Cardiomyocyte-targeted HIF-1α gene therapy inhibits cardiomyocyte apoptosis and cardiac allograft vasculopathy in the rat
Keywords: AAV; apoptosis; CAV; HIF-1α; ischemia;
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Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth
Keywords: EGLN; Egl-9 homologue; HIF-1; hypoxia-inducible factor-1; HNSCC; head and neck squamous cell carcinoma; PHD; prolyl hydroxylation domain protein; pVHL; von Hippel-Lindau protein; TMA; tissue microarray; RT-PCR; real-time PCR; Colon carcinoma; HIF-1α; Hyp
Hypoxia and succinate antagonize 2-deoxyglucose effects on glioblastoma
Keywords: GBM; glioblastoma multiforme; BMP2; bone morphogenetic protein2; HIF-1α; hypoxia inducible factor 1α; PHD2; prolyl hydroxylase2; SDH; succinate dehydrogenase; 2-Deoxyglucose; Hypoxia; Hypoxia inducible factor-1α; Prolyl hydroxylase 2; GBM differentiati
Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: An in vivo bioluminescence imaging study
Keywords: Triple-negative breast cancer; Breast cancer metastasis; in vivo bioluminescence imaging; Rapamycin; mTOR; Cyclophosphamide; HIF-1α;
Aquaporins in spinal cord injury: the janus face of aquaporin 4
Keywords: human spinal cord injury; AQP4-negative astrocytes; AQP4-overexpressing astrocytes; bumetanide; pain; fluid-filled cavity; ALS; amyotrophic lateral sclerosis; AQPs; aquaporins; AQP4; aquaporin 4; ARE; antioxidant-responsive element; BBB; Basso, Beattie, B
Regulation of brain aquaporins
Keywords: ANP; atrial natriuretic peptide; AQP; aquaporin; ATP; adenosine triphosphate; BBB; blood-brain barrier; BSE; bovine spongiform encephalopathy; CaMKII; calcium/calmodulin dependent protein kinase II; cAMP; cyclic adenosine monophosphate; cGMP; cyclic gua
Hypoxia-inducible factor-1α has a key role in hypoxic preconditioning
Keywords: Hypoxic preconditioning; Tissue oxygenation; Hypoxia; HIF-1α; Inducible nitric oxide synthase;
Transcriptional activation of hypoxia-inducible factor-1α by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1
Keywords: HIF-1; hypoxia-inducible factor-1; ODD; oxygen-dependent degradation; FIH-1; factor inhibiting HIF-1; HDAC; histone deacetylase; HRE; hypoxia-response element; C-TAD; C-terminal activating domain; ID; inhibitory domain; TSA; trichostatin A; pVHL; von Hipp
Dual role of HIF-1α in delivering a survival or death signal in hypoxia exposed human K562 erythroleukemia cells
Keywords: HIF-1α; CREB; p38MAPK; Hypoxia; K562 erythroleukemia cells;
Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways
Keywords: SOD; superoxide dismutase; MnP, MnIIITE-2PyP5+; Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin (AEOL-10113); MnTnHex-2-PyP5+; Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin; FeTM-4-PyP5+; Fe(III) meso-tetrakis(N-methylpyridinium-4-yl)por
Inhibition of PKHD1 may cause S-phase entry via mTOR signaling pathway
Keywords: PKHD1; Rapamycin; mTOR; HIF-1α; VEGF;
Special relationship between sterols and oxygen: Were sterols an adaptation to aerobic life?
Keywords: CHO; Chinese hamster ovary; DHCR24; 3β-hydroxysterol-Î24-reductase; EPR; electron paramagnetic resonance; ESR; electron spin resonance; H2O2; hydrogen peroxide; HIF-1α; hypoxia-inducible factor 1α; HMG-CoA reductase; 3-hydroxy-3-methyl-glutaryl-coenzy
Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1α involvement in CYP3A4 repression
Keywords: Hypoxia; HIF-1α; Cytochrome P450; CYP3A4; Hepatocellular carcinoma; HepaRG; Chemoresistance;
Functions and mechanisms of action of CCN matricellular proteins
Keywords: AVSD; atrioventricular septal defects; BMP; bone morphogenetic protein; ECM; extracellular matrix; FAK; focal adhesion kinase; HIF-1α; hypoxia-inducible factor-1α; HSPG; heparan sulfate proteoglycan; LRP; lipoprotein receptor-related protein; MMP; matri
Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression
Keywords: Diacylglycerol kinase; DGK; Sphingosine kinase; SPK; Ceramide kinase; CERK; Vascular endothelial growth factor; VEGF; Hepatocyte growth factor; HGF; Epidermal growth factor; EGF; Protein kinase C; PKC; Protein kinase D; PKD; Peroxisome proliferator-activa
Regulation of Membrane-Type 4 Matrix Metalloproteinase by SLUG Contributes to Hypoxia-Mediated Metastasis
Keywords: ChIP; chromatin immunoprecipitation; EMT; epithelial-mesenchymal transition; FBS; fetal bovine serum; HIF-1α; hypoxia-inducible factor-1; HNSCC; head and neck squamous cell carcinoma; ICC; immunocytochemistry; IHC; immunohistochemistry; MMP; matrix metal
Expression of cyclooxygenase-1/-2, microsomal prostaglandin-E synthase-1 and E-prostanoid receptor 2 and regulation of inflammatory mediators by PGE2 in the amoeboid microglia in hypoxic postnatal rats and murine BV-2 cells
Keywords: microglia; hypoxia; COX-1/-2; mPGES-1; EP2 receptor antagonist; PGE2; AA; arachidonic acid; AMC; amoeboid microglial cells; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; COX-1; cyclooxygenase-1; COX-2; cyclooxygenase-2; cPGES; cytosol
Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents
Keywords: 311; 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone; BpT; 2-benzoylpyridine thiosemicarbazone; CDK; cyclin-dependent kinase; CDKi; cyclin-dependent kinase inhibitor; DFO; desferrioxamine; DMT1; divalent metal ion transporter 1; DpT; di-2-pyridylketo
Therapeutic role of sirolimus in non-transplant kidney disease
Keywords: AKI; acute kidney injury; AMPK; AMP-activated kinase; ADPKD; autosomal dominant polycystic kidney disease; CAN; chronic allograft nephropathy; CD2AP; CD2-associated protein; Cdk; cyclin-dependent kinase; CNI; calcineurin inhibitor; CTGF; connective tissue
Increased Expression of Hypoxia-inducible Factor-1α in Venous Stenosis of Arteriovenous Polytetrafluoroethylene Grafts in a Chronic Renal Insufficiency Porcine Model
Keywords: BUN; blood urea nitrogen; HIF-1α; hypoxia-inducible factor 1α; PTFE; polytetrafluoroethylene; VEGF; vascular endothelial growth factor; VGA; vein-to-graft anastomosis;
Mechanism of hyperbaric oxygen preconditioning in neonatal hypoxia-ischemia rat model
Keywords: ANOVA; analysis of variance; ATA; atmosphere absolute; BCIP; 5-bromo-4-chloro-3-indolylphosphate; BDNF; brain derived neurotrophic factor; CAT; catalase; HBO; hyperbaric oxygen; HBO-PC; hyperbaric oxygen preconditioning; HI; hypoxic ischemic; HIBD; HI bra
Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia?
Keywords: angiogenesis; HIF-1α; hypoxia; multifetal pregnancy; PlGF; preeclampsia; sFlt1; trophoblast; twin pregnancy;
Baicalein suppresses hypoxia-induced HIF-1α protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells
Keywords: Baicalein; Hypoxia; BV2 microglia; HIF-1α; PI 3-kinase; ROS;
Comparison of Hypoxia-inducible Factor-1α Expression before and after Transcatheter Arterial Embolization in Rabbit VX2 Liver Tumors
Keywords: HCC; hepatocellular carcinoma; HIF-1α; hypoxia-inducible factor-1α; SACE; subjective angiography chemoembolization endpoint; TAE; transcatheter arterial embolization;
Expression of Hypoxia Inducible Factor-1α, Macrophage Migration Inhibition Factor, Matrix Metalloproteinase-2 and â9, and Their Inhibitors in Hemodialysis Grafts and Arteriovenous Fistulas
Keywords: AVF; arteriovenous fistula; HIF-1α; hypoxia inducible factor-1α; IgG; immunoglobulin G; MIF; macrophage migration inhibition factor; MMP; matrix metalloproteinase; PTFE; polytetrafluoroethylene; SDS; sodium dodecyl sulfate; TIMP; tissue inhibitor of m
Overexpression of post-translationally modified peptides in Escherichia coli by co-expression with modifying enzymes
Keywords: Phosphorylation; Hydroxylation; Co-expression; Escherichia coli; B1 domain of protein G (GB1); CREB; HIF-1α;
Prognostic Significance of Tumor Hypoxia Inducible Factor-1α Expression for Outcome After Radiotherapy in Oropharyngeal Cancer
Keywords: HIF-1α; Hemoglobin; Oropharynx; Radiotherapy; Subsites;
Ischemic injury underlies the pathogenesis of aristolochic acidâinduced acute kidney injury
Keywords: AA; aristolochic acid; AAN; aristolochic acid nephropathy; ANOVA; one-way analysis of variance; ET-1; endothelin-1; HIF-1α; hypoxia inducible factor-1 alpha; NO; nitric oxide; PBS; phosphate buffer serum; RIA; radioimmunoassay; RT-PCR; reverse transcript
Selenium protects the hypoxia induced apoptosis in neuroblastoma cells through upregulation of Bcl-2
Keywords: CAD; Caspase activated DNAase; DCFH-DA; Dichlorofluorescein Diacetate; DTNB; Dithionitrobenzoic acid; EDTA; Ethylene Diamine Tetra Acetic Acid; GPx; Glutathione peroxidase; GR; Glutathione Reductase; GSH; Glutathione; GSSG; Oxidized glutathione; H; Hypoxi
Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
Keywords: ANOVA; analysis of variance; ELISA; enzyme-linked immunoabsorbent assay; EPO; erythropoietin; FITC; fluorescein isothiocyanate; HIF-1α; hypoxia-inducible factor 1α; HRE; hypoxia response element; IFNγ; interferon-γ; LPS; lipopolysaccharide; PCR; polym
Ginkgolides mimic the effects of hypoxic preconditioning to protect C6 cells against ischemic injury by up-regulation of hypoxia-inducible factor-1 alpha and erythropoietin
Keywords: AKT; serine-threonine protein kinase; DOR; delta-opioid receptor; EGb 761; the standardized Ginkgo biloba extract; EPO; erythropoietin; H11K; the protein H11 kinase; HIF-1α; hypoxia-inducible factor-1 alpha; MAPK; mitogen-activated protein kinase; NMDA;
Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells
Keywords: Hypoxia inducible factor 1α,; VEGF; bFGF, PI3K; angiogenesis, hypoxia; bFGF; basic fibroblast growth factor; ERK1/2; extracellular signal regulated kinase; HIF-1α; hypoxia inducible factor-1α; MEK-1; mitogen activated protein kinase kinase-1; PI3K; pho
NF-κB inhibition by an adenovirus expressed aptamer sensitizes TNFα-induced apoptosis
Keywords: Aptamer; NF-κB; HIF-1α; TNFα; Apoptosis;
Effect of Transcatheter Arterial Embolization on Levels of Hypoxia-inducible Factor-1α in Rabbit VX2 Liver Tumors
Keywords: HCC; hepatocellular carcinoma; HIF-1α; hypoxia-inducible factor-1α; TAE; transcatheter arterial embolization;
Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia
Keywords: ANOVA; analysis of variance; ATA; atmosphere absolute; ET; endothelin; ET-1; endothelin-1; HIF-1α; hypoxia-inducible factor-1α; HBO; hyperbaric oxygen; MCA; middle cerebral artery; MCAO; middle cerebral artery occlusion; PBS; phosphate-buffered saline;
Nonreceptor Tyrosine Kinases in Prostate
Keywords: Nonreceptor tyrosine kinase; prostate cancer; Src; FAK; ETK; Abl; v-Abl Abelson murine leukemia viral oncogene homolog; At; androgenindependent; Aid; v-akt murine thymoma viral oncogene homolog 1; AR; androgen receptor; ARG; Abelson-related gene; Bcr; bre
Confluence-dependent resistance to doxorubicin in human MDA-MB-231 breast carcinoma cells requires hypoxia-inducible factor-1 activity
Keywords: HIF-1α; Hypoxia; Cell density; Resistance; Solid tumour; Tumour microenvironment;
The role of ascorbate in the modulation of HIF-1α protein and HIF-dependent transcription by chromium(VI) and nickel(II)
Keywords: CA9; carbonic anhydrase 9; DHA; dehydroascorbate; HIF; hypoxia-inducible transcription factor; HRE; HIF response element; 2-OG; 2-oxoglutarate; ROS; reactive oxygen species; pVHL; von Hippel-Lindau protein; Ascorbate; Chromium(VI); Nickel(II); HIF-1α;
Increased Expression of Hypoxia-Inducible Factor-1α in the Internal Spermatic Vein of Patients With Varicocele
Keywords: hypoxia-inducible factor 1; alpha subunit; varicocele; infertility; male; AP; alkaline phosphatase; HIF-1α; hypoxia-inducible factor-1α; ISV; internal spermatic vein; VEGF; vascular endothelial growth factor;
Transient expression of hypoxia-inducible factor-1 alpha and target genes in peripheral nerves from diabetic rats
Keywords: Diabetic neuropathy; Sciatic nerves; HIF-1α; VEGF; Erythropoietin;
Inhibition of GSK3β by indirubins restores HIF-1α accumulation under prolonged periods of hypoxia/anoxia
Keywords: Hypoxia; PI3K; Akt; Indirubin; HIF-1α; Translation;
Hypergravity induces expression of cyclooxygenase-2 in the heart vessels
Keywords: COX-2; Hypergravity; Heart; Hypoxia; HIF-1α; iNOS; VEGF; HO-1;
Bacterially produced human HIF-1α is competent for heterodimerization and specific DNA-binding
Keywords: Hypoxia-inducible factor 1; HIF-1α; ARNT; Bacterial expression; Heterodimerization; DNA-binding;
Hypoxia and HIF-1α in chondrogenesis
Keywords: Hypoxia; HIF-1α; VHL; VEGF, Chondrocytes;
The metal-responsive transcription factor-1 contributes to HIF-1 activation during hypoxic stress
Keywords: MTF-1; HIF-1α; Hypoxia; GLUT1; Glutathione; Glutamate cysteine ligase catalytic subunit;
Hypoxia-induced expression of HIF-1α and its target genes in umbilical venous endothelial cells of Tibetans and immigrant Han
Keywords: Hypoxia; HIF-1α; VEGF; NOS; Tibetan;
Correlation of hypoxia inducible factor-1α with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer
Keywords: Esophageal squamous cell carcinoma; HIF-1α; VEGF-C; Immunohistochemistry; RT-PCR; Lymphatic invasion; Lymph node metastasis; Lymphangiogenesis;
Hypoxia-induced IL-6 production is associated with activation of MAP kinase, HIF-1, and NF-κB on HEI-OC1 cells
Keywords: IL-6; interleukin-6; DFX; desferrioxamine; MAPK; mitogen-activated protein kinase; HIF-1α; hypoxia-inducible factor-1α; NF-κB; nuclear factor-kappa B; Cochlear auditory cells; Hypoxia; IL-6; MAPK; HIF-1α; NF-κB;
Hypoxia reduces constitutive and TNF-α-induced expression of monocyte chemoattractant protein-1 in human proximal renal tubular cells
Keywords: MCP-1; Hypoxia; Desferrioxamine; TNF-α; HIF-1α; Human proximal tubular cells;
Hypoxia-induced dedifferentiation of tumor cells - A mechanism behind heterogeneity and aggressiveness of solid tumors
Keywords: Hypoxia; Differentiation; Neuroblastoma; Sympathetic nervous system; Breast carcinoma; HIF-1α; HIF-2α;