کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8522882 | 1557785 | 2018 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy
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کلمات کلیدی
ARDCHBORFscccDNAHBxNtcpHBcAgHBsAgpgRNAHBeAgHGSNLSHBcrAgrcDNArelaxed circular DNANASESCRThepatitis B x proteindsDNAHepadnaviridaedouble-stranded DNA - DNA رشته ایHCC - HCCHSPGs - HSPG هاQuasispecies - Quoospeciespregenomic RNA - RNA pregenomicAlix - آلیکسHepatitis B surface antigen - آنتی ژن سطحی هپاتیت BVertical transmission - انتقال عمودیNatural killer cells - سلولهای کشنده طبیعیHepatocyte growth factor-regulated tyrosine kinase substrate - سوسپانیت تیروزین کیناز تنظیم شده توسط عامل رشد هپاتوسیتnuclear localization signal - سیگنال محلی سازی هسته ایanti-HBc - ضد HBcOpen reading frames - فریم های خواندن را باز کنیدHepatitis B e antigen - هپاتیت B آنتی ژنchronic hepatitis B - هپاتیت B مزمن، هپاتیت ب مزمنhepatitis B core antigen - هپاتیت B هسته آنتی ژنHBV - هپاتیت بhepatitis B virus - ویروس هپاتیت بیheparan sulfate proteoglycans - پروپوگلیکان های سولفات heparanViral life cycle - چرخه عمر ویروسیHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The hepatitis B virus (HBV) is the prototype member of the Hepadnaviridae, an ancient family of hepatotropic DNA viruses, which may have originated from 360 to 430 million years ago and with evidence of endogenization in reptilian genomes >200 million years ago. The virus is currently estimated to infect more than 250 million humans. The extremely successful spread of this pathogen among the human population is explained by its multiple particulate forms, effective transmission strategies (particularly perinatal transmission), long induction period and low associated mortality. These characteristics confer selective advantages, enabling the virus to persist in small, disperse populations and spread worldwide, with high prevalence rates in many countries. The HBV replication strategy is remarkably complex and includes a multiplicity of particulate structures. In addition to the common virions containing DNA in a relaxed circular (rcDNA) or double-stranded linear (dslDNA) forms, the viral population includes virion-like particles containing RNA or “empty” (viral envelopes and capsids without genomes), subviral particles (only an envelope) and even naked capsids. Consequently, several forms of the genome coexist in a single infection: (i) the “traveler” forms found in serum, including rcDNA and dslDNA, which originate from retrotranscription of a messenger RNA (the pregenomic RNA, another form of the viral genome itself) and (ii) forms confined to the host cell nucleus, including covalently closed circular DNA (cccDNA), which leads to a minichromosome form associated with histones and viral proteins, and double-stranded DNA integrated into the host genome. This complex composition lends HBV a kind of “multiple personality”. Are these additional particles and genomic forms simple intermediaries/artifacts or do they play a role in the viral life cycle?
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 158, October 2018, Pages 34-44
Journal: Antiviral Research - Volume 158, October 2018, Pages 34-44
نویسندگان
Andrea Caballero, David Tabernero, Maria Buti, Francisco Rodriguez-Frias,