Keywords: ژن وابسته به اتر-أ-go-go انسان است; ASK1; apoptosis signal-regulating kinase 1; ASK2; apoptosis signal-regulating kinase 2; DMSO; dimethyl sulphoxide; hERG; human ether-a-go-go-related gene; JNK; c-Jun N-terminal kinase; MKK7; mitogen activated kinase kinase 7; MTT; 3-(4,5-dimethylthiazol-2
مقالات ISI ژن وابسته به اتر-أ-go-go انسان است (ترجمه نشده)
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Keywords: ژن وابسته به اتر-أ-go-go انسان است; AV; atrioventricular; CSI; cardiosomatic index; CAT; catalase; CS; citrate synthase; d.m.; dry mass; EDV; end-diastolic volume; EF1α; elongation factor 1α; ESV; end-systolic volume; fH; contractile rate; GPX1a; glutathione peroxidase 1a; GST-pi; glutath
Keywords: ژن وابسته به اتر-أ-go-go انسان است; Channelopathy; Animal venom; Peptide toxin; Disease; Ligand-receptor interaction; Drug seeds; ASIC; acid-sensing ion channel; ATP; adenosine triphosphate; BK channel; big potassium channel; CFA; Freund's complete adjuvant; CFTR; cystic fibrosis transmembr
Keywords: ژن وابسته به اتر-أ-go-go انسان است; ADME-Tox; absorption, distribution, metabolism, excretion, and toxicity; AUC; area under the curve; BnSH; benzyl mercaptan; Xantphos; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; CYP2C19; hepatic cytochrome P450 2C19; CYP3A4; hepatic cytochrome P450 3
Keywords: ژن وابسته به اتر-أ-go-go انسان است; ADME-Tox; absorption, distribution, metabolism, excretion, and toxicity; CYP2C19; hepatic cytochrome P450 2C19; CYP3A4; hepatic cytochrome P450 3A4; DSC; differential scanning calorimetry; DIBAL-H; diisobutylaluminium hydride; DME; 1,2-dimethoxyethane; DM
Keywords: ژن وابسته به اتر-أ-go-go انسان است; MD; Molecular dynamics; QM; quantum mechanics; human Ether-a-go-go-Related Gene; hERG; VS; voltage-sensing domain; Voltage-gated ion channel modulation; Membrane dipole potential; hERG activators; Ion channel activators; Molecular dynamics;
Keywords: ژن وابسته به اتر-أ-go-go انسان است; Channelopathies; Long QT syndrome; Short QT syndrome; Brugada syndrome; Catecholaminergic polymorphic ventricular tachycardia; Sudden cardiac death; ATS; Anderson-Tawil syndrome; AP-A; anthopleurin-A; APD; action potential duration; BrS; Brugada syndrom
Keywords: ژن وابسته به اتر-أ-go-go انسان است; AP; action potential; APD; AP duration; ATX-II; anemonia sulcata toxin 2; DMSO; dimethylsulfoxide; ECG; electrocardiogram; eSC; embryonic stem cell; FP; field potential; FPD; FP duration; HEK; human embryonic kidney; hERG; human ether-a-go-go-related gene
Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report
Keywords: ژن وابسته به اتر-أ-go-go انسان است; Safety pharmacology; Cardiotoxicity; Human-induced pluripotent stem cell-derived cardiomyocytes; Multi-electrode array technology; APD; action potential duration; APC; automated patch clamp; CiPA; Comprehensive in vitro Proarrhythmia Assay; CSRC; Cardiac
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4
Keywords: ژن وابسته به اتر-أ-go-go انسان است; ABC; Activated B Cell-like; BTK; Bruton's Tyrosine Kinase; CD79; Cluster of Differentiation 79; CDK; Cyclin Dependent Kinase; CLK; CDC-Like Kinase; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-DicyanobenzoQuinone; DIPEA; N,N-diisopropylethylamine; DLBCL;
In vitro secondary pharmacological profiling: An IQ-DruSafe industry survey on current practices
Keywords: ژن وابسته به اتر-أ-go-go انسان است; AUC; Area Under the Curve; CRO; Contract Research Organization; CTA; Clinical Trial Authorization; GLP; Good Laboratory Practice; hERG; human ether-a-go-go-related gene; ICH; International Conference on Harmonization; IND; Investigational New Drug; IQ; In
Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay
Keywords: ژن وابسته به اتر-أ-go-go انسان است; Human stem cell cardiomyocytes; Calcium fluorescent dye; Calcium transient; Preclinical cardiac safety; Amp; amplitude; bpm; beats per minute; BR; beat rate; CiPA; Comprehensive in Vitro Proarrhythmia Assay; CTD; calcium transient duration; DMSO; dimethyl
Characterization and structure-activity relationship of natural flavonoids as hERG K+ channel modulators
Keywords: ژن وابسته به اتر-أ-go-go انسان است; HEK293 cells; human embryonic kidney 293 cells; hERG; human ether-Ã -go-go-related gene; IC50; 50% inhibiting concentration; Emax; maximum efficacy; Flavonoids; Quercetin; Fisetin; hERG currents;
Attenuation of ischemia/reperfusion-induced inhibition of the rapid component of delayed rectifier potassium current by Isosteviol through scavenging reactive oxygen species
Keywords: ژن وابسته به اتر-أ-go-go انسان است; I/R; ischemia/reperfusion; ROS; reactive oxygen species; IKr; rapid component of delayed rectifier potassium; APD; action potential duration; ECG; electrocardiogram; STVNa; Isosteviol sodium; Ito; transient outward potassium channel current; ISS; steady-s
Thaliporphine, an alkaloid from Neolitsea konishii, exerts antioxidant, anti-inflammatory, and anti-apoptotic responses in guinea pig during cardiovascular collapse in inflammatory disease
Keywords: ژن وابسته به اتر-أ-go-go انسان است; Thaliporphine; Cardiovascular; Reactive oxygen species; QT interval; Apoptosis; Inflammatory; Lipopolysaccharide (PubChem CID: 11970143); Thaliporphine (PubChem CID: 100020); Triphenyltetrazolium chloride (PubChem CID: 9283); 1400W hydrochloride (PubChem
The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study
Keywords: ژن وابسته به اتر-أ-go-go انسان است; AP; cardiac action potential; CiPA; comprehensive in vitro proarrhythmia assay; CSRC; Cardiac Safety Research Consortium; Cmax; maximal plasma concentration; CTWG; clinical translational working group; DRest; rate-normalized Tpeak â Tend = Tpe inter
Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1
Keywords: ژن وابسته به اتر-أ-go-go انسان است; LQTS; long QT syndrome; HERG; human-ether-a-go-go-related gene; HS; heat shock; HSP; heat shock protein; HSF; heat shock factor; GGA; geranyl geranyl acetone; Long QT syndrome; Human ether-a-go-go-related gene; Heat shock factor;
Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation
Keywords: ژن وابسته به اتر-أ-go-go انسان است; data mining; data science; drug-drug interaction; long QT syndrome; APD70; action potential duration at 70% of repolarization; DDI; drug-drug interaction; ECG; electrocardiogram; EHR; electronic health records; FAERS; Food and Drug Administration adverse
hERG blocking potential of acids and zwitterions characterized by three thresholds for acidity, size and reactivity
Keywords: ژن وابسته به اتر-أ-go-go انسان است; AZA; acids and zwitterionic ampholytes; DE; donor (electrophilic) superdelocalizability (a.u./eV); DEMaxN; the maximum of DE for all nitrogen atoms in a conformer (a.u./eV); DiamEff; conformer effective cross-sectional diameter, (Ã
); hERG; human ether-a-
The role of ubiquitin ligases in cardiac disease
Keywords: ژن وابسته به اتر-أ-go-go انسان است; AChRs; acetylcholine receptors; AKAP121; A-kinase anchor protein 121; c-Cbl; Casitas b-lineage lymphoma; Cav3; cavelin 3; CHIP; c-terminus of Hsp70-interacting protein; cIAP; cellular inhibitor of apoptosis; cMyBP-C; cardiac myosin binding protein C; Drp1
Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement
Keywords: ژن وابسته به اتر-أ-go-go انسان است; ADME; absorption, distribution, metabolism, and excretion; AMLV; amphotropic murine leukemia virus; BBB; blood-brain barrier; BIF; bioisostere factor; CNS; central nervous system; DCM; dichloromethane; DiEA; diisopropylethylamine; DIPEA; N,N-diisopropyl
An NMR investigation of the structure, function and role of the hERG channel selectivity filter in the long QT syndrome
Keywords: ژن وابسته به اتر-أ-go-go انسان است; Human ether-a-go-go-related gene; Phosphatidylcholine model membrane; Lipid bicelle; Multilamellar vesicle; Nuclear magnetic resonance; Cardiotoxic drugs;
Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile
Keywords: ژن وابسته به اتر-أ-go-go انسان است; hERG; human Ether-Ã -go-go-Related Gene; 18-MC; 18-Methoxycoronaridine; AP; action potential; Anti-addiction drug; hERG potassium channels; Ibogaine; 18-Methoxycoronaridine; QT interval prolongation; Voltage-gated ion channels;
A history of the role of the hERG channel in cardiac risk assessment
Keywords: ژن وابسته به اتر-أ-go-go انسان است; hERG; human ether-a-go-go-related gene; TdP; torsades de pointes; TQT; thorough QT trial; Agonists; Blockers; hERG; Methods; Modeling; Patch clamp; Trafficking;
Pharmacophore modeling for hERG channel facilitation
Keywords: ژن وابسته به اتر-أ-go-go انسان است; hERG; human ether-a-go-go-related gene; 3D-QSAR; three-dimensional-quantitative structure activity relationships; V1/2; the half maximal of voltage dependence of activation; IC50; the half maximal concentration for inhibition; EC50; the half maximal conce
A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval
Keywords: ژن وابسته به اتر-أ-go-go انسان است; APD; action potential duration; APD90; action potential duration at 90% repolarization; (±)-Bay K8644; methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate; bpm; beats per minute; chro-manol 293B; N-[(3R,4S)-6-cyano
Metabolic stress, reactive oxygen species, and arrhythmia
Keywords: ژن وابسته به اتر-أ-go-go انسان است; âΨm; mitochondrial membrane potential; ACE; angiotensin converting enzyme; ADP; adenosine diphosphate; AF; atrial fibrillation; AngII; angiotensin II; AP; action potential; ATP; adenosine-5â²-triphosphate; [Ca2+]i; intracellular Ca2+ concentration; CI
SNARE protein regulation of cardiac potassium channels and atrial natriuretic factor secretion
Keywords: ژن وابسته به اتر-أ-go-go انسان است; ABC; ATP-binding cassette; AK; adenylate kinase; ANF; atrial natriuretic factor; BNP; brain natriuretic peptide; CFTR; cystic fibrosis transmembrane regulator; Cav; voltage-gated calcium; CK; creatine kinase; CNP; c-type natriuretic peptide; DPP; dipeptid
Characterization of recombinant hERG K+ channel inhibition by the active metabolite of amiodarone desethyl-amiodarone
Keywords: ژن وابسته به اتر-أ-go-go انسان است; Amiodarone; Antiarrhythmic; Class III; Desethyl-amiodarone; hERG; human ether-Ã -go-go-related gene; IKr; QT interval; Potassium channel;
Torsades de pointes liability inter-model comparisons: The experience of the QT PRODACT initiative
Keywords: ژن وابسته به اتر-أ-go-go انسان است; APD; action potential duration; APD90; APD at 90% repolarization; APD30-90; APD between 30% and 90% repolarization; APD30-60; APD between 30% and 60% repolarization; AV; atrioventricular; EC10; effective concentration producing 10% changes; IKr; rapid
Model systems for the discovery and development of antiarrhythmic drugs
Keywords: ژن وابسته به اتر-أ-go-go انسان است; Arrhythmias; Ion channel blockers; Ion currents; Reentry; AF; atrial fibrillation; APD; action potential duration; CAVB; chronic atrio-ventricular block; CHF; congestive heart failure; DAD; delayed afterdepolarization; EAD; early afterdepolarization; hERG
The Combined Use of Ibutilide as an Active Control With Intensive Electrocardiographic Sampling and Signal Averaging as a Sensitive Method to Assess the Effects of Tadalafil on the Human QT Interval
Keywords: ژن وابسته به اتر-أ-go-go انسان است; CI; confidence interval; ECG; electrocardiogram; ED; erectile dysfunction; HERG; human ether-a-go-go-related gene; HR; heart rate; MUSE; Marquette Universal System for Electrocardiography; PDE5; phosphodiesterase-5; QTc; corrected QT; QTcB; corrected QT (
Nonclinical proarrhythmia models: Predicting Torsades de Pointes
Keywords: ژن وابسته به اتر-أ-go-go انسان است; AP; Action potential; APD; Action potential duration; APD90; Action potential duration at 90% repolarization; A-V; Atrioventricular; CAVB; Chronically A-V block; CV; Conduction velocity; EADs; Early after-depolarizations; ECG; Electrocardiogram; hERG; Hum