Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors

A series of thirty novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety were synthesized and evaluated for their inhibition potential against human carbonic anhydrase isoforms, hCA I, II, IV and IX.218