Keywords: میکروسومهای کبدی; CLint; Intrinsic hepatic clearance; HLM; Human liver microsomes; LC/MS/MS; Liquid chromatography tandem mass spectrometry; LC/UV/RAD; Liquid chromatography/ultraviolet/radioactive detection; MRM; Multiple reaction monitoring; NADPH; Nicotinamide adenine d
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Keywords: میکروسومهای کبدی; Dictamnine; Metabolism; Liver microsomes; CYP450; Mass spectrometry
Keywords: میکروسومهای کبدی; Antiandrogenic activity; Carbaryl; Estrogenic activity; Liver microsomes; Methiocarb; Methiocarb sulfoxide; Plasma
Keywords: میکروسومهای کبدی; Asarone; Liver microsomes; Metabolism; Carcinogenicity; Phenylpropanoid; Alkenylbenzene;
Keywords: میکروسومهای کبدی; Epoxy-eicosatrienoic acids; Angiogenesis; Liver microsomes; High throughput screening; Di-substituted ureas;
A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes
Keywords: میکروسومهای کبدی; Angiotensin II type 2 receptor antagonists; AT2R antagonists; Sulfonyl carbamates; Transesterification; Liver microsomes;
Interaction between 3,4âdichlorophenylâpropenoylâsec.âbutylamine (3,4âDCPB), an antiepileptic drug, and cytochrome P450 in rat liver microsomes and recombinant human enzymes in vitro
Keywords: میکروسومهای کبدی; 3,4âdichlorophenylâpropenoylâsec.âbutylamine (3,4âDCPB); Antiepileptic drug; Cytochrome P450 (CYP450); Liver microsomes; Recombinant enzymes;
Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes
Keywords: میکروسومهای کبدی; Mouse; Cytochrome P450; Liver microsomes; Liver lobe differences; AhR; aryl hydrocarbon receptor; Alas1; delta-aminolevulinate synthase 1; BCA; bicinchoninic acid; BSA; bovine serum albumin; CAR; constitutive androstane receptor; CPR; cytochrome P450 redu
Involvement of UDP-glucuronosyltransferases in higenamine glucuronidation and the gender and species differences in liver
Keywords: میکروسومهای کبدی; Higenamine; UGT1A9; Liver microsomes; Glucuronidation; Species;
Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human
Keywords: میکروسومهای کبدی; Monoamine oxidase B; Aldehyde oxidase; Iminium ion; Piperazine; Metabolism; In vitro in vivo extrapolation; Hepatocyte; Liver microsomes;
Screening and identiï¬cation of the main metabolites of 2-amino-9H-pyrido[2,3-b]indole (AαC) in liver microsomes and rat urine by using UPLC-Q-TOF-MS/MS
Keywords: میکروسومهای کبدی; ï¼UPLC-Q-TOF-MS/MS; 2-Amino-9H-pyrido[2,3-b]indole; Metabolites; Liver microsomes; Rat urine;
Environmentally relevant organophosphate triesters in herring gulls: In vitro biotransformation and kinetics and diester metabolite formation using a hepatic microsomal assay
Keywords: میکروسومهای کبدی; In vitro biotransformation; Organophosphate esters; Herring gull; Liver microsomes; Metabolism
Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4
Keywords: میکروسومهای کبدی; 20-Hydroxyvitamin D3; CYP3A4; Hydroxylation; Liver microsomes;
In vitro glucuronidation of methyl gallate and pentagalloyl glucopyranose by liver microsomes
Keywords: میکروسومهای کبدی; Methyl gallate; Pentagalloyl glucopyranose; Glucuronidation; Liver microsomes; β-glucuronidases; Methyl gallate (PubChem CID: 7428); Pentagalloyl glucopyranose (PubChem CID: 65238);
Identification and comparative oridonin metabolism in different species liver microsomes by using UPLC-Triple-TOF-MS/MS and PCA
Keywords: میکروسومهای کبدی; Oridonin; Metabolites; UPLC-Triple-TOF-MS/MS; Liver microsomes; In vitro
In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data
Keywords: میکروسومهای کبدی; BCA, Biochanin A; CYP, Cytochrome P450; FMN, Formononetin; Cmax, Maximum systemic concentration; SD, Sprague DawleyIsoflavones; liver microsomes; Cytochrome P450; Herb–drug interaction; Enzyme inhibition
Comparative metabolism of Lappaconitine in rat and human liver microsomes and in vivo of rat using ultra high-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry
Keywords: میکروسومهای کبدی; Lappaconitine; Metabolism; Liver microsomes; In vivo; UHPLC-Q/TOF-MS;
The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent
Keywords: میکروسومهای کبدی; Phospho-sulindac amide; Cytochrome P450; Liver microsomes; Hydroxylation; Sulfoxidation; CYP; cytochrome P450; FMO; flavin monooxygenase; HL; Mhuman liver microsomes; ML; Mmouse liver microsomes; PS; phospho-sulindac; PSA; phospho-sulindac amide;
CYP-dependent Metabolism of Antitumor Pyrazolo[3,4-d]pyrimidine Derivatives Is Characterized by an Oxidative Dechlorination Reaction
Keywords: میکروسومهای کبدی; anticancer agents; cytochrome P450; CYP3A4; liver microsomes; metabolite kinetics; metabolite identification
Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes
Keywords: میکروسومهای کبدی; TP; triptolide; TWHF; Tripterygium wilfordii Hook. F.; CYP; cytochrome P450; RLM; rat liver microsomes; SCRH; sandwich-cultured rat hepatocytes; LDH; lactate dehydrogenase; AST; aspartate transaminase; ALT; alanine aminotransferase; MDA; malondialdehyde;
Comparative metabolism study of β-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography-tandem mass spectrometry
Keywords: میکروسومهای کبدی; β-Lapachone; Comparative metabolism; Liver microsomes; LC-MS/MS;
Carbonyl reduction of triadimefon by human and rodent 11β-hydroxysteroid dehydrogenase 1
Keywords: میکروسومهای کبدی; Triadimefon; 11β-Hydroxysteroid dehydrogenase; Metabolism; Liver microsomes; Azole fungicide; Molecular docking;
Pivaloylcodeine, a new codeine derivative, for the inhibition of morphine glucuronidation. An in vitro study in the rat
Keywords: میکروسومهای کبدی; Codeine; Acetylcodeine; Pivaloylcodeine; Morphine-3-glucuronide; Liver microsomes; Glucuronidation;
Design, synthesis and biological evaluation of 2-substituted quinolines as potential antileishmanial agents
Keywords: میکروسومهای کبدی; 2-Substituted quinolines; Antileishmanial activity; Luciferase assay; Liver microsomes; Metabolic stability
Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture
Keywords: میکروسومهای کبدی; Danshen (Salvia miltiorrhiza Bunge); Tincture; CYP1A2 and 3A; Liver microsomes;
Characterization of the metabolism of sibiricaxanthone F and its aglycone in vitro by high performance liquid chromatography coupled with Q-trap mass spectrometry
Keywords: میکروسومهای کبدی; Sibiricaxanthone F; 1,3,6-Trihydroxy-2,7-dimethoxyxanthone; Metabolism; Intestinal bacteria; Liver microsomes; LC-MS/MS;
Xenobiotic metabolism of bank vole (Myodes glareolus) exposed to PCDDs
Keywords: میکروسومهای کبدی; Cytochrome P450; CYP; CYP1A; CYP2A; CYP2B; Liver microsomes; Dioxins; PCBs; Bank vole;
High performance liquid chromatography determination of cytochrome P450 1A and 2C activities in bovine liver microsomes
Keywords: میکروسومهای کبدی; EROD; TMH; HPLC; Bovine; Liver microsomes
Glucuronidation of racemic O-desmethyltramadol, the active metabolite of tramadol
Keywords: میکروسومهای کبدی; Tramadol; O-Desmethyltramadol; Glucuronidation; Intestinal microsomes; Liver microsomes; Stereoselectivity
Enzyme-assisted synthesis and structural characterization of pure benzodiazepine glucuronide epimers
Keywords: میکروسومهای کبدی; Enzyme-assisted synthesis; Benzodiazepines; Benzodiazepine glucuronides; Oxazepam; Temazepam; Lorazepam; Liver microsomes; UGT
The metabolism and N-oxide reduction of olaquindox in liver preparations of rats, pigs and chicken
Keywords: میکروسومهای کبدی; Olaquindox; Metabolism; N-Oxide reduction; Liver microsomes; Liver cytosol; Non-enzymatic reduction
Inhibition of acetylcholinesterase by metabolites of copper pyrithione (CuPT) and its possible involvement in vertebral deformity of a CuPT-exposed marine teleostean fish
Keywords: میکروسومهای کبدی; 2,2′-dipyridyldisulfide; 2,2′-dithiobispyridine-N-oxide; Antifouling biocide; Fundulus heteroclitus; In vitro metabolism; Liver microsomes; Thin-layer chromatography
Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides
Keywords: میکروسومهای کبدی; Clenbuterol; Glucuronidation; Koenigs–Knorr reaction; Liver microsomes; Stereoselectivity
Microsomal omega-hydroxylated metabolites of N-arachidonoyl dopamine are active at recombinant human TRPV1 receptors
Keywords: میکروسومهای کبدی; Lipid signaling; Mass spectrometry; Cytochrome P450; N-Arachidonoyl dopamine; Cannabinoid; Vanilloid; Liver microsomes; TRPV1; Hydroxylated metabolites;
Endotoxin causes functional endoplasmic reticulum failure, possibly mediated by mitochondria
Keywords: میکروسومهای کبدی; 2-DE; 2D electrophoresis; AIF; apoptosis inducing factor; ALT; alanine aminotransferase; ASS; argininosuccinate synthase; AST; aspartate aminotransferase; ATF6; activating transcription factor 6; BHT; 3,5-di-tert-butyl-4-hydroxytoluene; CPË; 3-carboxypro
Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead
Keywords: میکروسومهای کبدی; SAR; Itk inhibitor; Metabolic stability; Liver microsomes
In vivo and in vitro metabolism of lefucoxib in rats
Keywords: میکروسومهای کبدی; Lefucoxib; Metabolism; Rat; Liver microsomes; LC–MS; NMR
In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes
Keywords: میکروسومهای کبدی; Nemorubicin oxidative metabolism; PNU-159682; Liver microsomes; CYP3A enzymes; Sex-and species-related differences
Effect of treatment with cadmium on kinetic properties of Na+, K+-ATPase and glucose-6-phosphatase activity in rat liver microsomes: A correlative study on influence of lipid/phospholipid make-up
Keywords: میکروسومهای کبدی; Liver microsomes; Cadmium; Microsomal Na+; K+ ATPase; Microsomal G6Pase
Thin film voltammetry of metabolic enzymes in rat liver microsomes
Keywords: میکروسومهای کبدی; Liver microsomes; Thin film voltammetry; Kinetics; Cytochrome P450s; Oxidoreductases
Comparison of the inhibition effect of different anticoagulants on vitamin K epoxide reductase activity from warfarin-susceptible and resistant rat
Keywords: میکروسومهای کبدی; Vitamin K epoxide reductase; Liver microsomes; Warfarin resistance; Inhibition parameters; Chlorophacinone; Diphacinone; Bromadiolone; Difenacoum; Brodifacoum; Coumatetralyl; Coumachlor; Rattus norvegicus;
Species-specific testicular and hepatic microsomal metabolism of benzo(a)pyrene, an ubiquitous toxicant and endocrine disruptor
Keywords: میکروسومهای کبدی; Benzo(a)pyrene; Polycyclic aromatic hydrocarbons; Testicular microsomes; Liver microsomes; Metabolism; HPLC
Fatty acid composition and lipid peroxidation of soft-shelled turtle, Pelodiscus sinensis, fed different dietary lipid sources
Keywords: میکروسومهای کبدی; Fatty acid composition; Fish oil; Highly unsaturated fatty acids; Lard; Lipid peroxidation; Lipid source; Liver microsomes; Olive oil; Polar lipid; Soft-shelled turtle; Soybean oil
Both translocon and a cation channel are involved in the passive Ca2+ leak from the endoplasmic reticulum: A mechanistic study on rat liver microsomes
Keywords: میکروسومهای کبدی; Endoplasmic reticulum; Calcium leak; Translocon pore; Cation channels; Liver microsomes
Biotransformation of letrozole in rat liver microsomes: Effects of gender and tamoxifen
Keywords: میکروسومهای کبدی; Metabolism; Liver microsomes; Letrozole; Tamoxifen; Gender
The solubilisation pattern of lutein, zeaxanthin, canthaxanthin and β-carotene differ characteristically in liposomes, liver microsomes and retinal epithelial cells
Keywords: میکروسومهای کبدی; BC; β-carotene; BHT; Di-t-butyl-p-toluene; CTX; Canthaxanthin; DMEM; Dulbecco Modified Eagle Medium; DMF; Dimethyl formamide; EC; Effective concentration; EM; Emission; EtOH; Ethanol; EXC; Excitation; EYPC; Egg Yolk phosphatidylcholine; FCS; Fetal calf s
An in vitro microdialysis methodology to study 11β-hydroxysteroid dehydrogenase type 1 enzyme activity in liver microsomes
Keywords: میکروسومهای کبدی; Microdialysis; LC/MS/MS; 11β-HSD1; Cortisone; Cortisol; Stable-isotope-labeled; Liver microsomes; Metabolism; Enzyme
A streamlined method to predict hepatic clearance using human liver microsomes in the presence of human plasma
Keywords: میکروسومهای کبدی; Protein binding; Hepatic metabolism; Clearance; Liver microsomes; Scaling
Characterization of CYP1A enzyme in Adélie penguin liver
Keywords: میکروسومهای کبدی; Adélie penguin; Antarctica; CYP1A; P450; Drug metabolism; Liver microsomes; Environment; Pygoscelis adeliae
Determination of the 4-monohydroxy metabolites of perhexiline in human plasma, urine and liver microsomes by liquid chromatography
Keywords: میکروسومهای کبدی; HPLC; Liver microsomes; Metabolites; Perhexiline; Pharmacokinetics