Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 25, Issue 16, 15 August 2017, Pages 4259-4264

Hitomi Yuki, Ko Kikuzato, Yasuko Koda, Junko Mikuni, Yuri Tomabechi, Mutsuko Kukimoto-Niino, Akiko Tanaka, Fumiyuki Shirai, Mikako Shirouzu, Hiroo Koyama, Teruki Honma,