دانلود مقالات ISI درباره Hsp90 + ترجمه فارسی

Hsp90 inhibition renders iNOS aggregation and the clearance of iNOS aggregates by proteasomes requires SPSB2

Keywords: Hsp90; heat shock protein 90; NO; nitric oxide; iNOS; inducible NO synthase; SPSB2; SPRY domain-containing SOCS box protein 2; CHIP; carboxyl terminus of Hsc70 interacting protein; UPS; ubiquitin-proteasome system; GA; geldanamycin; Nitric oxide; Inducibl

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Nickel ions bind to HSP90β and enhance HIF-1α-mediated IL-8 expression

Keywords: Nickel; Interleukin 8; HSP90; HIF-1α; HIF-1β; THP-1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Activation of HRI is mediated by Hsp90 during stress through modulation of the HRI-Hsp90 complex

Keywords: HRI; Heme regulated inhibitor; eIF2α; Eukaryotic initiation factor 2 alpha; Hsp90; Heat shock protein 90; Cdc37; Cell division Cycle 37; iRDP; in silico Rational Design of Proteins; M2H; Mammalian two-hybrid; HRI; Hsp90; Co-immunoprecipitation; Lead acet

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90

Keywords: Zebrafish; Hsp90; Stress response; Migration; Motility; Cell cycle; Cancer; in vivo;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacologic inhibition of AKT leads to cell death in relapsed multiple myeloma

Keywords: AKT; Anti-Cancer drug; HS1793; HSP90; Multiple myeloma;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Hypericin affects cancer side populations via competitive inhibition of BCRP

Keywords: ABC transporters; ATP-binding cassette transporters; ALDH; aldehyde dehydrogenase; BCRP; breast carcinoma resistance protein; CDH1; cadherin 1 gene encoding E-cadherin; CSLCs; cancer stem-like cells; DEAB; N,N-diethylaminobenzaldehyde; EDTA; ethylenediami

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Co-chaperon p23 inhibitors: Identification of anticancer compounds from traditional Chinese medicine database

Keywords: Hsp; heat shock protein; TCM; Traditional Chinese Medicine; VS; virtual screening; PDB; Protein Data Bank; Co-chaperon p23; Anticancer; TCM compounds; Hsp90; Apoptosis; Virtual screening;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals

Keywords: Thioredoxin reductase; Thioredoxin; Synaptic vesicles; Botulinum neurotoxins; Tetanus neurotoxin; Hsp90; Geldanamycin; PX-12; Ebselen; Inhibitors;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2018 سفارش ترجمه

Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies

Keywords: NF-κB; nuclear factor kappa B; AP-1; activator protein; STAT3; signal transducer and activator of transcription 3; NK cells; natural killer cells; TNF-α; tumor necrosis factor-α; NO; nitric oxide; iNOS; inducible nitric oxygen synthase; ROS; reactive o

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2018 سفارش ترجمه

PKM2, a potential target for regulating cancer

Keywords: PK; pyruvate kinase; HCC; hepatocellular carcinoma; FBP; fructose 1,6-bisphosphate; SAICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-50-phosphate; hnRNPs; heterogeneous nuclear ribonucleoproteins; PTB; polypyrimidine tract-binding protein; NEK2; n

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

SIRT2 reduces actin polymerization and cell migration through deacetylation and degradation of HSP90

Keywords: APC/C; anaphase-promoting complex/cyclosome; CHX; cycloheximide; EMT; epithelial-mesenchymal transition; F-actin; filamentous actin; FOXO3a; forkhead box O3a; G-actin; globular actin; HCC; hepatocellular carcinoma; HSP90; heat shock protein 90; HOXA10; ho

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice

Keywords: Novobiocin analog; Hsp90; Liposomes; Drug delivery; Orthotopic;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice

Keywords: αMHC-Cre; α-myosin heavy chain promoter-driven Cre recombinase; BCL2L13; Bcl-2-like protein 13; CCCP; mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone; ER; endoplasmic reticulum; FKBP8; FK506-binding protein 8; GRP78; glucose-regulated p

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Comparative studies of the low-resolution structure of two p23 co-chaperones for Hsp90 identified in Plasmodium falciparum genome

Keywords: p23; Hsp90; Sba1; Molecular chaperone; Plasmodium falciparum;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway

Keywords: AhR; aryl hydrocarbon receptor; ARNT; ah receptor nuclear translocator protein; ATP; adenosine triphosphate; ASC; apoptosis-associated speck-like protein containing CARD; BMDM; bone marrow-derived macrophage; BSA; bovine serum albumin; Caspase-1; cysteiny

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

Gene expression and promoter characterization of heat-shock protein 90B gene (HSP90B) in the model unicellular green alga Chlamydomonas reinhardtii

Keywords: Chlamydomonas; ER; Gene expression; Heat-shock protein; HSP90; Promoter analysis;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Transposable element dysregulation in systemic lupus erythematosus and regulation by histone conformation and Hsp90

Keywords: Adar; RNaseL; Lupus; Heat shock; Epigenetics; Histone deacetylase inhibitor; 17-AAG; 17-Demethoxy-17-(2-propenylamino) geldanamycin; APOBEC; Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide-Like; ERV; Endogenous retrovirus; H3K4me3; Histone 3, l

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Protein kinase C mediated internalization of ErbB2 is independent of clathrin, ubiquitination and Hsp90 dissociation

Keywords: CHX; cycloheximide; EEA1; early endosome antigen 1; GA; geldanamycin; LAMP1; lysosomal-associated membrane protein 1; PMA; phorbol 12-myristate 13-acetate; RTK; receptor tyrosine kinase; ErbB2; Protein kinase C (PKC); Endocytosis; Endosomal sorting; Hsp90

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

DCZ3112, a novel Hsp90 inhibitor, exerts potent antitumor activity against HER2-positive breast cancer through disruption of Hsp90-Cdc37 interaction

Keywords: Cdc37; DCZ3112; Geldanamycin; Hsp90; HER2-positive breast cancer;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

FLCN: The causative gene for Birt-Hogg-Dubé syndrome

Keywords: AEC; alveolar epithelial type II cell; AKT; protein kinase B; AMPK/Ampk; 5′-AMP activated protein kinase; AMPKα (also AAK-2); AMPKα subunit; ATP; adenosine triphosphate; Bcl-2; B-cell lymphoma 2; BHD; Birt-Hogg-Dubé; BAT; brown adipose tissue; C. ele

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism

Keywords: AHR; aryl hydrocarbon receptor; ARNT; AHR nuclear translocator; p23; p23 co-chaperone; Hsp90; heat shock protein 90; XAP2; hepatitis virus B X-associated protein 2; 3-MC; 3-methylcholanthrene; βNF; β-napthoflavone, DRE, dioxin response element; GST; glu

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Plant-biotic interactions under elevated CO2: A molecular perspective

Keywords: ABA; abscisic acid; ACC-S; amino-cyclopropane-1-carboxylate synthase; aCO2; ambient CO2; AOS1; ALLENE OXIDE SYNTHASE1; APR; Acyrthosiphon pisum Resistance; BYDV; Barley Yellow Dwarf Virus; C/N ratio; Carbon/nitrogen ratio; CGA; chlorogenic acid; CMV; Ca

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

In silico identification and analysis of the binding site for aminocoumarin type inhibitors in the C-terminal domain of Hsp90

Keywords: Hsp90; C-terminal domain; N-terminal domain; Aminocoumarin binding site; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2018 سفارش ترجمه

Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery

Keywords: Antiplasmodial; Antimalarial; Arylamino alcohol; Multi-stage activity; Hsp90; Enantiomer separation;

دانلود رایگان متن کامل مقاله ISI 75 صفحه سال انتشار : 2018 سفارش ترجمه

Virtual screening and biophysical studies lead to HSP90 inhibitors

Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; 17-DMAG; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG); ADP; adenosine diphosphate; AMPPCP; 5′-adenylylmethylenediphosphonate; ASP; Astex statistical potential; ATP; adenosine triphosphat

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors

Keywords: Hsp90; Structure-based design; Cancer; Antiproliferative; Pyrrolo[2,3-d]pyrimidines;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

C0818, a novel curcumin derivative, interacts with Hsp90 and inhibits Hsp90 ATPase activity

Keywords: Curcumin derivative; Hsp90; ATPase activity; Fluorescence spectrometry; Interaction;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Predictive role of GSTP1-containing exosomes in chemotherapy-resistant breast cancer

Keywords: GSTP1; glutathione S-transferase P1; PD; progressive disease; SD; stable disease; PR; partial response; CR; complete response; TSG101; tumour susceptibility gene 101 protein; BCa; breast cancer; microRNA; miRNA; DNA; deoxyribonucleic acid; HSP70; heat sho

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Proteasome inhibitor-induced cleavage of HSP90 is mediated by ROS generation and caspase 10-activation in human leukemic cells

Keywords: HSP90; Cleavage; Proteasome inhibitor; ROS; Caspase; VDUP1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleEpigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer

Keywords: HSP90; Ganetespib; DNA methylation; Pancreatic cancer; Colorectal cancer;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

HSP90 maintains boar spermatozoa motility and mitochondrial membrane potential during heat stress

Keywords: boar; spermatozoa; motility; HSP90; heat stress;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular cloning, sequencing, and expression profiles of heat shock protein 90 (HSP90) in Hyriopsis cumingii exposed to different stressors: Temperature, cadmium and Aeromonas hydrophila

Keywords: Hyriopsis cumingii; HSP90; Sequence analysis; Temperature stress; Cadmium exposure; Bacterial infection; EST; expressed sequence tag; GSP; gene specific primer; HSP; heat shock protein; PBS; phosphate-buffered saline; RACE; rapid amplification of cDNA end

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells

Keywords: MLK3; Mixed Lineage Kinase 3; MLK4; Mixed Lineage Kinase 4; MAPK; mitogen-activated protein kinase; MAP3K; MAPK kinase kinase; MAP2K; MAPK kinase; JNK; c-Jun N-terminal kinase; siRNA; short interfering RNA; ERK; extracellular signal-regulated kinase; HEK2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor

Keywords: Everolimus; Platycodin D; Hsp90; Cdc37; EGFR; IGF1R;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Protein mediated regulation of the NHE1 isoform of the Na+/H+ exchanger in renal cells. A regulatory role of Hsp90 and AKT kinase

Keywords: AKT kinase; Hsp70; Hsp90; Na+/H+ exchanger;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The oxidized phospholipid POVPC impairs endothelial function and vasodilation via uncoupling endothelial nitric oxide synthase

Keywords: eNOS; endothelial nitric oxide synthase; POVPC; 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine; HUVECs; human umbilical vein endothelial cells; NO; nitric oxide; O2−;  superoxide anion; HSP90; heat shock protein 90; LDL; low-density lipoprot

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The crystal structure of the Hsp90 co-chaperone Cpr7 from Saccharomyces cerevisiae

Keywords: Hsp90; heat shock protein 90; TPR domain; tetratricopeptide repeat domain; PPIase; peptidyl-prolyl isomerase; PPI domain; peptidyl-prolyl isomerase domain; MEEVD; amino acid Met, Glu, Glu, Val and Asp; ITC; Isothermal Titration Calorimetry; CD; circular d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleHDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis

Keywords: Histone deacetylase 6; HDAC6-selective inhibitor; p53; Hsp90; Apoptosis; CHX; cycloheximide; CRC; colorectal cancer cells; DBD; DNA-binding domain; HDAC6; histone deacetylase 6; HDACi; histone deacetylase inhibitors; Hsp90; heat shock protein 90; KO; Knoc

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Insights on the structural dynamics of Leishmania braziliensis Hsp90 molecular chaperone by small angle X-ray scattering

Keywords: Leishmania; Molecular chaperones; Hsp90; SAXS; Multi-domain flexible proteins;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Angiotensin II dependent cardiac remodeling in the eel Anguilla anguilla involves the NOS/NO system

Keywords: AT2 receptor; ERK1-2; Hsp90; Myocardial growth; NOSTRIN; ACE; Angiotensin Converting Enzyme; Akt; protein kinase B; AngII; Angiotensin II; cGMP; cyclic Guanosine Mono-Phosphate; EE; Endocardial Endothelium; eNOS; endothelial Nitric Oxide Synthase; ERK1-2;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

HSP90 and pCREB alterations are linked to mancozeb-dependent behavioral and neurodegenerative effects in a marine teleost

Keywords: ACS; amino cupric silver stain; CCe; corpus of the cerebellum; DIG; digoxigenin-11-dUTP; Dl; lateral part of the dorsal telencephalon; Dm; medial part of the dorsal telencephalon; HSP90; heat shock protein 90; mz; mancozeb; NDLI; diffuse nucleus of the in

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleSynergistic anti-tumor effect of 17AAG with the PI3K/mTOR inhibitor NVP-BEZ235 on human melanoma

Keywords: HSP90; Melanoma; PI3K/mTOR; RTK;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Short-term molecular and physiological responses to heat stress in neritic copepods Acartia tonsa and Eurytemora affinis

Keywords: Acclimation; Biomarker; GRP78; Heat-shock; HSP70; HSP90; Oxygen consumption; Stress proteins;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells

Keywords: Honokiol; HSP90; Autophagy; EGFR; Gefitinib-resistance;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Hsp90 Sensitivity to ADP Reveals Hidden Regulation Mechanisms

Keywords: NTDs; N-terminal domains; SAXS; small-angle X-ray scattering; FRET; fluorescence resonance energy transfer; Hsp90; chaperone; inhibition; regulation; ATPase;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Enhanced effect of geldanamycin nanocomposite against breast cancer cells growing in vitro and as xenograft with vanquished normal cell toxicity

Keywords: Breast cancer; Geldanamycin; Hepatocellular toxicity; Hsp90; Nanocomposite; SPION;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Interaction of E. coli Hsp90 with DnaK Involves the DnaJ Binding Region of DnaK

Keywords: Hsp90; 90-kDa heat shock protein; NBD; nucleotide-binding domain; SBD; substrate-binding domain; NEF; nucleotide exchange factor; BLI; bio-layer interferometry; Hsp40; CbpA; HtpG; molecular chaperone; protein remodeling;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways

Keywords: D-gal; D-galactose; H2S; Hydrogen Sulfide; ROS; Reactive Oxygen Species; CD; Common Deletion; GSH; Glutathione; SOD; Superoxide Dismutase; DMEM; Dulbecco's Modified Eagle Medium; PI3K; Phosphatidylinositol 3-kinase; CaMKKβ; Ca2+/calmodulin-dependent prot

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Large Rotation of the N-terminal Domain of Hsp90 Is Important for Interaction with Some but Not All Client Proteins

Keywords: Hsp90; 90-kDa heat shock protein; NBD; nucleotide-binding domain; MD; middle domain; DD; dimerization domain; BMH; 1,6-bis(maleimido)hexane; HX; hydrogen exchange; BMOE; 1,6-bis(maleimido)ethane; FOA; 5-fluoroorotic acid; GR; glucocorticoid receptor; GFP;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

4-Hydroxynonenal (HNE) modified proteins in metabolic diseases

Keywords: AcLDL; Acetylated low density lipoprotein; AD; Alzheimer's disease; ADH; Alcohol dehydrogenase; ADP; Adenine dinucleotide; ADPRT; ADP ribosyl-transferase; ALDH; Aldehyde dehydrogenase; Arg; Arginine; ATPase; ATP synthase; CYP2E1; P450 cytochrome 2E1; Cys;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه