دانلود مقالات ISI درباره Hobt + ترجمه فارسی

Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease

Keywords: PK; pharmacokinetics; DMF; N,N,-dimethylfornamide; DCM; dichloromethane; CDI; carbonyl diimidazole; TLC; thin layer chromatography; EDCI; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; HOBt; N-hydroxybenzotriazole; DIEA; diisopropylethylamine; DTT; dithio

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders

Keywords: PTPRZ1; CNS disorders; Drug addiction; Molecular dynamics; Synthesis; EDCI; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide; HOBt; hydroxybenzotriazole; MCPBA; meta-chloroperbenzoic acid; MK; Midkine; PAMPA-BBB; membrane permeability assay for the blood-bra

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity

Keywords: Amyloid-β; Alzheimer's disease; Caffeic acid; Divalent caffeic amide; Inhibitor; Cytotoxicity; Aβ; amyloid-β; AD; Alzheimer's disease; CA; caffeic acid; CCS; collision cross-section; DMF; dimethylformamide; EDCI; 1-ethyl-3-(3-dimethylaminopropyl) carbo

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2018 سفارش ترجمه

Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship

Keywords: Cefiderocol; Siderophore; Siderophore cephalosporin; Multi-drug resistant Gram-negative pathogens; ESBL; extended-spectrum β-lactamase; MDR; multi-drug resistant; PG; protecting group; ACLE·HCl; (7-amino-3-chloromethyl-3-cephem-4-carboxylate p-methoxybe

دانلود رایگان متن کامل مقاله ISI 83 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis of hybrid materials using graft copolymerization on non-cellulosic polysaccharides via homogenous ATRP

Keywords: AAP; 4-aminoantipyrine; AGET; activators generated by electron transfer; AGP; agarose palmitate; AGU; anhydroglucose unit; AMIMB; 1-allyl-3-methylimidazolium bromide; AS; acetylated starch; Au NPs; gold nanoparticles; BIBA; α-bromoisobutyric acid; BIBB;

دانلود رایگان متن کامل مقاله ISI 125 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery and evaluation of Cav3.1-selective T-type calcium channel blockers

Keywords: AcOH; acetic acid; 9-BBN; 9-borabicyclo(3.3.1)nonane; DAST; diethylaminosulfur trifluoride; DIPEA; N,N-diisopropylethylamine; DMAP; 4-(dimethylamino)pyridine; DMF; N,N-dimethylformamide; EDC·HCl; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochlorid

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen

Keywords: EDCI; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; HATU; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate; HCK; hematopoietic cell kinase; HOBt; hydroxybenzotriazole; NABH(OAc)3; sodium triacetoxyborohydride;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery and evaluation of Cav3.2-selective T-type calcium channel blockers

Keywords: AcOH; acetic acid; Boc; tert-butylocycarbonyl; DIPEA; N,N-diisopropylethylamine; DMAP; 4-(dimethylamino)pyridine; DMF; N,N-dimethylformamide; EDC·HCl; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt; hydroxybenzotriazole; KHMDS; potassi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Highly potent antiobesity effect of a short-length peptide YY analog in mice

Keywords: Ac; acetylated; Aib; 2-aminoisobutyric acid; tBu; tert-butyl; Cha; 3-cyclohexylalanine; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; DIO; diet-induced obese; DIPCDI; N,N′-diisopropylcarbodiimide; DMF; N,N-dimethylformamide; DMSO; di

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Comparison of extracellular Cys/Trp motif between Schizosaccharomyces pombe Ctr4 and Ctr5

Keywords: Ctr; copper transporter; BCA; bicinchoninic acid; Fmoc; 9-fluorenylmethyloxycarbonyl; NMP; N-methylpyrrolidone; HBTU; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; HOBt; 1-hydroxybenzotriazol; DIEA; N,N-diisopropylethylamine; DM

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Coating lanthanide nanoparticles with carbohydrate ligands elicits affinity for HeLa and RAW264.7 cells, enhancing their photodamaging effect

