Hypoxia-inducible factor-1 alpha regulates prion protein expression to protect against neuron cell damage
Keywords: prp106-126; Neuron cell; Hypoxia; HIF-1α; PrPC;
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Effect of trifluoperazine on toxicity, HIF-1α induction and hepatocyte regeneration in acetaminophen toxicity in mice
Keywords: APAP; acetaminophen; ALT; alanine aminotransferase; cPLA2; cytosolic phospholipase A2; (CYC); cyclosporine A; GSH; glutathione; HIF-1α; hypoxia inducible factor-1α; MPT; mitochondrial permeability transition; PCNA; proliferating cell nuclear antigen; PG
The regulation of cancer cell death and metabolism by extracellular matrix attachment
Keywords: ECM; extra cellular matrix; ROS; reactive oxygen species; PPP; pentose phosphate pathway; TCA; tricarboxylic acid; PDH; pyruvate dehydrogenase; PDK4; pyruvate dehydrogenase kinase 4; ANGPTL4; angiopoietin-like 4; PK; pyruvate kinase; TIGAR; TP53-induced g
HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons
Keywords: Ψm; mitochondrial transmembrane potential; BCA; bicinchoninic acid; DIV; days in vitro; DTT; dithiothreitol; EGTA; ethylene glycol-bis (β-aminoethyl ether)-N,N,Nâ²,Nâ²,-tetraacetic acid; FCCP; carbonyl cyanide p-trifluoromethoxyphenylhydrazone; GFP; g
Sorafenib inhibits growth, migration, and angiogenic potential of ectopic endometrial mesenchymal stem cells derived from patients with endometriosis
Keywords: Endometriosis; mesenchymal stem cells; sorafenib; VEGF; ezrin; HIF-1α;
STAT5b as Molecular Target in Pancreatic Cancer-Inhibition of Tumor Growth, Angiogenesis, and Metastases
Keywords: MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; DMEM; Dulbecco's modified Eagle's medium; FCS; fetal calf serum; VEGF-A; vascular endothelial growth factor-A; VEGF-D; vascular endothelial growth factor-D; STAT5b; signal
The transferrin receptor and the targeted delivery of therapeutic agents against cancer
Keywords: AD; adamantane; ADEPT; antibody-directed enzyme prodrug therapy; ADR; doxorubicin/adriamycin; Av; avidin; AVET; adenovirus-enhanced transferrinfection; ART; artemisinin; BAP; biotin-adaptor peptide; BBB; blood-brain barrier; BFU-E; blast forming unit-er
The sphingosine-1-phosphate derivative NHOBTD inhibits angiogenesis both invitro and invivo
Keywords: CAM; chorioallantoic membrane; ELISA; enzyme-linked immunosorbent assay; FBS; fetal bovine serum; HIF-1α; hypoxia inducible factor-1 alpha; HUVEC; human umbilical vein endothelial cell; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide;
Spatial relationship of phosphorylated epidermal growth factor receptor and activated AKT in head and neck squamous cell carcinoma
Keywords: Head and neck cancer; pEGFR; pAKT; PI3-K/AKT pathway; Hypoxia; ARCON; accelerated radiotherapy with carbogen and nicotinamide; EGFR; epidermal growth factor receptor; FpAKT; fraction of pAKT positive cells; FpAKT[pEGFR]; fraction of pAKT positive cells al
Cytotoxic T cells - Stroma interactions
Keywords: hypoxia; STAT3; HIF-1α; endothelial cells; tumor cells; CTLs;
Traditional Chinese medicine, Xue-Fu-Zhu-Yu decoction, potentiates tissue plasminogen activator against thromboembolic stroke in rats
Keywords: Caspase-3; HIF-1α; iNOS; TNF-α; Thromboembolic stroke; Xue-Fu-Zhu-Yu decoction;
Analiza ekspresji HIF-1α i COX-2 w utkaniu guza oraz korelacja ze stopniem inwazyjnoÅci zmian nowotworowych u chorych z rakiem krtani - badania wstÄpne
Keywords: rak pÅaskonabÅonkowy krtani; HIF-1α; COX-2; inwazyjnoÅÄ zmian nowotworowych; squamous cell laryngeal carcinoma; HIF-1α; COX-2; neoplastic invasiveness;
Transcriptional up-regulation of RhoE by hypoxia-inducible factor (HIF)-1 promotes epithelial to mesenchymal transition of gastric cancer cells during hypoxia
Keywords: Hypoxia; Gastric cancer; RhoE; HIF-1α; EMT; Invasion;
Trichinella spiralis infection induces angiogenic factor thymosin β4 expression
Keywords: Trichinella spiralis; Thymosin β4; VEGF; HIF-1α; Hypoxia; Angiogenesis;
Blockade of hypoxia-inducible factor-1α by YC-1 attenuates interferon-γ and tumor necrosis factor-α-induced intestinal epithelial barrier dysfunction
Keywords: IFN-γ; interferon-γ; TNF-α; tumor necrosis factor-α; MLC; myosin light chain; MLCK; myosin light chain kinase; HIF-1α; hypoxia-inducible factor-1α; YC-1; 3-(5â²-hydroxymethyl-2â²-furyl)-1-benzylindazole; TER; transepithelial electrical resistance;
Research ReportCerebral metabolism after forced or voluntary physical exercise
Keywords: Cerebral metabolism; Exercise; HIF-1α; PFK-1; GLUT; Glycolysis;
NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α
Keywords: NGF/TrkA; BDNF/TrkB; VEGF; HIF-1α; Dorsal root ganglion neurons; Cerebellar granule neurons; Neuroblastoma;
Stem Cell Engraftment and Survival in the Ischemic Heart
Keywords: ADSCs; adipose derived stem cells; Ang-1; angiopoietin-1; BM cells; bone marrow cells; CABG; coronary artery bypass grafting; ES cells; embryonic stem cells; FGF-2; fibroblast growth factor 2; GMP; good manufacturing practice; HIF-1α; hypoxia-inducible f
Thioredoxin 1 enhances neovascularization and reduces ventricular remodeling during chronic myocardial infarction: A study using thioredoxin 1 transgenic mice
Keywords: AKAP12; A kinase anchoring protein 12; HIF-1α; hypoxia inducible factor alpha; LAD; left anterior descending coronary artery; LVIDd; left ventricular internal diameter at diastole; LVIDs; left ventricular internal diameter at systole; MI; myocardial infa
Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40
Keywords: CyP40; RACK1; NF45; RPS3; Ku70; HIF-1α;
Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes
Keywords: iNOS; inducible nitric oxide; NO; nitric oxide; HIF-1α; hypoxia-inducible factor-1α; O2; oxygen; ROS; reactive oxygen species; EtOH; alcohol/ethanol; OCR; oxygen consumption rate; FCCP; carbonyl cyanide-p-trifluoromethoxyphenylhydrazone; CcOX; cytochrom
Clinical Significance of CD133 and Hypoxia Inducible Factor-1α Gene Expression in Rectal Cancer after Preoperative Chemoradiotherapy
Keywords: CD133; HIF-1α; preoperative chemoradiotherapy; rectal cancer;
Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC
Keywords: Diabetic neuropathy; Hypoxia; High glucose; TRPV1; PKC; Sensory neuron; Phosphorylation; HIF-1α;
Soy isoflavones sensitize cancer cells to radiotherapy
Keywords: APE/Ref-1; apurinic/apyrimidinic endonuclease 1/redox factor-1; EMSA; electrophoretic mobility-shift assay; γ-H2AX; nucleosomal histone protein H2AX phosphorylated at Ser 139; HIF-1α; hypoxia-inducible factor 1α; NF-κB; nuclear factor κB; PARP; poly(
Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE2 synthesis
Keywords: ACP; acid phosphatease; BMD; bone mineral density; BM-MSCs; bone marrow-derived mesenchymal stem cells; BMP-2; bone morphogenetic protein-2; Cbfa1/Runx2; core binding factor A1/runt-related transcription factor 2; COX-2; cyclo-oxygenase type-2; DMSO; dime
Interscapular brown adipose tissue metabolic reprogramming during cold acclimation: Interplay of HIF-1α and AMPKα
Keywords: BAT; brown adipose tissue; IBAT; interscapular BAT; L-NAME; NÏ-nitro-L-arginine methyl ester; phospho-AMPKα; phosphorylated AMP-activated protein kinase α; HIF-1α; hypoxia-inducible factor-1α; COX IV; subunit IV of cytochrome c oxidase; PDH; pyruvate
HIF-1α inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues
Keywords: Moracin; Arylbenzofuran; HIF-1α; Structure-activity relationships;
Research ArticleHuman carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells
Keywords: CBR1; carbonyl reductase 1; HCC; hepatocellular carcinoma cell; HRE; hypoxia-responsive element; SDR; short chain dehydrogenase/reductase; ONE; 4-oxonon-2-enal; HIF-1α; hypoxia inducible factor-1α; TACE; transarterial chemoembolization; HO-1; heme oxyge
Uncovering the role of hypoxia inducible factor-1α in skin carcinogenesis
Keywords: Bax; Bcl-2-associated X protein; BCC; Basal cell carcinoma; Bcl-2; B cell lymphoma; Bcl-xL; B-cell lymphoma-extra large; BNIP3; BCL2/adenovirus E1B 19Â kDa protein-interacting protein 3; CMM; Cutaneous malignant melanoma; CBP; cyclic-AMP response element
The role of low-grade inflammation in the polycystic ovary syndrome
Keywords: ADMA; asymmetric dimethylarginine; A-FABP; adipocyte fatty acid-binding protein; AGEs; advanced glycation endproducts; MA; molecular adhesions; Akt/PKB; Akt/protein kinase B; CRP; C reacting protein; ESR; erothrocyte sedimentation rate; ET-1; endothelin-1
Research ReportLinking hypoxic and oxidative insults to cell death mechanisms in models of ALS
Keywords: Amyotrophic lateral sclerosis; Oxidative toxicity; Motor neuron; Apoptosis; ALS; amyotrophic lateral sclerosis; Aif; apoptosis inducing factor; Hif-1α; hypoxia inducing factor-1α; HO-1; heme oxygenases-1; UCP4; uncoupling protein 4; GSH; chronic sustain
Targeting autophagy during cancer therapy to improve clinical outcomes
Keywords: AMPK; AMP activated protein kinase; ATG; autophagy-related genes; Bif-1; endophilin B1; BNIP3; Bcl-2/adenovirus E1B 19Â kDa-interacting protein; CML; chronic myeloid leukemia; CQ; chloroquine; DAP1; death-associated protein 1; HCQ; hydroxychloroquine; HDA
Animal models relevant to human prostate carcinogenesis underlining the critical implication of prostatic stem/progenitor cells
Keywords: ADT; androgen deprivation therapy; AI; androgen-independent; ALDH; aldehyde dehydrogenase; AR; androgen receptor; ARR2; two androgen-responsive regions; BM; bone marrow; CXCR4; CXC chemokine receptor 4; CK; cytokeratin; ECM; extracellular matrix; EGFR; ep
Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain
Keywords: multifunctional drug; iron chelation; hypoxia-inducible factor; brain-derived neurotrophic factor; pro-survival signaling pathways; systemic chronic administration; AD; Alzheimer's disease; BDNF; brain-derived neurotrophic factor; DFO; deferoxamine; dNTP;
Adaptive response to oxidative stress: Bacteria, fungi, plants and animals
Keywords: AHP1; alkylhydroperoxide reductase; AHR; aryl hydrocarbon receptor; ARE; antioxidant response element; 2CPA; 2-Cys peroxiredoxin-A; CRD; cysteine rich domain; Cul3; Cullin 3; DPH; diphenylhexatriene; EpRE; electrophile response element; ERK; extracellular
Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling
Keywords: α-SMA; α-smooth muscle actin; CTGF; connective tissue growth factor; Eng; endoglin; ER; endoplasmatic reticulum; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Hif-1α; hypoxia inducible factor 1α; HSC; hepatic stellate cell(s); IP; immunoprecipitati
Role of Notch and its oncogenic signaling crosstalk in breast cancer
Keywords: 4T1 cells; mouse mammary cancer cell line; ADAM; a disintegrin and metalloprotease; Akt; protein kinase B; ALDH; aldehyde dehydrogenase; ANK; ankyrin; Axin2; the Axin-related protein; BALB/c; an albino, laboratory-bred strain of the house mouse; Bcl-2; B-
Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases
Keywords: ACE2; angiotensin-converting enzyme 2; ADP; adenosine diphosphate; AGE; advanced glycation end-products; APV; DL-2-amino-5-phosphonovaleric acid; AT1; angiotensin II type I receptor; Aβ25-35; β-amyloid; Bcl-2; B-cell leukemia/lymphoma-2; BKCa; large-con
Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells
Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; BACE; β-site APP cleaving enzyme; sAPPα; soluble amyloid precursor protein α; HIF-1α; hypoxia-inducible factor 1α; HRE; hypoxia res
Hypoxia inducing factor-1α regulates tumor necrosis factor-related apoptosis-inducing ligand sensitivity in tumor cells exposed to hypoxia
Keywords: Hypoxia; HIF-1α; TRAIL;
Hypoxia-induced Phenotypic Switch of Fibroblasts to Myofibroblasts through a Matrix Metalloproteinase 2/Tissue Inhibitor of Metalloproteinase-mediated Pathway: Implications for Venous Neointimal Hyperplasia in Hemodialysis Access
Keywords: HIF-1α; hypoxia-inducible factor-1α; Ig; immunoglobulin; MMP; matrix metalloproteinase; TIMP; tissue inhibitor of metalloproteinase; PTFE; polytetrafluoroethylene; SDS; sodium dodecyl sulfate; SMA; smooth muscle actin;
Increased Expression of HIF-1α, VEGF-A and Its Receptors, MMP-2, TIMP-1, and ADAMTS-1 at the Venous Stenosis of Arteriovenous Fistula in a Mouse Model with Renal Insufficiency
Keywords: ADAMTS-1; a disintegrin and metalloproteinase thrombospondin-1; AVF; arteriovenous fistula; ESRD; end-stage renal disease; HIF-1α; hypoxia inducible factor-1 alpha; MMP-2; matrix metalloproteinase-2; PTFE; polytetrafluoroethylene; RT-PCR; realtime polyme
Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1α mediated transcription
Keywords: VHL tumour suppressor; Protein kinase CK2; Degradation; p53; HIF-1α;
Manganese-mediated up-regulation of HIF-1α protein in Hep2 human laryngeal epithelial cells via activation of the family of MAPKs
Keywords: ATF-2; activating transcription factor-2; CHX; cycloheximide; COX-2; cyclooxygenase-2; ECL; enzyme-linked chemiluminescence; ERK-1/2; extracellular-regulated protein kinase-1/2; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HRE
Heterotopic ossification induced by Achilles tenotomy via endochondral bone formation: Expression of bone and cartilage related genes
Keywords: Heterotopic ossification; Chondrogenesis; Endochondral ossification; HIF-1α; Achilles tenotomy;
Tumor-stroma co-evolution in prostate cancer progression and metastasis
Keywords: AR; androgen receptor; ARCaP; androgen refractory prostate cancer; β2M; β2-microglobulin; BDNF; brain derived neurotropic factor; BMP; bone morphogenetic protein; BSP; bone sialoprotein; CAF; cancer-associated fibroblast; CCL5; chemokine (C-C) ligand
HIF-1α and -2α genes in a hypoxia-sensitive teleost species Megalobrama amblycephala: cDNA cloning, expression and different responses to hypoxia
Keywords: Megalobrama amblycephala; HIF-1α; HIF-2α; Hypoxia; Gene expression;
Beta tubulin affects the aryl hydrocarbon receptor function via an Arnt-mediated mechanism
Keywords: AhR; aryl hydrocarbon receptor; Arnt; Ah receptor nuclear translocator; HIF-1α; hypoxia inducible factor 1 alpha; βME; β-mercaptoethanol; DRE; dioxin response element; HRE; hypoxia response element; βNF; β-napthoflavone; HEDG; 25 mM HEPES, pH 7.4, 1
Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α
Keywords: IL-1β; HIF-1α; CXCL8; Cell migration; Breast cancer;
An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p
Keywords: Hif-1α; hypoxia-inducible factor 1alpha; Sirt1; sirtuin-1; HPC; hypoxia preconditioning; miRNA; microRNA; IPC; ischemia preconditioning; TAC; transverse aortic constriction; caAKT; constitutively active AKT; ILK; integrin-linked kinase; βAR; beta-adrene