دانلود مقالات ISI درباره مهار ثابت + ترجمه فارسی

ارزیابی فعالیت مهار کننده ترومبین کاتچین ها با استفاده از میکروسکوپ آنزیمی مونوکلئورید مویرگ الکتروفورز و تکینگی مولکولی

Evaluation of thrombin inhibitory activity of catechins by online capillary electrophoresis-based immobilized enzyme microreactor and molecular docking

Keywords: مهار ثابت; THR; Thrombin; EC; Epicatechin; EGC; Epigallocatechin; ECG; Epicatechin gallate; EGCG; Epigallocatechin gallate; CE; Capillary electrophoresis; EMMA; Electrophoretically mediated microanalysis; IMER; Immobilized enzyme microreaction; pNA; para-nitroanilin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

تعیین الکتروفیزیولوژیک ثابت کننده مهار کننده فسفودی استراز -6 در شبکیه چشم نامرئی

Electrophysiological determination of phosphodiesterase-6 inhibitor inhibition constants in intact mouse retina

Keywords: مهار ثابت; Phosphodiesterase-6; Inhibitor; Inhibition constant; Retina; Photoreceptors; Ex vivo electroretinography; A; activation coefficient; cAMP; adenosine 3′,5′ cyclic monophosphate; cGMP; guanosine 3′,5′ cyclic monophosphate; CNG channel; cyclic nucleo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

خواص خاک اثر سینتیک اسید فسفاتاز خاک در پاسخ به سمیت آرسنیک

Soil properties influence kinetics of soil acid phosphatase in response to arsenic toxicity

Keywords: مهار ثابت; Arsenic; Soil acid phosphatase; Soil property; Inhibition constant; Noncompetitive inhibition;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

سنتز و ارزیابی مشتقات بیارییل برای مشخص ساختاری ممانعت کننده های مونوآمین اکسیداز انتخابی ب در درمان بیماری پارکینسون

Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy

Keywords: مهار ثابت; AD; Alzheimer's disease; DA; dopamine; DAergic; dopaminergic; hMAO-A; human monoamine oxidase A; hMAO-B; human monoamine oxidase B; HRP; horseradish peroxidase; IC50; the half maximal inhibitory concentration; i.p.; intraperitoneal; Ki; inhibition const

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

مدلسازی فیزیولوژیکی مبتنی بر فارماکوکینتیک از نظر قرارگیری و تعاملات دارویی و داروئی برای والپروئیک اسید و دیوالپروکس

Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex

Keywords: مهار ثابت; ADAM; advanced dissolution, absorption, and metabolism; AED; antiepileptic drug; AUC; area-under-the-curve; B/P; blood to plasma ratio; BID; twice daily; BMI; body mass index; CBZ; carbamazepine; CLint; intrinsic clearance; CLR; renal clearance; CL; clear

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2018 سفارش ترجمه

در مورد استفاده از ثابت پایدار شدن آنزیم ثابت به عنوان اندازه گیری وابستگی مطلق مطلوب است

On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity

Keywords: مهار ثابت; Dissociation constant; Inhibition constant; Affinity; Nonspecific binding; Nontarget site binding; Adsorption; Ki; enzyme inhibition constant; AChE; acetylcholinesterase; eeAChE; Electrophorus electricus AChE; ATCh; acetylthiocholine chloride; bis(7)-tacr

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

عمل پپتید تکسور تگزاس در سطح زیرین کانال کانونی یون

Scorpion toxin peptide action at the ion channel subunit level

Keywords: مهار ثابت; Scorpion; Venom; Neurotoxin; Neuropeptide; Ion channels; AC50; toxin concentration for activation to 50%; Cav; voltage-gated calcium channel; EC50; half maximal effective concentration; ED50; median effective dose; ER; endoplasmic reticulum; IC50; half ma

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

تجزیه و تحلیل تغییر در زمان تمرکز غلظت خون ناشی از تعاملات مجتمع دارو و مواد مخدر در کبد با توجه به گردش سلولی: بررسی اینکه آیا ثابت شدن مهار برای جذب، متابولیسم و ​​دفع ادرار

Analysis of the Change in the Blood Concentration-Time Profile Caused by Complex Drug-Drug Interactions in the Liver Considering the Enterohepatic Circulation: Examining Whether the Inhibition Constants for Uptake, Metabolism, and Biliary Excretion Can be

Keywords: مهار ثابت; physiologically based pharmacokinetic modeling; drug interactions; Monte Carlo; in vitro-in vivo correlations (IVIVC); nonlinear regression; biliary excretion; biliary recycling; hepatic metabolism; hepatic transport; AUC; area under the curve of concen

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2017 سفارش ترجمه

Cathepsin B inhibitors: Further exploration of the nitroxoline core

Keywords: مهار ثابت; Abz; 2-aminobenzoyl; AMC; 7-amido-4-methylcoumarin; catB; cathepsin B; DIPEA; N,N-diisopropylethylamine; DMSO; dimethyl sulfoxide; ECM; extracellular matrix; EDC; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; HATU; 1-[bis(dimethylamino)methylene]-1H-1,2,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Anthranilate phosphoribosyltransferase: Binding determinants for 5′-phospho-alpha-d-ribosyl-1′-pyrophosphate (PRPP) and the implications for inhibitor design

Keywords: مهار ثابت; AnPRT; anthranilate phosphoribosyltransferase; IC50; absolute IC50, that is the concentration of inhibitor which decreased enzyme activity by 50%; Km; Michaelis-Menten constant; Ki; inhibition constant; Mtb; Mycobacterium tuberculosis; PPi; pyrophosphate;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors

Keywords: مهار ثابت; Carbonic anhydrase inhibitors; Isoforms I, II, IV, IX; Benzenesulfonamide; 1,2,3-Triazole; CA; Carbonic anhydrase; hCA; human carbonic anhydrase; CAIs; Carbonic anhydrase inhibitors; AAZ; Acetazolamide; Ki; Inhibition constant; nM; nanomolar; μM; micromo

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold

Keywords: مهار ثابت; A. flavus; Aspergillus flavus; C. albicans; Candida albicans; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CNS; central nervous system; COX; cyclooxygenase; CRF; corticotropin-releasing hormone; CRK; cdc2-related kinase; CYC6; cycli

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms

Keywords: مهار ثابت; AChR; nicotinic acetylcholine receptor; ACh; acetylcholine; TCAs; tricyclic antidepressants; α-BTx; α-bungarotoxin; MLA; methyllycaconitine; RT; room temperature; IC50; ligand concentration that produces 50% inhibition (of binding or of agonist activati

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

In silico and in vitro analysis of coumarin derivative induced anticancer effects by undergoing intrinsic pathway mediated apoptosis in human stomach cancer

Keywords: مهار ثابت; SBC; Apoptosis; Docking; ADME; Stomach cancer cell line (AGS); Anti-proliferative; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; ADME; absorption, distribution, metabolism and excretion; FBS; fetal bovine serum; RPMI; rosewell park m

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches

Keywords: مهار ثابت; GPCR; G protein-coupled receptor; EP4; prostaglandin E2 receptor EP4 subtype; LPAR; lysophosphatidic acid receptor; DTI; drug-target interaction; ADE; adverse drug event; MoA; mechanism of action; Ki; inhibition constant; Kd; dissociation constant; IC50;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of Alzheimer's disease

Keywords: مهار ثابت; Alzheimer's disease; Binding energy; Inhibition constant; Amino acid residues; Molecular interactions;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment

Keywords: مهار ثابت; A2aR; adenosine A2a receptor; CAF; cancer-associated fibroblast; CHO; Chinese hamster ovary; IC50; concentration of compound that displaces the binding of radioligand by 50%; Kb; binding constant; Ki; inhibition constant; NECA; 5″-N-ethylcarboxamidoaden

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

Keywords: مهار ثابت; AUC; area under the curve; DDI; drug-drug interaction; fu; fraction unbound; IC50; inhibition constant; IV; intravenous; IVIVE; in vitro/in vivo extrapolation; Ki; inhibition constant; OAT; organic anion transporter; PBPK; physiologically based pharmacoki

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia

Keywords: مهار ثابت; Mnk inhibitor; FLT3 inhibitor; Dual inhibitor; AML; Drug discovery; Anti-leukaemic agent; AML; acute myeloid leukaemia; CDK; cyclin-dependent kinase; eIF; eukaryotic initiation factor; Erk; extracellular signal-regulated kinase; FLT3; Fms-like tyrosine ki

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods

Keywords: مهار ثابت; drug interaction; cytochrome P450s; membrane transport/transporters; regulatory; guidance/guideline; ADME; absorption, distribution, metabolism and excretion; BCRP; breast cancer resistance protein; CYP; cytochrome P-450; d; induction calibration factor;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism

Keywords: مهار ثابت; PTP1B; protein tyrosine phosphatase 1B; IC50; the inhibitor concentration leading 50% activity loss; Ki; inhibition constant; Kiapp; apparent Ki; Vmax; maximum velocity; Km; Michaelis-Menten constant; Kobs; apparent first-order rate constant for the trans

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data

Keywords: مهار ثابت; clinical trial simulations; drug interactions; pharmacokinetics; physiologically based pharmacokinetic modeling; organic anion-transporting polypeptide transporters; CYP enzymes; AUC; area under the blood concentration-time curve; AUCR; area under the b

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Selectivity of coronaridine congeners at nicotinic acetylcholine receptors and inhibitory activity on mouse medial habenula

Keywords: مهار ثابت; AChR; nicotinic acetylcholine receptor; ACh; acetylcholine; NCA; noncompetitive antagonist; RT; room temperature; MHb; medial habenula; VI; ventral inferior; Ki; inhibition constant; Kd; dissociation constant; IC50; ligand concentration that produces 50%

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Kinetics of soil dehydrogenase in response to exogenous Cd toxicity

Keywords: مهار ثابت; Cadmium; Dehydrogenase; Kinetic; Inhibition constant;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport

Keywords: مهار ثابت; drug transport; drug interactions; organic anion-transporting polypeptide transporters; hepatocytes; hepatic transport; pharmacokinetics; physiologically based pharmacokinetic modeling; AUC; area under the plasma concentration-time curve; CsA; cyclosporin

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models

Keywords: مهار ثابت; cytochrome P450; drug interaction; hepatic clearance; mathematical model; organic anion-transporting polypeptide transporters; pharmacokinetics; AUC; area under the plasma concentration-time curve; CL; clearance; CLint,all; overall hepatic intrinsic cle

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors

Keywords: مهار ثابت; Human α4β2 nicotinic acetylcholine receptor; Bupropion; (±)-SADU-3-72; Molecular docking; Luminal and non-luminal sites; Ca2+ influx; AChR; nicotinic acetylcholine receptor; NCA; noncompetitive antagonist; (±)-BP; (±)-bupropion [(±)-2-(tert-butylami

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content

Keywords: مهار ثابت; 5-HT; 5-hydroxytryptamine (serotonin); m5-HT3AR; murine serotonin type 3A receptor; AChR; nicotinic acetylcholine receptor; ACh; acetylcholine; NMDAR; N-methyl-D-aspartate receptor; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; NI

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Ethnomedical research and review of Q'eqchi Maya women's reproductive health in the Lake Izabal region of Guatemala: Past, present and future prospects

Keywords: مهار ثابت; COX-2; Cyclooxygenase 2; E2; Estradiol; ERα, ERβ; estrogen receptor alpha and beta; ERE; estrogen responsive element; GC; granulosa cells; 5-HT; Serotonin; 5-HT1-7; Serotonin receptors 1-7; IC50; median inhibitory concentration; Ki; Inhibition constant;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

Microwave assisted synthesis of novel acridine-acetazolamide conjugates and investigation of their inhibition effects on human carbonic anhydrase isoforms hCA I, II, IV and VII

Keywords: مهار ثابت; CA; carbonic anhydrase; hCA; human carbonic anhydrase; Quinacrine; (RS)-N′-(6-Chloro-2-methoxy-acridin-9-yl)-N,N-diethylpentane-1,4-diamine; Proflavine; acridine-3,6-di-amine; Amsacrine; N-(4-(acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide; IR; i

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

Radiosynthesis and in vitro validation of 3H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand

Keywords: مهار ثابت; Bmax; maximum density; 125I-BTX; 125I-α-bungarotoxin; Kd; dissociation constant; Ki; inhibition constant; NSB; non-specific binding; OD; optical density; PAM; positive allosteric modulator; SB; specific binding; TB; total binding; TE; tissue equivalent;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Dissecting the functional roles of the conserved NXXE and HXE motifs of the ADP-dependent glucokinase from Thermococcus litoralis

Keywords: مهار ثابت; ADP; adenosine-diphosphate; ATP; adenosine triphosphate; GK; glucokinase; TlGK; glucokinase from Thermococcus litoralis; glucose-6-P; glucose-6-phosphate; KM; Michaelis constant; kcat; turnover rate; Ki; inhibition constant; Ka; activation constant; KD; d

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune

Keywords: مهار ثابت; Carbonic anhydrase; Metalloenzymes; Hydratase activity; Antarctic organisms; Cyanobacteria; Anions; Inhibition constant;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Aqueous extracts and suspensions of restructured pork formulated with Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis distinctly affect the in vitro α-glucosidase activity and glucose diffusion

Keywords: مهار ثابت; Alpha-glucosidase; Glucose diffusion; Restructured pork; Inhibition mechanism; Hypoglycaemic effects; CVD; cardiovascular disease; CRP; control-RP; GOD; glucose oxidase; Ki; inhibition constant; Km; Michaelis-Menten constant; NRP; restructured pork cont

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Comparative inhibitory effect of prenylated coumarins, ferulenol and ferprenin, contained in the 'poisonous chemotype' of Ferula communis on mammal liver microsomal VKORC1 activity

Keywords: مهار ثابت; VKOR; vitamin K epoxide reductase; VKORC1; vitamin K epoxide reductase complex subunit 1; Vitamin K > O; vitamin K epoxide; Ferula communis L. (Apiaceae); Ferulenol; Ferprenin; VKORC1; Inhibition constant; Interspecies variability;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Coronaridine congeners inhibit human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites

Keywords: مهار ثابت; AChR; nicotinic acetylcholine receptor; NCA; noncompetitive antagonist; RT; room temperature; Ki; inhibition constant; Kd; dissociation constant; IC50; ligand concentration that produces 50% inhibition of binding (or of agonist activation); nH; Hill coeff

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Functional and structural interaction of (−)-lobeline with human α4β2 and α4β4 nicotinic acetylcholine receptor subtypes

Keywords: مهار ثابت; AChR; nicotinic acetylcholine receptor; (−)-lobeline (α-lobeline) (−); -2S, 6R, 8S-lobeline, Ct-AChBP, acetylcholine binding protein from Capitella teleta; Ac-AChBP; acetylcholine binding protein from Aplysia californica; CCh; carbamylcholine; RT; ro

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Bowman-Birk proteinase inhibitor from Clitoria fairchildiana seeds: Isolation, biochemical properties and insecticidal potential

Keywords: مهار ثابت; BBI; Bowman-Birk inhibitor; CD; circular dichroism; DTT; dithiothreitol; RP-HPLC; reversed-phase high performance liquid chromatography; Ki; inhibition constant; MALDI-TOF; matrix assisted laser desorption ionisation time of flight mass spectrometry; PI

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Enediynyl peptides and iso-coumarinyl methyl sulfones as inhibitors of proprotein convertases PCSK8/SKI-1/S1P and PCSK4/PC4: Design, synthesis and biological evaluations

Keywords: مهار ثابت; aa; amino acid; AMC; 7-amino 4-methyl coumarin; Amu; atomic mass unit; Au; arbitrary unit; Aufs; absorption units full scale; IMS; iso-coumarinyl methyl sulfone; Eda; enediyne amino acid; h; human; IC50; inhibitor concentration required for 50% inhibition

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Binding cooperativity between a ligand carbonyl group and a hydrophobic side chain can be enhanced by additional H-bonds in a distance dependent manner: A case study with thrombin inhibitors

Keywords: مهار ثابت; Cooperativity; Protein-ligand binding; Ligand binding affinity; Scoring functions; B-factor; Thrombin; Non-additivity; Me; methyl; Bn; benzyl; Boc; tert-butoxycarbonyl; ΔG˚; standard Gibbs free energy; Ki; inhibition constant; EDCI; 1-(3-dimethylaminopr

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors

Keywords: مهار ثابت; CA; carbonic anhydrase; Ki; inhibition constant; ZBG; zinc binding group; Saccharin; Metalloenzyme; Carbonic anhydrase IX; CA IX-mimic; Structure-based drug design;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2015 سفارش ترجمه

Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. Part 5

Keywords: مهار ثابت; Pyrido[1,2-c]pyrimidines; Antidepressants; Dual SSRI/5-HT1A activity; Quinoline derivatives; SERT; serotonin transporter; SAR; structure-activity relationship; 5-HT1AR; serotonin 5-HT1A receptors; 8-OH-DPAT; 8-hydroxy-2-(di-n-propylamino)tetralin; Ki; inh

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2015 سفارش ترجمه

Quantitative determination of active Bowman-Birk isoinhibitors, IBB1 and IBBD2, in commercial soymilks

Keywords: مهار ثابت; BAPNA; N-α-benzoyl-DL-arginine-p-nitroanilide; BBI; Bowman-Birk inhibitors; BBIC; Bowman-Birk inhibitor concentrate; BTEE; N-benzoyl-L-tyrosine ethyl ester; CIA; chymotrypsin inhibitor activity; CIU; chymotrypsin inhibitor units; CRC; colorectal cancer;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings

Keywords: مهار ثابت; SARS-CoV; Severe Acute Respiratory Syndrome coronavirus; 3CLpro; 3 Chymotrypsin-like cysteine protease; MD; molecular dynamics; VS; virtual screening; CSM; computational solvent mapping; ROC; receiver operating characteristic; RMSD; root mean square devia

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities

Keywords: مهار ثابت; 5-HT; 5-hydroxy tryptamine (serotonin); 5-HTT; serotonin transporter; AAP; atypical antipsychotics; ACH; acetylcholine; ADR; adverse drug reaction; AP; antipsychotic; CDSR; cochrane database of systematic reviews; CTZ; chemotrigger zone; DAT; dopamine tra

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

A hydrophobic residue in position 15 of the rP2X3 receptor slows desensitization and reveals properties beneficial for pharmacological analysis and high-throughput screening

Keywords: مهار ثابت; P2X3 receptor; Desensitization; Mechanism of antagonism; Drug screening; Calcium imaging; αß-meATP; αß-methylene-ATP; CI; confidence interval; EC50; 50% effective concentration; IC50; 50% inhibitory concentration; Ki; inhibition constant; pA2; negativ

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery and SAR studies of methionine-proline anilides as dengue virus NS2B-NS3 protease inhibitors

Keywords: مهار ثابت; HQRJJHXKCFABSI-UONOGXRCSA-N; SAR; structure and activity relationship; NS2B-NS3; nonstructural protein 2B and 3; DENV; dengue virus; Ki; inhibition constant; TFA; trifluoroacetic acid; EtOAc; ethyl acetate; DCM; dichloromethylene; EtOH; ethyl alcohol; DMA

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa

Keywords: مهار ثابت; IC50; the inhibitor concentration leading to 50 % activity loss; Ki; inhibition constant; Km; Michaelis-Menten constant; SARS-CoV PLpro; Paulownia tomentosa; Geranylated flavonoids; PLpro inhibitor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Concentration-dependent inhibitory effects of baicalin on the metabolism of dextromethorphan, a dual probe of CYP2D and CYP3A, in rats

Keywords: مهار ثابت; S. baicalensis; Scutellaria baicalensis; CYP; cytochrome P450; CYP2D; cytochrome P450 2D; CYP3A; cytochrome P450 3A; DXM; dextromethorphan; BG; baicalin; RLMs; rat liver microsomes; Km; substrate concentration at half-maximal product formation rate; Ki; i

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Bioinsecticidal activity of a novel Kunitz trypsin inhibitor from Catanduva (Piptadenia moniliformis) seeds

Keywords: مهار ثابت; Bioinsecticidal; Kunitz trypsin inhibitor; Insect pests; Piptadenia moniliformis; ED50; effective dose to inhibit 50% of an enzymatic pool; HPLC; high-performance liquid chromatography; TCA; trichloroacetic acid; Ki; inhibition constant; DTT; dithiothreit

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه