دانلود مقالات ISI درباره Ic50 + ترجمه فارسی

Curcumin suppresses proliferation and in vitro invasion of human prostate cancer stem cells by ceRNA effect of miR-145 and lncRNA-ROR

Keywords: HuPCaSCs; human prostate cancer stem cells; lncRNA-ROR; long non-coding RNA-ROR; miR-145; microRNA-145; ceRNAs; competitive endogenous RNAs; iPS; induced pluripotent stem cells; BSA; bovine serum albumin; bFGF; basic fibroblast growth factor; EGF; epiderm

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry

Keywords: Hepatitis C virus; Natural compounds; Antivirals; Cortex moutan; Penta-O-Galloyl-Glucose; Entry inhibitor; Bioavailability; TCM; Traditional Chinese Medicine; CM; Cortex Moutan; PGG; Penta-O-Galloyl-Glucose; HCV; hepatitis C virus; IC50; half maximal effe

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Interaction of nonionic detergents with the specific sites of lysozyme amyloidogenic region − inhibition of amyloid fibrillization

Keywords: CMC; critical micelle concentration; DDM; n-dodecyl-β-d-maltoside; DH; hydrodynamic diameter of micelles; HEWL; hen egg white lysozyme; IC50; half-maximal inhibitory concentration; ThT; thioflavin T; TX-100; Triton X-100; Nonionic detergent; Amyloid aggr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Antileishmanial and immunomodulatory activities of lupeol, a triterpene compound isolated from Sterculia villosa

Keywords: Leishmania donovani; IC50; Membrane potential; Nitric oxide; Cytokines; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Research ArticlePharmacophore based 3D-QSAR modeling, virtual screening and docking for identification of potential inhibitors of β-secretase

Keywords: BACE1; β-secretase; AD; Alzheimer's disease; Aβ; amyloid-β; BBB; blood brain barrier; PDB; protein data bank; rmsd; root mean square deviation; IC50; inhibitory concentration; β-secretase; Alzheimer's disease; Pharmacophore; Virtual screening; Doc

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Antiproliferative activity and apoptosis induction by 3′,4′-dibenzyloxyflavonol on human leukemia cells

Keywords: Apoptosis; Caspases; Cell cycle; Cytotoxicity; Flavonoids; ERK; extracellular signal-regulated kinase; FL; 3′,4′-dibenzyloxyflavonol; H2-DCF-DA; 2′,7′-dichlorodihydrofluorescein diacetate; IC50; 50% inhibition of cell growth; JNK/SAPK; c-jun N-ter

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Enhancement of apoptotic activities on brain cancer cells via the combination of γ-tocotrienol and jerantinine A

Keywords: Jerantinine A; γ-Tocotrienol; Tabernaemontana corymbosa; Growth inhibition; Apoptosis; Brain cancer; γ-T3; γ-tocotrienol; JA; jerantinine A; U87MG; human brain glioblastoma; MRC5; normal human lung fibroblast; IC50; half maximal inhibitory concentratio

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

Keywords: AUC; area under the curve; DDI; drug-drug interaction; fu; fraction unbound; IC50; inhibition constant; IV; intravenous; IVIVE; in vitro/in vivo extrapolation; Ki; inhibition constant; OAT; organic anion transporter; PBPK; physiologically based pharmacoki

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Research ArticleAnti-Parkinsonian L-Dopa can also act as anti-systemic amyloidosis-A mechanistic exploration

Keywords: Human lysozyme; Amyloids; IC50; Disaggregation; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids

Keywords: AUDA; 212-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid; 4-HBP; 4-hydroxybenzophenone; ACN; acetonitrile; CLother(AA); aggregate clearance of other pathways of AA; CLother(EET); aggregate clearance of other pathways of EET; AA; arac

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity#

Keywords: Peptides; Helix stabilization; Protein-protein interactions; Trypanothione reductase; Leishmania infantum; Cell-penetrating peptides; CPP; cell-penetrating peptide; DSSP; define secondary structure of proteins algorithm; ELISA; Enzyme-Linked ImmunoSorbent

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

P2Y12 Receptor Function and Response to Cangrelor in Neonates With Cyanotic Congenital Heart Disease

Keywords: antithrombotic; avatar mice; microfluidics; neonates; shunt thrombosis; ADP; adenosine diphosphate; ATE; acute thromboembolic events; CHD; congenital heart disease; EC50; the concentration of a drug that gives half-maximal response; IC50; the concentratio

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Synthetic polyphenol compounds inhibit β-catenin/Tcf signaling: Structure-activity relationship

Keywords: APC; Axin-adenomatous polyposis coli; BCA; bicinchoninic acid; CBP; CREB binding protein; CRC; colorectal cancer; DMSO; dimethyl sulfoxide; Dsh; disheveled; EMSA; electrophoretic mobility shift assay; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSK;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells

Keywords: Flavonoids; Apigenin; Luteolin; Kaempferol; Quercetin; Cytochrome P450 CYP1 enzymes; Antiproliferation; Breast cancer; CYP1; cytochrome P450 CYP1B1, CYP1A1 and CYP1A2; HPLC; high pressure liquid chromatography; IC50; 50% inhibitory concentration; MTT; 3-(

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

5-Bromoindirubin 3′-(O-oxiran-2-ylmethyl)oxime: A long-acting anticancer agent and a suicide inhibitor for epoxide hydrolase

Keywords: ATP; adenosine 5′-triphosphate; C1; methylene; C2; ethylene; C3; propylene; CDK; cyclin-dependent kinase; Cys; cysteine residue; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; EI; electron impact; Epox/5-Br-Ind; 5-bromoindirubin 3′-(O-oxiran-2-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, characterization, in vitro SAR and in vivo evaluation of N,N′bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC

Keywords: NCI; National Cancer Institute; IC50; inhibitory concentration 50%; NSCLC; non-small cell lung cancer; IC23; 4,5-dichloro-1,3-bis(naphthalen-2-ylmethyl)imidazolium bromide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; CD; cyclodextri

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

OP16, a novel ent-kaurene diterpenoid, potentiates the antitumor effect of rapamycin by inhibiting rapamycin-induced feedback activation of Akt signaling in esophageal squamous cell carcinoma

Keywords: Akt; protein kinase B; DMSO; dimethyl sulfoxide; ESCC; esophageal squamous cell carcinoma; FBS; fetal bovine serum; IC50; half maximal inhibitory concentration; mTOR; mammalian target of rapamycin; PI3K; phosphatidylinositol 3 kinase; Rapa; rapamycin; Rap

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells

Keywords: SIRT1; Sirtunin; AURKB; Aurora B kinase; CRC; Colorectal cancer; BMFC; Butea monosperma flower compounds; mRNA; Messenger ribonucleic acid GSK Glycogen synthase kinase; WHO; World health organization; HDAC; Histone deacetylase; CSCs; Cancer stem cells; Bm

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Dual 7-ethyl-10-hydroxycamptothecin conjugated phospholipid prodrug assembled liposomes with in vitro anticancer effects

Keywords: SN38; 7-ethyl-10-hydroxycamptothecin; CPT-11; irinotecan; TEM; transmission electron microscopy; cyro-TEM; cryogenic transmission electron microscopy; FDA; Food and Drug Administration; DDS; drug delivery system; EPR; enhanced permeability and retention;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewDesign strategies of oxidosqualene cyclase inhibitors: Targeting the sterol biosynthetic pathway

Keywords: CC50; concentration of the compound that cause a 50% reduction in cell viability; EC50; half maximal effective concentration; GI; growth inhibition; IC50; concentration of the compound that decrease the enzymatic conversion by 50%; LDL; low density lipopr

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation

Keywords: STAT1 gain of function; IFN-γ; ruxolitinib; autoimmunity; TH1 cell; TH17 cell; follicular T helper cell; T helper cell polarization; ATG; Anti-thymocyte globulin; BSA; Body surface area; GOF; Gain of function; IC50; Half-maximal inhibitory concentration

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Triphenyltin(IV) benzoates with diazenyl/imino scaffold exhibiting remarkable apoptosis mediated by reactive oxygen species

Keywords: ROS; reactive oxygen species; IC50; compound concentrations that produce 50% of cell growth inhibition; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; DCFH-DA; dichlorodihydrofluorescein diacetate; PI; propidium iodide; CDDP; cisplatin

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Efficacy and safety of “Yahom” as a traditional Thai herbal therapy: A systematic review

Keywords: 2-AA; 2-aminoanthracene; Ach; Acetylcholine; AF2; 2-aminofluorene; Aq; Aqueous; BMI; Body mass index; BP; Blood pressure; BUN; Blood urea nitrogen; CYPs; Cytochromes P450; DBP; Diastolic blood pressure; DPPH; 2,2-diphenyl-1-picrylhydrazyl; ECG; Electrocar

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Pittosporum viridiflorum Sims (Pittosporaceae): A review on a useful medicinal plant native to South Africa and tropical Africa

Keywords: ATCC; American Type Culture Collection; ATM; African traditional medicine; COX; cyclooxygenase; DCM; dichloromethane; EtOH; ethanol; GC; gas chromatography; GC/MS; gas chromatography-mass spectrometry; IC50; 50% inhibitory concentration; LC50; 50% lethal

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases

Keywords: NOX; NADPH oxidase; DUOX; dual oxidase; ROS; reactive oxygen species; DPI; diphenylene iodonium; DTI; di-2-thienyliodonium chloride; DMSO; dimethyl sulfoxide; FMOC; fluorenylmethyloxycarbonyl; IC50; inhibitory concentration 50%; RLU; relative light units;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Mycobacterium tuberculosis chorismate mutase: A potential target for TB

Keywords: Tuberculosis; Mycobacterium tuberculosis; Chorismate mutase; Inhibitors; BsCM; Bacillus subtilis chorismate mutase; CM; chorismate mutase; DAHP; 3-deoxy-d-arabinoheptulosonate 7-phosphate; EcCM; Escherichia coli chorismate mutase; HIV/AIDS; human Immunode

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Pyrrolizines: Design, synthesis, anticancer evaluation and investigation of the potential mechanism of action

Keywords: ALK1; activin receptor-like kinase; CDCl3; deuterated chloroform; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; DSV; discovery studio visualizer; DYRK3; dual specificity tyrosine phosphorylation-regulated kinase; CDK2; cyclin-depende

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

(−)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects

Keywords: FAS fatty acid synthase; C75 derivatives; CPT1 carnitine palmitoyltransferase 1; Ovarian cell cancer; 18S; 18S ribosomal RNA; BIP; binding immunoglobulin protein; BSA; bovine serum albumin; CASP3; caspase-3; CPT1; carnitine palmitoyltransferase 1; DDIT4/R

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Prediction of Hepatic Efflux Transporter-Mediated Drug Interactions: When Is it Optimal to Measure Intracellular Unbound Fraction of Inhibitors?

Keywords: transporters; drug interaction; hepatocytes; pharmacokinetics/pharmacodynamics; protein binding; AFE; average fold error; AUC; area under the curve; BSA; bovine serum albumin; CLBile; biliary clearance; CLBL; basolateral efflux clearance; CLUptake; uptake

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity

Keywords: AITC; allyl isothiocyanate; ALT; alanine transaminase; An V; annexin V; ANOVA; analysis of variances; APC; allophycocyanin; AST; aspartate transaminase; b.w.; body weight; BITC; benzyl isothiocyanate; BTMS; bromotrimethylsilane; BuITC; butyl isothiocyanat

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Bivalent SIRT1 inhibitors

Keywords: β-NAD+; β-nicotinamide adenine dinucleotide; NAM; nicotinamide; 2′-O-AADPR; 2′-O-acyl-ADP-ribose; RP-HPLC; reversed-phase high performance liquid chromatography; HRMS; high-resolution mass spectrometry; EDC-MeI; 1-(3-dimethylaminopropyl)-3-ethylcarb

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Characterization of estrogenic and androgenic activity of phthalates by the XenoScreen YES/YAS in vitro assay

Keywords: BBP; butyl benzyl phthalate; DEP; diethyl phthalate; DBP; dibutyl phthalate; DEHP; di(2-ethylhexyl) phthalate; DINP; di-izo-nonyl phthalate; EC50; effective concentration; EDC; endocrine disrupting chemical; IC50; inhibitory concentration; NOEC; no-observ

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, crystal structure, characterization and antifungal activity of 3,4-diaryl-1H-Pyrazoles derivatives

Keywords: 3,4-Diaryl-1H-pyrazoles; The single crystal X-ray diffraction; Phytopathogens fungi; Antifungal activity; HRMS; High resolution mass spectrometry; TLC; Thin-layer chromatography; Mp.; Melting point; IC50; Half-maximal inhibitory concentration;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of invitro α-amylase and α-glucosidase inhibitory potential of N2O2 schiff base Zn complex

Keywords: ABTS; 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid; DNS; dinitro salicylic acid; DPPH; 1-1-diphenyl 2-picryl hydrazyl; IC50; half maximal inhibitory concentration; LB; Lineweaver-Burk; MIC; minimum inhibitory concentration; S. aureus; Staphylo

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Cloning, characterization and subcellular localization of Nuclear LIM interactor interacting factor gene from Leishmania donovani

Keywords: VL; Visceral Leishmaniasis; NLI; Nuclear LIM interacting-interactor like protein; Ldb; LIM domain binding protein; LdNLI; Leishmania donovani Nuclear LIM interacting-interactor like protein; CDRI; Central Drug Research Institute; ORF; Open reading frame;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Na+/K+-ATPase interaction with methylglyoxal as reactive metabolic side product

Keywords: aa residue; amino acid residue; AMG; aminoguanidine, also pimagedine; Arg (R); arginine; ATP; adenosine triphosphate; BSA; bovine serum albumin; CHER; catalytic hydrogen evolution reaction; CML; Nε-(carboxymethyl)lysine; CPS; constant-current chronopoten

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism

Keywords: PTP1B; protein tyrosine phosphatase 1B; IC50; the inhibitor concentration leading 50% activity loss; Ki; inhibition constant; Kiapp; apparent Ki; Vmax; maximum velocity; Km; Michaelis-Menten constant; Kobs; apparent first-order rate constant for the trans

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV

Keywords: DPP-IV; dipeptidyl peptidase IV; mg V·kg− 1; mg Vanadium injected/weight of mice in kg; GLP-1; glucagon-like peptide-1; GIP; glucose-dependent insulinotropic peptide; BEOV; bis(ethylmaltolato)oxovanadium(IV); PTP1B; protein tyrosine phosphatase 1B; P

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of BPA on global DNA methylation and global histone 3 lysine modifications in SH-SY5Y cells: An epigenetic mechanism linking the regulation of chromatin modifiying genes

Keywords: 5-mC; 5-methylcytosine; 5-hmC; 5-hydroxymethylcytosine; BPA; bisphenol A; EFSA; European Food Safety Authority; H3K9ac; histone H3 lysine 9 acetylation; H3K9me3; histone H3 lysine 9 trimethylation; H3K27me3; histone H3 lysine 27 trimethylation; H3K4me3; h

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS-12, induces apoptosis pathways in human colorectal cancer cell lines

Keywords: Antiproliferation; Apoptosis; Secretion metabolites; Yeast; 5-FU; 5-fluorouracil; cDNA; complementary DNA; CFS; cell-free supernatant; DAPI; 4′,6-diamidino-2-phenylindole; DMEM; Dulbecco modified Eagle medium; IC50; half-maximal inhibitory concentration

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Current state of knowledge on the traditional uses, phytochemistry, and pharmacology of the genus Hymenaea

Keywords: CNS; Central nervous system; DI; Diameter of inhibition; DPPH; 2,2-Diphenyl-1-picrylhydrazyl; EC50; Half maximal effective concentration; HPLC; High-performance liquid chromatography; IC50; Half maximal inhibitory concentration; MIC; Minimum inhibitory co

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

The overall fatty acid absorption controlled by basolateral chylomicron excretion under regulation of p-JNK1

Keywords: apoB; Apolipoprotein B; BEL; Bromoenol lactone; CD36; Cluster of differentiation 36; cFABP; Cytosolic fatty acid binding protein; COP-II; Coat protein complex-II; CM; Chylomicron; DRM; Detergent-resistant membranes; FABPPM; Plasma membrane fatty acid-bind

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

BCL11B-Mediated Epigenetic Repression Is a Crucial Target for Histone Deacetylase Inhibitors in Cutaneous T-Cell Lymphoma

Keywords: CTCL; cutaneous T-cell lymphoma; HDAC; histone deacetylase; HDACi; histone deacetylase inhibitor; IC50; half maximal inhibitory concentration; MF; mycosis fungoides; SAHA; suberoylanilide hydroxamic acid;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

LPE-1, an orally active pyrimidine derivative, inhibits growth and mobility of human esophageal cancers by targeting LSD1

Keywords: LSD1; histone lysine specific demethylase 1; ESCC; esophageal squamous cell carcinoma; E2F1; E2F transcription factor; FAD; flavin adenine dinucleotide; ERBB2; epidermal growth factor receptor 2; CCNA2; cyclin-A2; NSCLC; non-small cell lung cancer; PHLDB2

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-inflammatory effect of Cortex Eucommiae via modulation of the toll-like receptor 4 pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages

Keywords: CE; Cortex Eucommiae; LPS; lipopolysaccharide; HPLC; high-performance liquid chromatography; RT-PCR; reverse transcriptase-polymerase chain reaction; IC50; inhibitory concentration of 50%; TLR-4; toll-like receptor 4; Myd88; myeloid differentiation primar

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, physicochemical and biological studies of technetium-99m labeled tacrine derivative as a diagnostic tool for evaluation of cholinesterase level

Keywords: Tac; tacrine (1,2,3,4-tetrahydroacridin-9-amine); AD; Alzheimer's disease; AChE; acetylcholinesterase; CNS; central nervous system; IC50; half maximal inhibitory concentration; BM; biologically active molecule; BFCA; Bifunctional Coupling Agent; NS3; tr

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-function studies of BPP-BrachyNH2 and synthetic analogues thereof with Angiotensin I-Converting Enzyme

Keywords: Docking; Molecular dynamics simulations; Molecular mechanics Poisson-Boltzmann surface area; g_mmpbsa; proline-Rich oligopeptide; Toxicological prediction; ACE; Angiotensin-I converting enzyme; ADT; AutoDock Tools; CC50; Mean cytotoxic concentration; IC50

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides

Keywords: α/β-Peptides; Foldamers; Proteolysis; Protein-protein interactions; Trypanothione reductase; Leishmania infantum; CPP; cell-penetrating peptide; DSSP; define secondary structure of proteins algorithm; ELISA; Enzyme-Linked ImmunoSorbent Assay; 5-FITC; fl

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Contribution of presynaptic HCN channels to excitatory inputs of spinal substantia gelatinosa neurons

Keywords: DRG; dorsal root ganglia; FSK; forskolin; GAD67; glutamic acid decarboxylase-67; GFP; green fluorescent protein; HCN channels; hyperpolarization-activated cyclic nucleotide-gated channels; Ih; h-current; IC50; half-maximal inhibitory concentration; IR; im

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Exosome is a mechanism of intercellular drug transfer: Application of quantitative pharmacology

Keywords: Exosome; Exocytosis; Intercellular drug transfer; Quantitative pharmacology; Chemoresistance; AChE; acetylcholinesterase; Conditioned Medium; culture medium collected after incubating cells under preselected conditions; CV; coefficient of variation; Cytot

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه