Comparative inhibitory effect of prenylated coumarins, ferulenol and ferprenin, contained in the 'poisonous chemotype' of Ferula communis on mammal liver microsomal VKORC1 activity

Ferulenol, and to a lesser extent, ferprenin, are both inhibitors of VKORC1 enzymes in all animals exposed to Ferula communis, and thus are both responsible for 'ferulosis'.