کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7754569 1499424 2016 44 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity
چکیده انگلیسی
Tacrine-(hydroxybenzoyl-pyridone) hybrids were designed, synthesized and evaluated as potential multitarget anti-Alzheimer's disease drugs. They are dual-binding site acetylcholinesterase inhibitors, with sub-micromolar activity as the parent tacrine, while the hydroxybenzoyl-pyridone moiety assures good radical scavenging capacity and moderate/good chelating power towards redox-active and/or amyloid-β-binding metal ions (Fe, Cu, Zn).299
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 163, October 2016, Pages 266-277
نویسندگان
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