دانلود مقالات ISI درباره Gpcr + ترجمه فارسی

Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst1 receptor

Keywords: Somatostatin; GPCR; Somatostatin sst1 receptor; Selective sst1 receptor antagonists; Ergolines; Lysergic acid derivatives

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Tonic activity of Gα-gustducin regulates taste cell responsivity

Keywords: CMF; calcium-magnesium free; CV; circumvallate; GFP; green fluorescent protein; GPCR; G protein-coupled receptor; Gus; gustducin; IP3R3; inositol trisphosphate receptor type III; PDE; phosphodiesterase; PKA; protein kinase A; PKC; protein kinase C; PLCÎ

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein Gαi2β1γ2

Keywords: AM 251; 6-iodopravadoline; AM 630; (6-iodo-2-methyl-1-[2-4(morpholinyl)-ethyl]-[1H-indol-3-yl]-(4-methoxyphenyl)methan-none); β2ARβ; 2-adrenoceptor; CP 55, 940; [(-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol];

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Use of the X-ray structure of the β2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds

Keywords: β2-Adrenergic receptor; GPCR; Timolol; High-throughput docking; Carvedilol; Corazolol

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators

Keywords: mGluR4; PAM; Positive allosteric modulator; Parkinson’s disease; GPCR

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetration

Keywords: 5-HT; GPCR; Guanidine; DMPK; Molecular properties

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Use of the X-ray structure of the Beta2-adrenergic receptor for drug discovery

Keywords: Beta2-adrenergic receptor; X-ray structure; High-throughput docking; Computer-aided design; GPCR; Molecular modeling; Corazolol; Carvedilol; Propranolol; Butoxamine; Timolol; Celiprolol; Dichloroisoprenaline

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Viral hijacking of human receptors through heterodimerization

Keywords: Epstein-Barr virus; Herpesvirus; GPCR; Heterodimerization; Chemokines

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Differing pharmacological activities of thiazolidinone analogs at the FSH receptor

Keywords: GPCR; FSH; Gonadotropin; Allosteric modulator

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation

Keywords: Estrogen; GPCR; Hippocampus

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Type-1 cannabinoid receptors colocalize with caveolin-1 in neuronal cells

Keywords: Caveolin; Cholesterol; Endocannabinoids; G protein-coupled receptors; Lipid rafts; Neurodegeneration; Signal transduction; Trafficking; AEA; anandamide (arachidonoylethanolamide); 2-AG; 2-arachidonoylglycerol; CAV1; caveolin-1; CB1/2R; type 1/2 cannabinoi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Functional role of the conserved proline in helix 6 of the human bradykinin B2 receptor

Keywords: B2R; bradykinin B2 receptor; GPCR; G-protein coupled receptor; BK; bradykinin; TMD; transmembrane domain; WT; wild-type; HPP-HOE140; hydroxyphenyl-propionyl-HOE 140; IP; inositol phosphate; G-protein coupled receptor (GPCR); Bradykinin; Proline; Activatio

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Multiple G proteins compete for binding with the human gonadotropin releasing hormone receptor

Keywords: GnRHR; G protein specificity; G protein-coupled receptor; GPCR

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Activation of PKCβII and PKCθ is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation

Keywords: Egr-1; Erk1/2 MAPK; GPCR; Low-density lipoprotein; PKC; Smooth muscle cell;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure–activity relationship elucidation

Keywords: 5-HT; GPCR; SAR; Guanidine

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Identification of small molecule agonists of the motilin receptor

Keywords: Motilin; Receptor; Agonist; GPCR

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity

Keywords: Bradykinin; GPCR; Pain; PXR; P-glycoprotein

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Biochemical characterization of genetic mutations of GPR56 in patients with bilateral frontoparietal polymicrogyria (BFPP)

Keywords: GPCR; Surface expression; Glycosylation; Protein trafficking

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

The anti-apoptotic activity associated with phosphatidylinositol transfer protein α activates the MAPK and Akt/PKB pathway

