کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8646263 | 1570074 | 2018 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Co-chaperon p23 inhibitors: Identification of anticancer compounds from traditional Chinese medicine database
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The heat shock protein 90 (Hsp90) is a molecular chaperon, which plays a vital action to favor tumor growth and metastasis among different types of cancers due to its significant role in stimulating the over-expression of anti-apoptotic proteins Hsp70 and Hsp27, which assist in the sustainable development of cancer cells. For the activation of the chaperoning activity, Hsp90 requires a small protein called co-chaperon p23. Recently, it has been reported that the binding of gedunin, a natural compound, with co-chaperon p23, inhibits p23 co-chaperoning activity through blocking its molecular interaction with Hsp90 and leads to cancer cell death by apoptosis. Hence, the above facts support the strong position of co-chaperon p23 as a potential therapeutic target for cancer treatment. In this study, we employed the virtual screening technique to explore the potent inhibitors of co-chaperon p23 from Traditional Chinese Medicine (TCM) database. Total 200 inhibitors from TCM against co-chaperon p23 were screened and only four TCM compounds like dihydro-n-caffeoyltyramine, lithospermic acid, oleuropein and salvianolic acid were selected for further analysis, which showed binding energies, â 6.0, â 6.6, â 6.2 and â 6.7 kcal/mol, respectively. The findings of this study suggest that these TCM compounds can be considered as potent inhibitors of co-chaperon p23 for further in vitro and in vivo validation for designing new potential drugs for cancer treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Reports - Volume 10, March 2018, Pages 135-140
Journal: Gene Reports - Volume 10, March 2018, Pages 135-140
نویسندگان
Vivek Dhar Dwivedi, Arpita Dwivedi, Manas Mishra, Umesh Yadava, Sarad Kumar Mishra,