دانلود مقالات ISI درباره Ic50 + ترجمه فارسی

Contribution of presynaptic HCN channels to excitatory inputs of spinal substantia gelatinosa neurons

Keywords: DRG; dorsal root ganglia; FSK; forskolin; GAD67; glutamic acid decarboxylase-67; GFP; green fluorescent protein; HCN channels; hyperpolarization-activated cyclic nucleotide-gated channels; Ih; h-current; IC50; half-maximal inhibitory concentration; IR; im

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

E-configuration structures of EPA and DHA derived from Euphausia superba and their significant inhibitive effects on growth of human cancer cell lines in vitro

Keywords: DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; HRESIMS; high resolution electrospray ionization mass spectroscopy; NMR; nuclear magnetic resonance; HPLC; high performance liquid chromatography; TLC; thin layer chromatography; GC-MS; gas chromatogr

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

The photodynamic action of pheophorbide a induces cell death through oxidative stress in Leishmania amazonensis

Keywords: AA; antimycin A; CCCP; cyanide m-chlorophenylhydrazone; DAF-FM diacetate; 4-amino-5-methylamino-2′,7′-difluoro fluoresceín; DMSO; dimethylsulfoxide; DPPP; diphenyl-1-pyrenylphosphine; DTNB; 2,2′-dinitro-5,5′-dithiobenzoic acid; FBS; fetal bovine

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Proanthocyanidins from Uncaria rhynchophylla induced apoptosis in MDA-MB-231 breast cancer cells while enhancing cytotoxic effects of 5-fluorouracil

Keywords: Uncaria rhynchophylla; Proanthocyanidins; 5-Fluorouracil; Breast cancer; Apoptosis; AAE/g dw; ascorbic acid equivalent/g dry weight; ABTS; 2,20-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid; CI; combination index; CIwt; weighted average; DCF-DA; 2′,

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

The toxicity and the acaricidal mechanism against Psoroptes cuniculi of the methanol extract of Adonis coerulea Maxim

Keywords: AChE; Acetylcholinesterase; CAT; Catalase; CLL model; The complementary log-log model; GST; Glutathione-S-transferase; HPLC; High performance liquid chromatography; IC50; : 50% inhibitory concentration; LD50; Median lethal dose; MDA; Malonyldialdehyde;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PET neuroimaging probes

Keywords: Quinoline; Fluorination; Phosphodiesterase 5; Radiotracer; Positron emission tomography; AD; alzheimer's disease; AllocCl; allyl chloroformate; ATR; attenuated total reflectance; cAMP; cyclic adenosine 3′,5′-monophosphate; cGMP; cyclic guanosine 3′,

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Selectivity of coronaridine congeners at nicotinic acetylcholine receptors and inhibitory activity on mouse medial habenula

Keywords: AChR; nicotinic acetylcholine receptor; ACh; acetylcholine; NCA; noncompetitive antagonist; RT; room temperature; MHb; medial habenula; VI; ventral inferior; Ki; inhibition constant; Kd; dissociation constant; IC50; ligand concentration that produces 50%

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Comparative effect of imatinib and ponatinib on autophagy and miRNome in chronic myeloid leukemia

Keywords: TKI; tyrosine kinase inhibitor; CML; chronic myeloid leukemia; LSC; leukemia stem cells; WST-1; Water Soluble Tetrazolium-1; GFP; Green Florescent Protein; TR-FRET; Time-resolved Fluorescence Energy Transfer; LC3B; light chain 3 B; miRNA; Micro Ribonuclei

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Facile encapsulation of hydroxycamptothecin nanocrystals into zein-based nanocomplexes for active targeting in drug delivery and cell imaging

Keywords: NPs; nanoparticles; HCPT; hydroxycamptothecin; PFA; folate-conjugated polydopamine; NCs; nanocomplexes; DDSs; drug delivery systems; PDA; polydopamine; DNC; drug nanocrystals; SAS; supercritical anti-solvent; BUDP; built-in ultrasonic dialysis process; FA

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

In vitro safety and efficacy evaluations of a complex botanical mixture of Eugenia dysenterica DC. (Myrtaceae): Prospects for developing a new dermocosmetic product

Keywords: AAAPVN; N-succinyl-ala-ala-ala-p-nitroanilide; BCOP; Bovine Corneal Opacity and Permeability; CBPI; cytokinesis-block proliferation index; CV80; non-cytotoxic concentration of test substance that maintain cell viability ≥ 80%; DNCB; 1-chloro-2,4-dinitr

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Medicinal plants for in vitro antiplasmodial activities: A systematic review of literature

Keywords: IC50; Half-maximal inhibitory concentration; NP; Natural products; Traditional herbs; Systematic review; Antiplasmodial; In vitro; IC50;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

New bimetallic dicyanidoargentate(I)-based coordination compounds: Synthesis, characterization, biological activities and DNA-BSA binding affinities

Keywords: Dicyanidoargentat(I); 2,2′-(ethylenedioxy)bis(ethylamine); Anticancer activity; Antimicrobial activity; Antifugal activity; Apoptosis; Bcl-2; B-cell lymphoma 2; CC1; cell conditioning 1; CK7; Cytokeratin 7; CK20; Cytokeratin 20; CPT; camptothecin; HIER;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling

Keywords: Mitochondrial Uncoupler; Treatment; Liver Cancer; Big Data; AFP; α-fetoprotein; CDC37; cell division cycle 37; CCLE; Cancer Cell Line Encyclopedia; CMap; Connectivity Map; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; GEO; Ge

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Interactions between salicylic acid and antioxidant enzymes tilting the balance of H2O2 from photorespiration in non-target crops under halosulfuron-methyl stress

Keywords: Phytotoxicity; Secondary target; Halosulfuron-methyl; Reactive oxygen species; Non-target crop; Sulfonylurea herbicide; HSM; halosufuron-methyl; SU; sulfonylurea herbicide; ALS; acetolactate synthase; BCAAs; branched chain amino acids; ROS; reactive oxyge

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Tilia tomentosa pectins exhibit dual mode of action on phagocytes as β-glucuronic acid monomers are abundant in their rhamnogalacturonans I

Keywords: AGII; arabinogalactan type II; AUAC; anhydrouronic acid content; BSA; bovine serum albumin; CD18; marker for β2-integrin; CD62L; marker for L-selectin; CL; chemiluminescence; DA; degree of acetylation; DM; degree of methoxylation; DSS; sodium 4,4-dimethy

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo

Keywords: Antiproliferative agents; Antitumor agents; Bis(hydroxymethyl) alkanoate curcuminoids; Curcumin; Triple-negative breast cancer; BUN; blood urea nitrogen; DMAP; N,N-dimethylaminopyridine; DMF; dimethylformamide; DMSO; dimethylsulfoxide; EtOAc; ethyl acetat

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport

Keywords: drug transport; drug interactions; organic anion-transporting polypeptide transporters; hepatocytes; hepatic transport; pharmacokinetics; physiologically based pharmacokinetic modeling; AUC; area under the plasma concentration-time curve; CsA; cyclosporin

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

Measuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay

Keywords: Dopamine transporter; Norepinephrine transporter; Serotonin transporter; Fluorescent monoamine substrate; Designer drugs; Drug screening; 2C-B; 2,5-dimethoxy-4-bromophenethylamine; 4-FA; 4-fluoroamphetamine; 5-APB; 5-(2-aminopropyl)benzofuran; 25B-NBOMe;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

Coloaded Nanoparticles of Paclitaxel and Piperlongumine for Enhancing Synergistic Antitumor Activities and Reducing Toxicity

Keywords: paclitaxel; piperlongumine; nanoparticles; synergistic effect; 5-FU; 5-fluorouracil; C6; Coumarin-6; Cmax; maximum concentration; CD31; cluster of differentiation 31; CI; combination index; CLSM; confocal laser scanning microscopy; DL; drug loading; DMEM;

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2017 سفارش ترجمه

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling

Keywords: CHO-hPAR2; Chinese hamster ovary cells transfected with human PAR2; EC50; molar concentration that produces 50% of the maximum response of an agonist; ECL2; extracellular loop 2; Fluo-3; {[2-(2-{2-[Bis(carboxymethyl)amino]-5-(2,7-dichloro-6-hydroxy-3-oxo-

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design

Keywords: Phenyl [(phenylcarbamoyl)amino]benzene-1-sulfonate derivatives; N-Phenyl-[(phenylcarbamoyl)amino]benzene-1-sulfonamide derivatives; Fragment-linking strategy; Dengue virus; NS5 methyltransferase inhibitors; Antiviral activity; DENV; dengue virus; NS; non-

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities

Keywords: Anti-SCLC hybrids; β-carboline; bis(hydroxymethyl)pyrrole; indolizino[8,7-b]indole; DNA cross-linking; Topoisomerase inhibition; Ac2O; acetic anhydride; ACN; acetonitrile; CCRF-CEM; human lymphoblastic leukemia; CCRF-CEM/VBL; vinblastine-resistant CCRF-C

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of novel inverse agonists of estrogen-related receptors ERRγ and ERRβ

Keywords: ERRs; estrogen-related receptors; ER; estrogen receptor; NRs; nuclear receptors; LBD; ligand-binding domain; SAR; structureactivity relationship; MCAD; medium-chain acyl coenzyme A dehydrogenase; IC50; half maximal inhibitory concentration; Estrogen-relat

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2017 سفارش ترجمه

Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes

Keywords: Anti-proliferative activity; Tumor selectivity; Gewald reaction; 5-Alkyl-2-aminothiophenes; Intracellular uptake; IC50; 50% inhibitory concentration; THF; tetrahydrofuran; MeOH; methanol; EtOH; ethanol; DMF; dimethylformamide; EtOAc; ethoxyacetate; CNS; c

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N′-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines

Keywords: NCI; National Cancer Institute; IC50; inhibitory concentration 50%; NSCLC; non-small cell lung cancer; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; SAR; structure-activity relationship; GI50; growth inhibition 50%; TGI; total growth

دانلود رایگان متن کامل مقاله ISI 66 صفحه سال انتشار : 2017 سفارش ترجمه

Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity

Keywords: cSENP1; catalytic human SUMO-specific protease; DUB; deubiquitinating enzyme; IC50; half maximal inhibitory concentration; rhSENP1; recombinant human SUMO-specific protease; SENP; SUMO-specific protease; SUMO; small ubiquitin-related protein modifier; SUM

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Improved synthesis of MC4-PPEA and the biological evaluation of its hydroxymethyl derivative

Keywords: Nampt; nicotinamide phosphoribosyltransferase; MC4-PPEA; 1-(4′-(trans-3″-(3‴-pyridyl) acrylamide)butyl)-1,7-dicarba-closo-dodecaborane; BNCT; boron neutron capture therapy; BOP; benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosp

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Edoxaban, a direct factor Xa inhibitor, suppresses tissue-factor induced human platelet aggregation and clot-bound factor Xa in vitro: Comparison with an antithrombin-dependent factor Xa inhibitor, fondaparinux

Keywords: AUC5 min; area under the curve of 5 min-aggregation response; DMSO; dimethyl sulfoxide; F1 + 2; prothrombin fragment F1 + 2; FXa; factor Xa; IC50; 50% inhibition concentration; PPP; platelet-poor plasma; PRP; platelet-rich plasma; SEM; standard erro

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Induction of apoptosis and differentiation by atractylenolide-1 isolated from Atractylodes macrocephala in human leukemia cells

Keywords: AML; acute myeloblastic leukemia; A. macrocephula; Atractylodes macrocephula; ATL-I; atractylenolide I; CML; chronic myeloblastic leukemia; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; ELISA; enzyme-linked immunosorbent assay; H

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

In vitro neuraminidase inhibitory concentration (IC50) of four neuraminidase inhibitors against clinical isolates of the influenza viruses circulating in the 2010–2011 to 2014–2015 Japanese influenza seasons

Keywords: Influenza; Neuraminidase inhibitor; Resistance; A(H3N2); B; IC50

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and binding characteristics of [3H]neuromedin N, a NTS2 receptor ligand

Keywords: BH; Bolton-Hunter; Bmax; maximal number of the binding sites; BSA; bovine serum albumin; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; EC50; half maximal effective concentration; Emax; maximal stimulation (Efficacy); GDP; guanosine 5′-

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Biodegradability and aquatic toxicity of quaternary ammonium-based gemini surfactants: Effect of the spacer on their ecological properties

Keywords: Gemini surfactants; Spacer; Aerobic biodegradation; Mineralization; Aquatic toxicity; Daphnia magna; ISO; International Organization for Standardization; SDS; sodium n-dodecyl sulfate; IC50; estimated concentration to immobilize 50% of the daphnias after

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring Nε-thioacetyl-lysine

Keywords: β-NAD+; β-nicotinamide adenine dinucleotide; MBHA; 4-methylbenzhydrylamine; SPPS; solid phase peptide synthesis; DMF; N,N-dimethylformamide; TFA; trifluoroacetic acid; DCM; dichloromethane; HBTU; 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexa

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Mitochondrial permeability and toxicity of diethylhexyl and monoethylhexyl phthalates on TK6 human lymphoblasts cells

Keywords: DEHP; diethylhexyl phthalate; MEHP; monoethylhexyl phthalate; DMSO; dimethyl sulfoxide; JC-1; 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide; ROS; reactive oxygen species; FSU; fluorescence standard units; IC50; inhibit

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Production of a soluble single-chain variable fragment antibody against okadaic acid and exploration of its specific binding

Keywords: Okadaic acid; CLEIA; Single-chain variable fragment; Binding complex; OA; okadaic acid; DSP; diarrhetic shellfish poisoning; ELISA; enzyme-linked immunosorbent assay; scFv; single-chain variable fragment; CDR; complementarity-determining region; PDB; Prot

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Immunogenicity of next-generation HPV vaccines in non-human primates: Measles-vectored HPV vaccine versus Pichia pastoris recombinant protein vaccine

Keywords: HPV; human papilloma virus; CC; cervical cancer; MV; measles virus; rMV; recombinant MV; EZ; Edmonston Zagreb strain; IFN-ϒ; interferon gamma; IL-5; interleukin 5; IC50; concentration that gives a response halfway between baseline and maximal; N; nucleoc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays

Keywords: cyclodextrins; drug delivery; cell culture; solubility; CD; cyclodextrin; CDtot; total concentration of substrate; CHO; Chinese hamster ovary cells; EC50; half maximal effective concentration; FLIPR; fluorometric imaging plate readers; fu.cal; calculated

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, in vitro antitumor activity, dihydrofolate reductase inhibition, DNA intercalation and structure-activity relationship studies of 1,3,5-triazine analogues

Keywords: DHFR; dihydrofolate reductase; ct-DNA; calf thymus DNA; NADPH; nicotinamide adenine dinucleotide phosphate; TGI; total growth inhibition; LC50; 50% lethal concentration; GI50; 50% growth inhibition; IC50; 50% inhibitory concentration; Ka; binding constant

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats

Keywords: DPP-4; dipeptidyl peptidase-4; GLP-1; glucagon-like peptide-1; ·OH; hydroxyl-radical; O2−; superoxide; ESR; electron spin resonance; 8-OHdG; 8-hydroxy-2′-deoxyguanosine; XOD; xanthine oxidase; DMPO; 5.5-dimethyl-l-pyrroline-N-oxide; HPX; hypoxanthine

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

In silico and in vitro analyses of the angiotensin-I converting enzyme inhibitory activity of hydrolysates generated from crude barley (Hordeum vulgare) protein concentrates

Keywords: ACE-I inhibition; In silico; Barley proteins; Peptides; IC50; Mass spectrometry;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A

Keywords: HPLC; high performance liquid chromatography; IC50; half maximal inhibitory concentration; KCC; K+, Cl− cotransporter; NKCC; Na+-K+-Cl− cotransporter; TALH; thick ascending limb of Henle's loop; Cation-chloride cotransporters; Brain disorders; Epi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates

Keywords: EST; embryonic stem cell test; ECVAM; European Center for the Validation of Alternative Methods; PBPK; physiologically based pharmacokinetics; MIC; metabolically inapplicable candidate; PBS; phosphate buffered saline; DMSO; dimethyl sulfoxide; MD; maximum

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Kinetics of chemotaxis, cytokine, and chemokine release of NR8383 macrophages after exposure to inflammatory and inert granular insoluble particles

Keywords: BET; brunauer, emmett, teller; CCL; chemokine (C-C motif) ligand; CXCL; chemokine (C-X-C motif) ligand; dHL-60; differentiated human leukemia cells; DLS; dynamic light scattering; FCS; fetal calf serum; IC50; half maximal inhibitory concentration; PBS; ph

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Curcumin-cyclodextrin complexes enhanced the anti-cancer effects of curcumin

Keywords: CD; β-cyclodextrin; CD15; curcumin-cyclodextrin complexes; CDK; cyclin-dependent kinase; CUR; curcumin; FACS; fluorescence activated cell sorter; FTIR; Fourier transform infrared; IC50; 50% inhibitory concentration; MTT; 3-(4,5-Dimethyl-thiagol-2yl)- 2,5

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Retinoid N-(1H-benzo[d]imidazol-2-yl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide induces p21-dependent senescence in breast cancer cells

Keywords: ATRA; all-trans-retinoic acid; CDK; cyclin-dependent kinase; ER; estrogen receptor; RA; retinoic acid; OIS; oncogene-induced senescence; PICS; PTEN-loss induced cellular senescence; SRB; Sulforhodamine B; SABG; senescence-associated β-galactosidase; siRN

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Purification of a dimeric arginine deiminase from Enterococcus faecium GR7 and study of its anti-cancerous activity

Keywords: ADI; arginine deiminase; ASS; argininosuccinate synthetase; CK; carbamate kinase; CF; cytoplasmic fractions; DMSO; dimethylsulfoxide; GRAS; generally recognized as safe; HKC; heat-killed cells; Hep-G2; Human hepatocellular carcinoma cell line; IC50; half-

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors

Keywords: Indoleamine 2; 3-dioxygenase 2; IDO2 bioassay system; IDO2 inhibitor; Tryptanthrin derivatives; hIDO2; human indoleamine 2, 3-dioxygenase 2; IDO1; indoleamine 2, 3-dioxygenase 1; L-1-MT; L-1-methyl-tryptophan; TDO; tryptophan 2, 3-dioxygenase; LLC; Lewis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery of N-(benzyloxy)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives as potential antiproliferative agents by inhibiting MEK

Keywords: MEK; mitogen-activated protein kinase; BRAF; V-RAF murine sarcoma viral oncogene homologue B1; ERK; extracellular regulated kinase; BRAFV600E; V600E mutant BRAF; BRAFV600K; V600K mutant BRAF; IC50; half maximal inhibitory concentration; GI50; the concentr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Use of ferrous iron by metallo-β-lactamases

Keywords: MBL; metallo-β-lactamase; SBL; serine-β-lactamase; BcII; metallo-β-lactamase II from Bacillus cereus; VIM-2; Verona integron-encoded metallo-β-lactamase 2; CPSF; cleavage/polyadenylation specificity factor; SNM; sensitivity to nitrogen mustard; ROO; r

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and anticancer potential of novel xanthone derivatives with 3,6-substituted chains

Keywords: Xanthone derivatives; 3,6-Substituted long chains; Synthesis; Anticancer potential; IC50; A549; Structure–activity relationship; Apoptosis; Cell cycle arrest; Caspase 3/7 activity

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه