کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8478491 | 1551133 | 2016 | 49 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neurodevelopmental origins of bipolar disorder: iPSC models
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کلمات کلیدی
INSLCLShESCsIPSCsDLPFCMDDMGEBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز NPCs - NPC هاPCA - PCAMajor depressive disorder - اختلال افسردگی عمدهbipolar disorder - اختلال دو قطبیautism spectrum disorders - اختلالات طیف اوتیسمCNS - دستگاه عصبی مرکزیhuman embryonic stem cells - سلول های بنیادی جنینی انسانInduced pluripotent stem cells - سلول های بنیادی پرتوان القاییNeural progenitor cells - سلولهای پیش گیاه عصبیcentral nervous system - سیستم عصبی مرکزیbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استdorsolateral prefrontal cortex - قشر پیشانی غدد درون رحمیmedial ganglionic eminence - میانه گانگلیونیASD - نقص سپتوم یا دیوارهی دهلیزیInduced Neurons - نورونهای تحریک شدهhealthy controls - کنترل های سالم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Bipolar disorder (BP) is a chronic neuropsychiatric condition characterized by pathological fluctuations in mood from mania to depression. Adoption, twin and family studies have consistently identified a significant hereditary component to BP, yet there is no clear genetic event or consistent neuropathology. BP has been suggested to have a developmental origin, although this hypothesis has been difficult to test since there are no viable neurons or glial cells to analyze, and research has relied largely on postmortem brain, behavioral and imaging studies, or has examined proxy tissues including saliva, olfactory epithelium and blood cells. Neurodevelopmental factors, particularly pathways related to nervous system development, cell migration, extracellular matrix, H3K4 methylation, and calcium signaling have been identified in large gene expression and GWAS studies as altered in BP. Recent advances in stem cell biology, particularly the ability to reprogram adult somatic tissues to a pluripotent state, now make it possible to interrogate these pathways in viable cell models. A number of induced pluripotent stem cell (iPSC) lines from BP patient and healthy control (C) individuals have been derived in several laboratories, and their ability to form cortical neurons examined. Early studies suggest differences in activity, calcium signaling, blocks to neuronal differentiation, and changes in neuronal, and possibly glial, lineage specification. Initial observations suggest that differentiation of BP patient-derived neurons to dorsal telencephalic derivatives may be impaired, possibly due to alterations in WNT, Hedgehog or Nodal pathway signaling. These investigations strongly support a developmental contribution to BP and identify novel pathways, mechanisms and opportunities for improved treatments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 73, June 2016, Pages 63-83
Journal: Molecular and Cellular Neuroscience - Volume 73, June 2016, Pages 63-83
نویسندگان
K. Sue O'Shea, Melvin G. McInnis,