Generation of mouse oocytes defective in cAMP synthesis and degradation: Endogenous cyclic AMP is essential for meiotic arrest
Keywords: cAMP; GPCR; PDE3A; Oocyte; Meiotic arrest;
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Ecdysteroids, juvenile hormone and insect neuropeptides: Recent successes and remaining major challenges
Keywords: GPCR; Insect hormones; Ecdysone; Juvenile hormone; Sex hormone; Neuropeptide; DAPIT; Prolactin; Prothoracic gland
Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages
Keywords: Arrestin-2; Arrestin-3; Beta-arrestin; TLR; GPCR; TLR4; GRK2; GRK5; GRK6; GPCR kinase; TLR3; TLR2; TLR7
Gene expression profiling for the identification of G-protein coupled receptors in human platelets
Keywords: Platelets; mRNA; P2 receptors; Microarray; Adenosine; GPCR
Somatostatin receptor subtype 1 is a PDZ ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics
Keywords: cortical neuron; GPCR; growth cone collapse; MAGUK; protein interaction; CTD; C-terminal tail domain; d.i.v.; days in vitro; DMEM; Dulbecco's modified Eagle medium; EDTA; ethylene diamine tetraacetic acid; GFP; green fluorescent protein; GPCR; G proteinâ
P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecular-1 expression and enhances lymphocyte adherence to a human submandibular gland cell line
Keywords: BSA; bovine serum albumin; [Ca2+]i; intracellular free calcium concentration; DMEM; Dulbecco's Modified Eagle's Medium; EGF; epidermal growth factor; EGFR; EGF receptor; ERK; extracellular signal regulated kinase; FBS; fetal bovine serum; GPCR; G protein-
Honey, we need to talk about the membrane progestin receptors
Keywords: Membrane progestin receptor; GPCR; Endoplasmic reticulum; Progesterone; Signalling; PAQR
BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies
Keywords: BacMam; 293 cells; GPCR; Parathyroid hormone receptor; Frizzled; US28; Chemokine; Fractalkine; Purification; Crystallization
Protein kinase D isozymes activation and localization during mitosis
Keywords: PKD; PKD2; PKD3; Mitosis; Centrosomes; Spindles; GPCR; PKC; HDAC5;
RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy
Keywords: Regulator of G protein signaling; RGS5; Vascular hypertrophy; Hypertension; Aorta; Coarctation; GPCR; Artery contraction; Vascular remodeling
Identification of ETA and ETB binding domains using ET-derived photoprobes
Keywords: Endothelin; ETA; ETB; Photolabeling; Binding domains; ACN; acetonitrile; Boc; tert-butyloxycarbonyl; BOP; benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; Bpa; p-benzoyl-phenylalanine; BSA; bovine serum albumine; CHO cells; Chines
Structural basis of cholecystokinin receptor binding and regulation
Keywords: Cholecystokinin; Gastrin; Photoaffinity labeling; GPCR; Molecular modelingBpa, p-benzoyl-l-phenylalanine; CCK, cholecystokinin; ECL, extracellular loop; G protein, guanine nucleotide-binding protein; GPCR, G protein-coupled receptor; pNO2-Phe, p-nitro-phe
Regulation of cardiac excitation and contraction by p21 activated kinase-1
Keywords: Protein phosphatase 2A; L-type Ca2+-channel; Sarcomeric protein phosphorylation; Ryanodine receptor; AC; denylate cyclase; Ad; adenovirus; BK channel; Ca2+-activated K+ currents; B(PR55); PP2A regulatory subunits; Bâ²(PR61); PP2A regulatory subunits; Bâ
Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells
Keywords: CREB; cyclic AMP response-element binding-protein; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; IBMX; 3-isobutyl-1-methylxanthine; mACh; muscarinic acetylcholine; MAPK; mitogen-activated protein kinase; PDBu; phorbol 12,13
Extracellular calcium as an integrator of tissue function
Keywords: CaR; calcium sensing receptor; Cao2+; extracellular calcium; GPCR; G protein-coupled receptor; Cai2+; intracellular calcium; NCX; Na+/Ca2+ exchanger; PTH; parathyroid hormone; PMCA; plasma membrane Ca2+ ATPase; 1,25(OH)2D; vitamin D; Extracellular calcium
Isolation and characterization of a novel human RGS mutant displaying gain-of-function activity
Keywords: RGS; Gain-of-function; GPCR; G protein;
Recruitment and activation of phospholipase C (PLC)-δ1 in lipid rafts by muscarinic stimulation of PC12 cells: Contribution of p122RhoGAP/DLC1, a tumor-suppressing PLCδ1 binding protein
Keywords: BHK; baby hamster kidney; BK; bradykinin; CCH; carbamylcholine; CIB; cell incubation buffer; DLC1; deleted in liver cancer 1; DSP; dithiobis-succinimidylpropionate; EGF; epidermal growth factor; GAP; GTPase activating protein; GPCR; G-protein-coupled rece
Receptor mosaics of neural and immune communication: Possible implications for basal ganglia functions
Keywords: Ab; amyloid-beta protein; ABGA; antibasal ganglia antibody; AD; Alzheimer's disease; AGE; advanced glycation endproducts; AIDS; acquired immunodeficiency syndrome; ALS; amyotrophic lateral sclerosis; CA; cornu ammonis; CB; cannabinoid; CD; cluster designa
Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase
Keywords: C-tail; carboxyl-terminal tail; FBS; foetal bovine serum; GFP; green fluorescent protein; GPCR; G protein-coupled receptor; GRK; GPCR receptor kinase; HA; hemagglutinin; HEK; human embryonic kidney; hIP; human IP; IC; intracellular; IP; prostacyclin recep
Agonist-dependent internalization and trafficking of the human prostacyclin receptor: A direct role for Rab5a GTPase
Keywords: C-tail; carboxyl-terminal tail; CCV; clathrin coated vesicles; FBS; foetal bovine serum; GFP; green fluorescent protein; GPCR; G protein-coupled receptor; GRK; GPCR receptor kinase; HA; hemagglutinin; HEK; human embryonic kidney; hIP; human IP; IP; prosta
Differential regulation of RhoA-mediated signaling by the TPα and TPβ isoforms of the human thromboxane A2 receptor: Independent modulation of TPα signaling by prostacyclin and nitric oxide
Keywords: GPCR; G protein-coupled receptor; HA; hemagglutinin; HEK; human embryonic kidney; IP; prostacyclin receptor; IP3; inositol 1, 4, 5-trisphosphate; NO; nitric oxide; eNOS; endothelial nitric oxide synthase; PAGE; polyacrylamide gel electrophoresis; PG; pros
Bile acids and signal transduction: Role in glucose homeostasis
Keywords: CDCA; chenodeoxycholic acid (3α,7α-dihydroxy-5β cholan-24-oic acid); CA; cholic acid (3α,7α,12α-trihydroxy-5β cholan-24-oic acid); DCA; deoxycholic acid (3α,12α-dihydroxy-5β cholan-24-oic acid); LCA; lithocholic acid (3α-monohydroxy-5β cholan-
Diversity of actions of GnRHs mediated by ligand-induced selective signaling
Keywords: GnRH; GnRH receptor; Ligand-induced selective-signaling; Reproduction; Antiproliferation; GPCR; Signal trafficking; Cancer
Extracellular calcium-sensing receptors in fishes
Keywords: CaSR, calcium-sensing receptor; CAS, plant calcium-sensing receptor; EC50, effective concentration producing a 50%; response; ECD, extracellular domain; ERK, extracellular signal-regulated kinase; FW, freshwater-acclimated; GPCR; G protein-coupled recepto
A genome-wide inventory of neurohormone GPCRs in the red flour beetle Tribolium castaneum
Keywords: GPCR; Neurohormone; Neuropeptide; Biogenic amine; Monoamine; Glycoprotein hormone; Insect; Agriculture; Genomics; Evolution
The nerve growth factor and its receptors in airway inflammatory diseases
Keywords: ADAM; a disintegrin and metalloprotease domain; AP-1; activating protein 1; AP-2; clathrin adaptative protein-2; APPL; amyloid precursor protein-like; ARMS; ankyrin repeat-rich membrane spanning; BDNF; brain-derived neurotrophic factor; bFGF; basic fibrob
Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers
Keywords: Receptor tyrosine kinases; Src; GPCR; Wnt/PKC; Notch; WISP-2 and -3; TGFβ; AKT; NF-κB; MicroRNAs
Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2
Keywords: CRTH2; DP2; Prostaglandin D2; 7TM receptor; GPCR; Antagonist; Radioligand
Comparison of the binding modes of TT-232 in somatostatin receptors type 1 and 4
Keywords: TT-232; Somatostatin receptor type 1; Somatostatin receptor type 4; Docking; GPCR;
Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series
Keywords: Cannabinoid; CB1; GPCR; Obesity; Pyrazine; ADME; Hypophagia; Antagonist
New ‘chemical probes’ to examine the role of the hFPRL1 (or ALXR) receptor in inflammation
Keywords: hFPRL1; IL-6; Neutrophil migration; GPCR; Benzimidazole
A system for receptor functional analysis based on c-fos mRNA expression: Analysis of GnRH receptors as a test system
Keywords: D-MEM; Dulbecco's Modified Eagle's Medium; GnRH; gonadotropin-releasing hormone; GPCR; G protein-coupled receptor; IP; inositol phosphate; RT; reverse transcription.; c-fos; Receptor functional analysis; COS-7 cells; Competitive PCR; GnRH;
Discovery of 5-HT6 receptor ligands based on virtual HTS
Keywords: Serotonin receptor; 5-HT6; GPCR; Molecular modeling; vHTS
Interferon gamma-dependent transactivation of epidermal growth factor receptor
Keywords: EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; IFNγ; interferon gamma; IFNγR; interferon gamma receptor; JAK; Janus kinase; STAT; signal transducer and activator of transcription; TGF-α; transforming growth factor-α; HB-EGF; hep
Cloning and developmental expression of a chick G-protein-coupled receptor SCGPR1
Keywords: GPCR; GPR37; GPCR/CNS1; ETBR-LP; Neural tube; Notochord; Spinal cord; Motor neuron; Myotome; Tectum; Retina; Thyroid
Eye-open at birth phenotype with reduced keratinocyte motility in LGR4 null mice
Keywords: LGR4; GPR48; GPCR; Gene deletion mice; EOB; KeratinocyteLGR, leucine-rich repeat containing G-protein coupled receptor; GPCR, G-protein coupled receptor; FSHR, follicle-stimulating hormone receptor; LH/CGR, luteinizing hormone/chorionic gonadotropin recep
Sensitisation of TRPV1 in rat sensory neurones by activation of SNSRs
Keywords: Pain; Primary sensory neurone; Nociceptor; TRPV1; GPCR; SNSR;
Caveolin-1 affects serotonin binding and cell surface levels of human 5-HT7(a) receptors
Keywords: 5-HT, 5-hydroxytryptamine, serotonin; 5-MeOT, 5-metoxytryptamine; GPCR, G protein coupled receptor; Cav-1, caveolin-1; siRNA, small interfering RNA; KD, dissociation constant; MβCD, methyl-β-cyclodextrinCaveolae; Lipid rafts; Receptor trafficking; GPCR; 5
Diaryl substituted pyrazoles as potent CCR2 receptor antagonists
Keywords: Chemokines; CCR2; MCP-1; GPCR
Remnant lipoproteins stimulate proliferation and activate MAPK and Akt signaling pathways via G protein-coupled receptor in PC-3 prostate cancer cells
Keywords: PC; Prostate cancer; CM; chylomicrons; RLPs; remnant lipoproteins; MAPK; mitogen-activated protein kinase; EGFR; epidermal growth factor receptor; GPCR; G protein-coupled receptor; PKC; protein kinase C; PI3K; phosphoinositide 3-kinase; FBS; fetal bovine
Identification of one capa and two pyrokinin receptors from the malaria mosquito Anopheles gambiae
Keywords: Malaria; Mosquito; Insect; GPCR; Neuropeptide; Capa; Pyrokinin; PBAN; Ecdysis-triggering hormone; Neuromedin U
Heterologous expression and characterization of the recombinant bradykinin B2 receptor using the methylotrophic yeast Pichia pastoris
Keywords: GPCR; Bradykinin receptor; Heterologous expression; Glycosylation; Localization
Multiplexing G protein-coupled receptors in microarrays: A radioligand-binding assay
Keywords: GPCR; Microarrays; High-throughput screening; Radioligands; Adrenergic; Typhoon;
Large-scale molecular dynamics of a G protein-coupled receptor, the human 5-HT4 serotonin receptor, in a lipid bilayer
Keywords: Molecular dynamic; Free energy calculations; Molecular model; 5HT4 receptor; GPCR; Protein-ligand interaction;
Molecular Characterization of TMPRSS2-ERG Gene Fusion in the NCI-H660 Prostate Cancer Cell Line: A New Perspective for an Old Model
Keywords: TMPRSS2-ERG; prostate cancer; cell line; gene fusion; translocation; AR; androgen receptor; FISH; fluorescence in situ hybridization; PrSC; prostate stromal cell; PSA; prostate-specific antigen; gPCR; quantitative polymerase chain reaction; RT-PCR; revers
The regulation of uterine relaxation
Keywords: Myometrium; GPCR; Cyclic nucleotides; Phosphodiesterases; Tocolytics
Role of diacylglycerol kinase in cellular regulatory processes: A new regulator for cardiomyocyte hypertrophy
Keywords: ANF; atrial natriuretic factor; DAG; diacylglycerol; DGK; diacylglycerol kinase; DGKζ-TG; transgenic mouse with cardiac specific expression of DGKζ; ERK; extracellular signal regulated kinase; ET-1; endothelin-1; GPCR; G protein-coupled receptor; MHC; m
Action of Pasteurella multocida toxin on Gαq is persistent and independent of interaction with G-protein-coupled receptors
Keywords: GPCR; G protein coupled receptor; IP; inositol phosphates; MEF; mouse embryonic fibroblasts; PMT; Pasteurella multocida toxin; PLC-β; phospholipase CβHeterotrimeric G protein; Gαq; Pasteurella multocida toxin; GTPase cycle; GPCR; Adrenoceptor
Allosteric properties of G protein-coupled receptor oligomers
Keywords: GPCR; Dimerization; Allostery; Binding cooperativity;
Alpha 1-adrenoceptor agonists protect against stress-induced death of neural progenitor cells
Keywords: α1-adrenoceptor; GPCR; Neural progenitor cell; Cell death; Cell stress; Phenylephrine; Cirazoline;