Keywords: DIC; 1,3-diisopropylcarbodiimide; DIPEA; N,N-diisopropylethylamine; DLS; dynamic light scattering; DMAP; N,N-dimethyl-4-aminopyridine; DMF; N,N-dimethylformamide; DMEM; Dulbecco's Modified Eagle Medium; EPR effect; enhanced permeability and retention ef

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Insights into amyloid-like aggregation of H2 region of the C-terminal domain of nucleophosmin

Keywords: TIS; Triisopropylsilane; TFA; Trifluoroacetic acid; DMF; Dimethylformamide; HBTU; 1-H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-Hexafluorophosphate(1-),3 oxide; HOBt; N-hydroxybenzotriazole; DIEA; Di-isopropylethylamine; Fmoc; Fluorenylmethoxycarbo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and evaluation of novel ureido/thioureido derivatives of amino acid conjugated 2,3-dichlorophenyl piperazine as highly potent antiglycating agents

Keywords: AGE; advanced glycation end products; Boc; t-butoxycarbonyl; BSA; bovine serum albumin; EDCI; 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide·HCl; HOBt; 1-hydroxybenzotriazole; NMM; N-methyl morpholine; PBS; phosphate buffer saline; PZN; 1-(2,3-dichloroph

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and biological activity of cyclolinopeptide A analogues modified with γ4-bis(homo-phenylalanine)

Keywords: Boc; tert-Butoxycarbonyl; C8; octyl stationary phase; C18; octadecyl stationary phase; CLA; cyclolinopeptide A; COSY-DQF; double quantum filtered proton spin correlation; CsA; cyclosporine A; DIPEA; N,N-diisopropylethylamine; DMF; dimethylformamide; DMSO;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase

Keywords: CPME; cyclopentyl methyl ether; DCM; dichloromethane; DMA; N,N-dimethylacetamide; DMAP; 4-dimethylaminopyridine; DME; 1,2-dimethoxyethane; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; EDCI; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochlor

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones

Keywords: Cell division cycle 7 (Cdc7); Pharmacophore model; Dihydrothieno[3,2-d]-pyrimidin-4(1H)-one; CSA; (+/−)-camphor-10-sulfonic acid; DCM; dichloromethane; DMA; N,N-dimethylacetamide; DME; 1,2-dimethoxyethane; DMF; N,N-dimethylformamide; DMSO; dimethyl sulf

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of spiro[indole-3,2′-pyrrolidin]-2(1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP

Keywords: CDCl3; deuterated chloroform; DHX29; DEAH-Box helicase 29 (an ATP-dependent RNA helicase); DIPEA; N,N′-diisopropylethylamine; DMSO-d6; dimethyl sulfoxide-d6; EDC·HCl; 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride; eIF4A1; eukaryotic ini

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Design and optimization of purine derivatives as in vivo active PDE10A inhibitors

Keywords: DIEA; N,N-diisopropylethylamine; DME; dimethoxyethane; DMF; N,N-dimethylformamide; EDC; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; HOBt; 1-hydroxybenzotriazole; rt; room temperature; TEA; triethylamine; THF; tetrahydrofuran; Phosphodiesterase; PDE10A;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach

Keywords: AcOEt; ethyl acetate; chloramine-T; N-chloro 4-methylbenzenesulfonamide sodium salt; DMAP; N,N-4-dimethylaminopyridine; DMF; N,N-dimethylformamide; hERG; human Ether-a-go-go Related Gene; HOBt; 1-hydroxybenzotriazole; IBX; o-iodoxybenzoic acid; LDA; lithi

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential

Keywords: ADME; absorption, distribution, metabolism, and excretion; AML; acute myelogenous leukemia; AUC; area under the blood concentration time curve; b.i.d.; twice a day; CDK; Cyclin-dependent kinase; CLtotal; clearance; Cmax; maximum drug concentration; CRC; c

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Bivalent SIRT1 inhibitors

Keywords: β-NAD+; β-nicotinamide adenine dinucleotide; NAM; nicotinamide; 2′-O-AADPR; 2′-O-acyl-ADP-ribose; RP-HPLC; reversed-phase high performance liquid chromatography; HRMS; high-resolution mass spectrometry; EDC-MeI; 1-(3-dimethylaminopropyl)-3-ethylcarb

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Ser422 phosphorylation blocks human Tau cleavage by caspase-3: Biochemical implications to Alzheimer's Disease

Keywords: Aa; amino acid; ACN; acetonitrile; AUFS; absorbance units full scale; CHCA; 1-Cyano 4-Hydroxy Cinnamic Acid; Da; Dalton; DHB; 2,5-dihydroxy benzoic acid; DMF; N,N′-dimethyl formamide; EDT; ethane dithiol; h; human; HATU; 1-[Bis(dimethylamino)methylene]-

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists

Keywords: 2-PCCA; (1R,2R)-2-(pyridin-2-yl)cyclopropane carboxylic acid ((2S,3S)-2-amino-3-methylpentyl)-(4′-propylbiphenyl-4-yl)amide; 2-AMPP; (2S)-N-((1R)-2-amino-1-(4-(2-methyl-pentyloxy)phenyl)ethyl)-2-phenylpropanamide; SAR; structure activity relationship; P

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Effect of TLR ligands co-encapsulated with multiepitopic antigen in nanoliposomes targeted to human DCs via Fc receptor for cancer vaccines

Keywords: AAA; amino acid analysis; C18; octadecylsilica; DIEA; N,N-diisopropyl-ethylamine; DIPCDI; N,N'-Diisopropylcarbodiimide; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide Fmoc, 9-fluorenylmethoxycarbonyl; HOAt; 1-hydroxy-7-azabenzotriazole (3-hydroxy-

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo

Keywords: Antiproliferative agents; Antitumor agents; Bis(hydroxymethyl) alkanoate curcuminoids; Curcumin; Triple-negative breast cancer; BUN; blood urea nitrogen; DMAP; N,N-dimethylaminopyridine; DMF; dimethylformamide; DMSO; dimethylsulfoxide; EtOAc; ethyl acetat

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF1 receptor antagonist

Keywords: CRF; corticotropin-releasing factor; HPA; hypothalamus-pituitary-adrenocortical; ACTH; adrenocorticotropic hormone; SAR; structureactivity-relationship; CDI; N,N′-carbodiimidazole; WSC; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of 3,4-dihydro-2H-thiochromene 1,1-dioxide derivatives with a phenoxyethylamine group as highly potent and selective α1D adrenoceptor antagonists

Keywords: Phenoxyethylamine derivatives; Selective human α1D adrenoceptor antagonist; 3,4-Dihydro-2H-thiochromene 1,1-dioxide; Ligand-lipophilicity efficiency (LLE); AR; Adrenoceptor; BH3; borane; Boc2O; di-tert-butyl bicarbonate; t-BuXphos; 2-di-tert-butylphosp

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of selective ATP-competitive eIF4A3 inhibitors

Keywords: RNA helicase; Eukaryotic initiation factor 4A3 (eIF4A3) inhibitors; Exon junction complex (EJC); ATP-competitive type inhibitors; Isothermal titration calorimetry (ITC); Surface plasmon resonance (SPR); BRR2; bad response to refrigeration 2 (an ATP-depend

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation

Keywords: Thrombin; Protein-ligand binding; Desolvation; Bioisosterism; Hydrogen bond; Cooperativity; Nonadditivity; B3LYP/6-31G∗; Bn; benzyl; tert-Bu; tertiary butyl; DCM; dichloromethane; DIEA; diisopropylethylamine; DMF; dimethylformamide; EDCI.HCl; 1-ethyl-3-

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2017 سفارش ترجمه

Progress in the development of β-lactams as N-Acylethanolamine Acid Amidase (NAAA) inhibitors: Synthesis and SAR study of new, potent N-O-substituted derivatives

Keywords: N-Acylethanolamine acid amidase; Cysteine hydrolase; N-O-Substituted β-lactams; Inhibitors; Structure-activity relationships (SAR); NAAA; N-acylethanolamine acid amidase; FAEs; fatty acid ethanolamides; OEA; oleoylethanolamide; PEA; palmitoylethanolami

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus

Keywords: SSTR5; somatostatin receptor subtype 5; OGTT; oral glucose tolerance test; hERG; human ether-a-go-go related gene; DM; diabetes mellitus; HFD; high-fat diet; NCS; N-chlorosuccinimide; WSC; 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride; HOB

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition of amyloid fibril formation and cytotoxicity by caffeic acid-conjugated amyloid-β C-terminal peptides

Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; CA; caffeic acid; DCFH-DA; 2′,7′-dichlorodihydrofluorescein diacetate; DHCA; dihydrocaffeic acid; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; Gly; glycine; HBTU; O

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and binding characteristics of [3H]neuromedin N, a NTS2 receptor ligand

Keywords: BH; Bolton-Hunter; Bmax; maximal number of the binding sites; BSA; bovine serum albumin; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; EC50; half maximal effective concentration; Emax; maximal stimulation (Efficacy); GDP; guanosine 5′-

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization

Keywords: DIPEA; N,N-diisopropylethylamine; EDCI; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; DMF; dimethylformamide; EDT; ethanedithiol; HOBt; 1-hydroxybenzotriazole; TFA; trifluoroacetic acid; TIS; triisopropylsilane; EGF; epidermal growth factor; TGF; transfo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome

Keywords: 20S Eukaryotic proteasome; Internally quenched peptides; Fluorescence; UPS; ubiquitin-proteasome system; ACC; 7-amino-4-carbamoylmethylcoumarin; AMC; 7-amino-4-methylocoumarin; FRET; fluorescent resonance energy transfer; ABZ; 2-aminobenzoic acid; Tyr(3

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Research reportAntinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile9]PK20 in an acute pain treatment in rodents

Keywords: CHO; Chinese hamster ovary (cells); Dmt; 2',6'-dimethyl-(S)-tyrosine; EC50; half maximal effective concentration; [35S]-GTPγS; guanosine-5-[γ-35S]-triphosphate; HOBt; 1-hydroxybenzotriazole; RP-HPLC; reverse phase-high preparative liquid chromatogra

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors

Keywords: AcOH; acetic acid; Ang I; angiotensin I; Ang II; angiotensin II; AUC; area under the blood concentration-time curve; C5min; concentration in plasma 5 min after administration; CLtotal; total clearance; Cmax; maximum concentration in plasma; DIEA; N,N-d

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Structural requirements of acylated Gly-l-Ala-d-Glu analogs for activation of the innate immune receptor NOD2

Keywords: Muramyl dipeptide; Immunomodulator; Desmuramylpeptide; NOD2 agonist; Immunostimulant; Immunoadjuvant; CARD; caspase activation and recruitment domain; DCC; dicyclohexylcarbodiimide; DMAP; 4-dimethylaminopyridine; EDC; 1-ethyl-3-(3-dimethylaminopropyl)carb

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Poly(α-hydroxy acid)s and poly(α-hydroxy acid-co-α-amino acid)s derived from amino acid

Keywords: COCl2; phosgene; EDC; N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride; NHS; N-hydroxysuccinimide; DCC; N,N′-dicyclohexylcarbodiimide; HOBt; hydroxybenzotriazole; PTSA; 4-toluenesulfonic acid/p-toluenesulfonic acid; PEA; poly(esteramide);

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

In vivo effective dibenzo[b,d]furan-1-yl-thiazoles as novel PDE-4 inhibitors

Keywords: PDE; phosphodiesterase; TNF-α; tumour necrosis factor; nm; nanomolar; IL; interleukin; μM; micromolar; @; at; PBMC; peripheral blood mononuclear cells; LPS; lipopolysaccharides; COPD; chronic obstructive pulmonary disease; CC; column chromatography; HCl

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

High stability and biological activity of the copper(II) complexes of alloferon 1 analogues containing tryptophan

Keywords: CD; Circular Dichroism Spectroscopy; DAPI; 4′,6-diamidino-2-phenyloindole; DMF; N,N-dimethylformamide; DOPA; 3,4-dihydroxyphenylalanine; EPR; Electron Paramagnetic Resonance Spectroscopy; ESI-MS; Electrospray Ionization Mass Spectrometry; Fmoc; 9-fluo

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups

Keywords: S1P1 receptor agonist; Immunomodulator; Lymphocyte count; Aminomethyl pyridine; Aminomethyl benzene; Aminomethyl thiophene; Phototoxicity; BuLi; n-butyl lithium; CC; column chromatography; DCM; dichloromethane; DIPEA; diisopropylethylamine; DEAD; diethyl

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei

Keywords: Mip; macrophage infectivity potentiator; PPIase; peptidyl-prolyl cis/trans isomerase; LpMip; L. pneumophila Mip; BpMip; B. pseudomallei Mip; SAR; structure-activity relationship; HSQC; Heteronuclear Single Quantum Coherence; NMM; N-methylmorpholine; DIP

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2016 سفارش ترجمه

Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors

Keywords: BK; bradykinin; BR; bradykinin receptor; CNS; central nervous system; DALKD; [des-Arg10,Leu9]-kallidin; DIPEA; diisopropylethylamine; DMF; N,N-dimethylformamide; Dyn A; dynorphin A; HR MS; high resolution mass spectroscopy; Fmoc; 9-fluorenylmethoxycarbony

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis and biological evaluation of the [d-MeAla11]-epimer of coibamide A

Keywords: Hva; α-hydroxyisovaleric acid; HATU; O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; BTC; bis(trichloromethyl) carbonate; DIC; 1,3-diisopropylcarbodiimide; HOBt; 1-hydroxybenzotriazole; HOAt; 1-hydroxy-7-azabenzotriazole; TFA;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Synthetic study of peptide aldehyde via acetal/thioacetal transformation: application for Lys/Ser-containing peptides

Keywords: Peptide aldehyde; Acetal; Thioacetal; Cysteine protease inhibitor; SPPS; solid phase peptide synthesis; NBS; N-bromo succinimide; SARS; severe acute respiratory syndrome; DMF; dimethyl formamide; DIPEA; diisopropylethylamine; DIPC; diisopropylcarbodiimide

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Structure-activity relationship study of syringolin A as a potential anticancer agent

Keywords: Fmoc; 9-fluorenylmethyloxycarbonyl; EDCI; 1-ethyl-3-(3-dimethylaminopropyl)carboxamide; HOBt; 1-hydroxybenzotriazole; DMF; N,N-dimethylformamide; Proteasome inhibitor; Cancer; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Brassinosteroid-BODIPY conjugates: Design, synthesis, and properties

Keywords: BS; brassinosteroids; BODIPY; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; (DHQD)2AQN; hydroquinidine anthraquinone-1,4-diyl diether; EDC; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; DIPEA; N,N-diisopropylethylamine; HOBt; 1-hydroxybenzo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Scaffolded multimers of hIAPP20-29 peptide fragments fibrillate faster and lead to different fibrils compared to the free hIAPP20-29 peptide fragment

Keywords: AFM; Atomic force microscopy; CD; circular dichroism; CC; Critical concentration of fibrillation; CuAAC; Cu(I)-catalyzed alkyne-azide cycloaddition; αCD; α-cyclodextrin; N3P3; cyclotriphosphazene; DIC; Diisopropylcarbodiimide; DIPEA; N,N-diisopropylet

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Cyclen-based double-tailed lipids for DNA delivery: Synthesis and the effect of linking group structures

Keywords: Boc; tert-butoxycarbonyl; cyclen; 1, 4, 7, 10-tetraazacyclododecane; lipoplexes; liposome/DNA complexes; TE; gene transfection efficiency; EDC HCl; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt; 1-hydroxybenzotriazole; TFA; trifluoroac

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه