کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1909828 | 1046741 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Special relationship between sterols and oxygen: Were sterols an adaptation to aerobic life?
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کلمات کلیدی
3-hydroxy-3-methyl-glutaryl-coenzyme A reductaseSREBPDHCR24HIF-1αESRRBCHMG-CoA reductase - HMG-CoA ردوکتازROS - ROSHydrogen peroxide - آب اکسیژنهcataracts - آب مرواریدErythrocytes - اریتروسیت هاSterol - استرولOxygen - اکسیژنMolecular oxygen - اکسیژن مولکولیCho - برایChinese Hamster Ovary - تخمدان هامستر چینیEPR - تشدید پارامغناطیس الکترونElectron paramagnetic resonance - تشدید پارامغناطیس الکترونElectron spin resonance - رزونانس اسپین الکترونseladin-1 - سالادین-1Surfactant - سورفکتانتhypoxia-inducible factor 1α - عامل القایی هیپوکسی 1αEvolution - فرگشت Mitochondria - میتوکندریاH2O2 - هیدروژن پراکسیدsterol regulatory element binding protein - پروتئین اتصال دهنده عصاره استرولcholesterol - کلسترولred blood cell - گلبول قرمز، اریتروسیتReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
A fascinating link between sterols and molecular oxygen (O2) has been a common thread running through the fundamental work of Konrad Bloch, who elucidated the biosynthetic pathway for cholesterol, to recent work supporting a role of sterols in the sensing of O2. Synthesis of sterols by eukaryotes is an O2-intensive process. In this review, we argue that increased levels of O2 in the atmosphere not only made the evolution of sterols possible, but that these sterols may in turn have provided the eukaryote with an early defence mechanism against O2. The idea that nature crafted sterols as a feedback loop to adapt to, or help protect against, the hazards of O2 is novel and enticing. We marshal several lines of evidence to support this thesis: (1) coincidence of atmospheric O2 and sterol evolution; (2) sterols regulate O2 entry into eukaryotic cells and organelles; (3) sterols act as O2 sensors across eukaryotic life; (4) sterols serve as a primitive cellular defence against O2 (including reactive oxygen species). Therefore, sterols may have evolved in eukaryotes partially as an adaptive response to the rise of terrestrial O2, rather than merely as a consequence of it.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 47, Issue 6, 15 September 2009, Pages 880-889
Journal: Free Radical Biology and Medicine - Volume 47, Issue 6, 15 September 2009, Pages 880-889
نویسندگان
Anne M. Galea, Andrew J. Brown,