Keywords: 2xYT; double strength YT medium; AUC; analytical ultracentrifugation; CHAPS; 3-[(3-cholamidopyropyl)dimethylammonio]-1-propanesulfonate; CHS; cholesteryl hemisuccinate Tris salt; DDM; n-dodecyl-β-d-maltoside; DLS; dynamic light scattering; E. coli; Esche
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Keywords: EGFR; Epidermal growth factor receptor; FITC; Fluorescein isothiocyanate; GPCR; G protein coupled receptor; IP3; Inositol-tris-phosphate; PIP2; Phosphatidyl-inositol-bis-phosphate; PLCγ; Phospholipase Cγ; PKA/C; Protein kinase A/C; PDGFR; Platelet-deriv
Keywords: ACTH; adrenocorticotropic hormone; BT; 2-sec-butyl dihydrothiazole; CAII; carbonic anhydrase II; CO2; carbon dioxide; CS2; carbon disulfide; cVA; 11-cis-vaccenyl acetate; DB; dehydro-exo-brevicomin; GC-D; guanylyl cyclase D; ELG; extraorbital lacrimal gla
Keywords: ABC; ATP-binding cassette; ADH; alcohol dehydrogenase; ADR; adrenodoxin reductase; ADX; adrenodoxin; ARE2; sterol acyltransferase; ARV1; mediator of sterol homeostasis; BTS1; GGPP synthase; CPR; cytochrome P450 reductase; CRT; carotenogenic (genes); CYP;
Keywords: Aβ; amyloid β; AADC; L-amino acid decarboxylase; ACC; Anterior cingulate cortex; AD; Alzheimer's disease; aMCI; Amnestic mild cognitive impairment; APP; Amyloid precursor protein; AR; Adrenergic receptor; ATMX; atomoxetine; BDNF; Brain-derived neurotrop
Keywords: ARC; arachidonate-regulated Ca2+ entry channels; BBB; blood-brain barrier; BCEC; bovine brain capillary endothelial cells; BK; bradykinin; CaM; calmodulin; CaMKII; Ca2+/calmodulin-dependent kinase II; cGMP; cyclic guanosine monophosphate; CRAC; Ca2+ rel
Keywords: Angiogenesis; Antiangiogenic agents; Angiogenic cytokines/peptides; EC; endothelial cells; VEGF; vascular endothelial growth factor; VEGF Receptor; VEGFR; FGF; fibroblast growth factor; EGF; epidermal growth factor; epidermal growth factor receptor; EGFR;
Keywords: GPR55; Neuropathic pain; GPCR; Antagonist; Cancer
Identification of mRNA of the Inflammation-associated Proteins CXCL8, CXCR2, CXCL10, CXCR3, and β-Arrestin-2 in Equine Wounded Cutaneous Tissue: a Preliminary Study
Keywords: Horse; Cutaneous wound healing; Chemokines; GPCR;
Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 predicts poor prognosis in hepatocellular carcinoma
Keywords: Liver cancer; LGR5; Immunohistochemistry; Clinicopathology; Overall survival; HBs; hepatitis B virus; EMT; epithelial-to-mesenchymal transition; Flot2; flotillin-2; GPCR; G-protein-coupled receptor; GPR49; G-protein coupled receptor 49; GRP78; glucose-reg
G-protein coupled receptors (GPCR) and environmental exposure. Consequences for cell metabolism using the β-adrenoceptors as example
Keywords: G-protein coupled receptor; GPCR; Endocrine disruptor; Environmental contaminant; Polycyclic aromatic hydrocarbon; Adrenoreceptor; Adrenergic receptor; Beta-adrenergic receptor; Inflammation; Non-communicable disease; PAH; Energetic metabolism;
Discovery of a novel potent GPR40 full agonist
Keywords: GPR40 full agonist; Insulin secretagogues; Type 2 diabetes mellitus; GPCR; GSIS;
Bile acid receptors in the biliary tree: TGR5 in physiology and disease
Keywords: AC; adenylate cyclase; BS; bile salt; BSEP; bile salt export pump (ABCB11); CA; cholic acid/cholate; cAMP; cyclic AMP; CBDL; common bile duct ligation; CCA; cholangiocarcinoma; CDCA; chenodeoxycholic acid/chenodeoxycholate; CD95L; CD95 ligand; CFTR; cysti
Activation of β- and α2-adrenergic receptors stimulate tubulin polymerization and promote the association of Gβγ with microtubules in cultured NIH3T3 cells
Keywords: Microtubules; Gβγ; GPCR; Tubulin; Signal transduction;
Tauroursodeoxycholic acid binds to the G-protein site on light activated rhodopsin
Keywords: Bile acid; Chemical biology; G protein; G proteinâcoupled receptor (GPCR); Molecular docking; Photoreceptor; Phototransduction; Retina; Rhodopsin; Signal transduction; GPCR; G-protein coupled receptor; G-protein; heterotrimeric GTP-binding protein; R; d
Local injection of d-lys-3-GHRP-6 in the rat amygdala, dentate gyrus or ventral tegmental area impairs memory consolidation
Keywords: CNS; Central nervous system; CTA; Conditioned taste aversion; GHS-R; Growth hormone secretagogue receptor; GPCR; G-protein coupled receptors; i.c.v.; intracerebroventricular; LTP; Long-term potentiation; NST; Number of step-through into the dark compartme
Gender-specific desensitization of group I metabotropic glutamate receptors after maternal l-glutamate intake during lactation
Keywords: l-Glu; l-glutamate; mGluR; metabotropic glutamate receptor; CNS; Central Nervous System; GPCR; G-protein coupled receptor; PLC; phospholipase C; A.U.; arbitrary units; Group I-metabotropic glutamate receptor; Lactation; l-glutamate; Neonatal brain;
Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects
Keywords: ACh; acetylcholine; ChE; cholinesterase; GPCR; G-protein-coupled receptors; mAChR; muscarinic acetylcholine receptor; OP; organophosphate; TA; mixture of trimedoxime bromide and atropine; CIE; clathrin-independent endocytosis; CDE; clathrin-dependent endo
Oximes short-acting CB1 receptor agonists
Keywords: CB1; CB2; cannabinoid receptors; GPCR; Î9-THC; (-)-Î9-Tetrahydrocannabinol; Î8-THC; Î8-THC-DMH; Arachidonoylethanolamine (AEA); 2-Arachidonoylglycerol (2-AG); Analgesia; Anorexia Nervosa (AN);
The anaphylatoxin C3a primes model colonic epithelial cells for expression of inflammatory mediators through Gαi
Keywords: DSS; dextran sulphate sodium; h; hour; IEC; intestinal epithelial cell; HRP; horse radish peroxidase; min; minute(s); PTX; pertussis toxin; Anaphylatoxin; C3a; C3aR; Intestinal epithelium; GPCR; Chemokine;
Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation
Keywords: ACh; acetylcholine; GPCR; G protein-coupled receptor; KCa; calcium-activated potassium ion channel; NOS; nitric oxide synthase; PAR2-AP; protease-activated receptor 2 activating peptide (NH2-SLIGRL-COOH); ROS; reactive oxygen species; TRPV4; transient r
Discovery of novel benzo[b]thiophene tetrazoles as non-carboxylate GPR40 agonists
Keywords: GPR40 agonist; Tetrazole; Type 2 diabetes; GPCR; GSIS;
Cascade reactions leading to the mechanism of action of vinaxanthone and xanthofulvin, natural products that drive nerve repair
Keywords: Methodology; Total synthesis; Biosynthesis; Natural product; Regeneration; SUCNR1; Succinate receptor; Allosteric; GPCR;
Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway
Keywords: Adropin; Mitochondria; PDK4; GRP19; GPCR; Pyruvate dehydrogenase; Metabolism;
G protein-coupled receptor kinases: Past, present and future
Keywords: αN-helix; N-terminal α-helical domain; α2AAR; α2A-adrenergic receptor; AST; active site tether; βAR; β-adrenergic receptor; β2AR; β2-adrenergic receptor; βARK; β-adrenergic receptor kinase; CLBD; C-terminal lipid binding domain; EM; electron mic
5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus
Keywords: CGS12066; 7-trifluoromethyl-4-(4-methyl-1-piperaziny)pyrrolo-[1,2-a]quinoxaline; 5-HT1B receptors; 5-hydroxytryptamine 1B receptors; 4-AP; 4-aminopyridine; GPCR; G protein-coupled receptor; AC; adenylate cyclase; PKA; protein kinase A; VGLUT1; vesicular t
Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner
Keywords: Lysophosphatidylcholine (LPC); GPR40 (FFAR1); GPR55; GPR119; Insulin secretion; [Ca2+]i; intracellular calcium ions concentration; cAMP; cyclic AMP; GSIS; glucose-stimulated insulin secretion; GPCR; G protein coupled receptor; IBMX; 3-isobutyl-1-methylxan
Internalization of G-protein-coupled receptors: Implication in receptor function, physiology and diseases
Keywords: GPCR; cAMP; receptor internalization; TSH; LH; endosomal signaling; G protein-coupled receptor; (GPCR); protein kinase A; (PKA); cyclic adenosine monophosphate; (cAMP); mitogen-activated protein kinase; (MAPK); thyroid stimulating hormone; (TSH); parathyr
Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4
Keywords: AUC; Area under Curve; EDTA; Ethylenediaminetetraacetic acid; FCS; Foetal calf serum; FSC; Forward scatter; GPCR; G protein-coupled receptor; PBS; Phosphate buffered saline; SEM; Standard Error of Means; SSC; Side scatter; Chemokine receptor; Chemotaxis;
An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation
Keywords: Tri-agonist; Signaling cascade; Pancreatic islets; Insulin secretion; G proteins; TRP channels; AC; Adenylyl cyclase; cAMP; Cyclic adenosine monophosphate; ECL; Extracellular loop; EPAC; Exchange protein directly activated by cAMP; FCS; Fetal calf serum;
Small molecules targeting heterotrimeric G proteins
Keywords: GPCR; G protein; Pharmacology; Signaling; Drug; Small molecule;
COX-2 Forms Regulatory Loop with YAP to Promote Proliferation and Tumorigenesis of Hepatocellular Carcinoma Cells
Keywords: HCC; hepatocellular carcinoma; HB; hepatoblastoma; TEAD; TEA domain; CTGF; connective tissue growth factor; Cyr61; gene encoding cysteine rich 61; COX; cyclooxygenase; YAP; Yes-associated protein; PGE2; prostaglandin E2; VP; verteporfin; Cel; celecoxib; E
Design and synthesis of 1-(1-benzothiophen-7-yl)-1H-pyrazole, a novel series of G protein-coupled receptor 52 (GPR52) agonists
Keywords: GPR52; G protein-coupled receptor 52; SAR; structure-activity relationship; cAMP; 3â²,5â²-cyclic adenosine monophosphate; EC50; half maximal effective concentration; MAP; methamphetamine; NMDA; N-methyl-d-aspartate; PK; pharmacokinetic; CHO; Chinese h
The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids
Keywords: Enteroid; Intestinal stem cells; Lgr5; LPA; Octadecyl thiophosphate; Radiation; Radioprotection; Radiomitigation; LPA; lysophosphatidic acid; ARS; acute radiation syndrome; Lgr5; leucine-rich repeat-containing G protein-coupled receptor 5; OTP; octadecyl
PK2β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor
Keywords: Prokineticin 2β; Prokineticin receptors; G protein coupled receptor; Yeast-STAT3; Thermal hyperalgesia; Tactile allodynia; GPCR; G Protein-Coupled Receptor; PK; Prokineticin; PKR; Prokineticin Receptor; PK2β; Prokineticin 2β; ERK; Extracellular signal-
Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A
Keywords: Orexins; Neuropeptide; GPCR; Inflammation; Inflammatory bowel disease; Ulcerative colitis;
Assessment of the transmembrane domain structures in GPCR Dock 2013 models
Keywords: GPCR; Homology model; Transmembrane; Ligand docking; RMSD; Classification;
Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology
Keywords: ACTH; Adrenocorticotropic hormone; AgRP; Agouti-related protein; α-MSH; α-melanocyte-stimulating hormone; BSA; bovine serum albumin; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CNS; central nervous system; DMEM; Dulbecco's Modified Eagle Medium; ECL
Biased signaling of G protein-coupled receptors - From a chemokine receptor CCR7 perspective
Keywords: GPCR; Biased signaling; CCR7; CCL19; CCL21;
GABAB receptor subtypes differentially regulate thalamic spindle oscillations
Keywords: KCTD12; KCTD16; GPCR; Epilepsy; Sleep;
α1b-Adrenergic Receptor Localization and Relationship to the D1-Dopamine Receptor in the Rat Nucleus Accumbens
Keywords: ABC; avidinbiotin complex; ADHD; Attention Deficit Hyperactivity Disorder; ANOVA; analysis of variance; BSA; bovine serum albumin; D1R; D1-dopamine receptor; DA; dopamine; DAB; 3,3-diaminobenzidine tetrahydrochloride; GPCR; G protein-coupled receptor; HQ;
Up-regulation of μ-, δ- and κ-opioid receptors in concanavalin A-stimulated rat spleen lymphocytes
Keywords: Opioids receptors; Up-regulation; Concanavalin A; Rat spleen lymphocytes; G proteins; β-arrestin-1/2; Ab; antibodies; Bt, Bnsp, Bsp; total, non-specific and specific radioligand binding; Con A; Concanavalin A; DAMGO; [(2-D-alanine-2-4-methylphenylalanine
Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells
Keywords: AC; adenylyl cyclase; 2-APB; 2-aminoethoxyphenylborane; ASM; airway smooth muscle; cAMP; 3',5'-cyclic AMP; COPD; chronic obstructive pulmonary disease; [Ca2+]i; intracellular free Ca2+ concentration; DMSO; dimethyl sulfoxide; EC50 (IC50); half-maximally e
The tamoxifen derivative ridaifen-B is a high affinity selective CB2 receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effects
Keywords: Cannabinoid receptors; G-protein coupled receptors; Inverse agonist; Antagonist; Drug action; AC; adenylyl cyclase; CB1R; cannabinoid receptor type 1; CB2R; cannabinoid receptor type 2; CHO; Chinese hamster ovary; CP-55,940; 5-(1,1-dimethylheptyl)-2-[5-hy
Induction of oxidative stress by long-term treatment of live HEK293 cells with therapeutic concentration of lithium is associated with down-regulation of δ-opioid receptor amount and function
Keywords: AAS; atomic absorption spectroscopy; Ab; antibody; BD; bipolar disorder; DADLE; (2-d-alanine-5-d-leucine)-enkephalinâ¯=â¯Tyr-d-Ala-Gly-Phe-d-Leu; DCF; 2â²,7â²-dichlorofluorescein; DCFH-DA; 2â²,7â²-dichlorofluorescin diacetate (synonym dichlorodihydr
Paroxetine and Low-dose Risperidone Induce Serotonin 5-HT1A and Dopamine D2 Receptor Heteromerization in the Mouse Prefrontal Cortex
Keywords: FRET; fluorescence resonance energy transfer; GPCR; G-protein-coupled receptor; HTRF; homogenous time-resolved fluorescence resonance energy transfer; PCX; the prefrontal cortex; PLA; proximity ligation assay; paroxetine; risperidone; dopamine D2 receptor
Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease
Keywords: biased ligands; G protein-coupled receptor kinases; G protein-coupled receptors; AR; adrenergic receptor; AT1R; angiotensin II type 1A receptor; CRF; corticotropin-releasing factor; EGFR; epidermal growth factor receptor; ERK1/2; extracellular signal-
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells
Keywords: G-protein coupled receptors; Interleukin-1β; C-Jun N-terminal kinase; Purinergic receptors; Inflammation; YM-254890 (PubChem CID: 9919454); H-89 (PubChem CID: 449241); NF340 (PubChem CID: 73755007); MRS2179 (PubChem CID: 24867852); ZM241385 (PubChem CID:
CCR5: Established paradigms and new frontiers for a 'celebrity' chemokine receptor
Keywords: Chemokine; CCR5; HIV; GPCR; Pharmacology;
Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: Implications for lung health and disease
Keywords: ASM; airway smooth muscle; BAL; bronchoalveolar; CHO; Chinese hamster ovary; COX; cyclooxygenase; EP; prostanoid E; ERK; extracellular signal-regulated kinase; GPCR; G protein-coupled receptors; GSK-3; glucogen synthase kinase-3; HMLC; human lung mast cel