Keywords: هوپرزین A; Aβ; amyloid-beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APCI; atmospheric pressure chemical ionization; APOE; apolipoprotein E; APP; amyloid precursor protein; APPI; atmospheric pressure photoionization; CE; capillary electrophor
مقالات ISI هوپرزین A (ترجمه نشده)
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Keywords: هوپرزین A; Organophosphate prophylaxis; Acetylcholinesterase inhibition; Neurobehavioral performance; Huperzine A; Galantamine; Donepezil
Keywords: هوپرزین A; Acetic acid; Cholinergic; Colitis; Huperzine A; Nicotine; Rat;
Comprehensive relative quantitative metabolomics analysis of lycopodium alkaloids in different tissues of Huperzia serrata
Keywords: هوپرزین A; Huperzia serrata; Different tissues; Metabolomics; Metabolite identification; In-silico fragmentations prediction; UPLC-MS; ultra-performance liquid chromatography-mass spectrometry; HPLC-MS; high-performance liquid chromatography-mass spectrometry; IS; i
Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease
Keywords: هوپرزین A; Huperzine A; Acetylcholinesterase; Nicotinic; Seizure; Alzheimer's disease; Antiepileptic; ppTMS;
Abcb1a but not Abcg2 played a predominant role in limiting the brain distribution of Huperzine A in mice
Keywords: هوپرزین A; Huperzine A; Alzheimer's disease; Brain distribution; ABCB1; Brain to plasma concentration ratio; ABCB1; ATP Binding Cassette Subfamily B Member 1; ABCG2; ATP Binding Cassette Subfamily G Member 2; BBB; Blood-Brain Barrier; BCRP; Breast Cancer Resistant P
Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression
Keywords: هوپرزین A; Post-stroke depression; Huperzine A; Neurological function; Cognitive function; Neurotransmitter;
Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid
Keywords: هوپرزین A; Huperzia serrata; Lycopodiaceae; Huperzine A; L-lysine decarboxylase; Copper amine oxidase; 5-Aminopentanal;
Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake
Keywords: هوپرزین A; Huperzine A; Self-microemulsion; Drug delivery systems; SMEDDS; Bioavailability; Single-pass intestinal perfusion; Lymphatic transport;
Molecular cloning, expression, and functional analysis of the copper amine oxidase gene in the endophytic fungus Shiraia sp. Slf14 from Huperzia serrata
Keywords: هوپرزین A; Copper amine oxidase; Endophytic fungus; Huperzine A; Cloning and expression; Enzyme activity
Evaluation of the in vitro and in vivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A
Keywords: هوپرزین A; Huperzine A; Metabolic pathway; CYP inhibition; CYP induction; Drug interaction;
Huperzine A protects sepsis associated encephalopathy by promoting the deficient cholinergic nervous function
Keywords: هوپرزین A; Sepsis associated encephalopathy; Huperzine A; Choline acetyltransferase; Muscarinic acetylcholine receptor 1; Acetylcholinesterase; Acetylcholine;
Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity
Keywords: هوپرزین A; Hydroxybenzoyl-pyridones; Tacrine; Anti-neurodegeneratives; Anti-AChE activity; Anti-oxidant activity; Metal chelation; Aβ; amyloid-β; ACh; acetylcholine; AChE; acetylcholinesterase; AChI; acetylthiocholine iodide; AD; Alzheimer's disease; BuChE; butyry
Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition
Keywords: هوپرزین A; Huperzine A; PTZ; Rat; Cortical inhibition; Paired-pulse TMS;
Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease
Keywords: هوپرزین A; Huperzine A; Alzheimer's disease; Brain iron; Transferrin receptor 1; Double transgenic APPswe/PS1dE9 mice (APP/PS mice); The neuronal amyloid precursor protein (APP);
Bis(9)-(â)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice
