Keywords: کانال یون لیگاند دار; Toxins; Pharmacology; Neuronal; Voltage-gated ion channel; Ligand-gated ion channel; Receptor;
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Keywords: کانال یون لیگاند دار; AM; adrenomedulin; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMY; amylin; AT; angiotensin type; β-CCT; beta-carboline-3-carboxylate-t-butyl ester; CT; calcitonin; CTR; calcitonin receptor; CLR; calcitonin receptor-like receptor; DZ; di
Keywords: کانال یون لیگاند دار; ZAC; zinc-activated channel; LGIC; ligand-gated ion channel; nACh; nicotinic acetylcholine; 5-HT; 5-hydroxytryptamine; GFP; green fluorescent protein; MOPS; 10 3-(N-morpholino)propanesulfonic acid; CTR1; high affinity copper uptake protein 1; GLIC; Gloeob
Keywords: کانال یون لیگاند دار; Single molecule fluorescence imaging; Protein tracking; P2X1; 5HT3; Fluorescence; LGIC; Ligand-gated ion channel; GPCR G-protein coupled receptor; Molecular machine; Stochastic;
Keywords: کانال یون لیگاند دار; ACh; acetylcholine; IACh; acetylcholine-elicited current; LA; local anaesthetic; LGIC; ligand-gated ion channel; nAChR; nicotinic acetylcholine receptor; QX-222; 2-(trimethylammonio)-N-(2,6-dimethylphenyl) acetamide chloride; QX-314; 2-(triethylammonio)-N
Optimising the transient expression of GABA(A) receptors in adherent HEK293 cells
Keywords: کانال یون لیگاند دار; GABAA receptor; Ligand-gated ion channel; Transient expression; HEK293; IMP; integral membrane protein; BacMam; baculovirus infection of mammalian cells; CaP; calcium phosphate; PEI; polyethyleneimine; SV40; Simian vacuolating virus 40; SV40-ori; SV40 ori
Auxiliary subunits of AMPA receptors: The discovery of a forebrain-selective antagonist, LY3130481/CERC-611
Keywords: کانال یون لیگاند دار; ABHD6; alpha/beta-hydrolase domain-containing protein 6; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionate; CKAMP; cystine-knot AMPAR modulating protein; CNIH; cornichon; CPT1c; carnitine palmitoyltransferase 1C; FRRS1L; ferric chelate reductase 1-
Molecular characterization and expression pattern of three GABA receptor-like subunits in the small brown planthopper Laodelphax striatellus (Hemiptera: Delphacidae)
Keywords: کانال یون لیگاند دار; GABA; γ-aminobutyric acid; LGIC; ligand-gated ion channel; TM; transmembrane; nAchR; nicotinic acetylcholine receptor; GPCR; G protein-coupled receptor; RDL; resistance to dieldrin; LCCH3; ligand-gated chloride channel homolog 3; GRD; GABA and glycine re
A possible desensitized state conformation of the human α7 nicotinic receptor: A molecular dynamics study
Keywords: کانال یون لیگاند دار; Epibatidine; Ligand-gated ion channel; Homology modeling; Molecular dynamics; Desensitized state;
Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells
Keywords: کانال یون لیگاند دار; Neural induction; Neural progenitor cells; hiPSC; Electron microscopy; Patch clamp; 2D-3D neural induction; AD; Alzheimer's disease; AQP4; Aquaporin 4; ASD; Autism spectrum disorder; bFGF; Basic Fibroblast Growth Factor; CNS; Central Nervous System; D; Da
The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors
Keywords: کانال یون لیگاند دار; Antidepressant; Bupropion; Hydroxybupropion; 5-HT3A receptors; Pentameric ligand-gated ion channels; 5-HT3AR; 5-hydroxytryptamine type 3A receptor; 5-HT; 5-hydroxytryptamine; ACh; acetylcholine; α-BgTx; α-bungarotoxin; CNS; central nervous system; DA; d
Molecular mechanisms of LL-37-induced receptor activation: An overview
Keywords: کانال یون لیگاند دار; AMP; antimicrobial peptide; APD; antimicrobial peptide database; IFN; interferon; DC; dendritic cell; NK-cells; natural killer cells; GPCR; G protein-coupled receptor; RTK; receptor tyrosine kinase; LGIC; ligand-gated ion channel; TLR; toll-like receptor;
Invited reviewInvestigating ion channel conformational changes using voltage clamp fluorometry
Keywords: کانال یون لیگاند دار; Fluorescence; Voltage clamp; Ion channel; Conformational change; Protein structure; 6TM; 6 transmembrane; fUAA; fluorescent unnatural amino acid; GABAAR; GABA A-type receptor; GlyR; glycine receptor; LGIC; ligand-gated ion channel; MTS; methanethiosulphon
The coupling interface and pore domain codetermine the single-channel activity of the α7 nicotinic receptor
Keywords: کانال یون لیگاند دار; Nicotinic receptor; Patch-clamp; Channel gating; Channel coupling; nAChR; nicotinic acetylcholine receptor; ACh; acetylcholine; α-BTX; alpha-bungarotoxin; LGIC; ligand-gated ion channel; 5-HT3R; serotonin receptor type 3; GABAR; γ-aminobutyric acid rece
Flexible subunit stoichiometry of functional human P2X2/3 heteromeric receptors
Keywords: کانال یون لیگاند دار; Heteromeric P2X receptors; P2X2/3 receptors; Subunit stoichiometry; Mutagenesis; 2-MeSATP; 2-methylthio ATP; ASIC; acid-sensing ion channel; BN-PAGE; blue native PAGE; DRG; dorsal root ganglion; EC50; half maximal effective concentration; FR; fluorescent
Inflammation-induced increase in nicotinic acetylcholine receptor current in cutaneous nociceptive DRG neurons from the adult rat
Keywords: کانال یون لیگاند دار; AITC; allyl isothiocyanate; ANOVA; analysis of variance; Cap; capsaicin; CFA; complete Freund's adjuvant; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²-tetramethylindocarbocyanine perchlorate; DMSO; dimethyl sulfoxide; DRG; dorsal root ganglion; EGTA; ethylene
The discovery of diazepinone-based 5-HT3 receptor partial agonists
Keywords: کانال یون لیگاند دار; 5-HT3 receptor partial agonist; Irritable bowel syndrome (IBS); Ligand-gated ion channel; Ramosetron; Alosetron; Diazepinone;
Pharmacological characterisation of α6β4⁎ nicotinic acetylcholine receptors assembled from three chimeric α6/α3 subunits in tsA201 cells
Keywords: کانال یون لیگاند دار; Nicotinic; α6; α6*; α6β4; Ligand-gated ion channel; Cys-loop receptor
Carbamazepine derivatives with P2X4 receptor-blocking activity
Keywords: کانال یون لیگاند دار; Heterocycles; Inflammation; Ligand-gated ion channel; Negative allosteric modulator; Neuropathic pain; P2X4 receptor; Structure-activity relationship; Synthesis; Tricyclics;
Characterization of cys-loop receptor genes involved in inhibitory amine neurotransmission in parasitic and free living nematodes
Keywords: کانال یون لیگاند دار; LGIC; ligand-gated ion channel; LGCC; ligand-gated chloride channel; nAChR; nicotinic acetylcholine receptor; cDNA; copy DNA; RT-PCR; reverse-transcription polymerase chain reaction; RACE; rapid amplification of cDNA ends; TM; transmembrane; bp; base pair
New insights in endogenous modulation of ligand-gated ion channels: Histamine is an inverse agonist at strychnine sensitive glycine receptors
Keywords: کانال یون لیگاند دار; Glycine; Histamine; Modulation; Ligand-gated ion channel; Endogenous modulator; Competitive antagonist
N3,N7-diaminophenothiazinium derivatives as antagonists of α7-nicotinic acetylcholine receptors expressed in Xenopus oocytes
Keywords: کانال یون لیگاند دار; ACh; acetylcholine; BAPTA; 1,2-bis(o-aminophenoxy) ethane-N,N,Nâ²,Nv-tetraacetic acid; HEPES; 4-(2-hydroxyethyl) piperazineethanesulfonic acid; LGIC; ligand-gated ion channel; nAChR; nicotinic acetylcholine receptor; Phenothiazines; Diaminophenothiaziniu
Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists
Keywords: کانال یون لیگاند دار; Vanilloid receptor; Ligand-gated ion channel; TRPV1; Pain; Indolizine; Pyrrolopyridazine;
Upregulation of high-affinity GABAA receptors in cultured rat dorsal root ganglion neurons
Keywords: کانال یون لیگاند دار; primary afferent; presynaptic inhibition; nociceptor; ligand-gated ion channel; protein trafficking; DRG; dorsal root ganglia; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; MEM; minimal essential media; sqRt-PCR; semiquantitative reverse tran
Chemotography for multi-target SAR analysis in the context of biological pathways
Keywords: کانال یون لیگاند دار; GPCR; G-protein coupled receptor; LGIC; ligand-gated ion channel; SAR; structure-activity relationship; Chemical space; Color; Visualization; Molecular fingerprints; Chemogenomics; Systems pharmacology; Molecular pathways;
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome
Keywords: کانال یون لیگاند دار; 5-HT3 receptor partial agonist; Irritable bowel syndrome; IBS; Ligand-gated ion channel; Ramosetron; Alosetron; Indole; Indazole;
Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization
Keywords: کانال یون لیگاند دار; Acetylcholine receptor; Ligand-gated ion channel; Nicotinic receptor; Positive allosteric modulator;
Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor
Keywords: کانال یون لیگاند دار; GABAA receptor; Benzodiazepine efficacy; Oocyte expression; Allosteric modulation; Pentobarbital; GABA; BZD; benzodiazepine; GABAR; GABA-A receptor; MTSEA-Biotin; N-biotinaminoethyl methanethiosulfonate; MTSES; 2-sulfonatoethyl methanethiosulfonate; DMCM;
Characterization of a novel tyramine-gated chloride channel from Haemonchus contortus
Keywords: کانال یون لیگاند دار; BP; base pairs; cDNA; copy DNA; LGCC; ligand-gated chloride channel; LGIC; ligand-gated ion channel; ML; macrocyclic lactone; RACE; rapid amplification of cDNA ends; SL; spliced leader; SNP; single nucleotide polymorphism; UTR; untranslated region; qRT-PC
Functional interactions between nicotinic and P2X receptors in celiac ganglia neurons
Keywords: کانال یون لیگاند دار; Ion channels; Protein interactions; ATP; Acetylcholine; Ionotropic receptors; Ligand-gated ion channel; Sympathetic neurons; Electrophysiology
Identification and experimental verification of a novel family of bacterial cyclic nucleotide-gated (bCNG) ion channels
Keywords: کانال یون لیگاند دار; Ligand-gated ion channel; Cyclic nucleotide-gated (CNG) channel; Bacterial ion channel; Data mining; Membrane proteins
Binding of [3H]A-778317 to native transient receptor potential vanilloid-1 (TRPV1) channels in rat dorsal root ganglia and spinal cord
Keywords: کانال یون لیگاند دار; TRPV1; Ligand-gated ion channel; Dorsal root ganglia; Spinal cord; Vanilloid; Resiniferatoxin
Native glycine receptor subtypes and their physiological roles
Keywords: کانال یون لیگاند دار; Chloride channel; Inhibitory synaptic transmission; Ligand-gated ion channel; Cys-loop receptor;
Antagonism of recombinant and native GluK3-containing kainate receptors
Keywords: کانال یون لیگاند دار; Ligand-gated ion channel; Glutamate receptor; Kainate receptor; Hippocampus; Mossy fibre; Presynaptic receptor;
Importance of the C-terminus of the human 5-HT3A receptor subunit
Keywords: کانال یون لیگاند دار; LGIC; 5-HT3A receptor 5-HT3A receptor subunit; C-terminus; Protein folding and stability; HEK; human embryonic kidney; LGIC; ligand-gated ion channel; nAChR; nicotinic acetylcholine receptor; 5-HT; 5-hydroxytryptamine;
Comparative models of P2X2 receptor support inter-subunit ATP-binding sites
Keywords: کانال یون لیگاند دار; Ligand-gated ion channel; P2X receptor; ATP; Purinergic; Gating; ASIC; Comparative modeling; Secondary structure predictions
5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function
Keywords: کانال یون لیگاند دار; Ligand-gated ion channel; Cys-loop receptor; Serotonin receptor; Partial agonist; Binding site; Homology model;
Expression of the GABAA receptor γ4-subunit gene in discrete nuclei within the zebra finch song system
Keywords: کانال یون لیگاند دار; behavioral learning; development; inhibitory neurotransmitter receptor; ligand-gated ion channel; robust nucleus of the arcopallium; song system-specific markercDNA, complementary DNA; DLM, medial nucleus of the dorsolateral thalamus; Hb, habenula; HD, de
Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function
Keywords: کانال یون لیگاند دار; NMDA receptor; Glutamate receptor; Agonist binding; Ligand-gated ion channel; Glycine binding site
Human glycine α1 receptor inhibition by quercetin is abolished or inversed by α267 mutations in transmembrane domain 2
Keywords: کانال یون لیگاند دار; Que, quercetin; TM2, transmembrane domain 2Flavonoid; Quercetin; Glycine; Glycine receptor; Ligand-gated ion channel; Xenopus oocytes
Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system
Keywords: کانال یون لیگاند دار; Capsaicin; Anandamide; Protons; TRPV1 (transient receptor potential vanilloid 1); Ligand-gated ion channel; Pain
Neuroactive steroids and affective disorders
Keywords: کانال یون لیگاند دار; Antidepressants; CCK-4; Electroconvulsive therapy; GABAA-receptor; Ligand-gated ion channel; Neurosteroids; Panic disorder; Partial sleep deprivation; Transcranial magnetic stimulation;
Keynote review: Allosterism in membrane receptors
Keywords: کانال یون لیگاند دار; Biochemistry; Biotechnology; Drug Discovery; Pharmaceutical Science; G protein-coupled receptors; ligand-gated ion channel; tyrosine kinase receptors; allosteric enhancer; guanylate cyclase receptor; transmembrane helix;
Co-expression of the 5-HT3B subunit with the 5-HT3A receptor reduces alcohol sensitivity
Keywords: کانال یون لیگاند دار; Neurotransmitters, modulators, transporters, and receptors; Serotonin receptors; 5-HT3A; 5-HT3A/B; Ligand-gated ion channel; Ethanol; Trichloroethanol;
A yellow fluorescent protein-based assay for high-throughput screening of glycine and GABAA receptor chloride channels
Keywords: کانال یون لیگاند دار; Ligand-gated ion channel; YFP; GFP; Green fluorescent protein; Drug discovery;
Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist
Keywords: کانال یون لیگاند دار; Suramin analogue; Recombinant P2X receptors; Xenopus oocytes; Two-electrode voltage-clamp electrophysiology; Antagonistic profile; Ligand-gated ion channel; αβmeATP; α,β-methyleneadenosine 5â²-trisphosphate lithium salt; rP2X; rat P2X; TNP-ATP; trini
Ethanol differentially affects ATP-gated P2X3 and P2X4 receptor subtypes expressed in Xenopus oocytes
Keywords: کانال یون لیگاند دار; Purinergic receptors; P2X3 receptors; P2X4 receptors; Xenopus oocytes; Adenosine 5â²-triphosphate-gated receptors; Ethanol; Ligand-gated ion channel;