کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8260174 | 1534658 | 2014 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of resveratrol on mitochondrial function: Implications in parkin-associated familiar Parkinson's disease
ترجمه فارسی عنوان
تاثیر رزوراترول بر عملکرد میتوکندری: پیامدهای مرتبط با بیماری پارکینسون آشنا با پارکینس
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کلمات کلیدی
Sirt1NAD-dependent deacetylase sirtuin-1CIVOCRsirtuin 1SOD2CIITFAMPGC-1αLC3DNPdichlorodihydrofluoresceinPINK1MPTP6-HydroxydopamineGAPDHAMPKCATDcf6-OHDAOXPHOSCOXAMP activated protein kinase - AMP پروتئین کیناز فعال شده استcAMP - cAMPDMSO - DMSOPTEN-induced putative kinase 1 - PTEN-induced kinase assay 1ROS - ROSCyclic adenosine monophosphate - آدنوزین مونوفسفات CyclicParkinson's disease - بیماری پارکینسونdinitrophenol - دینیتروفنلDimethyl sulfoxide - دیمتیل سولفواکسیدResveratrol - رسوراترولRespiratory chain - زنجیر تنفسیMitochondrial superoxide dismutase - سوپراکسید دیسموتاز میتوکندریcytochrome c oxidase - سیتوکروم سی اکسیدازOxidative phosphorylation system - سیستم فسفوریلاسیون اکسیداتیوmitochondrial transcription factor A - عامل رونویسی میتوکندری AComplex I - مجتمع IComplex IV - مجتمع IVComplex II - مجتمع دومMitochondria - میتوکندریاOxygen consumption rates - میزان مصرف اکسیژنNAD - نادانnicotinamide adenine dinucleotide - نیکوتین آمید adenine dinucleotideParkin - پارکینCatalase - کاتالازglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژنازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Mitochondrial dysfunction and oxidative stress occur in Parkinson's disease (PD), but the molecular mechanisms controlling these events are not completely understood. Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) is a transcriptional coactivator known as master regulator of mitochondrial functions and oxidative metabolism. Recent studies, including one from our group, have highlighted altered PGC-1α activity and transcriptional deregulation of its target genes in PD pathogenesis suggesting it as a new potential therapeutic target. Resveratrol, a natural polyphenolic compound proved to improve mitochondrial activity through the activation of several metabolic sensors resulting in PGC-1α activation. Here we have tested in vitro the effect of resveratrol treatment on primary fibroblast cultures from two patients with early-onset PD linked to different Park2 mutations. We show that resveratrol regulates energy homeostasis through activation of AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) and raise of mRNA expression of a number of PGC-1α's target genes resulting in enhanced mitochondrial oxidative function, likely related to a decrease of oxidative stress and to an increase of mitochondrial biogenesis. The functional impact of resveratrol treatment encompassed an increase of complex I and citrate synthase activities, basal oxygen consumption, and mitochondrial ATP production and a decrease in lactate content, thus supporting a switch from glycolytic to oxidative metabolism. Moreover, resveratrol treatment caused an enhanced macro-autophagic flux through activation of an LC3-independent pathway. Our results, obtained in early-onset PD fibroblasts, suggest that resveratrol may have potential clinical application in selected cases of PD-affected patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 7, July 2014, Pages 902-915
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 7, July 2014, Pages 902-915
نویسندگان
Anna Ferretta, Antonio Gaballo, Paola Tanzarella, Claudia Piccoli, Nazzareno Capitanio, Beatrice Nico, Tiziana Annese, Marco Di Paola, Claudia Dell'Aquila, Michele De Mari, Ermanno Ferranini, Vincenzo Bonifati, Consiglia Pacelli, Tiziana Cocco,