Keywords: Guatteria latifolia; Leishmania amazonensis; Leishmanicidal activity;
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Keywords: Leishmaniosis; Leishmania amazonensis; Trypanosomatids; Metabolic pathway enzymes inhibitors; Dihydroorotate dehydrogenase
Keywords: Leishmania amazonensis; Chemotherapy; Drug resistance; TamoxifenTM, tamoxifen; MNNG, N-methyl-N-nitroso-N′-nitroguanidine; MT, miltefosine transporter; PBS, phosphate buffered solution; NBD-PC, 2-(6-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl-1-hexa
Keywords: Asc; ascaridole; Car; carvacrol; Caryo; caryophyllene oxide; DMPO; 5,5-dimethyl-1-pyrroline-N-oxide; DMSO; dimethyl sulfoxide; DPPH; 2,2-diphenyl-1-picrylhydrazyl; EO; essential oil; ESR; electron spin resonance; FIC; fractional inhibitory concentration;
Keywords: Quinoxaline derivatives; Leishmania amazonensis; Trypanosoma cruzi; Anti-trypanosomatid agentsT. cruzi, Trypanosoma cruzi; L. amazonensis, Leishmania amazonensis; IC, inhibitory concentration; EC, effetive concentration; SI, selective index; CC, cytotoxic
Keywords: Dipteryx alata; Jacaranda cuspidifolia; Murine macrophage; Leishmania amazonensis; Promastigotes; Amastigotes;
Keywords: Leishmania amazonensis; Lupane; Liposomes; Macrophages;
Keywords: Antileishmanial activity; Leishmania braziliensis; Leishmania amazonensis; Tetrazole;
Keywords: Flavonoids; Lantana balansae; Leishmania amazonensis; L. braziliensis; 12-oxo-phytodienoic acid
Effects of nanoemulsions prepared with essential oils of copaiba- and andiroba against Leishmania infantum and Leishmania amazonensis infections
Keywords: Leishmania infantum; Leishmania amazonensis; Copaiba; Andiroba; Nanoemulsions;
Caryocar coriaceum extracts exert leishmanicidal effect acting in promastigote forms by apoptosis-like mechanism and intracellular amastigotes by Nrf2/HO-1/ferritin dependent response and iron depletion
Keywords: AMB; amphotericin B; CBA; cytometric bead array; DMSO; dimethyl sulfoxide; EAC; ethyl acetate leaf extract; FBS; fetal bovine serum; FPR; free promastigote recovery; FSC-H; forward scatter-height; H2DCFDA; diacetate 2â²,7â²-dichlorofluorescein probe; HO
Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity
Keywords: %GI; percentage of parasite growth inhibition at 100â¯Î¼M; GI50; 50% growth inhibition concentration; Bnz; benznidazole; MW; microwave; NA; not active at the tested concentration; ND; not determined due to absence of trypanocidal activity; SI; selectivit
Implications of the use of serological and molecular methods to detect infection by Leishmania spp. in urban pet dogs
Keywords: Leishmania braziliensis; Leishmania amazonensis; Leishmania infantum; Dogs; Serological assays;
Inhibition of Leishmania amazonensis arginase by fucogalactan isolated from Agrocybe aegerita mushroom
Keywords: Agrocybe aegerita; Fucogalactan; Chemical structure; Leishmania amazonensis; Arginase; Competitive inhibitor;
Therapeutic vaccine of killed Leishmania amazonensis plus saponin reduced parasite burden in dogs naturally infected with Leishmania infantum
Keywords: Immunotherapy; Canine visceral leishmaniosis; Leishmania amazonensis; Saponin;
Synthesis, antileishmanial activity and mechanism of action studies of novel β-carboline-1,3,5-triazine hybrids
Keywords: β-carboline; 1,3,5-Triazine; Antileishmanial; Leishmania amazonensis; Cell death mechanism;
The potent cell permeable calpain inhibitor MDL28170 affects the interaction of Leishmania amazonensis with macrophages and shows anti-amastigote activity
Keywords: Leishmaniasis; Leishmania amazonensis; Calpain inhibitor; Interaction process; Intracellular amastigotes;
Antileishmanial activity of verbascoside: Selective arginase inhibition of intracellular amastigotes of Leishmania (Leishmania) amazonensis with resistance induced by LPS plus IFN-γ
Keywords: Leishmania amazonensis; Polyamines; Arginase; Nitric oxide; Verbascoside;
Full length articleAnti-Leishmania activity of essential oil of Myracrodruon urundeuva (Engl.) Fr. All.: Composition, cytotoxity and possible mechanisms of action
Keywords: Myracrodruon urundeuva; Anti-Leishmania activity; Leishmania amazonensis; Cytotoxity; Essential oil; IC50; Half-maximal inhibitory concentration; CC50; Half-maximal cytotoxicity concentration; HC50; Half-maximal hemolytic concentration; MIC; Minimum inhib
Research paperA recombinant fusion protein displaying murine and human MHC class I- and II-specific epitopes protects against Leishmania amazonensis infection
Keywords: Tegumentary leishmaniasis; Polypeptide vaccine; Th1 immune response; CD4+ T cells; CD8+ T cells; Leishmania amazonensis;
High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro
Keywords: Leishmania amazonensis; Macrophage; Cytokine; Antimonium crudum;
The photodynamic action of pheophorbide a induces cell death through oxidative stress in Leishmania amazonensis
Keywords: AA; antimycin A; CCCP; cyanide m-chlorophenylhydrazone; DAF-FM diacetate; 4-amino-5-methylamino-2â²,7â²-difluoro fluoresceÃn; DMSO; dimethylsulfoxide; DPPP; diphenyl-1-pyrenylphosphine; DTNB; 2,2â²-dinitro-5,5â²-dithiobenzoic acid; FBS; fetal bovine
Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis
Keywords: Natural product analogues; Drug design; Isoxazole; Trypanosoma cruzi; Leishmania amazonensis; Trypanothione reductase; %GI; percentage of growth inhibition; AB; amphotericin B; BZN; benznidazol; logP; partition coefficient octanol/water; MW; microwave; ND
A calmodulin-like protein (LCALA) is a new Leishmania amazonensis candidate for telomere end-binding protein
Keywords: Leishmania amazonensis; Telomere end-binding protein; Telomerase; Calcium; Calmodulin;
Consequences of acute oxidative stress in Leishmania amazonensis: From telomere shortening to the selection of the fittest parasites
Keywords: Leishmania amazonensis; Oxidative stress; Telomere shortening; LaRPA-1; DNA repair;
Full length articleAminoquinoline compounds: Effect of 7-chloro-4-quinolinylhydrazone derivatives against Leishmania amazonensis
Keywords: Leishmania amazonensis; 4-Aminoquinoline derivatives; Quinolinylhydrazone derivatives; Mitochondrial dysfunction;
Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex
Keywords: Leishmania amazonensis; Central nervous system; Cytokines; Anxiety; Neurotrophic factors;
C5 induces different cell death pathways in promastigotes of Leishmania amazonensis
Keywords: Leishmania amazonensis; β-carboline; Oxidative damage; Cell death
Full length articlePoloxamer 407 (Pluronic® F127)-based polymeric micelles for amphotericin B: In vitro biological activity, toxicity and in vivo therapeutic efficacy against murine tegumentary leishmaniasis
Keywords: Amphotericin B; Poloxamer 407; Toxicity; Tegumentary leishmaniasis; Treatment; Leishmania amazonensis;
In vivo near-infrared fluorescence imaging of Leishmania amazonensis expressing infrared fluorescence protein (iRFP) for real-time monitoring of cutaneous leishmaniasis in mice
Keywords: Leishmania amazonensis; iRFP; BALB/c mouse; Cutaneous leishmaniasis; Near-infrared molecular imaging;
Structural and dynamic insights into the C-terminal extension of cysteine proteinase B from Leishmania amazonensis
Keywords: C-Terminal extension of cysteine proteinase B; Leishmania amazonensis; Protein structure prediction; Molecular dynamics;
Antileishmanial activity and mechanism of action from a purified fraction of Zingiber officinalis Roscoe against Leishmania amazonensis
Keywords: Antileishmanial activity; Zingiber officinalis Roscoe; Leishmania amazonensis; Treatment; Nitric oxide; Purified compounds;
Inhibitory effects promoted by 5â²-nucleotides on the ecto-3â²-nucleotidase activity of Leishmania amazonensis
Keywords: Leishmania amazonensis; Ecto-3â²-nucleotidase; Extracellular nucleotides; 3â²-AMP; 5â²-GMP; Uncompetitive inhibition;
IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms
Keywords: IL-18; Leishmania amazonensis; Macrophage; Leishmaniasis;
Synthesis and biological evaluation of novel piperidine-benzodioxole derivatives designed as potential leishmanicidal drug candidates
Keywords: Leishmaniasis; Piperine; Leishmanicidal activity; Leishmania amazonensis; Medicinal chemistry;
Antileishmanial activity and trypanothione reductase effects of terpenes from the Amazonian species Croton cajucara Benth (Euphorbiaceae)
Keywords: Leishmania amazonensis; Terpenes; trans-Deydrocrotonin; Croton cajucara; Macrophage; Antiprotozoal activityAnal. calc., analysis calculated; FCS, fetal calf serum; IC50, half-maximal inhibitory concentration; IC50 ± SD, half-maximal inhibitory concentrati
Antileishmanial activity of standardized fractions of Stryphnodendron obovatum (Barbatimão) extract and constituent compounds
Keywords: RBCs, red blood cells; OF, organic fraction; AF, aqueous fraction; GA, gallic acid; EGC, epigallocatechin; C, catechin; GC, gallocatechin; EGCG, epigallocatechin gallateCerrado; Tannins; Gallic acid; Gallocatechin; Antioxidant; Leishmania amazonensis
The pentavalent antimonial therapy against experimental Leishmania amazonensis infection is more effective under the inhibition of the NF-κB pathway
Keywords: Leishmania amazonensis; Antimonial therapy; TNF-α inhibition; IL-1β; Nitric oxide; Immune response
Leishmanicidal activity of lipophilic extracts of some Hypericum species
Keywords: Hypericum species; Leishmaniasis; Leishmania amazonensis; Leishmanicidal activity;
A putative role for inosine 5â² monophosphate dehydrogenase (IMPDH) in Leishmania amazonensis programmed cell death
Keywords: Leishmania amazonensis; IMPDH; Ribavirin; Mycophenolic acid (MPA); Apoptosis-like programmed cell death;
In vitro evaluation of (−)α-bisabolol as a promising agent against Leishmania amazonensis
Keywords: (−)α-bisabolol; Leishmania amazonensis; Promastigotes; Cutaneous leishmaniasis
E-NTPDase (ecto-nucleoside triphosphate diphosphohydrolase) of Leishmania amazonensis inhibits macrophage activation
Keywords: Leishmania amazonensis; E-NTPDase; Adenosine; Nitric oxide; Cytokines;
Novel 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones: Synthesis and antileishmanial effects against Leishmania amazonensis
Keywords: Leishmania amazonensis; Promastigotes; Amastigotes; Thiosemicarbazones;
Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds
Keywords: Prenylated chalcone; Leishmanicidal activity; Trypanocidal activity; Leishmania amazonensis; Leishmania infantum; Trypanosoma cruzi; Drug discovery;
High selective antileishmanial activity of vanadium complex with stilbene derivative
Keywords: Leishmania amazonensis; Vanadium complex; Stilbenes; Mitochondrial dysfunction; Nitric oxide;
The effect of the phytol-rich fraction from Lacistema pubescens against Leishmania amazonensis is mediated by mitochondrial dysfunction
Keywords: Lacistema pubescens; Phytol; Leishmania amazonensis; Antileishmanial activity; Mitochondrial dysfunction;
Synthesis of poinsettifolin A
Keywords: Prenylated flavonols; Poinsettifolin A; Leishmania amazonensis; Leishmania braziliensis; Cytotoxicity;
Leishmania amazonensis: Characterization of an ecto-pyrophosphatase activity
Keywords: Ecto-PPase; ecto-pyrophosphatase; Pi; inorganic phosphate; PPi; pyrophosphate; PPase; pyrophosphatase; sPPase; soluble pyrophosphatase; Leishmania amazonensis; Ecto-pyrophosphatase; Inorganic pyrophosphate;
In vitro and in vivo antileishmania activity of sesquiterpene lactone-rich dichloromethane fraction obtained from Tanacetum parthenium (L.) Schultz-Bip
Keywords: Leishmania amazonensis; Phytochemical; Leishmaniasis;
Functional properties and stability of spray-dried pigments from Bordo grape (Vitis labrusca) winemaking pomace
Keywords: Encapsulation; Spray drying; Anthocyanin; Antimicrobial activity; Leishmania amazonensis;