Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake

Compared with the Hup-A suspension, SMEDDS formulation can enhance the oral bioavailability and intestinal absorption of Hup-A. According to the detection of Hup-A concentration in mesenteric lymph nodes and the results of the chylomicron flow blocking experiments, Hup-A SMEDDS was confirmed to be absorbed through the lymphatic route.82