V-ATPase inhibition overcomes trastuzumab resistance in breast cancer
Keywords: V-ATPase; Endocytosis; Trastuzumab; HER2; Breast cancer;
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EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules
Keywords: EGFR; epidermal growth factor receptor; HER2; human epidermal receptor 2; ECM; extracellular matrix; MMPs; matrix metalloproteinases; MT-MMPs; membrane type-matrix metalloproteinases; TIMPs; tissue inhibitor of matrix metaloproteinases; uPA; plasminogen a
T47D breast cancer cells switch from ER/HER to HER/c-Src signaling upon acquiring resistance to the antiestrogen fulvestrant
Keywords: Antiestrogen resistance; Breast cancer; Fulvestrant; HER2; c-Src
PELP1 oncogenic functions involve alternative splicing via PRMT6
Keywords: Alternative splicing; Breast cancer; Epigenetics; PELP1; PRMT6; BCAS2; breast cancer amplified sequence2; ChIP; chromatin immunoprecipitation; CDK; cell cycle dependent kinases; E2; Estrogen; ERα; estrogen receptor alpha; HER2; human epidermal growth fac
HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4)
Keywords: MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; MAP3K4; mitogen-activated protein kinase kinase kinase 4; MEKK4; mitogen-activated, extracellular signal-regulated kinase kinase; MTK1; mitogen activated protein three kin
Inhibition of p300 suppresses growth of breast cancer. Role of p300 subcellular localization
Keywords: BC; breast cancer; CREB; cAMP responsive element binding protein; DMSO; dimethylsulfoxide; VV56; 2-(3-(3,4-dichlorobenzyloxy)phenoxy)pentadecanoic acid; VV59; 2-(3-(3,4-dichlorobenzyloxy)phenoxy)hexadecanoic acid; DMEM; Dulbecco's modified Eagle's medium;
Nrf2, the master redox switch: The Achilles' heel of ovarian cancer?
Keywords: ARE; antioxidant response element; ATF; artificial transcription factor; BER; base excision repair; β-TrCP; beta-transducin repeat-containing protein; CNL; copy number loss; dsDNA; double strand DNA; EOC; epithelial ovarian cancer; EEE; engineered epigen
Nanomedicines in the future of pediatric therapy
Keywords: ACTs; artemisinin combined therapies; ALN; alendronate; ANMAT; Administración Nacional de Medicamentos, Alimentos y TecnologÃa Médica; ARV; antiretrovirals; AS; antisense; AUC; area-under-the-curve; BMS; burning mouth syndrome; CD; cytosine deaminase;
Polymorphic Ala-allele carriers at residue 1170 of HER2 associated with Parkinson's disease
Keywords: Parkinson's disease; Polymorphism; Ala carrier; HER2;
Generation and characterization of new HER2 monoclonal antibodies
Keywords: Monoclonal antibodies; HER2; Overexpression; Immunohistochemistry;
Prognostic factors of brain metastases from breast cancer: Impact of targeted therapies
Keywords: Breast cancer; Brain metastases; Prognostic factors; HER2; Targeted therapies;
Role of FDG-PET/CT in evaluating surgical outcomes of operable breast cancer - Usefulness for malignant grade of triple-negative breast cancer
Keywords: Breast cancer; PET/CT; SUVmax; Prognosis; Triple-negative breast cancer; AUC; area under the curve; CT; computed tomography; DFS; disease-free survival; ER; estrogen receptor; FDG-PET; [18F]-fluoro-2-deoxyglucose-positron emission tomography; HER2; human
Inhibition of vacuolar H+ ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells
Keywords: Breast cancer; CHOP; Estrogen receptor; HER2; Tamoxifen; Vacuolar H+ ATPase;
Immunohistochemical prediction of brain metastases in patients with advanced breast cancer: The role of Rad51
Keywords: Brain metastases; Breast cancer; Estrogen receptor; HER2; Ki-67; Rad51;
Determining efficacy of breast cancer therapy by PET imaging of HER2 mRNA
Keywords: Copper-64; Doxorubicin; Peptide nucleic acid; HER2; Breast cancer;
Consistency and inconsistency in testing biomarkers in breast cancer. A GRELL study in cut-off variability in the Romance language countries
Keywords: Biomarkers; Breast cancer; HER2; Oestrogen receptor; Progesterone receptor; Proliferation index;
Validation and workflow optimization of human epidermal growth factor receptor 2 testing using INFORM HER2 dual-color in situ hybridization
Keywords: HER2; human epidermal growth factor receptor 2; IHC; immunohistochemistry; ISH; in situ hybridization; FFPE; formalin-fixed, paraffin-embedded; GOLDFISH; nanogold with enhancement in situ hybridization; FISH; fluorescence in situ hybridization; CISH; chro
A HER2-targeted RNA aptamer molecule labeled with 99mTc for single-photon imaging in malignant tumors
Keywords: Aptamer; Specific binding; Radionuclide; 99mTc; HER2;
Randomized phase II study of sunitinib versus standard of care for patients with previously treated advanced triple-negative breast cancer
Keywords: Sunitinib; Triple-negative breast cancer; Standard-of-care chemotherapy; Phase II; Receptor tyrosine kinases; BC; Breast Cancer; TNBC; Triple-negative breast cancer; ER; the estrogen receptor; HER2; human epidermal growth factor receptor 2; VEGFR; vascula
Clinical outcomes and treatment practice patterns of patients with HER2-positive metastatic breast cancer in the post-trastuzumab era
Keywords: Breast cancer; Central nervous system; HER2; Metastases; Trastuzumab;
Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer
Keywords: HER2; Breast cancer; Oscillation; MAPK; PI3K; Systems biology;
β2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytes
Keywords: Erbin; β2-AR; Her2; Cardiomyocyte; Apoptosis;
Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues
Keywords: Anticancer; Breast cancer; Marine natural products; HER2; Antiproliferative activity;
HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription
Keywords: HER2; Aryl hydrocarbon receptor; Cancer stem cells; IL-6; MCF-7;
RON confers lapatinib resistance in HER2-positive breast cancer cells
Keywords: RON; Lapatinib resistance; HER2; HER2-targeted agents;
HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain
Keywords: ALLN; N-acetyl-leucyl-leucyl-norleucinal; Brk; breast tumor kinase; CHX; cycloheximide; DMEM; Dulbecco's modified Eagle's medium; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; Erk; extracellular signal-regulated kinase; FAK;
Targeting epidermal growth factor receptor/human epidermal growth factor receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder carcinoma
Keywords: Bladder cancer; Radiotherapy; Afatinib; EGFR; HER2;
An European Organisation for Research and Treatment of Cancer phase I study of lapatinib and docetaxel as neoadjuvant treatment for Human Epidermal Growth Factor Receptor 2 (HER2) positive locally-advanced/inflammatory or large operable breast cancer
Keywords: Breast cancer; HER2; Lapatinib; Neoadjuvant chemotherapy; P-glycoprotein;
Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells
Keywords: AKT; protein kinase B; FAS; fatty acid synthase; HER2; human epidermal growth factor receptor 2; MAPKs; mitogen-activated protein kinases; MMP-2/-9; matrix metalloproteinase (MMP)-2/-9; EGF; epidermal growth factor; PARP; poly-ADPribose polymerase; SREBP-
Quantitative proteomic analysis of HER2 normal and overexpressing MCF-7 breast cancer cells revealed proteomic changes accompanied with HER2 gene amplification
Keywords: HER2; Breast cancer; Biomarker discovery; 2-MEGA; Proteomics; Tissue microarray;
HER2-targeted therapy in breast cancer: A systematic review of neoadjuvant trials
Keywords: Neoadjuvant breast cancer; Pathological complete response; Trastuzumab; Lapatinib; Pertuzumab; Novel agents; HER2;
Overcoming the stromal barrier for targeted delivery of HPMA copolymers to pancreatic tumors
Keywords: HPMA copolymer; Pancreatic cancer; HER2; Imaging; Hyaluronidase; Targeting; APMA-CHX-Aâ²â²-DTPA; N-methacryloylaminopropyl-2-amino-3-(isothiourea-phenyl)propyl-cyclohexane-1,2-diamine-N,N-Nâ²,Nâ²,Nâ²â²,Nâ²â²-pentaacetic acid; CPDT; 2-cyano-2-propy
Gene expression analysis in biomarker research and early drug development using function tested reverse transcription quantitative real-time PCR assays
Keywords: ALAS1; Aminolevulinate, delta- synthase-1; Cq; quantification cycle; FFPET; formalin-fixed paraffin-embedded tissue; HER2; human epidermal growth factor receptor 2; HPRT1; hypoxanthine phosphoribosyltransferase-1; PHC; personalized health care; qPCR; quan
Analysing the mutational status of PIK3CA in circulating tumor cells from metastatic breast cancer patients
Keywords: Circulating tumor cells; Metastatic breast cancer; PIK3CA mutations; SNaPshot assay; PIK3CA; Phosphatidylinositol-4,5-bisphosphate 3-kinase; Catalytic subunit alpha; APC; allophycocyanin; CK-PE; cytokeratin-phycoerythrin; CS; CellSearch®; CTC(s); circula
HER2 discordance between primary and metastatic breast cancer: Assessing the clinical impact
Keywords: Breast cancer; Discordance; HER2; Prognosis; Rebiopsy; Recurrence; Trastuzumab;
Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability
Keywords: Breast cancer; HER2; Ado-trastuzumab emtansine; T-DM1; Toxicology; Antibody-drug conjugates;
Comparison of dual-color dual-hapten brightfield in situ hybridization (DDISH) and fluorescence in situ hybridization in breast cancer HER2 assessment
Keywords: Breast cancer; HER2; Chromosome 17; FISH; DDISH
The first total synthesis and biological evaluation of marine natural products ma’edamines A and B
Keywords: Ma’edamine A; Cytotoxic; Antiproliferative; Comet assay; HER2
Change in HER2 (ERBB2) gene status after taxane-based chemotherapy for breast cancer: polyploidization can lead to diagnostic pitfalls with potential impact for clinical management
Keywords: Invasive breast carcinoma; taxanes; HER2; amplification; polyploidization
Immunohistochemical expression of HER2 in urothelial bladder carcinoma and its correlation with p53 and p63 expression
Keywords: HER2; p53; p63; Immunohistochemistry; Urothelial bladder carcinoma
Electrochemical detection of HER2 using single stranded DNA aptamer modified gold nanoparticles electrode
Keywords: Breast cancer; HER2; Aptamer; Aptasensor; Impedance spectroscopy
HER2 mediates epidermal growth factor-induced down-regulation of E-cadherin in human ovarian cancer cells
Keywords: E-cadherin; HER2; EGF; Ovarian cancer
HER2 status in gastric cancer: A comparison of two novel in situ hybridization methods (IQ FISH and dual color SISH) and two immunohistochemistry methods (A0485 and HercepTest™)
Keywords: Silver-enhanced in situ hybridization; Fluorescence in situ hybridization; Gastric carcinoma; HER2; Immunohistochemistry
Pathological response and survival after neoadjuvant therapy for breast cancer: A 30-year study
Keywords: Breast cancer; HER2; Triple-negative; Pathological complete response; Prognostic factor
The two sides of HER2/neu: immune escape versus surveillance
Keywords: HER2; immune escape; immunotherapy; HLA; tumor; immune escape
Retinoic Acid Receptor Alpha Amplifications and Retinoic Acid Sensitivity in Breast Cancers
Keywords: All-trans-retinoic acid; Coamplification; HER2; IRF1; RARA
Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody
Keywords: HER2; Nanobody; Breast cancer; VHH; Radioiodination; IB-Mal-d-GEEEK
HER2 expression in Brazilian patients with estrogen and progesterone receptor-negative breast carcinoma
Keywords: Breast neoplasms; Receptor; HER2; Survival analysis
US-Guided Optical Tomography: Correlation with Clinicopathologic Variables in Breast Cancer
Keywords: Breast cancer; Ultrasound; Optical imaging; Diffuse optical tomography; HER2;
Assessment of new anti-HER2 ligands using combined docking, QM/MM scoring and MD simulation
Keywords: Protein kinase; HER2; Molecular dynamics; AMBER; QM/MM scoring