HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis
Keywords: SIRT2; HBx; HCC;
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St6gal1 knockdown alters HBV life cycle in HepAD38 cells
Keywords: Hepatitis B virus; N-glycan; Sialylated N-glycan; Complex-type N-glycan; HBV; Hepatitis B virus; SVP; Sub-viral particle; WT; Wild-type; Tet(+); Tetracycline-supplemented; Tet(â); Tetracycline-free; ER; Endoplasmic reticulum; St6gal1; β-galactoside α2
The role of ROS-induced autophagy in hepatocellular carcinoma
Keywords: Autophagy; Hepatocellular carcinoma (HCC); Pathogenesis; Reactive oxygen species (ROS); Chemotherapy; 8-OHdG; 8-Hydroxydeoxyguanosine; FFAs; free fatty acids; HBV/HCV; hepatitis B/C virus; HBx; HBV X protein; HCC; hepatocellular carcinoma; NASH; nonalcoho
Hepatitis B Virus X protein elevates Parkin-mediated mitophagy through Lon Peptidase in starvation
Keywords: HCC; Hepatocellular Carcinoma; HBV; Hepatitis B virus; HBx; Hepatitis B Virus X protein; PINK1; PTEN Induced Putative Kinase 1; UPRmt; Mitochondrial Unfolded-Protein Response; LONP1; Lon Peptidase 1; EBSS; Earle's balance salt solution; LC3; microtubule-a
Hepatitis B virus X protein and proinflammatory cytokines synergize to enhance TRAIL-induced apoptosis of renal tubular cells by upregulation of DR4
Keywords: Chip; chromatin immunoprecipitation; DR4; death receptor-4; DR5; death receptor-5; DLR; dual luciferase reporter; HBV; hepatitis B virus; HBx; hepatitis B virus X protein; HBV-GN; HBV-associated glomerulonephritis; IFN-γ; interferon gamma; NF-κB; nuclea
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Keywords: 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous
MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma
Keywords: c-Myc/EZH2 double positive; microRNA-26a; Epigenetics modification; Metastasis; Advanced hepatocellular carcinoma; AAV; adeno-associated virus; CDK8; cyclin dependent kinase 8; CTDSP2; CTD small phosphatase 2; DEN; diethylnitrosamine; DZNep; 3-deazaneplan
Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic IGF-1 effects in HepG2 cells
Keywords: CHB; chronic hepatitis B; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular carcinoma; IGF-1; insulin-like growth factor 1; IGFBP1; insulin-like growth factor binding protein 1; STS; staurosporine; TG; thapsigargin; HBs; viral surface protei
Exosomes in virus-associated cancer
Keywords: Exosome; Onco-virus; miRNAs; Virus-associated cancer; EBV; Epstein-Barr virus; HPV; human papillomavirus; HBV; hepatitis B virus; HCV; hepatitis C virus; KSHV; Kaposi's sarcoma herpesvirus; MVBs; micro-vesicular bodies; ESCRT; endosomal sorting complexes
Hepatitis B virus upregulates host microRNAs that target apoptosis-regulatory genes in an in vitro cell model
Keywords: cFLIP; cellular FLICE-inhibitory protein; CHB; chronic hepatitis B; ER; endoplasmic reticulum; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular carcinoma; MOMP; mitochondrial outer membrane permeabilization; SODD; silencer of death domains;
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy
Keywords: Hepatitis B virus; Chronic hepatitis B; Hepadnaviridae; Vertical transmission; Viral life cycle; p22cr; 22-kDa core-related protein; anti-HBc; anti hepatitis B core protein antibodies; Alix; apoptosis linked gene II interacting protein X; ARD; arginine-ri
Downregulation of miR-200a-3p induced by hepatitis B Virus X (HBx) Protein promotes cell proliferation and invasion in HBV-infection-associated hepatocarcinoma
Keywords: Hepatocellular carcinoma; HBV; HBx; MiR-200a-3p;
Expression, purification and characterization of hepatitis B virus X protein BH3-like motif-linker-Bcl-xL fusion protein for structural studies
Keywords: Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra large; BH3; Bcl-2 homology 3; HBV; hepatitis B virus; HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; HSQC; heteronuclear single quantum coherence; BH3-like motif; Bcl-xL; Fusion pro
Linc00152 promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma
Keywords: ï¼Hepatocellular carcinoma; Linc00152; HBx; Epithelial-mesenchymal transition; EZH2;
Original ArticleHepatitis B virus X protein stimulates high mobility group box 1 secretion and enhances hepatocellular carcinoma metastasis
Keywords: Hepatitis B virus X protein; High mobility group box 1; Calmodulin dependent protein kinase; Hepatocellular carcinoma; Metastasis; HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; DAMP; damage-associated molecular pattern; HMGB1; high-mobi
Original ArticleAnti-HBV drugs suppress the growth of HBV-related hepatoma cells via down-regulation of hepatitis B virus X protein
Keywords: LdT; ETV; IFN-α2b; HCC; HBx; HCC; hepatocellular carcinoma; HBV; hepatitis B virus; HBx; hepatitis B virus X protein; HBV-Tg mice; HBV-transgenic mice; NAs; nucleos(t)ide analogues; LdT; telbivudine; ETV; entecavir; IFN-α2b; interferon-α2b; NF-κB; nuc
Comparative characterization of hepatitis B virus surface antigen derived from different hepatitis B virus genotypes
Keywords: HBV; Hepatitis B Virus; HBsAg; Hepatits B Virus surface antigen; HBcAg; Hepatitis B Virus core antigen; HBeAg; Hepatitis B Virus e antigen; L/M/SHBs; large/middle/small Hepatitis B Virus surface protein; HBx; Hepatitis B Virus regulatory protein; HBV/X; H
Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription
Keywords: Hepatitis B virus; Sirtuin; HBx; cccDNA; SIRT1;
Research articlemiR-203a is involved in HBx-induced inflammation by targeting Rap1a
Keywords: MiR-203a; HBx; Inflammation; Rap1a;
The hepatitis B virus X protein promotes pancreatic cancer through modulation of the PI3K/AKT signaling pathway
Keywords: Survival; HBx; Migration; Risk factor; PI3K/AKT signaling;
Research ArticleRandomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B
Keywords: AE; adverse event; ALT; alanine aminotransferase; Anti-HBs; hepatitis B surface antibody; AST; aspartate aminotransferase; CI; confidence interval; HBeAg; hepatitis B e antigen; HBsAg; hepatitis B surface antigen; HBV; hepatitis B virus; HBx; hepatitis B
The role of long non-coding RNAs in hepatitis B virus-related hepatocellular carcinoma
Keywords: lncRNA; HBV; HCC; HBx-LINE1; HBx
Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein
Keywords: P53 transcription; HBx; ChIP-Seq; Phosphorylation; p53 serine 315; ChIP; chromatin immunoprecipitation; HBx; hepatitis B virus X protein; IPA; ingenuity pathway analysis; LC-MS/MS; liquid chromatography-tandem mass spectrometry; MS; mass spectrometry; PLA
Oncogenic circuit constituted by Ser31-HBx and Akt increases risks of chronic hepatitis and hepatocellular carcinoma
Keywords: HBx; Akt; Phosphorylation; Hepatocellular carcinoma;
Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication
Keywords: HBV; Hepatitis B virus; HCC; Hepatocellular carcinoma; HBx; HBV X protein; cccDNA; Covalently closed circular DNA; ORF; Open reading frame; mTORC1; Mammalian target of rapamycin (mTOR) complex 1; TSC2; Tuberous-sclerosis complex-2; AMPK; AMP-activated pro
Stronger activation of SREBP-1a by nucleus-localized HBx
Keywords: HBx; SREBP-1a; Fatty acid synthase; Lipid accumulation; Cell proliferation; HBV enhancers/promoters and replication;
Hepatitis B virus X promotes hepatocellular carcinoma development via nuclear protein 1 pathway
Keywords: Hepatitis B virus X; Hepatocellular carcinoma; Vasculogenic mimicry; Cell proliferation; Migration; NUPR1; com-1; candidate for metastasis-1; DAPI 4â²; 6-diamidino-2-phenylindole; FBS; fetal bovine serum; GAPDH; Glyceraldehyde 3-phosphate dehydrogenase;
Research ArticleIntracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI level
Keywords: HBV; hepatitis B virus; HBcAg; hepatitis B core antigen; HBeAg; hepatitis B e antigen; HBx; hepatitis B x protein; HBsAg; hepatitis B surface antigen; Nrf2; NF-E2-related factor 2; MVB; multivesicular body; ESCRT; endosomal sorting complex required for tr
MicroRNA-29A/PTEN pathway modulates neurite outgrowth in PC12 cells
Keywords: DMEM; Dulbecco's Minimum Essential Medium; FBS; Fetal Bovine Serum; GAPDH; Glyceraldehyde-3-Phosphate Dehydrogenase; HBx; hepatitis B virus X; MREs; miRNA response elements; NGF; nerve growth factor; PBS; Phosphate Balanced Solution; PVDF; Polyvinylidene
HBx affects CUL4-DDB1 function in both positive and negative manners
Keywords: Hepatitis B virus; HBx; DDB1; cccDNA; PRMT1;
Hepatitis B virus X increases immune cell recruitment by induction of chemokine SDF-1
Keywords: ER stress; HBx; Immune cell recruitment; SDF-1; XBP1;
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) promotes apoptosis of HBx-positive liver cells
Keywords: 15d-PGJ2; HBx; Liver cell; Apoptosis
Ground-glass hepatocytes co-expressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis
Keywords: Ground-glass hepatocytes; Pre-S2 deletion mutant; HBx; mTOR signals; Hepatocellular carcinoma;
Hepatitis Virus Infection Affects DNA Methylation in Mice With Humanized Livers
Keywords: Epigenetic; Inflammatory Response; Liver Cancer; Gene Regulation; ESR1; estrogen receptor 1; HBV; hepatitis B virus; HBx; hepatitis B virus X; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; HOXA6; homeobox A6; IFN; interferon; MCAM; methylated CpG
15d-PGJ2 decreases PGE2 synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter
Keywords: Early growth response 1 (EGR1); Microsomal prostaglandin E synthase 1 (mPGES-1); Promoter; HBV X protein (HBx); Hepatocyte; HBV; Hepatitis B virus; HCC; hepatocellular carcinoma; HBx; HBV X protein; PGE2; prostaglandin E2; COX; cyclooxygenase; mPGES-1; mi
Sorafenib overcomes the chemoresistance in HBx-expressing hepatocellular carcinoma cells through down-regulation of HBx protein stability and suppresses HBV gene expression
Keywords: 3-MA; 3-methyladenine; AIF; apoptosis-inducing factor; BAF; Bafilomycin A1; CQ; Chloroquine; HBV; Hepatitis B virus; HBx; Hepatitis B virus X; HCC; Hepatocellular carcinoma; IFNα; interferon alpha; LC3II; dynein light chain 3; MMP; mitochondrial membrane
Research ArticleHBV core promoter mutations promote cellular proliferation through E2F1-mediated upregulation of S-phase kinase-associated protein 2 transcription
Keywords: CP; core promoter; HCC; hepatocellular carcinoma; HBx; hepatitis B virus X-protein; TA variant; A1762T/G1764A variant; Combo variant; T1753A/A1762T/G1764A/T1768A variant; WT; wild type; SKP; S-phase kinase-associated protein; PHH; primary human hepatocyte
Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1
Keywords: CAD; C-terminal transactivation domain; DEN; diethylnitrosamine; FIH-1; factor inhibiting hypoxia-inducible factor-1; firefly-luciferase; F-Luc; H&E; hematoxylin and eosin; HBX; hepatitis B virus X protein; HCC; hepatocellular carcinoma; HIF; hypoxia-indu
Research ArticleHepatitis B virus HBx protein impairs liver regeneration through enhanced expression of IL-6 in transgenic mice
Keywords: PH; partial hepatectomy; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HBx; hepatitis B virus X protein;
Hepatitis B virus X protein protects hepatoma and hepatic cells from complement-dependent cytotoxicity by up-regulation of CD46
Keywords: HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; mCRPs; membrane-bound complement regulatory proteins; CDC; complement-dependent cytotoxicity; COX-2; cyclooxygenase-2; PGE2; prostaglandin E2; CREB; cAMP response element-binding protein; RN
p21-activated kinases and gastrointestinal cancer
Keywords: AID; auto-inhibitory domain; CDK5RAP3; CDK5 kinase regulatory subunit-associated protein 3; CRC; colorectal carcinoma; EGFR; epithelial growth factor receptor; GAP; GTPase-activating protein; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular
Research ArticleSUMOylated CPAP is required for IKK-mediated NF-κB activation and enhances HBx-induced NF-κB signaling in HCC
Keywords: ChIP; chromatin immunoprecipitation assay; CPAP; centrosomal protein P4.1-associated protein; EMSA; electrophoretic mobility shift assay; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular carcinoma; ICAM-1; intercellular adhesion molecule 1;
Liver, Pancreas and Biliary TractHepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis
Keywords: ChIP; chromatin immunoprecipitation; CYP3A4; cytochrome P450 3A4; DMSO; dimethyl sulfoxide; GST; glutathione S-transferase; HBV; hepatitis B virus; HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; PCN; pregnenolone 16α carbonitrile; PXR;
An integrated proteomics and bioinformatics analyses of hepatitis B virus X interacting proteins and identification of a novel interactor apoA-I
Keywords: HBV; hepatitis B virus; HBx; hepatitis B virus X proteins; apoA-I; apolipoprotein A-I; GO; Gene Ontology; GST; glutathione S-transferase; DMPC; dimyristoyl-phosphatidylcholine; DNP; 2,4-dinitrophenylhydrazine; ELISA; enzyme-linked immunosorbent assay; HBe
DNA methyltransferase inhibitor assay system based on the HBx-induced DNA methylation of E-cadherin
Keywords: DNA methyltransferase; DNA methylation; E-cadherin; Epi-drug; HBx;
iNOS promotes HBx-induced hepatocellular carcinoma via upregulation of JNK activation
Keywords: HBx; iNOS; JNK; Hepatocellular carcinoma
Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand
Keywords: R249S; Hepatitis B virus; Hepatocellularcarcinoma; HBX
SREBP-1a activation by HBx and the effect on hepatitis B virus enhancer II/core promoter
Keywords: HBx; SREBP-1a; C/EBP; E4BP4; HBV enhancer II/core promoter; Transcription
miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A
Keywords: HCC; hepatocellular carcinoma; HBx; hepatitis B virus x; miR-101; microRNA-101; DNMT3A; DNA methyltransferase 3A; UTR; untranslated region; MSP; methylation-specific PCR; TSG; tumor-suppressor gene; GSTP1; glutathione S-transferase pi 1; RASSF1; Ras assoc
C-terminal region of HBx is crucial for mitochondrial DNA damage
Keywords: HBx; mtDNA damage; 8-Oxoguanine; 8-oxoG; C-terminal truncated HBx8-oxoG, 8-Oxoguanine; HBV, Hepatitis B virus; HBx, Hepatitis B virus X protein; HCC, Hepatocellular carcinoma; mtCYTB, Mitochondrial cytochrome B; mtDNA, Mitochondrial DNA; nDNA, Nuclear DNA