Keywords: هوپرزین A; AChE; acetylcholinesterase; AChEIs; acetylcholinesterase inhibitors; AD; Alzheimer's disease; BBB; the blood brain barrier; Bis-Mep; Bis(9)-(â)-nor-meptazinol; CAS; catalytic anionic site of AChE; PAS; peripheral anionic site of AChE; Scop; scopolamine;
Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures
Keywords: هوپرزین A; Acetylcholinesterase inhibitor; Astrocyte; Dementia; Huperzine A; Nicotine; S100B;
Research ReportHuperzine A promotes hippocampal neurogenesis in vitro and in vivo
Keywords: هوپرزین A; Huperzine A; Neurogenesis; Neural stem cells; MAPK/ERK;
Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro
Keywords: هوپرزین A; Huperzia serrata; Huperziaceae; Huperzine A; UPLC-MS; Q-IMS-TOFMS; Lycopodium alkaloids;
Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A
Keywords: هوپرزین A; Huperzine A; Solid lipid nanoparticles; Nanostructured lipid carriers; Transdermal delivery system; Alzheimer's disease; Elevated plus maze
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors
Keywords: هوپرزین A; Alzheimer’s disease; Acetylcholinesterase; Heterodimer; Huperzine A
The anti-inflamm-aging and hepatoprotective effects of huperzine A in d-galactose-treated rats
Keywords: هوپرزین A; d-Galactose; Huperzine A; Inflamm-aging; Inflammation and anti-inflammation; Cholinergic anti-inflammatory pathway; Nuclear factor-kappa B
Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain
Keywords: هوپرزین A; Huperzia quadrifariata; Huperzia reflexa; Lycopodiaceae; Acetylcholinesterase activity; Lycopodium alkaloids; Huperzine A;
Pharmacological prevention and treatment of vascular dementia: Approaches and perspectives
Keywords: هوپرزین A; Antihypertensives; Statins; Acetylsalicylic acid; Memantine; Donepezil; Galantamine; Rivastigmine; Ginkgo biloba; Huperzine A; Folic acid;
Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography
Keywords: هوپرزین A; Huperzine A; Huperzine B; Huperzia serrata; Macroporous resin; Preparative HPLC; Trifluoroacetic acid
Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression of T cell-mediated neuronal inflammation in mice
Keywords: هوپرزین A; Huperzine A; Spinal cord; Multiple sclerosis; Experimental autoimmune encephalomyelitis; Inflammation; Demyelination
Improving general intelligence with a nutrient-based pharmacological intervention
Keywords: هوپرزین A; Intelligence; Huperzine A; Vinpocetine; Acetyl-l-carnitine; Alpha-lipoic acid; Rhodiola Rosea, raven progressive matrices
Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method
Keywords: هوپرزین A; Galanthamine; Huperzine A; Binding energy; ONIOM
Photohuperzine A—A new photoisomer of huperzine A: Structure elucidation, formation kinetics and activity assessment
Keywords: هوپرزین A; Huperzine A; Photoisomerization; Kinetics; Stability; NMR
Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats
Keywords: هوپرزین A; Alzheimer's disease; Huperzine A; Ligustrazine phosphate; Coadministration; Scopolamine
Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway
Keywords: هوپرزین A; Acetylcholinesterase; Endotoxemia; Galantamine; Huperzine A; Cytokines; Brain muscarinic receptors; Vagus nerve; α7-Subunit-containing nicotinic acetylcholine receptor; The cholinergic anti-inflammatory pathway; Inflammation
Botanicals and Herbs: A Traditional Approach to Treating Epilepsy
Keywords: هوپرزین A; Epilepsy; herbal medicine; botanical; dietary supplement; complementary and alternative therapies; huperzine A;
Clinical use of an herbal-derived compound (Huperzine A) to treat putative complex partial seizures in a dog
Keywords: هوپرزین A; Complex partial seizures; Dog; Huperzine A; Electroencephalography; Phenobarbital
Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of senescence accelerated mouse prone/8 mice is modulated by anti-Alzheimer's disease drugs
Keywords: هوپرزین A; Alzheimer's disease; calcium/calmodulin-dependent protein kinase II-α; senescence accelerated mouse; anti-AD drugs; AD; Alzheimer's disease; ANOVA; analysis of variance; BW; Ba-Wei-Di-Huang decoction; CaMKII; calcium/calmodulin-dependent protein kinase I
Pharmacokinetics of Huperzine A after transdermal and oral administration in beagle dogs
Keywords: هوپرزین A; Huperzine A; Dogs; Pharmacokinetics; Transdermal administration
In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease
Keywords: هوپرزین A; Huperzine A; Phlegmariurus squarrosus; Huperzia serrata; In vitro propagation; Alzheimer's disease; Lycopodium alkaloid; LC-MS;
Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: Next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase
Keywords: هوپرزین A; Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Huperzine A; Pyridostigmine bromide; Soman; WRAIR whole blood cholinesterase assay;
Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia
Keywords: هوپرزین A; Alzheimer's disease; Huperzine A; Acetylcholinesterase inhibitor; β-Amyloid; Mitochondrial dysfunction; Inflammation
Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector
Keywords: هوپرزین A; Huperzine A; HPLC fluorescence; Rat plasma; Determination
Controlled release of huperzine A from biodegradable microspheres: In vitro and in vivo studies
Keywords: هوپرزین A; Biodegradable microspheres; Huperzine A; Poly(d,l-lactide-co-glycolide); Controlled release
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI TOF MS) study of Huperzine A, a natural anti-Alzheimer's disease product, its derivatization and its detection by highly sensitive laser induced fluorescence (LIF)
Keywords: هوپرزین A; Huperzine A; Derivatization; MALDI TOF MS; CE-LIF
Huperzine A in rat plasma and CSF following intranasal administration
Keywords: هوپرزین A; Huperzine A; Plasma; CSF; Intranasal administration
Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography
Keywords: هوپرزین A; Huperzia serrata; Huperzine A; Huperzine B; Acetylcholinesterase inhibitors; pH-zone refining; Centrifugal partition chromatography
Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge
Keywords: هوپرزین A; AChE, acetylcholinesterase (EC 3.1.1.7); AU, absorbance units; DTNB, 5,5′-dithiobis(2-nitrobenzoic acid); RBC, red blood cellCarbamate prophylaxis; Nerve agents; Soman; Acetylcholinesterase; Pyridostigmine; Physostigmine; Huperzine A; Kinetic analysis; Co
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695
Keywords: هوپرزین A; huperzine A; amyloid precursor protein; Aβ; protein kinase C; mitogen-activated protein kinase; muscarinic acetylcholine receptorAβ, amyloid-β peptide; AChE, acetylcholinesterase; AD, Alzheimer’s disease; ADAM, a disintegrin and metalloprotease; APP, amyl
A radical mediated approach to the core structure of huperzine A
Keywords: هوپرزین A; Huperzine A; Pyridylmethyl radicals; Selenation; Radical cyclisation;
Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS
Keywords: هوپرزین A; Huperzine A; Huperzia serrata; HPLC/DAD/MS
Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection
Keywords: هوپرزین A; ZT-1; Huperzine A
Pharmacokinetics and in vitro and in vivo correlation of huperzine A loaded poly(lactic-co-glycolic acid) microspheres in dogs
Keywords: هوپرزین A; Poly(lactic-co-glycolic acid); Microspheres; Huperzine A; Pharmacokinetics; In vitro/in vivo correlation
Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice
Keywords: هوپرزین A; Huperzine A; Acetylcholinesterase inhibitor; Transient cerebral ischemia and reperfusion; Learning and memory; Nerve growth factor; Brain-derived neurotrophic factor; Transforming growth factor-β1; Mitogen-activated protein kinase/extracellular signal-reg