کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2502575 1557388 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A
چکیده انگلیسی

The purpose of the present investigation was to explore feasibility of nanocarrier based transdermal delivery of Huperzine A (HupA) for the treatment of Alzheimer's disease. For this investigation, microemulsion (ME), solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs) were formulated and characterized for physicochemical parameters. The pseudo-ternary phase diagrams for microemulsion region were developed using generally recognized as safe (GRAS) excipients. The SLNs and NLCs were prepared by microemulsion template technique. These nanodispersions were formulated into gels for transdermal application and evaluated for various physicochemical parameters. In vitro permeation profiles in rat skin exhibited zero-order kinetics. HupA loaded ME exhibited superior permeation than NLCs followed by SLNs and cumulative amount permeated after 24 h was found to be 147.68 ± 9.42 μg/cm2, 129.11 ± 32.76 μg/cm2 and 10.74 ± 0.68 μg/cm2, respectively. Furthermore, optimized gels were subjected to primary skin irritation testing over a period of 48 h and were found to be safe for skin application. In vivo efficacy tested in scopolamine induced amnesia model indicated significant improvement in cognitive function in mice group treated with developed nanocarrier based formulations as compared to the control group.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 446, Issues 1–2, 25 March 2013, Pages 16–23
نویسندگان
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