دانلود مقالات ISI درباره Hdacs + ترجمه فارسی

Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups

Keywords: BRD4; BI2536; Indoline; WPF binders; c-Myc; PD-L1; BCPs; Bromodomain-containing proteins; BET; bromodomain and extra-terminal; BRD4-BD1; first bromodomain of BRD4; CREB; cyclic-AMP response element binding protein; FA; fluorescence anisotropy; FBDD; fragm

دانلود رایگان متن کامل مقاله ISI 77 صفحه سال انتشار : 2018 سفارش ترجمه

The role of SIRT1 in diabetic cardiomyopathy

Keywords: SIR2; Silent Information Regulator2; HDACs; histone deacetylases; NAD +; nicotinamide adenine dinucleotide; DM; diabetes mellitus; CAD; coronary artery disease; HF; heart failure; DCP; diabetic cardiomyopathy; MRI; magnetic resonance imaging; MAPK; mitoge

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Research articleThe histone deacetylase inhibitor sodium butyrate protects against noise-induced hearing loss in Guinea pigs

Keywords: 3-NT; 3-nitrotyrosine; DAPI; 4′,6-diamidino-2-phenylindole; ABR; auditory brainstem response; HATs; histone acetyltransferases; HDACs; histone deacetylases; H3-AcK9; acetyl-histone H3 (Lys9); HC; hair cell; IHC; inner hair cell; NIHL; noise-induced hear

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers

Keywords: SRCs; steroid receptor coactivators; NR; nuclear receptor; PR; progesterone receptor; HATs; histone acetyltransferases; CBP; CREB-binding protein; HDACs; histone deacetylases; HMTs; histone methyltransferases; BRDs; bromodomains; bHLH-PAS; basic helix-loo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin

Keywords: albumin; protein binding; protein structure; distribution; molecular modeling; ER; endoplasmic reticulum; HDACs; histone deacetylases; M-PB; methyl 4-phenylbutyrate; PA; phenylacetic acid; PB; sodium 4-phenylbutyrate; PC; 6-phenylcaproic acid; PH; 7-pheny

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

The roles of class I histone deacetylases (HDACs) in memory, learning, and executive cognitive functions: A review

Keywords: Epigenetics; Cognition; Histones; HDACs; Learning; Memory; Attention; Working memory; Animal models;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

HDAC2 was involved in placental P-glycoprotein regulation both in vitro and vivo

Keywords: Placenta; P-glycoprotein; HDACs; Epigenetic regulation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines

Keywords: Placenta; P-glycoprotein; HDACs; Epigenetic regulation;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleHDAC4 and HDAC6 sustain DNA double strand break repair and stem-like phenotype by promoting radioresistance in glioblastoma cells

Keywords: HDAC4; HDAC6; Glioblastoma; Radiotherapy; Radioresistance; GBM; glioblastoma; TMZ; temozolomide; RT; radiotherapy; HDACs; Histone deacetylases; HATs; Histone acetyltransferases; DSBs; DNA double-strand breaks; OS; Overall survival; shRNA; short hairpin RN

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-androgenic mechanisms of Bisphenol A involve androgen receptor signaling pathway

Keywords: AR; androgen receptor; BPA; Bisphenol A; EDCs; endocrine-disrupting chemicals; DHT; dihydrotestosterone; AREs; androgen response elements; N/C; amino- and carboxyl-terminal regions; SRC-1; steroid receptor coactivator-1; SMRT; silencing mediator of retino

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study

Keywords: HDACs; HDACIs; Benzamides; Anti-tumor drugs; In vivo oral activity;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and tumor cell growth inhibitory activity of 3-nitro-2H-cheromene derivatives as histone deacetylaes inhibitors

Keywords: HDACs; HDAC inhibitors; 3-Nitro-2H-chromenes; Coumarins; Anticancer agents; Zinc-dependent hydrolases; Isoform selective;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Functional relevance of miRNAs in premature ageing

Keywords: CRP; C-reactive protein; DDR; DNA damage response; DSB; double-strand breaks; HATs; histone acetyltransferases; HDACs; histone deacetylases; hMSCs; human mesenchymal stem cells; HRR; homologous recombination repair; MEFs; mouse embryonic fibroblast; ROS;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration

Keywords: bps; base pairs; DHS; DNase Hypersensitive sites; TFBS; transcription factor binding sites; PTMs; post-translational modifications; HDACs; histone deacetylases; H3K4me3; histone 3 lysine 4 tri-methylation; H3K27me3; histone 3 lysine 27 tri-methylation; Ch

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Sub-cellular localization specific SUMOylation in the heart

Keywords: AMPK; adenosine monophosphate-activated protein kinase; CAMKK; calcium-calmodulin-activated protein kinase kinase; CHIP; carboxyl terminus of HSP70-interacting protein; CVD; cardiovascular disease; cTnI; cardiac troponin I; d-flow; disturbed flow; DeSI; d

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and in vitro evaluation of amidoximes as histone deacetylase inhibitors for cancer therapy

Keywords: Amindoximes; HDACs; Cytotoxicity; G2/M arrest;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

mTOR inhibition sensitizes human hepatocellular carcinoma cells to resminostat

Keywords: Hepatocellular carcinoma; HDACs; Resminostat; mTOR; Mitochondrial apoptosis pathway; Chemo-sensitization;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Acetylation of histones in neocortex and hippocampus of rats exposed to different modes of hypobaric hypoxia: Implications for brain hypoxic injury and tolerance

Keywords: SH; severe hypoxia; HDACs; histone deacetylases; HATs; histone acetyltransferases; DNMTs; DNA methyltransferases; GR; glucocorticoid receptor; MR; mineralocorticoid receptor; pan-ac; pan-acetyl proteins; H3K24ac; acetylated histone H3 (Lys24); Acetylation

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis

Keywords: Liver fibrosis; HDACs; Reversal of liver fibrosis; HDAC2;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Engineering EMT using 3D micro-scaffold to promote hepatic functions for drug hepatotoxicity evaluation

Keywords: EMT; 3D micro-scaffold; Hepatic functions; HDACs; Drug hepatotoxicity evaluation

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells

Keywords: Zfat; zinc-finger protein with AT-hook; DP; CD4+ CD8+ double-positive; TSSs; transcription start sites; H3K9ac/K27ac; histone H3 acetylations at lysine 9 and lysine 27; H3K9me3; tri-methylation of histone H3 at lysine 9; HDACs; histone deacetylases; HATs

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis

Keywords: AMN082; N,N′-bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride; CBP; CREB binding protein; CNS; central nervous system; CREB; cyclic adenosine 3′,5′-monophosphate response element binding protein; Curcumin; diferuloylmethane; DIV; days in vitro;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Modulating epigenetic HAT activity for reinstating acetylation homeostasis: A promising therapeutic strategy for neurological disorders

Keywords: HATs; HDACs; Histone acetylation; HAT modulators; HDACi; Neurodegenerative diseases;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

The effects of Rpd3 on fly metabolism, health, and longevity

Keywords: HDACs; histone deacetylases; HATs; histone acetyltransferases; SIR2; silent information regulator 2; HDAC; rpd3; dSir2; Drosophila melanogaster; Dietary restriction; Aging; Longevity;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway

Keywords: HDAC6; HPOB; Glucocorticoid receptor; Mitochondrial translocation; Hsp90; Cort; corticosterone; DRP1; dynamin-related protein 1; Fis1; mitochondrial fission molecule 1; GCs; glucocorticoids; GR; glucocorticoid receptor; HDACs; histone deacetylases; Hsps;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

Keywords: RGFP966 (PubChem CID: 56650312); N,N-Dimethylformamide (PubChem CID: 6228); Suberoylanilide hydroxamic acid (PubChem CID: 5311); Lysine acetylation; HDACs; Inflammation; NF-κB p65; HDAC inhibitors; Lung disease;

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2016 سفارش ترجمه

RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor

Keywords: ABCA1; ATP-binding cassette transporter A1; ABCG1; ATP-binding cassette transporter G1; apoA-I; apolipoprotein A-I; CD36; cluster of differentiation 36; ERR; estrogen receptor-related receptor; HDL; high-density lipoprotein; LXR; liver X receptor; LXRE; l

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Antidepressant action of HDAC inhibition in the prefrontal cortex

Keywords: HDACs; histone deacetylases; PBS; phosphate-buffered saline; MS-275; HDAC inhibitors; depression; gene expression;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation of skeletal muscle development and homeostasis by gene imprinting, histone acetylation and microRNA

Keywords: HDACs; HDACi; DNA methylase; MyomiRs;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

skNAC and Smyd1 in transcriptional control

Keywords: skNAC; Smyd1/m-Bop; HMTs; HDACs; Myogenic differentiation

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

ReviewSchizophrenia: Evidence implicating hippocampal GluN2B protein and REST epigenetics in psychosis pathophysiology

Keywords: BDP; psychotic bipolar disorder; CK1; casein kinase 1; DG; dentate gyrus; HC; healthy controls; HDACs; histone deacetylases; MeCP2; methyl CpG binding protein 2; MR; magnetic resonance; NMDA; N-methyl-d-aspartate; NMDAR; NMDA receptor; PcG; polycomb group

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity

Keywords: HDACs; HDACIs; Anti-tumor drugs; Antiproliferative activity; In vivo oral activity

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice

Keywords: ACSF; artificial cerebrospinal fluid; ALC; acetyl-l-carnitine; BDNF; brain-derived neurotrophic factor; CNS; central nervous system; CUMS; chronic unpredictable mild stress; DMI; desipramine; FST; forced swimming test; HDACs; histone deacetylases; ICR; im

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Epigenetics and muscle dysfunction in chronic obstructive pulmonary disease

Keywords: ANOVA; Analysis of variance; COPD; chronic obstructive pulmonary disease; MyHC; myosin heavy chain; CH3; methyl group; coA; coenzyme A; CpG; cytosine and guanosine nucleotides; DNA; deoxyribonucleic acid; HSP; heat shock proteins; HTAs; histone acetyltran

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Development of N-hydroxybenzamide derivatives with indole-containing cap group as histone deacetylases inhibitors

Keywords: HDACs; HDACIs; HDAC inhibitory activity; Antiproliferative activity; Class I and class IIa cellular activity

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Luotonin-A based quinazolinones cause apoptosis and senescence via HDAC inhibition and activation of tumor suppressor proteins in HeLa cells

Keywords: Quinazolinone hybrids; Click chemistry; HDACs; Senescence; Docking studies;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat

Keywords: Autophagy; HDAC inhibitor; Diabetic nephropathy; NF-κB/iNOS signaling; Proteinuria; Sodium valproate; Ac-H3/Ac-H4; acetylated histone H3/H4; CaB; calbindin; CaM; calmodulin; DN; diabetic nephropathy; FITC; fluorescein isothiocyanate; HDACs; histone deace

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

MTA1 regulates higher-order chromatin structure and histone H1-chromatin interaction in-vivo

Keywords: MTA1; Chromatin; Histone H1; in-vivo; Nucleosome remodeling and histone deacetylation complex (NuRD); MTA1; metastasis-associated gene 1; NuRD; nucleosome remodeling and histone deacetylase; NRL; nucleosome repeat length; HATs; histone acetyltransferases;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2015 سفارش ترجمه

Epigenetic enzymes are the therapeutic targets for CD4+CD25+/highFoxp3+ regulatory T cells

Keywords: CGIs; CpG islands; DNMTs; DNA methyltransferases; H2Bub1; histone H2B ubiquitylation; H3S10; serine 10 of H3; HAT; histone acetyl transferase; HDACi; histone deacetylase inhibitors; HDACs; histone deacetylases; LAP; latency associated peptide; Mbd; methyl

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2015 سفارش ترجمه

Histone deacetylases in cardiac fibrosis: Current perspectives for therapy

Keywords: HDACs; Histone deacetylases; ECM; Extracellular matrix; α-SMA; α-smooth muscle actin; HATs; Histone acetyltransferases; TGF-β1; Transforming growth factor β1; PDGF; Platelet-derived growth factor; FGF; Fibroblast growth factor; TIMPs; Tissue inhibitor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

The effects of selected inhibitors of histone modifying enzyme on C6 glioma cells

Keywords: 3DZNep; 3-deazaneplanocin; GBM; glioblastoma; HDACs; histone deacetylases; TSA; trichostatin A; VPA; valproic acid; Glioma; Epigenetics; Histone modification; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Largazole, an inhibitor of class I histone deacetylases, attenuates inflammatory corneal neovascularization

Keywords: Angiogenesis; CNV; HDACs; Largazole

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages

Keywords: SAA; serum amyloid A; H3K27me3; trimethylation of histone H3 at lysine 27; HDACs; histone deacetylases; FPR2; formyl peptide receptor 2; G-CSF; granulocyte colony-stimulating factor; IL-23p19; interleukin-23 alpha subunit p19; IL-12p40; interleukin-12 p40

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors

Keywords: HDACs; HDACs inhibitor; Hydroxamic acid; Thieno[2,3-d]pyrimidines;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and preliminary evaluation of α-sulfonyl γ-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors

Keywords: Matrix metalloproteinase-2; Aminopeptidase N; HDACs; Inhibitors; Hyp-Gly derivatives; Synthesis

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-β1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats

Keywords: ECM; extracellular matrix; CTGF; connective tissue growth factor; eNOS; endothelial nitric oxide synthase; iNOS; inducible nitric oxide synthase; HDACs; histone deacetylases; α-SMA; alpha smooth muscle actin; NFκB; nuclear factor kappa B; STZ; streptozo

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Tetramethylpyrazine promotes SH-SY5Y cell differentiation into neurons through epigenetic regulation of Topoisomerase IIβ

Keywords: Ac-H3; acetylated histone H3; Ac-H4; acetylated histone H4; ChIP; chromatin immunoprecipitation; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethylsulfoxide; HATs; histone acetyltransferases; HDACs; histone deacetylases; MAP2; microtubule-associ

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

NFAT as cancer target: Mission possible?

Keywords: ADP; adenosine di-phosphate; AICD; activation-induced cell death; AKAP79; A-kinase anchor protein 79; Ang-2; angiopoietin-2; AP1; activator protein 1; ARRE-2; antigen receptor response element-2; BMP4; bone morphogenetic protein 4; CABIN1; calcineurin-bin

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Neuroepigenetics of stress

Keywords: 5-HT; Serotonin; ACTH; adrenocorticotropic hormone; AVP; arginine-vasopressin; BDNF; brain-derived neurotrophic factor; BLA; basolateral amygdala; COMT; catechol-O-methyltransferase; CpG; cytosine-guanine dinucleotides; CRH; corticotropin-releasing hormon

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2014 سفارش ترجمه

Down-regulation of NAMPT expression by miR-182 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation

Keywords: HIV-1; human immunodeficiency virus type 1; LTR; long terminal repeats; PTM; post-translational modification; SIRT1; sirtuin 1; NAD+; nicotinamide adenine dinucleotide; NAMPT; nicotinamide phosphoribosyltransferase; DMEM; Dulbecco's modified Eagle's mediu

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه