Keywords: Human pluripotent stem cells; Embryonic stem cells; Single-cell cloning; Induced pluripotent stem cells; hPSCs; hESCs; Genome engineering; CRISPR-Cas9;
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Keywords: Human pluripotent stem cells; Endothelial cells; Smooth muscle cells; Biomechanical cues; Vascular differentiation; Con-vSMCs; contractile vSMCs; CXCR4; C-X-C chemokine receptor type 4; ECM; Extracellular matrix; ECs; Endothelial cells; hESCs; Human embry
Keywords: APC; allophycocyanin; aMEM; medium eagle alpha modification; ANOVA; one-way analysis of variance; BALF; bronchoalveolar lavage fluid; bFGF; basic fibroblast growth factor; BM-MSC; bone marrow-derived mesenchymal stem cell; Ccl; chemokine (C-C motif) ligan
Keywords: Label-free cells; Capture and concentration; Stem cells; Cancer stem cells (CSCs); Circulating tumor cells (CTCs); ABC transporter; adenosine triphosphate-binding cassette transporter; BCRP; breast cancer resistance protein; CKs; cytokeratins; CSCs; cance
Keywords: hESCs; Pluripotency; Cortical neurogenesis; Saturated fatty acid; Cell proliferation and differentiation; Neurodevelopment;
Keywords: Polyaniline; Biomaterials; Electrical conductivity; Biocompatibility; Electrical stimulation; aECM; artificial extracellular matrix; AFM; atomic force microscopy; ALP; alkaline phosphatase; APS; ammonium persulfate; [BMIM][BF4]; 1-butyl-3-methylimidazoliu
Keywords: HA; hyaluronic acid; Tregs; regulatory T cells; T1DM; type 1 diabetes mellitus; IBD; inflammatory bowel disease; RA; rheumatoid arthritis; MHC; major histocompatibility complex; HLA; human leukocytes antigens; TLRs; toll-loke receptors; PRRs; pattern reco
Keywords: PD; Parkinson's disease; iPSCs; induced pluripotent stem cells; hiPSCs; human induced pluripotent stem cells; PSCs; pluripotent stem cells; DA; dopamine; mDA; midbrain dopamine; fVM; fetal ventral mesencephalon; hESCs; human embryonic stem cells; SNpc;
Keywords: BMP4; bone morphogenetic protein-4; CRALBP; cellular retinaldehyde binding protein; DHA; docosahexaenoic acid; FBS; fetal bovine serum; FGF; fibroblast growth factor; hESCs; human embryonic stem cells; iPSCs; induced pluripotent stem cells; NR; neural ret
Keywords: AM; Atrial cardiomyocyte; AP; Action potential; APA; Action potential amplitude; APD; Action potential duration; CICR; Ca2+-induced Ca2+ release; CK; Creatine kinase; CM; Cardiomyocyte; cTNI; Troponin I, cardiac type; cTnT; Cardiac troponin T; CÂ ÃÂ 40;
Keywords: DE; definitive endoderm; hESCs; human embryonic stem cells; CDM; chemical-defined medium; AA; activin A; WNT3A; wingless-type MMTV integration site family member 3A; BMP4; bone morphogenetic protein 4; bFGF; basic fibroblast growth factor; Cell survival;
Keywords: MSCs; mesenchymal stem cells; RPE; retinal pigment epithelium; RP; retinitis pigmentosa; AMD; age related macular degeneration; hESCs; human embryonic stem cells; iPSCs; induced pluripotent stem cells; NGF; nerve growth factor; hUMSCs; human umbilical cor
Keywords: AD-MSCs; adipose tissue-derived mesenchymal stem cells; ANG-1; angiopoietin-1; ANG-2; Angiopoietin-2; ATP; adenosine triphosphate; BBB; blood brain barrier; BDNF; brain-derived neurotrophic factor; BME; β mercaptoethanol; BM-MNCs; bone marrow-derived mon
Keywords: Human induced pluripotent stem cells (hiPSCs); Plasma-activated medium (PAM); Selective elimination; Oxidative stress; Regenerative medicine; hPSCs; human pluripotent stem cells; hESCs; human embryonic stem cells; hiPSCs; human induced pluripotent stem ce
Keywords: BBB; blood-brain barrier; CNS; central nervous system; hPSCs; human pluripotent stem cells; BMECs; brain microvascular endothelial cells; P-gp; P-glycoprotein; RA; retinoic acid; UM; unconditioned medium; EC; endothelial cell; ECÂ +Â RA medium; EC mediu
Keywords: hESCs; human embryonic stem cells; iPSCs; induced pluripotent stem cells; PSCs; pluripotent stem cells; EBs; embryoid bodies; SMPs; skeletal muscle progenitors; TC; tissue culture; MRFs; myogenic regulatory factors; FACS; fluorescence activated cell sorti
Keywords: hESCs; human embryonic stem cells; OEPs; otic epithelial progenitors; ONPs; otic neural progenitors; FGF3; fibroblast growth factor 3; FGF10; fibroblast growth factor 10; EGF; epidermal growth factor; bFGF; basic fibroblast growth factor; RA; all-trans re
Keywords: hESCs; Cryopreservation; Recovery; Ice formation; Reactive oxidative species; AP; alkaline phosphate; bFGF; basic fibroblast growth factor; BCIP-NBT; 5-bromo-4-chloro-3-indolyl phosphate and nitro blue tetrazolium; BSA; bovine serum albumin; CPA; cryoprot
Keywords: AA; ascorbic acid; ALS; amyotrophic lateral sclerosis; BDNF; brain derived neurotropic factor; BMP; bone morphogenetic protein; DNMT; DNA methyltransferase; EB; embryoid body; EBNA1; Epstein-Barr nuclear antigen-1; ERK; extracellular signal-regulated ki
Keywords: adipose-derived stem cells; ASCs; atomic force microscopy; AFM; basic fibroblast growth factors; bFGFs; body mass index; BMI; bone morphogenetic protein; BMP; brown adipose tissue; BAT; CCAAT/enhancer-binding protein; C/EBP; cyclic adenosine monophosphate
Keywords: Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator protein; CFTR2; Correctors; Potentiators; Trial end-points; Amil; Amiloride; AMP; Accelerating Medicine Partnership; ANO; anoctamins; AONs; antisense oligonucleotides; ASL; airway surfac
Keywords: Ac-LDL; acetylated-low density lipoprotein; α-SMA; α-smooth muscle actin; BM-MSCs; bone marrow mesenchymal stem cells; CD; cluster of differentiation; DAPI; 4â²,6-diamidino-2-phenylindole; DePV; decellularized pulmonary valve; DMEM; Dulbecco Modified E
Keywords: BMPs; Bone morphogenetic proteins; CMs; Cardiomyocytes; CPCs; Cardiac progenitor cells; CPVT; Catecholamine polymorphic ventricular tachycardia; DMSO; Dimethylsulfoxide; ECs; Endothelial cells; END-2; Endoderm-like cell line; ESCs; Embryonic stem cells; F
Keywords: hiPSCs; human induced pluripotent stem cells; CMs; cardiomyocytes; hESCs; human embryonic stem cells; 2D; two dimensional; hPSCs; human pluripotent stem cells; EB; embryoid body; AP; action potential; APD 90; AP duration from the peak to 90% repolarizatio
Keywords: hESCs; human embryonic stem cells; RA; all-trans retinoic acid; ExE; extraembryonic; FGF-2; basic fibroblast growth factor; MEF; mouse embryonic fibroblasts; TGF-β; transforming growth factor beta;
Keywords: ALDHhi; high expression of aldehyde dehydrogenase; ALK; activin-like kinase receptor; AP; anterior-posterior; AVE; anterior visceral endoderm; BMPs; bone morphogenic proteins; CER1; Cerberus; CFC; conserved cysteine-rich domain; CSCs; cancer stem cells;
Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1
Keywords: PE; preeclampsia; ESCs; endometrial stromal cells; hESCs; human endometrial stromal cell lines; PGK1; phosphoglycerate kinase 1; PGK1P2; phosphoglycerate kinase 1, pseudogene 2; LncRNA; long non-coding RNA; ceRNA; competing endogenous RNA; SPE; severe pre
Extractive from Hypericum ascyron L promotes serotonergic neuronal differentiation in vitro
Keywords: Cell differentiation; Chemical modification; Depression; Chinese medicine; Neural differentiation; Serotonergic neuron; ESCs; embryonic stem cells; 5-HT; 5-hydroxytryptamine; MPLC; medium pressure liquid chromatography; HPLC; high-performance liquid chrom
Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix
Keywords: BCAN; Brevican; BrM; Bruch's membrane; CD44; cluster of differentiation 44; Col4A1; Collagen IV; ECM; extracellular matrix; FBS; Fetal bovine serum; FN1; Fibronectin; GCL; ganglion cell layer; HDBR; human developmental biology resource; hESCs; human emb
Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis
Keywords: Zebrafish; hESCs; Heart development; Cardiomyopathy; FilaminC;
Engineered exosomes: A new promise for the management of musculoskeletal diseases
Keywords: Engineered exosomes; Drug delivery; Musculoskeletal diseases; Regenerative medicine; Oncology; Immune system regulation; 3â²UTR; 3â²untranslated regions; 6-OHDA; 6-hydroxydopamine; APC; adenomatous polyposis coli; BRD7; bromo-domain-containing protein 7
Tumor-promoting cyanotoxin microcystin-LR does not induce procarcinogenic events in adult human liver stem cells
Keywords: HL1-hT1; Microcystin-LR; Adult liver stem cells; Liver tumor-promotion; OATP; Multidrug resistance proteins; AB; Alamar Blue; AFP; α-fetoprotein; ALB; albumin; BCRP; breast cancer resistance protein; BSP; bromosulfophthalein; CFDA-AM; 5-carboxyfluorescei
Meeting report for Odd Pols 2016: Ann Arbor 2.0
Keywords: FGFR2; FGF Receptor-2; hESCs; human embryonic stem cells; lncRNAs; long noncoding RNAs; NORs; Nucleolus Organizer Regions; RdDM; RNA-directed DNA Methylation; Pol I; RNA polymerase I; Pol II; RNA polymerase II; Pol III; RNA polymerase III; Pol IV; RNA pol
Research paperResveratrol promotes human embryonic stem cells self-renewal by targeting SIRT1-ERK signaling pathway
Keywords: bFGF; basic fibroblast growth factor; BrdU; 5 bromo-2-deoxyuridine; EB; embryoid body; ERK; extracellular signal regulated kinase; EX-527; 6-chloro-2 3 4 9-tetrahydro-1H-carbazole-1-carboxamide; hESCs; Human embryonic stem cells; iPSCs; induced pluripoten
Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA
Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; CAS9; CRISPR associated protein; gRNA; guide RNA; PAM; protospacer adjacent motif; RNP; ribonucleoprotein; HDR; homology directed repair; hESCs; human embryonic stem cells; NHEJ; non-homol
Epigenetic and transcriptional modulation of WDR5, a chromatin remodeling protein, in Huntington's disease human induced pluripotent stem cell (hiPSC) model
Keywords: AO; age of onset; CTR; control; DAPI; 4â²,6-Diamidino-2-phenylindole; DMRs; differentially methylated regions; DNAm; DNA methylation; FDR; false discovery rate; gDNA; genomic DNA; GO; gene ontology; HD; Huntington's disease; hESCs; human embryonic stem c
Inhibition of Cell Division and DNA Replication Impair Mouse-Naïve Pluripotency Exit
Keywords: cell division; DNA replication; primitive ectoderm-like cells; mouse embryonic stem cells introduction; mESCs; mouse embryonic stem cells; PELC; primitive ectoderm-like cell; hESCs; human embryonic stem cells; ES; embryonic stem cells;
miR-199a-5p and miR-495 target GRP78 within UPR pathway of lung cancer
Keywords: NSCLC; Non-small cell lung cancer; UPR; Unfolded Protein Response; FFPE; Formalin-Fixed Paraffin-Embedded; miRNAs; microRNAs; ER; endoplasmic reticulum; ICD-O; International classification of diseases for oncology; no-RT; no-reverse transcription; REST; r
2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells
Keywords: ADP; adenosine diphosphate; AK; adenylate kinase; ANT; adenine nucleotide translocator; ATP; adenosine triphosphate; BSA; bovine serum albumin; CAT; carboxyatractyloside; CK; creatine kinase; CKB; brain-type creatine kinase; CKMT1A; creatine kinase, mitoc
Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro
Keywords: BDNF; brain-derived neurotrophic factor; BMPs; bone morphogenic proteins; DNT; Developmental neurotoxicity; EBs; embryoid bodies; GDNF; glial cell line-derived neurotrophic factor; GW; gestational week; hESCs; human embryonic stem cells; hiPSCs; Human ind
Neurodevelopmental origins of bipolar disorder: iPSC models
Keywords: ASD; autism spectrum disorders; BA; Broadmann's area; BDNF; brain derived neurotrophic factor; BP; bipolar disorder; C; healthy controls; CNS; central nervous system; DLPFC; dorsolateral prefrontal cortex; hESCs; human embryonic stem cells; iNs; induced n
Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues
Keywords: bFGF; Basic fibroblast growth factor; BSA; Bovine serum albumin; DAPI; 4,6-Diamidino-2-phenylindole; FNDC5; Fibronectin type III domain containing 5 protein; GAPDH; Glyceraldehyde 3-phosphate dehydrogenase; hESCs; Human embryonic stem cells; mESCs; Mouse
Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells in vitro
Keywords: bFGF; basic fibroblast growth factor; BMP4; bone morphogenetic protein-4; CFU-E; erythroid-colony forming units; CFU-E/G; erythroid-granulocyte colony forming units; CFU-GM; granulo-macrophagic colony forming units; cyCD3-PE; cytoplasmic CD3-PE; DLL; de
Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro
Keywords: Organotypic skin; Fibroblast heterogeneity; Wound healing; Skin models; Skin substitutes; Tissue engineering; 3D; three-dimensional; AdSCs; adipose-derived stem cells; AP-1; activated protein-1; Blimp1; B lymphocyte-induced maturation protein-1; BP; bullo
Maternal exposure to bisphenol A may increase the risks of Parkinson's disease through down-regulation of fetal IGF-1 expression
Keywords: AMY; amygdala; AFP; alpha fetoglobulin; AKT; protein kinase B; BPA; bisphenol A; DA; dopamine; 6-OHDA; 6-OH-dopamine; DOPAC; dihydroxyphenylacetic acid; EB; embryoid body; EDC; environmental endocrine disruptors; ESCs; embryonic stem cells; FACS; fluoresc
Ethyl methanesulfonate induces mutations in Caenorhabditis elegans embryos at a high frequency
Keywords: Embryo mutagenesis; Ethyl methanesulfonate; C. elegans; unc-58; Di; dionized; Dpy; dumpy; EMS; ethyl methanesulfonate; hESCs; human embryonic stem cells; Unc; Uncoordinated;
Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies
Keywords: hESCs; human embryonic stem cells; hiPSC; human induced pluripotent stem cell; NOD-SCID; non-obese diabetes-severe combined immunodeficiency; EB; embryoid bodies; NEC; primitive neuroectoderm; NP; neural progenitors; RNSC; Rosette neural stem cell line; G
Heat shock instructs hESCs to exit from the self-renewal program through negative regulation of OCT4 by SAPK/JNK and HSF1 pathway
Keywords: ChIP; Chromatin-Immunoprecipitation; DAVID; Database for Annotation, Visualization and Integrated Discovery; DEGs; differentially expressed genes; DMEM; Dulbecco's modified Eagle's medium; EBs; embryoid bodies; GOBPs; GO biological processes; hESCs; human
The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells
Keywords: CAR; PXR; Hepatic differentiation; Lentivirus; siRNA; hESCs; Drug metabolism
FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells
Keywords: AA; Activin A; Cyclo; KAAD-cyclopamine; DE; definitive endoderm; F; FGF2; HBPI; hepatocyte blockade and pancreas induction stage; hESCs; human embryonic stem cells; LY; LY294002; NG; Noggin; PNP; PDX1- and NKX6.1-positive pancreatic progenitor; PPP; PDX1-