Keywords: PI-TP; phosphatidylinositol transfer protein; PI; phosphatidylinositol; PC; phosphatidylcholine; PLA; phospholipase A; MAPK; mitogen-activated protein kinase; ERK; extracellular signalling related kinase; IAP; inhibitor of apoptosis protein; PKB; protein

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Quantification of allatostatin receptor mRNA levels in the cockroach, Diploptera punctata, using real-time PCR

Keywords: Cockroach; Insect neuropeptide; GPCR; MRNA; Juvenile hormone

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors

Keywords: Δ; deletion mutant; AM; adrenomedullin; AMY; amylin receptor phenotype; CGRP; calcitonin gene-related peptide; CLR; calcitonin receptor-like receptor; CT; calcitonin; CTb receptor; calcitonin receptor b isoform; GPCR; G protein-coupled receptor; h; human;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Characterization of a novel vasopressin/oxytocin superfamily peptide and its receptor from an ascidian, Ciona intestinalis

Keywords: Ci-VP, Ciona vasopressin-related peptide; Ci-VP-R, Ci-VP receptor; GnRH, gonadotropin-releasing hormone; GPCR, G protein-coupled receptor; nt, nucleotide; OT, oxytocin; VP, vasopressinVasopressin; Oxytocin; Ascidian; Ciona intestinalis; GPCR; Neurophysin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Effect of GABAA receptor activation on UT-coupled signaling pathways in rat cortical astrocytes

Keywords: AC; adenylyl cyclase; [Ca2+]c; cytosolic calcium concentration; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; GABAAR; gamma-aminobutyric acid type A receptor; GFAP; glial fibrillary acidic protein; GPCR; G protein-coupled receptor; HE

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Simulations of a G protein-coupled receptor homology model predict dynamic features and a ligand binding site

Keywords: Molecular dynamics simulation; GPCR; Homology model; Beta(2) adrenoreceptor; Epinephrine; Ligand binding;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Chemotaxis, chemokine receptors and human disease

Keywords: Chemotaxis; Chemokine; GPCR; Inflammation; Human diseases

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

A role for MC3R in modulating lung inflammation

Keywords: Anti-inflammation; Cell trafficking; Leukocytes; Melanocortin; Cytokines; GPCR

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases

Keywords: 5-HT2A; 5-Hydroxytryptamine; Serotonin; PSD95; Arrestin; Caveolin; Lipid raft; RSK2; PKC; GPCR; Gq; PDZ; Post-synaptic density; Desensitization; Trafficking; Endocytosis; Internalization; Scaffolding

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Large-scale expression and purification of the major HIV-1 coreceptor CCR5 and characterization of its interaction with RANTES

Keywords: CCR5; HIV-1; GPCR; Membrane protein; RANTES; Secondary structure; NMR; ITC; CD; Baculovirus; Sf9 cells

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Evidence for a μ-δ opioid receptor complex in CHO cells co-expressing μ and δ opioid peptide receptors

Keywords: Opioid receptor; Dimerization; GPCR; Morphine; Ligand binding;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Characterization of the prostaglandin H2 mimic: Binding to the purified human thromboxane A2 receptor in solution

Keywords: Thromboxane A2; Thromboxane A2 receptor; G protein-coupling receptor; NMR spectroscopy; Prostaglandin H2; U46619; GPCR

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFκB serine 536 phosphorylation in human keratinocytes

Keywords: PAR-2; proteinase-activated receptor-2; PAR-2 AP; PAR-2 activating peptide; 2f-LIGKV-OH; 2-furoyl-LIGKV-hydroxyl; NFκB; nuclear factor kappa B; IKK; inhibitory kappa B kinase; PKC; protein kinase C; siRNA; small interfering ribonucleic acid; RNAi; ribonu

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Endogenous RGS proteins attenuate Gαi-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells

Keywords: LPA; lysophosphatidic acid; RGS; Regulator of G-protein Signaling; GPCR; G-protein Coupled Receptor; Ptx; Pertussis toxin; Ptxi; Pertussis toxin insensitive; RGSi; RGS protein insensitive; Lysophophatidic acid; LPA; Regulator of G-protein signaling; RGS;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

βγ subunits of Gi/o suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced

Keywords: BDNF; brain-derived neurotrophic factor; CTX; cholera toxin; DMEM; Dulbecco's modified Eagle's medium; EGF; epidermal growth factor; EPAC; exchange protein activated by cAMP; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; G3

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

The human angiotensin AT1 receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation

Keywords: GPCR; 7TM receptor; Differential activation; Angiotensin; Arrestin; AT1 receptor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Biological properties and functional determinants of the urotensin II receptor

Keywords: Urotensin II; Urotensin II receptor; GPCR; Structure; Signal transduction

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression

Keywords: Opioid; Opioid receptors; Chemokine; Chemokine receptors; Cytokine; Nociceptin; GPCR; HIV; ORL1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells

Keywords: Metabotropic glutamate receptors; Dimerization; GPCR

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

The internalization of the M2 and M4 muscarinic acetylcholine receptors involves distinct subsets of small G-proteins

Keywords: Muscarinic; Endocytosis; Small G-proteins; GPCR; Trafficking; Vesicle

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Desensitization of herpesvirus-encoded G protein-coupled receptors

Keywords: GPCR; Cytomegalovirus; KSHV; HCMV; MCMV; US28; M33; ORF74; GRK; Arrestin; Desensitization

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Characterisation of Aft1 a Fot1/Pogo type transposon of Aspergillus fumigatus

Keywords: Transposon; Aspergillus fumigatus; GPCR

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Cell surface targeting of VPAC1 receptors: Evidence for implication of a quality control system and the proteasome

Keywords: Cell surface expression; Glycosylation; GPCR; Proteasome; Trafficking; VIP receptor; VPAC1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Membrane partitioning of various δ-opioid receptor forms before and after agonist activations: The effect of cholesterol

Keywords: GPCR; hDOR; Lateral organization; Raft; Hydrophobic mismatch; Cholesterol

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor

Keywords: C5aR; C5a receptor; GPCR; G protein-coupled receptor; GRK; G protein-coupled receptor kinase; ERK1/2; extracellular signal-regulated kinase 1/2; CHO; Chinese hamster ovary; EndoH; endoglycosidase H; AR; adrenergic receptor; Chemoattractant receptor; Endoc

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Regulation of LPA receptor function by estrogens

Keywords: LPA1 receptor; PKC; PI3K; 17-β; estradiol; ERα; GPCR;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist

Keywords: Boc; tert-butyloxycarbonyl; Bpa; p-benzoyl-l-phenylalanine; BSA; bovine serum albumin; DMF; N,N-dimethylformamide; GPCR; G protein coupled receptor; HBTU; 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; HOBt; 1-hydroxybenzotriazo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Nonpeptide Urotensin-II receptor agonists and antagonists: Review and structure-activity relationships

Keywords: Urotensin-II; GPR14; Nonpeptide agonists and antagonists; GPCR; SAR; Pharmacophore;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Characterization of a conformationally sensitive TOAC spin-labeled substance P

Keywords: NK1r; neurokinin-1 receptor; SP; substance P; 4-TOAC SP; TOAC substance P with TOAC integrated at position 4; 9-TOAC SP; TOAC substance P with the TOAC spin label integrated at position 9; Nk1r; neurokinin-1 receptor; EPR; electron paramagnetic resonance

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Regulation of melanin-concentrating hormone receptor 1 signaling by RGS8 with the receptor third intracellular loop

Keywords: CBB; Coomassie Brilliant Blue; DTT; dithiothreitol; ECL; enhanced chemiluminescence; FBS; fetal bovine serum; GAP; GTPase-activating protein; GPCR; G protein-coupled receptor; GST; glutathione S-transferase; HA; hemagglutinin; HEK293T; human embryonic kid

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Molecular modeling of histamine H3 receptor and QSAR studies on arylbenzofuran derived H3 antagonists

Keywords: Histamine H3 receptor; GPCR; Molecular modeling; QSAR; Docking

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Identification of non-lipid LPA3 antagonists by virtual screening

Keywords: Lysophosphatidic acid; GPCR; Database mining; Pharmacophore

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه