muc1 Regulates T Helper 17-Cell Responses and Colitis in Mice

Keywords: مطالعات مرتبط با ژنوم; Susceptibility; Risk Factor; Mouse Model; Immune Regulation; CD; Crohn's disease; DC; dendritic cells; DKO; double knockout; FACS; fluorescence-activated cell sorter; GWAS; genome-wide association studies; HRP; horseradish peroxidase; IBD; inflammatory bo

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

New Virologic Tools for Management of Chronic Hepatitis B and C

Keywords: مطالعات مرتبط با ژنوم; Diagnostic Assay; Real-Time Polymerase Chain Reaction; Real-Time Transcription-Mediated Amplification; Next-Generation Sequencing; Antigen Quantification; Point-of-Care Tests; ALT; alanine aminotransferase; bp; base pair; DAA; direct-acting antiviral; DBS

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Genetics for clinicians: From candidate genes to whole genome scans (technological advances)

Keywords: مطالعات مرتبط با ژنوم; genetics; genome-wide association studies; linkage analysis; candidate gene

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Cardiovascular diseases and genome-wide association studies

Keywords: مطالعات مرتبط با ژنوم; Genome-Wide Association Studies; Cardiovascular diseases; Cardiovascular-related quantitative traits; Gene-gene interactions; Gene-environment interactions;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Genome-wide association studies of antidepressant outcome: A brief review

Keywords: مطالعات مرتبط با ژنوم; GWAS; Genome-wide association studies; STAR*D; Sequenced Treatment Alternatives to Relieve Depression; MARS; Munich Antidepressant Response Signature; GENDEP; Genome-based Therapeutic Drugs for Depression; MDD; Major depressive disorder; SNP; single nucle

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

A search for overlapping genetic susceptibility loci between non-Hodgkin lymphoma and autoimmune diseases

Keywords: مطالعات مرتبط با ژنوم; Non-Hodgkin lymphoma; Autoimmune diseases; Genome-wide association studies; Human leukocyte antigen

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Bayes factors in the presence of population stratification

Keywords: مطالعات مرتبط با ژنوم; Approximate Bayes factor; Clustering; Genome-wide association studies; Odds ratio; Population stratification

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

NCI, NHLBI First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: Etiology and Pathogenesis of Late Effects after HCT Performed in Childhood—Methodologic Challenges

Keywords: مطالعات مرتبط با ژنوم; Late effects; Pediatric allogeneic transplantation; Pediatric autologous transplantation; Genome-wide association studies; Candidate gene studies

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Blood-based biomarkers for Alzheimer's disease: plasma Aβ40 and Aβ42, and genetic variants

Keywords: مطالعات مرتبط با ژنوم; Plasma amyloid β; Cross-sectional study; Prospective study; Genome-wide association studies

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه