Keywords: Akt; protein kinase B; AL; ad labitum; BDNF; brain-derived neurotrophic factor; CR; caloric restriction; LC3; microtubule-associated protein 1 light chain 3; mTOR; mammalian target of rapamycin; MWM; Morris water maze; OFT; open field test; PI3K; phosphat
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Keywords: ANOVA; analysis of variance; ATF-4; activating transcription factor-4; ATF-6; activating transcription factor-6; C/EBP; CCAAT/enhancer-binding protein; CHOP; C/EBP homologous protein; eIf2α; eukaryotic translation initiation factor 2 subunit α; ER; endo
Keywords: BafA1; bafilomycin A1; CCK-8; cell counting kit-8; CNT; carbon nanotubes; CTRL; vehicle treated control; CQ; chloroquine; DTS; dense tubular system; ER; endoplasmatic reticulum; FESEM; field emission scanning electron microscopy; GFP; green fluorescence p
Keywords: UPS; ubiquitin-proteasome system; HSPs; heat shock proteins; UPR; unfolded protein response; eIF2α; eukaryotic translation initiation factor 2 alpha; LC3; autophagy related microtubule-associated protein 1 light chain 3; NAD(P)H; quinone oxidoreductase
Keywords: GABA; γ-aminobutyric acid; STZ; streptozotocin; DM; diabetes; FADD; Fas-associated death domain; C; catechin; EC; epicatechin; EGCG; epigallocatechin gallate; LC3; microtubule associated protein light chain 3; GABA tea; Diabetes mellitus; Apoptosis; Auto
Keywords: ALDH2; aldehyde dehydrogenase 2; ANT; adenine nucleotide transportor; AR; aldose reductase; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; ATG; AuTophaGy; ATM; ataxia-telangiectasia mutate; COPD; chronic obstructive pulmonary
Keywords: 6-OHDA; 6-hydroxydopamine; AMPK; AMP activated protein kinase; cAMP; cyclic adenosine monophosphate; CAT; catalase; CI; complex I; CII; complex II; CIV; complex IV; COX; cytochrome c oxidase; DMSO; dimethyl sulfoxide; DNP; dinitrophenol; DCF; dichlorodihy
Keywords: Aβ; β-amyloid; AGE; advanced glycation end product (here: proteins modified by AGEs); Atg; autophagy-related gene; CMA; chaperone-mediated-autophagy; 3-DG; 3-deoxyglucosone; FIP200; focal adhesion kinase family-interacting protein of 200 kDa; IP3; inos
Keywords: Azithromycin; Macrolide antibiotic; Mechanisms of action; Pharmacokinetics; Immunomodulation; Clinical efficacy; AECOPD; acute exacerbations of COPD; AP-1; activator protein-1; ARDS; acute respiratory distress syndrome; AUC; area under the plasma concentr
Keywords: Ap3A; diadenosine triphosphate; ERK; extracellular signal regulated kinase; FHIT; fragile histidine triad protein; GSSG; oxidized glutathione; GSH; reduced glutathione; LC3; microtubule associated protein 1 light chain 3; NAC; N-acetyl-cysteine; NADPH; ni
Keywords: Autophagy; GABARAP; GATE-16; Glial cytoplasmic inclusion; LC3; Lysosome; Multiple system atrophy; Oligodendrocyte;
Keywords: FOXO; forkhead box O; GC; glucocorticoids; MuRF-1; muscle RING-finger protein-1; mTOR; mammalian target of rapamycin; IGF-I; Insulin-like Growth Factor-I; eIF4E; eukaryotic translation initiation factor 4E; S6K1; ribosomal protein kinase 1; 4E-BP1; eukary
Keywords: CLX6; Calix[6]arene; CDKs; cyclin-dependent kinases; RB; retinoblastoma; PIM; proviral integration site for the moloney murine leukemia virus; AXL; tyrosine-protein kinase receptor UFO; Mer; tyrosine-protein kinase receptor; PI3K; phosphoinositide 3-kinas
Keywords: LKB1; liver kinase B1; AMPK; AMP-activated protein kinase; mTOR; mammalian target of rapamycin; ULK1/2; unc-51-like kinase1/2; FIP200; focal adhesion kinase family-interacting protein of 200Â kDa; PI; phosphatidylinositol; LC3; microtuble-associated prote
Keywords: 2D-DIGE; 2-dimensional differential gel electrophoresis; ACAD9; acyl-CoA dehydrogenase 9; AMPK; AMP-dependent protein kinase; ATG; autophagy-related protein; ATP5; ATP synthase subunit; BNIP3; BCL2/adenovirus E1B 19Â kDa protein-interacting protein 3; BNI
Keywords: 31P-NMR; 31P nuclear magnetic resonance; AIF; apoptosis-inducing factor; AngII; angiotensin II; Atg protein; autophagy-related protein; Bcl-2; B-cell leukemia-2; COPD; chronic obstructive pulmonary disease; COX; cytochrome c oxidase; CSA; cross-sectional
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Keywords: ER; endoplasmic reticulum; AMD; age-related macular degeneration; RPE; retinal pigment epithelium; PUFAs; polyunsaturated fatty acids; ROS; reactive oxygen species; NRF-2; nuclear factor-erythroid 2-related factor-2; ARE; antioxidant response element; Kea
FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia
Keywords: Atg7; autophagy associated gene 7; Bax; Bcl-2 associated X protein; Bak; Bcl-2 homologous antagonist/killer; Bcl-2; B-cell lymphoma-2; Beclin 1; Bcl-2 interacting protein 1; CCH; chronic cerebral hypoperfusion; Cleaved caspase-3; Cleaved cysteinyl asparta
Effect of Runx2 silencing on autophagy and RANKL expression in osteoblasts
Keywords: Runx2 silencing; Osteoblast; LC3; Beclin-1; RANKL;
Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke
Keywords: Oxymatrine; Ischemia/reperfusion; Hippocampus; p53; Bax; LC3; SIRT1;
Apoptosis and pro-death autophagy induced by a spirostanol saponin isolated from Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) on HL-60 cells
Keywords: Spirostanol saponin; Autophagy; Apoptosis; Rohdea chinensis; Human acute promyelocytic leukemia; Akt; protein kinase B; AMPK; adenosine 5â²-monophosphate-activated protein kinase; Baf-A1; bafilomycin A1; FBS; fetal bovine serum; JC-1; 5,5´,6,6´-tetrach
Autophagy-disrupted LC3 abundance leads to death of supporting cells of human oocytes
Keywords: Human granulosa cells; Autophagy; LC3; ATG7; Cell death; Cumulus cells;
Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity
Keywords: Ubiquitin C-Terminal Hydrolase L1 (UCHL1); Autophagy; Autophagosome; LC3; Parkinson's disease; UCHL1 inhibitor;
Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR/Ulk1 pathway
Keywords: MCAO; middle cerebral artery occlusion; Bcl-2; B cell lymphoma 2; Bax; Bcl-2-associated X protein; Ki-67; identified by monoclonal antibody; LDH; lactate dehydrogenase; MDA; malondialdehyde; NO; nitric oxide; IL; interleukin; TNF-; αtumor necrosis factor
A role for Glucagon-Like Peptide-1 in the regulation of β-cell autophagy
Keywords: Akt; protein kinase B; Ambra1; Autophagy And Beclin 1 Regulator 1; AMPK; 5â² AMP-activated protein kinase; Atg; autophagy related proteins; CAMKK; Ca2+/calmodulin-dependent protein kinase kinase; DFCP1; double FYVE-containing protein 1; DPP4; dipeptidyl
Hepatitis B Virus X protein elevates Parkin-mediated mitophagy through Lon Peptidase in starvation
Keywords: HCC; Hepatocellular Carcinoma; HBV; Hepatitis B virus; HBx; Hepatitis B Virus X protein; PINK1; PTEN Induced Putative Kinase 1; UPRmt; Mitochondrial Unfolded-Protein Response; LONP1; Lon Peptidase 1; EBSS; Earle's balance salt solution; LC3; microtubule-a
Polyphenolic derivatives from mango (Mangifera Indica L.) modulate fecal microbiome, short-chain fatty acids production and the HDAC1/AMPK/LC3 axis in rats with DSS-induced colitis
Keywords: AMPK; AMP-activated protein kinase; ATCC; American Type Culture Collection; Atgs; autophagy-related genes; DSS; dextran sodium sulfate; GAE; gallic acid equivalent; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GC-MS; gas chromatography-mass spectr
Celosins inhibit atherosclerosis in ApoE-/- mice and promote autophagy flow
Keywords: AS; Atherosclerosis; CES; Celosins; LDL; Low-density lipoprotein; Ox-LDL; Oxidized low-density lipoprotein; LC3; Microtubule-associated protein light chain3; CD36; Scavenger receptor B3; SR-A1; Scavenger receptor A 1; ABCA1; ATP-binding cassette transport
Comparative study on the essential oils of six Hawk tea (Litsea coreana Levl. var. lanuginosa) from China: Yields, chemical compositions and biological activities
Keywords: EOs; essential oils; GC-MS; Gas Chromatography-Mass Spectrometer; LC1; the sample from Mingshan; LC2; the sample from Qingchuan; LC3; the sample from Pingshan; LC4; the sample from Wuxi; LC5; the sample from Daozhen; LC6; the sample from Ningguo; CPX
Diethylstilbestrol (DES) induces autophagy in thymocytes by regulating Beclin-1 expression through epigenetic modulation
Keywords: DES; diethylstilbestrol; ER; estrogen receptor; miR; microRNA; miR-30a; microRNA-30a; Becn1; Beclin 1; LC3; microtubuleassociated protein light chain 3; Diethylstilbestrol; Thymus; Autophagy; Epigenetics; microRNA; Hypomethylation;
Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells
Keywords: MKI; multikinase inhibitor; ALT; alanine aminotransferase; AST; aspartate aminotransferase; DRP1; dynamin-related protein 1; FIS1; mitochondrial fission 1; ROS; reactive oxygen species; DMSO; dimethylsulfoxide; AK; adenylate kinase; PBS; phosphate buffere
Calcimycin induced IL-12 production inhibits intracellular mycobacterial growth by enhancing autophagy
Keywords: M. bovisBCG; Mycobacterium bovis BCG; M. tb; Mycobacterium tuberculosis; TB; Tuberculosis; P2RX7; Purinergic receptor P2X7; Atg; Autophagy-related gene; LC3; Microtubule-associated protein 1A/1B-light chain 3; 3-MA; 3-methyladenine; Baf-A1; Bafilomycin A1
Midazolam Attenuates Autophagy and Apoptosis Caused by Ketamine by Decreasing Reactive Oxygen Species in the Hippocampus of Fetal Rats
Keywords: Atg4; autophagy-related gene 4; Bax; Bcl-2-associated X protein; Bcl-2; beclin-1, B-cell lymphoma-2; c-caspase-3; cleaved-caspase-3; LC3; autophagy marker light chain 3; MDA; malondialdehyde; ROS; reactive oxygen species; SQSTM1; Atg5, p62; T-AOC; total a
Modeling endophilin-mediated Aβ disposal in glioma cells
Keywords: AD; Alzheimer disease; Aβ; amyloid-β; GO; gene ontology; LC3; microtubule-associated protein 1A/1B-light chain 3; WT; wide-type; CTSB; cathepsin B; WB; Western blot; ELISA; Intracellular enzyme-linked immunosorbent assay; UTR; untranslated region; GEO;
STAT3 contributes to lysosomal-mediated cell death in a novel derivative of riccardin D-treated breast cancer cells in association with TFEB
Keywords: STAT3; signal transducers and activators of transcription 3; RD-N; Riccardin D-N; CTSB; cathepsin B; LMP; lysosomal membrane permeabilization; LAMP1; lysosome associated membrane protein 1; LM-PCD; lysosomal-mediated programme of cell death; AO; acridine
Galangin's potential as a functional food ingredient
Keywords: Galangin; Propolis; Alpinia officinarum; Functional food ingredient; Polypharmacology; Flavonoid; AChE; acetylcholinesterase; AD; Alzheimer's disease; ADME; Administration, Distribution, Metabolism and Excretion; AHR; airway hyperresponsive; AhR; aryl h
Mitophagy is activated in brain damage induced by cerebral ischemia and reperfusion via the PINK1/Parkin/p62 signalling pathway
Keywords: PINK1; PTEN-induced kinase 1; i.p.; intraperitoneal; CCA; common carotid artery; ECA; external carotid artery; ICA; internal carotid artery; MCAO; middle cerebral artery occlusion; H&E; haematoxylin and eosin; LC3; Microtubule-associated protein 1 light c
The mechanism of tumour cell death by metal-based anticancer drugs is not only a matter of DNA interactions
Keywords: 15-LOX-1; 15-lipoxygenase; AIF; apoptosis inducing factor; APC; adenomatous polyposis coli; AKT or PKB; protein kinase B; ATG16L2; autophagy related 16 like 2; AUC; area under the curve; Bad; Bcl-2 associated death promoter; Bcl-2; B-cell lymphoma 2; Bcl-
Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway
Keywords: IRI; ischemia/reperfusion injury; OGD/R; oxygen-glucosedeprivation/reoxygenation; H2; hydrogen; RAP; rapamycin; 3-MA; 3-methyladenine; MTT; 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; ROS; reactive oxygen species; MMP; mitochondrial mem
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology
Keywords: AMPK; 5â²AMP-activated protein kinase; LRRK2; Leucine rich repeat kinase; LAMP1; Lysosomal associated membrane protein 1; iPD; idiopathic PD; mTOR; mammalian target of rapamycin; LC3; microtubule-associated protein1A/1B light chain 3; PD; Parkinson's d
Jaboticaba peel extract decrease autophagy in white adipose tissue and prevents metabolic disorders in mice fed with a high-fat diet
Keywords: FJE; Freeze-dried jaboticaba peel extract; eWAT; Epididymal white adipose tissue; iWAT; inguinal white adipose tissue; iBAT; interscapular brown adipose tissue; MCP-1; monocyte chemoattractant protein 1; NC; Normocaloric diet; HF; High-fat diet; TNF-α; T
Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients
Keywords: Multiple sclerosis; T cells; Autophagy; ATG5; LC3; SQSTM1; TNF;
ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition
Keywords: Atg4B; Autophagy; Delipidation; FMK-9a; FRET assay; Atg4B; autophagy-related 4B; Baf; bafilomycin A1; CM; complete medium; CQ; chloroquine; EBSS; Earle's Balanced Salt Solution; FMK; fluoromethylketone; FRET; fluorescence resonance energy transfer; GABARA
Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice
Keywords: Fatty Liver; Gene Regulation; Hepatic Protection; Mouse Model; Ad; adenovirus; AH; alcoholic hepatitis; ALD; alcoholic liver disease; ALT; alanine aminotransferase; ATP6V0E1; ATPase H+ transporting V0 subunit E1; ATP6V1D; ATPase H+ transporting V1 subunit
Correlation and clinical significance of LC3, CD68+ microglia, CD4+ T lymphocytes, and CD8+ T lymphocytes in gliomas
Keywords: Glioma; LC3; CD68+ microglia; CD4+ T lymphocytes; CD8+ T lymphocytes;
The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content
Keywords: ML9; 1-(5-chloronaphthalenesulfonyl) homopiperazine hydrochloride; STIM1; stromal-interacting molecule 1; GFP; green fluorescent protein; I/R; ischemia/reperfusion; LDH; lactate dehydrogenase; MTO; MitoTracker Orange; SOCE; store-operated Ca2+ entry; Auto
Naoxintong restores collateral blood flow in a murine model of hindlimb ischemia through PPARδ-dependent mechanism
Keywords: NXT; naoxintong; PAD; peripheral vascular disease; DVT; deep veins thrombus of lower limb; VEGF; vascular endothelial growth factor; p-Akt; phosphorylated-Akt; p-eNOS; phosphorylated-endothelial nitric oxide synthase; TUNEL; Terminal deoxynucleotidyl tran
PI3K/AKT/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis
Keywords: Psoriasis; IL-17A; Autophagy; Cholesterol; S100A7; LC3; mTOR (mammalian target of rapamycin); PI3K; AKT;
The feedback loop of “EMMPRIN/NF-κB” worsens atherosclerotic plaque via suppressing autophagy in macrophage
Keywords: Atherosclerosis; Extracellular matrix metalloproteinase inducer; Macrophage autophagy; Nuclear factor kappa B; Vulnerable plaque; AMPK; Adenosine Monophosphate Activated Protein Kinase; ApoEÂ â/â; Â Apolipoprotein E-deficient; AS; atherosclerosis; CQ;
Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells
Keywords: Triazine; Eumelanogenesis; Prohibitins; MITF; LC3; ERK; Cancer; Melanoma;