کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8963853 | 1646633 | 2018 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transposable element dysregulation in systemic lupus erythematosus and regulation by histone conformation and Hsp90
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کلمات کلیدی
LPSH3K4me3LTRADARAPOBECH3K27acsnoRNAsnRNAERV17-AAGTLRPhytohemagglutininHSP90PHARNASELPBMClncRNAlong non-coding RNA - RNA بدون رمزگذاری طولانیsmall nuclear RNA - RNA هسته ای کوچکsmall nucleolar RNA - RNA کوچک هسته ایSINE - آنهاEpigenetics - اپی ژنتیکLong terminal repeat - تکرار طولانی مدتToll-like receptor - تیالآرLINE - خط LINEEndogenous retrovirus - رتروویروس اندوژنperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیHeat shock - شوک حرارتیShort interspersed element - عنصر مبهم کوتاهlong interspersed element - عنصر مشتق شده طولانیLupus - لوپوسSystemic lupus erythematosus - لوپوس اریتماتوی سیستمیکSLE - لوپوس منتشر یا لوپوس اریتماتوس سیستمیکlipopolysaccharide - لیپوپلی ساکاریدhistone deacetylase inhibitor - مهار کننده هیستون داسیدلازHeat shock protein 90 - پروتئین شوک حرارت 90
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Systemic lupus erythematosus (SLE) represents an autoimmune disease in which activation of the type I interferon pathway leads to dysregulation of tolerance and the generation of autoantibodies directed against nuclear constituents. The mechanisms driving the activation of the interferon pathway in SLE have been the subject of intense investigation but are still incompletely understood. Transposable elements represent an enormous source of RNA that could potentially stimulate the cell intrinsic RNA-recognition pathway, leading to upregulation of interferons. We used RNA-seq to define transposable element families and subfamilies in three cell types in SLE and found diverse effects on transposable element expression in the three cell types and even within a given family of transposable elements. When potential mechanisms were examined, we found that Hsp90 inhibition could drive increased expression of multiple type of transposable elements. Both direct inhibition and the delivery of a heat shock itself, which redirects heat shock regulators (including Hsp90) off of basal expression promoters and onto heat shock-responsive promoters, led to increased transposable element expression. This effect was amplified by the concurrent delivery of a histone deacetylase inhibitor. We conclude that transposable elements are dysregulated in SLE and there are tissue-specific effects and locus-specific effects. The magnitude of RNAs attributable to transposable elements makes their dysregulation of critical interest in SLE where transposable element RNA complexed with proteins has been shown to drive interferon expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 197, December 2018, Pages 6-18
Journal: Clinical Immunology - Volume 197, December 2018, Pages 6-18
نویسندگان
Maurer Kelly, Shi Lihua, Zhang Zhe, Song Li, Paucar Yoselin, Petri Michelle, Sullivan Kathleen E.,