دانلود مقالات ISI درباره سایت آنیونی محیطی + ترجمه فارسی

اسید الاجیک: درک اثرات تقویت عصب شناختی و عصبی آن در بیماری آلزایمر اسپاستاک

Ellagic acid: Insights into its neuroprotective and cognitive enhancement effects in sporadic Alzheimer's disease

Keywords: سایت آنیونی محیطی; AchE; acetylcholinesterase; AD; Alzheimer's disease; ATCI; acetylthiocholine iodide; AS; anionic site; BMA; brain mitochondrial ATPase; BSA; bovine serum albumin; CA; cornus ammonis; CAE; correct arm entry; CAT; catalase; CRP; C-reactive protein; DAB; dia

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

ترکیبات چندتایی که مویرهای ساختاری و عملکردی تاکرین و دونپزیل را دارند، برای درمان بالقوه بیماری آلزایمر

Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

Keywords: سایت آنیونی محیطی; ACh; acetylcholine; ChEs; cholinesterases; AChE; acetylcholinesterase; EeAChE; AChE from Electrophorus electricus; hAChE; human acetylcholinesterase; BuChE; butyrylcholinesterase; eqBuChE; BChE from equine serum; ChEI; ChE inhibitor; AChEI; AChE inhibitor

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

توسعه هیبرید های سایانوپیریدین-تریازین به عنوان عوامل ضد آلزایمر چندگانه سرب

Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents

Keywords: سایت آنیونی محیطی; DOHQPHWDPCNACE-UHFFFAOYSA-N; ACh; acetylcholine; AChE; acetylcholinesterase; eelAChE; electric eel acetylcholinesterase; BuCh; butyrylcholine; BuChE; butyrylcholinesterase; eqBuChE; equine serum butyrylcholinesterase; ChE; cholinesterase; AD; Alzheimer'

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

طراحی، سنتز و ارزیابی مشتقات فلاونوئید به عنوان مهار کننده های استیلکولین استراز چند منظوره بالقوه علیه بیماری آلزایمر

Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease

Keywords: سایت آنیونی محیطی; JTLGJFBDQUBICH-UHFFFAOYSA-N; FEBATDALCUAQCM-UHFFFAOYSA-N; KZASLSLPFQAZRC-UHFFFAOYSA-N; APTXIDCPFDQWLD-UHFFFAOYSA-N; ZPMMPPBRCTWMHF-UHFFFAOYSA-N; LYXYENKXUDZGBB-UHFFFAOYSA-N; JKJRTNOOSNWMJV-UHFFFAOYSA-N; REFAZYLZAXUBGI-UHFFFAOYSA-N; RONHWZKWQSMGNP-UHFFFAOY

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease

Keywords: سایت آنیونی محیطی; AD; Alzheimer's disease; AChEIs; acetylcholinesterase inhibitors; NMDA; N-methyl-d-aspartate; Aβ; β-amyloid; τ; tau protein; ACh; acetylcholine; MTDLs; multi-target-directed ligands; MAO-B; monoamine oxidase B; MAO-A; monoamine oxidase A; BuChE; buty

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase

Keywords: سایت آنیونی محیطی; OP; organophosphate; hAChE; human acetylcholinesterase; ACh; acetylcholine; 2-PAM; pralidoxime; MINA; monoisonitrosoacetone; BBB; bloodbrain barrier; CNS; central nervous system; P-site; peripheral anionic site; PSL; peripheral site ligand; TIQ; tetrahydr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Neuroprotection and cognitive enhancement by treatment with γ-oryzanol in sporadic Alzheimer's disease

Keywords: سایت آنیونی محیطی; AchE; acetylcholinesterase; AD; Alzheimer's disease; ATCI; acetylthiocholine iodide; AS; anionic site; BMA; brain mitochondrial ATPase; CA; cornus ammonis; CAE; correct arm entry; CAT; catalase; CRP; C- reactive protein; DAB; diaminobenzidine; DG; denta

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease

Keywords: سایت آنیونی محیطی; Alzheimer's disease; Aurone Mannich base derivatives; Acetylcholinesterase inhibitors; Aβ aggregation inhibitors; Multifunctional agents; AD; Alzheimer's disease; AChE; acetylcholinesterase; BuChE; butyrylcholinesterase; EeAChE; Electrophorus electricus

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors

Keywords: سایت آنیونی محیطی; Alzheimer's disease; Donepezil; Benzylpyridinium; Acetylcholinesterase inhibitors antioxidant; β-Amyloid aggregation; Neuroprotection; AD; Alzheimer's disease; ChEs; Cholinesterases; ACh; acetylcholine; AChE; acetylcholinesterase; BuChE; butyrylcholinest

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease

Keywords: سایت آنیونی محیطی; Alzheimer's disease; Scutellarein-O-acetamidoalkylbenzylamines; Multifunctional agents; Acetylcholinesterase inhibitors; Aβ aggregation inhibitors; Antioxidant agents; AD; Alzheimer's disease; AChE; acetylcholinesterase; ACh; acetylcholine; Aβ; β-amylo

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment

Keywords: سایت آنیونی محیطی; Alzheimer's disease; 2-arylethenyl-N-methylquinolinium derivatives; Aβ aggregation; Cholinesterase inhibition; Neuroprotection; AAPH; 2, 2'-azobis (2-methylpropionamidine) dihydrochloride; Aβ; amyloid-β; AChE; acetylcholinesterase; AD; Alzheimer's di

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease

Keywords: سایت آنیونی محیطی; AD; Alzheimer's disease; AChE; acetylcholinesterase; BuChE; butyrylcholinesterase; Aβ; β-amyloid peptide; BBB; blood-brain barrier; ACh; acetylcholine; MTDL; multitarget-directed ligand; EeAChE; electric eel AChE; CAS; catalytic anionic site; PAS; p

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study

Keywords: سایت آنیونی محیطی; ACN; acetonitrile; AD; Alzheimer disease; AUCtotal; area under curve/bioavailability; CAS; catalytic anionic site; Cmax; maximal plasma concentration; CL; clearance; FDA; US Food and drug administration; hAChE/AChE; human acetylcholinesterase/acetylcholin

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2016 سفارش ترجمه

Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity

Keywords: سایت آنیونی محیطی; Hydroxybenzoyl-pyridones; Tacrine; Anti-neurodegeneratives; Anti-AChE activity; Anti-oxidant activity; Metal chelation; Aβ; amyloid-β; ACh; acetylcholine; AChE; acetylcholinesterase; AChI; acetylthiocholine iodide; AD; Alzheimer's disease; BuChE; butyry

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2016 سفارش ترجمه

Active and peripheral anionic sites of acetylcholinesterase have differential modulation effects on cell proliferation, adhesion and neuritogenesis in the NG108-15 cell line

Keywords: سایت آنیونی محیطی; Acetylcholinesterase; Peripheral anionic site; Acylation site; Cell adhesion; Proliferation; Neuritogenesis; ACh; acetylcholine; AChE; acetylcholinesterase; BSA; bovine serum albumin; ChE; cholinesterase; CV; crystal violet; dbcAMP; (dybutyryl cyclic-AMP)

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease

Keywords: سایت آنیونی محیطی; OLKLOVAJULLISR-UHFFFAOYSA-N; WUZJRHKAIFSDMM-UHFFFAOYSA-N; XKKFXCKMPXLPKK-UHFFFAOYSA-N; WKAJCZZPMZGMDI-UHFFFAOYSA-N; ZXEXKQSBZMYPAQ-UHFFFAOYSA-N; UTSQNVLOMVPCIW-YTTGMZPUSA-N; LBOYVYBBAFDIGX-NDEPHWFRSA-N; HLSFNIKGKKTOIA-TWAVRPEISA-N; HSQBZWURRKNSMR-TXMUIZFD

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors

Keywords: سایت آنیونی محیطی; AChE; acetylcholinesterase; BuChE; butyrylcholinesterase; AD; Alzheimer's disease; AChEI; acetylcholinesterase inhibitors; Aβ; β-amyloid; PAS; peripheral anionic site; eeAChE; Electrophorus electricus AChE; TcAChE; Torpedo californica AChE; hAChE; hum

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Identification of potential bivalent inhibitors from natural compounds for acetylcholinesterase through in silico screening using multiple pharmacophores

Keywords: سایت آنیونی محیطی; Acetylcholinesterase; Catalytic site; Peripheral anionic site; Bivalent inhibitors; Virtual screening; Pharmacophore based screening

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase

Keywords: سایت آنیونی محیطی; AChE; acetylcholinesterase; ACh; acetylcholine; ACN; acetonitrile; AmONO; isomamylnitrite; A-Site; active site; BBB; blood brain barrier; CNS; central nervous system; DCE; dichloroethane; DCM; dichloromethane; DMF; dimethylformamide; EtOAc; ethylacetate;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The emergence of designed multiple ligands for neurodegenerative disorders

Keywords: سایت آنیونی محیطی; ACh; acetylcholine; A2A; adenosine receptor subtype two-A; Aβ; amyloid-beta; ACE; angiotensin converting enzyme; BDNF; brain derived neurotrophic factor; GDNF; glial derived neurotrophic factors; MAO-B; monoamine oxidase B; AChE; acetylcholinesterase; AP

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease

Keywords: سایت آنیونی محیطی; Acetylcholinesterase inhibitors; Butyrylcholinesterase inhibitors; Quinolizidine derivatives; Bi- and tricyclic systems derivatives; Single-entity multi-target agents; Aβ; β-amyloid; ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's dise

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes

Keywords: سایت آنیونی محیطی; Bovine acetylcholinesterase; Cyclosarin; VR; Oxime reactivation; Peripheral anionic site; Molecular modeling

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Altered binding of thioflavin t to the peripheral anionic site of acetylcholinesterase after phosphorylation of the active site by chlorpyrifos oxon or dichlorvos

Keywords: سایت آنیونی محیطی; Organophosphorus insecticides; Organophosphates; Acetylcholinesterase; Peripheral anionic site

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

A piezoelectric sensor with propidium as a recognition element for cholinesterases

Keywords: سایت آنیونی محیطی; Propidium; Acetylcholinesterase; Detection; Affinity interaction; Peripheral anionic site; Rebinding kinetics;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE

Keywords: سایت آنیونی محیطی; AChE; acetylcholinesterase (mAChE, from mouse; TcAChE, from Torpedo californica); PAS; peripheral anionic site; Acetylcholinesterase; Active center gorge; Click-chemistry; Crystal structure; Dipolar cycloaddition; Femtomolar inhibitor; Freeze-frame triazo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه