کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8450539 | 1547685 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatitis B Virus X protein elevates Parkin-mediated mitophagy through Lon Peptidase in starvation
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کلمات کلیدی
PINK1LC33-MAEBSSHBxmicrotubule-associated protein 1 light chain 3BUPRmtPTEN induced putative kinase 13-methyladenine - 3-متیل آدنینHCC - HCCMitophagy - میتوفاژیhepatitis B virus X protein - هپاتیت B ویروس X پروتئینHBV - هپاتیت بhepatitis B virus - ویروس هپاتیت بیParkin - پارکینHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hepatocellular Carcinoma (HCC) is the fifth most prevalent cancer worldwide. Specially, Hepatitis B viurs X protein (HBx) is a leading factor in the progression of Hepatitis B viurs-related HCC. Nutrient-deprived tumor microenvironment also contributes to tumor development. However, the role of HBx in nutrient-deprived HCC has received little investigation. Here, we show that HBx elevates PINK1-Parkin mediating mitophagy in starvation. HBx not only increases the PINK1/Parkin gene expression but also accelerates Parkin recruitment to partial mitochondria. Further analysis indicates that, HBx either promotes mitochondrial unfolded protein response, with remarkable mitochondrial LONP1 increases, or reduces LONP1 expression in cytosol inducing LONP1-Parkin pathway, both consequently enhancing mitophagy. Moreover, the enhanced mitophagy lowers mitochondrial apoptosis in starved hepatoma cells, and Bax is implied in the machinery. In addition, we define differential centrifuge, 3000â¯g or 12,000â¯g to pellet mitochondria, as an effective method to obtain distinct mitochondria. In collect, HBx regulates diverse aspects of LONP1 and Parkin, enhancing mitophagy in starvation. This study may shed new insights into the machinery development of hepatocellular carcinoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 368, Issue 1, 1 July 2018, Pages 75-83
Journal: Experimental Cell Research - Volume 368, Issue 1, 1 July 2018, Pages 75-83
نویسندگان
Xiao-Yun Huang, Dan Li, Zhi-Xin Chen, Yue-Hong Huang, Wen-Yu Gao, Bi-Yun Zheng, Xiao-Zhong Wang,